• Molecules and Cells
• /
• 제39권6호
• /
• pp.508-513
• /
• 2016

To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1-${\beta}$ (IL-1-${\beta}$) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.

• Safety and Health at Work
• /
• 제14권4호
• /
• pp.398-405
• /
• 2023

Background: Starting from March 2020 until December 2021, different phases of Covid-19 pandemic have been identified in Italy, with several containing/lifting measures progressively enforced by the National government. In the present study, we investigate the change in occupational risk during the subsequent pandemic phases and we propose an estimate of the incidence of the cases by economic sector, based on the analysis of insurance claims for compensation for Covid-19. Methods: Covid-19 epidemiological data available for the general population and injury claims of workers covered by the Italian public insurance system in 2020-2021 were analyzed. Monthly Incidence Rate of Covid-19 compensation claims per 100,000 workers (MIRw) was calculated by the economic sector and compared with the same indicator for general population in different pandemic periods. Results: The distribution of Covid-19 MIRw by sector significantly changed during the pandemic related to both the strength of different waves and the mitigation/lifting strategies enforced. The level of occupational fraction was very high at the beginning phase of the pandemic, decreasing to 5% at the end of 2021. Healthcare and related services were continuously hit but the incidence was significantly decreasing in 2021 in all sectors, except for postal and courier activities in transportation and storage enterprises. Conclusion: The analysis of compensation claim data allowed to identify time trends for infection risk in different working sectors. The claim rates were highest for human health and social work activities but the distribution of risk among sectors was clearly influenced by the different stages of the pandemic.

• 한국응용곤충학회지
• /
• 제50권2호
• /
• pp.151-156
• /
• 2011

복분자딸기에서 차응애에 대한 경제적피해수준과 요방제수준을 평가하였다. 2008년 5월 7일 접종밀도(성충 0, 5, 10, 20, 40마리/주)에 따른 시기별 발생밀도는 무접종구를 제외하고는 6월 상순까지 점점 증가하다가 이후 감소하는 경향이었고, 접종밀도가 높을수록 더 크게 증가하였다. 차응애 접종밀도에 따른 수량은 접종밀도가 높을수록 감소하였고, 그에 따른 수량감소율은 접종밀도가 높아짐에 따라서 증가하였으며, 2009년 5월 8일 접종밀도(성충 0, 2, 5, 10, 20마리/주)에 따른 시기별 발생밀도와 수량 및 수량감소율도 2008년과 유사한 경향이었다. 차응애 접종밀도와 수량감소율과의 관계를 회귀식을 이용하여 분석한 결과는 2008년 Y = 0.6545X + 3.0425 ($R^2$ = 0.93), 2009년 Y = 0.9031X + 2.0899($R^2$ = 0.96)의 관계식을 얻을 수 있었다. 차응애 접종밀도별 수량감소율과의 관계식에 근거하여 GT값이 전체수량의 5%되는 수량감소율 (Y)을 추정해 보았을 때 복분자딸기에서 경제적피해수준(X)은 2008년 3.0마리/줄기, 2009년 3.2마리/줄기이었고, 요방제수준은 각각 2.4마리/줄기, 2.6마리/줄기이었다. 접종밀도와 방제적기로 고려되는 5월 중순 차응애 발생밀도와의 관계는 2008년 Y = 0.471X + 2.495($R^2$ = 0.95), 2009년 Y = 0.9938X + 3.1858($R^2$ = 0.96)로 회귀식이 성립되었으며, 회귀식에 의하면 복분자딸기 차응애 요방제수준(2008년 2.4마리/주, 2009년 2.6마리/주)에 따른 5월 중순 발생밀도는 각각 2008년 3.6마리/엽, 2009년 5.8마리/엽이었다.

