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http://dx.doi.org/10.7314/APJCP.2016.17.2.455

Roles of Galectin-7 in Cancer  

Kaur, Manpreet (Department of Human Genetics, Guru Nanak Dev University)
Kaur, Tarnjeet (Department of Human Genetics, Guru Nanak Dev University)
Kamboj, Sukhdev Singh (Department of Molecular Biology and Biochemistry, Guru Nanak Dev University)
Singh, Jatinder (Department of Molecular Biology and Biochemistry, Guru Nanak Dev University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.2, 2016 , pp. 455-461 More about this Journal
Abstract
Galectins are ${\beta}$-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.
Keywords
Carcinoma; galectin; lectin; lymphoma; Metastasis;
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