Asian Pacific Journal of Cancer Prevention

  • 제17권2호
  • /
  • Pages.455-461
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  • 2016
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Roles of Galectin-7 in Cancer

  • Kaur, Manpreet (Department of Human Genetics, Guru Nanak Dev University) ;
  • Kaur, Tarnjeet (Department of Human Genetics, Guru Nanak Dev University) ;
  • Kamboj, Sukhdev Singh (Department of Molecular Biology and Biochemistry, Guru Nanak Dev University) ;
  • Singh, Jatinder (Department of Molecular Biology and Biochemistry, Guru Nanak Dev University)
  • 발행 : 2016.03.07
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초록

Galectins are ${\beta}$-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.

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참고문헌

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피인용 문헌

  1. Galectin-7 in Epithelial Homeostasis and Carcinomas vol.18, pp.12, 2017, https://doi.org/10.3390/ijms18122760
  2. Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives vol.19, pp.1, 2018, https://doi.org/10.3390/ijms19010210
  3. Serum Galectin 7 is Not Useful to Predict Abortion in the First Trimester vol.37, pp.3, 2018, https://doi.org/10.1080/15513815.2018.1453001