• 한국농림기상학회지
• /
• 제25권3호
• /
• pp.142-150
• /
• 2023

기후온난화가 지속되면서 국내에도 열대거세미나방의 침입 시기가 빨라지고 유입량도 증가하여 작물에 대한 피해도 크게 증가하고 있는 실정이다. 본 연구는 열대거세미나방에 의한 작물의 피해를 최소화하고자 옥수수 포장에 요방제 수준을 통한 방제시기를 설정하고 사료용 옥수수 포장에서 약제 살포 방법에 따른 방제효과를 조사하였다. 옥수수 출사기에 피해율 4% 조건에서도 피해과율은 70%로 높은 피해 양상을 나타내었다. 열대거세미나방 2령 유충의 경제적 피해수준은 주당 0.7마리로 나타났으며, 요방제 수준은 0.6마리로 나타났다. 옥수수 도매 단가를 적용하여 소득을 산출한 결과, 피해율 4% 조건에서도 895,221원/10a 손실액이 났으며, 피해율이 높아질수록 소득 감소는 매우 큰 것으로 나타났다. 이를 방제하기 위하여 열대거세미나방에 등록된 단제 10종에 대해 살충효과를 검정한 결과, 4종 약제(에마멕틴벤조에이트, 클로란트라닐리프롤, 인독사카브, 스피네토람)에 대해 93.3% 이상의 높은 살충 활성을 나타내었으며, 약효 지속성 검정을 통해 3종 약제(클로란트라닐리프롤, 인독사카브, 스피네토람)에서 높은 잔류 효과로 열대거세미나방의 방제에 효과적인 것으로 생각된다. 따라서 열대거세미나방에 높은 활성을 나타내는 인독사카브 액상수화제, 클로란트라닐리프롤 입상수화제를 대상으로 사료용 옥수수의 출사 전에 관행방제와 항공방제를 각각 7일 간격으로 2회 실시하였다. 그 결과, 1차 방제를 통해 항공방제보다 관행방제에서 인독사카브 액상수화제 46.3%p, 클로란트라닐리프롤 입상수화제 21.7%p의 높은 방제가를 나타내었다. 2차 방제에서도 항공방제보다 관행방제에서 인독사카브 액상수화제 26.7%p, 클로란트라닐리프롤 입상수화제 40.4%p의 높은 방제가가 조사되었다. 이에 따라 인력방제 대체 수단을 많이 사용하는 최근 상황에서 방제 효과를 제고할 수 있는 방안 마련이 필요한 것으로 사료된다.

• 한국응용곤충학회지
• /
• 제21권3호
• /
• pp.163-166
• /
• 1982

The pine needle gall midge, Therodiplosis japonensis Uchida et Inouye, is the most important insect pest. It requires two different habitats for the development; on trees and under the ground. The habitat specific mortality rates ere $30\~40\%,\;and\;50\~60\%$ for the respective habitats. The key developmental stage is the prepupa, and the key mortality factor is the moisture contents of the soil and its variability. Since the insect is an exotic, the population status is the periphery and in the source of infestation are considerably different. Such a difference in habitats and the population status of the insect should be considered in relation to suppression of the insect. The control strategies should be directional and rational based on the reality of the pest status. There have been substantial information on the control methods of the pine needle gall midge, and each control method has an important place, but none has always provided a satisfactory solution to the many problems associated by this insect. These methods should be applied to a system based on the ecology of the insect. There should be continued support for directed effort on the development of operational management systems for the insect: specifically, estmation of the critical economic injury level, and of the absolute density of the insect.

• Clinics in Shoulder and Elbow
• /
• 제26권4호
• /
• pp.423-437
• /
• 2023

Background: Radiofrequency has seen an increase in use in orthopedics including cartilage lesion debridement in the hip and knee as well as many applications in arthroscopic shoulder surgery. The purpose of this systematic review is to evaluate the safety and usage of radiofrequency in the shoulder. Methods: This systematic review was registered with PROSPERO (international registry) and followed the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) guidelines. Embase and PubMed were searched using: "shoulder," "rotator cuff," "biceps," "acromion" AND "monopolar," "bipolar," "ablation," "coblation," and "radiofrequency ablation." The title and abstract review were performed independently. Any discrepancies were addressed through open discussion. Results: A total of 63 studies were included. Radiofrequency is currently utilized in impingement syndrome, fracture fixation, instability, nerve injury, adhesive capsulitis, postoperative stiffness, and rotator cuff disease. Adverse events, namely superficial burns, are limited to case reports and case series, with higher-level evidence demonstrating safe use when used below the temperature threshold. Bipolar radiofrequency may decrease operative time and decrease the cost per case. Conclusions: Shoulder radiofrequency has a wide scope of application in various shoulder pathologies. Shoulder radiofrequency is safe; however, requires practitioners to be cognizant of the potential for thermal burn injuries. Bipolar radiofrequency may represent a more efficacious and economic treatment modality. Safety precautions have been executed by institutions to cut down patient complications from shoulder radiofrequency. Future research is required to determine what measures can be taken to further minimize the risk of thermal burns.

