• Korean Journal of Child Studies
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• v.27 no.2
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• pp.15-37
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• 2006

In this investigation of child's psychological wellbeing and parental satisfaction with dual income family(DIF), subjects were 297 3rd and 5th grade elementary school students and their mothers. Results showed that boys and younger children were more satisfied with mother's working than girls and older children. Mothers' DIF satisfaction was dependent on gross family income, parents' occupations, working conditions of each parent, commuter marriage status, and length of time in DIF. Child's psychological wellbeing related positively to mother's parental satisfaction, and to mother's satisfaction with parental roles, parent-child relationships, spouse support and child support. Only sub factors of dilemmas in parental role related negatively to DIF status. Child's satisfaction with mother's roles, father's roles, and mother working influenced mother's parental role satisfaction.

• Asia pacific journal of information systems
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• v.24 no.1
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• pp.1-29
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• 2014

To provide a fundamental understanding on the inherent relationship between IT capabilities and sustainable firm heterogeneity, we investigate the dual roles that institutional pressures play, namely, as antecedents of IT capabilities and as moderator of the relationship between IT capabilities and IT innovation success, where IT innovation success plays a mediating role between IT capabilities and firm performance. The structural model was tested, and the results of the PLS analysis provided general support for the proposed hypotheses. IT capabilities had an indirect effect mediated by IT innovation success on firm performance. With IT activities assumed to be embedded in the institutional context, the dual roles of institutional pressures are verified. This study contributes to the literature on IT capabilities by considering both the determining role of institutional pressures on IT capabilities and the institutional context of the chain that connects IT capabilities to firm performance. The results suggest that a firm not only manages various institutional pressures to foster its IT capabilities but also adapts to different contexts with a certain level of institutional pressures to facilitate its IT capabilities and outperform its competitors, which could be sustained through IT innovation success.

• Journal of Families and Better Life
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• v.26 no.6
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• pp.143-158
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• 2008

The purpose of the study was to investigate the wife and husband role division in household financial management between dual-income household and single-income household. Household financial management included the following five categories: financial planning, consumption/expenditure management, savings/investment management, risk management and credit management. Data for this research was collected through 610 married women living in Seoul, Korea. Using SAS-PC program, Chi-square and t-test Analyses were executed. The results showed that dual- and single-income households tend to have different perspectives on marital role division in household management. Wives of dual-income households had more significant roles in financial management rather than wives of single income households. Especially, wives of dual-income managed more active credit management and saving/investment management. On the other hand, wives of single-income households played a major role in making decision over cheap items than that of wives of dual-income household.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.453-468
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• 2016

There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The inhibitors that target each of topo II and Hsp90 are intensively studied as anti-cancer drugs since they play very important roles in cell proliferation and survival. Therefore the development of dual targeting anti-cancer drugs for topo II and Hsp90 is suggested to be a promising area. The topo II and Hsp90 inhibitors, known to bind to their ATP binding site, were searched. All the inhibitors investigated were docked to both topo II and Hsp90. Four candidate compounds as possible dual inhibitors were selected by analyzing the molecular docking study. The pharmacophore model of dual inhibitors for topo II and Hsp90 were generated and the design of novel dual inhibitor was proposed.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8019-8026
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• 2014

The promyelocytic leukemia (PML) gene is a gene known to be a tumor suppressor, although recent data suggest that it has a dual function in tumorigenesis. It was initially discovered in acute promyelocytic leukemia (APL) in which a t(15; 17) chromosomal translocation fused it to the retinoic acid receptor alpha ($RAR{\alpha}$). It has been shown to be involved in various types of cancer. It has at least 6 nuclear isoforms and a cytoplasmic type with different characteristics. Its multiple functions in growth inhibition, apoptosis induction, replicative senescence, inhibition of oncogenic transformation, and suppression of migration and angiogenesis have made it a therapeutic target for cancer therapy. However, its dual role in the process of tumorigenesis has made this field challenging. In this review, we discuss PML structure, functions and expression in tumors.

• The Journal of Information Systems
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• v.26 no.1
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• pp.125-142
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• 2017

This study aims to identify and analyze the roles of incumbent smartphone's brand loyalty in smartphone adoption considering rational judgments and aesthetics evaluation. For this purpose, two hypotheses are developed based on dual process theory. For the validation of these hypotheses, G4, a smartphone brand from LG, was adopted as the target smartphone. The participants were university students in Korea, non-LG smartphones. In result, two hypotheses were statistically supported. This study showed that users with higher brand loyalty toward incumbent smartphone would be more sensitive to rational judgment while lower brand loyalty more sensitive to aesthetic evaluation.

• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.503-511
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• 2020

Autophagy is a major catabolic process that maintains cell metabolism by degrading damaged organelles and other dysfunctional proteins via the lysosome. Abnormal regulation of this process has been known to be involved in the progression of pathophysiological diseases, such as cancer and neurodegenerative disorders. Although the mechanisms for the regulation of autophagic pathways are relatively well known, the precise regulation of this pathway in the treatment of cancer remains largely unknown. It is still complicated whether the regulation of autophagy is beneficial in improving cancer. Many studies have demonstrated that autophagy plays a dual role in cancer by suppressing the growth of tumors or the progression of cancer development, which seems to be dependent on unknown characteristics of various cancer types. This review summarizes the key targets involved in autophagy and malignant transformation. In addition, the opposing tumor-suppressive and oncogenic roles of autophagy in cancer, as well as potential clinical therapeutics utilizing either regulators of autophagy or combinatorial therapeutics with anti-cancer drugs have been discussed.

• Journal of Construction Engineering and Project Management
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• v.2 no.2
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• pp.28-35
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• 2012

Critical to project success is effective stakeholder management. This paper presents a challenge for the project manager who uses traditional approaches to manage mid-level stakeholders in an organization. Dual roles of a mid-level stakeholder (as a stakeholder of a project and as an agent of the corporate) may cause problems that would result in difficulties for project managers in identifying the stakeholder's attributes and overcoming hierarchical authority expectation. However, the dual roles of the stakeholder result in its weakness in the project-stakeholder relationship. Can a project leverage its strategic role for effective upward influence by linking project objectives to corporate strategic objectives? To address this research question, case study method was used to gain a deeper understanding of mid-level stakeholder's salience. This research proposes an upward influence strategy to embed a project-stakeholder relationship in a hierarchical stakeholder network.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.455-461
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• 2016

Galectins are ${\beta}$-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.

• Korean Journal of Human Ecology
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• v.18 no.2
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• pp.301-311
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• 2009

This study focused on the traits of variables related to parenthood, family strengths and perceptions of future parent's roles. The subjects were the 409 middle school students in Gwangju. Using structured questionnaire surveyed between 2007. 6. 20 and 2007. 6. 26. Data were analyzed with Frequency, Percentage, Mean, Std, Cronbach's ${\alpha}$, T-test, Chi-Square, ANOVA, and Duncan's test using SPSS/PC WIN 14.0 program. The major findings were as follows: 1. When asked if you married, most students replied "yes", and childbirth plan replied "yes". The 78.2 percent of schoolgirls and 74.6 percent of schoolboys responded that responsibility of bringing up children was man and wife. The most important Parental meaning was 'fosterer'. The middle school students' family strengths scores were higher than median(3.00). Over all, the perceptions of future parent's roles were high. 2. Perceptions of future parent's roles showed partially significant difference according to the most important Parental meaning, responsibility of bringing up children, intimacy with parent, dual-income family, and family strengths.