• The Korean Journal of Pain
• /
• 제34권3호
• /
• pp.288-303
• /
• 2021

Background: Complex regional pain syndrome (CRPS) is an intractable pain disease with various symptoms. Here, we investigated the disease status, work life, sleep problems, medical insurance, economic status, psychological problems, and quality of life (QOL) of CRPS patients. Methods: CRPS patients from 37 university hospitals in South Korea were surveyed. The survey questionnaire consisted of 24 questions on the following aspects of CRPS patients: sex, age, occupation, cause of injury, activities of daily living (ADL), pain severity, sleep disturbance, level of education, economic status, therapeutic effect, and suicidal ideation. Additionally, the abbreviated World Health Organization Quality of Life (WHOQOL-BREF) questionnaire, consisting of 26 questions, was used to identify the status of QOL. Results: A total of 251 patients completed the questionnaire. According to the survey, 54.2% patients could not perform ADL on their own. Over the previous week, the mean pain score was 7.15 ± 1.78 (out of a total of 10 points); 92.1% of patients had sleep disorders and 80.5% had suicidal ideation, with most patients suffering from psychological problems. The average for each domain of WHOQOL-BREF was as follows: 21.74 ± 14.77 for physical, 25.22 ± 17.66 for psychological, 32.02 ± 22.36 for social relationship, and 30.69 ± 15.83 for environmental (out of a total of 100 points each). Occupation, ADL, sleep time, therapeutic effect, and suicidal ideation were statistically correlated with multiple domains. Conclusions: Most patients had moderate to severe pain, economic problems, limitations of their ADL, sleep problems, psychological problems, and a low QOL score.

• 한국응용곤충학회지
• /
• 제45권3호
• /
• pp.333-337
• /
• 2006

담배거세미나방에(Spodoptera litura)에 의한 콩의 피해해석을 하고자 콩 생육기 및 담배거세미나방 유충 밀도를 달리하여 조사한 결과 콩 생육시기별 유충 밀도에 따른 수량감소율과의 관계식은 개화기에는 (1) Y = 1.655X - 6.025 ($R^{2}=0.952$), 착협기에는 (2) Y = 0.725X - 0.475 ($R^{2}=0.986$), 립비대기에는 (3) Y = 0.635X - 1.325 ($R^{2}=0.986$)였다. 이 관계식을 근거로 하여 콩 생육시기별 피해허용수준(수량감소 5% 기준)을 산출한 결과, 주당 2-3령 유충의 밀도는 개화기6.7 마리, 착협기 7.5마리, 립비대기는 10.0마리였다. $28^{\circ}C$에서 1령, 2령, 3령, 4령, 5령 및 6령 유충의 1일 섭식량은 0.3, 0.7, 2.6, 4.0, 20.1 및 $55.8\;cm^{2}$ 이었다.

• 생물환경조절학회지
• /
• 제7권2호
• /
• pp.139-143
• /
• 1998

지중가온시설을 이용한 고구마뿌리혹선충(Meloidogyne incognita Chitwood) 방제를 위하여 지하 20cm 깊이의 최저지온을 각각 30. 40, $50^{\circ}C$ 가온구 및 관행의 무지중가온구로 설정하고 담수구와 무담수구로 나누어 8월 1일부터 8월 5일까지 5일간 가온한 결과, 담수구의 경우 지온 4$0^{\circ}C$에서 5일간, 무담수구의경우 지온 $50^{\circ}C$에 5일간 지중가온처리한 구에서 생존한 유충이 발견되지 않아 선충밀도를 경제적 피해수준 이하로 유지할 수 있을 것으로 사료되었다. 지중가온으로 토양내 OM. P$_2$ $O_{5}$, Ca, Mg함량과 EC는 시험전 토양에 비하여 감소하였는데, 특히 담수처리에서 EC가 현저히 저하하였다.

• 환경영향평가
• /
• 제27권1호
• /
• pp.33-55
• /
• 2018

생물다양성 감소의 가장 주요한 원인으로 외래생물의 유입이 지적되고 있으며, 특히 침입외래종으로 인한 서식지 파괴, 경제적 손실, 인체 피해 등이 가속화되고 있다. 국내에 유입된 외래생물은 2167종으로 생태계위해성평가를 통해 위해성이 높은 꽃매미(Lycorma delicatula), 붉은불개미(Solenopsis invicta), 뉴트리아(Myocastor coypus), 갯줄풀(Spartina alterniflora) 등 21종이 생태계교란 생물로 지정되어 있다. 국내에 유입될 경우 생태계에 부정적인 영향을 줄 수 있는 위해우려종은 생태계위해성심사를 통해 127종이 지정되어 있다. 이처럼 외래생물을 목록화하여 유입을 사전에 예방하고, 유입된 외래생물에 대한 피해를 최소화하기 위해 생물다양성 보전 및 이용에 관한 법률이라는 국가차원의 관리제도가 마련되었으나, 위험도에 따른 체계적인 관리체계 구축이 부족한 실정이며, 위해성 예측시 평가기준 및 분류군별 생태적 특성을 반영한 위해성평가표가 개발되어야 할 것이다.