• Journal of Nutrition and Health
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• 제55권2호
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• pp.250-262
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• 2022

Purpose: Elevated iodine intake is related to a higher prevalence of subclinical hypothyroidism (SCH). We investigated the short-term effect of dietary iodine restriction on thyroid function in patients with SCH with high iodine intakes. Methods: The iodine levels in 64 SCH patients with serum TSH levels from 4.0 to 10.0 mIU/L and normal serum fT4 levels (n = 64) were assessed using 24-hour urine iodine test results and iodine intake levels calculated using a semi-quantitative food frequency questionnaire. Dietary iodine restriction was not recommended for patients with an iodine intake in the normal range (group A, n = 13), but seaweed restriction was recommended for patients with high iodine intakes (group B, n = 33). Thyroid functions and iodine levels were rechecked after three months. Another eighteen patients were prescribed thyroid hormone replacement therapy according to clinical criteria. Results: Median baseline iodine intake for the 64 patients was 290.61 ㎍/day, and median 24-hour urine iodine was 33.65 µmol/g of creatinine. The major source of dietary iodine was seaweed, which accounted for 72.2% of median baseline intake. Urine iodine and calculated iodine intake levels were positively correlated with serum TSH levels (p < 0.001 and p = 0.027, respectively), and calculated iodine intakes were significantly correlated with urine iodine levels (p = 0.001). In group B, iodine restriction significantly decreased urine iodine (p = 0.042) and TSH levels (p = 0.004), and conversion to euthyroid status was achieved in 16 of the 33 patients (48.5%). Conclusion: Iodine intake and urine iodine levels are correlated with thyroid function in SCH patients, and dietary iodine restriction can aid functional thyroid recovery in patients with elevated iodine intakes.

• Journal of Nutrition and Health
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• 제50권1호
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• pp.64-73
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• 2017

본 연구는 국가적으로 시행된 대규모 국민건강영양조사 자료를 이용하여 나트륨 섭취량과 비만과의 연관성을 알아보기 위하여 나트륨 섭취량을 5그룹 (2,000 mg 미만, 2,000 mg 이상~4,000 mg 미만, 4,000 mg 이상~6,000 mg 미만, 6,000 mg 이상~8,000 mg 미만, 8,000 mg 이상)으로 분류하여 비만과의 연관성을 분석하였다. 연구대상자의 성별에 따른 일반적인 특징에서 신장과 체중, 체질량지수(BMI), 총 에너지섭취량은 남성이 여성보다 유의적으로 높게 확인되었고, 질병관련 변수에서 비만, 고혈압, 당뇨병, 뇌졸중 유병률 또한 남성이 여성보다 유의적으로 높은 값을 보였다. 성별에 따른 교육수준 (p < 0.001), 흡연여부 (p < 0.001), 음주여부 (p < 0.001)에서도 유의한 차이가 확인되었다. 나트륨 섭취량에 따른 신체계측치 및 건강관련 습관에 대해 분석한 결과, 전체 대상자에서 나트륨 섭취량이 증가할수록 신장, 체중, BMI, 총에너지섭취량이 유의적으로 높아지는 것을 확인할 수 있었으며, 남성과 여성에서도 같은 결과를 보였다. 비만, 고콜레스테롤혈증과 고중성지방혈증 유병률은 나트륨 섭취량이 높아짐에 따라 증가하는 경향을 보였고, 남성에서도 유사한 결과가 나타났다. 나트륨 섭취량에 따른 교육수준, 걷기실천율, 흡연여부, 음주여부에서도 유의한 차이가 확인되었다. 성별에 따른 나트륨 섭취량이 비만 유병에 미치는 영향을 교란변수 보정 전후로 비교하여 분석한 결과, 전체 대상자에서는 나트륨섭취량이 증가할수록 2,000 mg 미만 섭취자 대비 비만의 오즈비가 증가하였으며, 남성의 경우 4,000 mg 이상 섭취자부터 유의한 OR값을 보였다. 성별, 나이, 연도, 에너지밀도, 교육수준, 흡연여부, 음주여부, 만성질환 유병여부, 신체활동을 보정하였을 때, 4,000~6,000 mg 섭취그룹 및 8,000 mg 이상 섭취그룹이 2,000 mg 미만 섭취자보다 비만 유병위험이 높게 나타났으며, 남성은 8,000 mg 이상 섭취그룹에서, 여성은 4,000~6,000 mg 섭취자 그룹에서 각각 비만의 유의한 오즈비를 나타내었다.

• 대한영양사협회학술지
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• 제11권1호
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• pp.114-124
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• 2005

The nutritional status of pre-school children is important for both physical growth and functional development. This study investigated the anthropometric, nutrient intakes and dietary quality of the pre-school children living in Asan for planning nutritional education program. The dietary intakes were measured by 2-day 24 hr recall recorded by children's mothers and the anthropometric data were collected by measuring children's weights, heights, and percent body fat at Asan Public Health Center. The children were 161 boys and 129 girls aged 5 and 6 years. When children's nutritional status was determined by their anthropometric status (underweight, normal weight and overweight) determined by z-score (normal range between -1.00 and 1.00), only 1.4% of the children belonged to underweight group while 55.7% and 42.9% belonged to normal and overweight groups, respectively. Significantly higher number of children belonged to overweight group for 5 year-olds. No differences were observed in nutrient intakes, nutrient adequacy ratio (NAR) and index of nutritional quality (INQ) values among nutritional status groups. Intakes of the most nutrients were adequate, but NAR and INQ of calcium and zinc were low. When nutrient intakes, NAR and INQ were compared by sex or age, all nutrient intakes were appropriate except calcium and zinc intakes of 6 year-olds. Nutrient intakes of 5 years were higher than those of 6 years. The mean of nutrient adequacy ratio (MAR) was 0.85 and mean INQ was 1.51 for all participants. The nutritional management program for pre-school children in Asan would be directed differently by age groups and education material should contain contents educating to consume moderate amount of food for 5 year-olds and to increase intake of foods with mineral nutrients such as calcium and zinc for 6 year-olds.

• 한국식품영양과학회지
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• 제28권2호
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• pp.464-470
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• 1999

The purpose of this study was to investigate the effect of zinc intake on immune responses in high fat diet induced obese rats. The immune status was assessed by the measurements of immunoglobulins (IgG, A, and M) production by SRBC(sheep red blood cell) with mitogen in vivo. The delayed type hypersensitivity(DTH) response was also measured as an index of cell mediated immunity. The re sults are summarized as follows : 1) There were no significant differences in the feed intake, weight gain and feed efficiency ratio of obese rats by the different dietary zinc levels. 2) White blood cell (WBC) counts were significantly affected as the dietary zinc levels decreased. The capacity of Ig M production in obese rats was significantly higher in normal zinc group than that of low and high zinc group. Cell mediated immune response evaluated by means of DTH testing has also been found to be highly impaired by zinc deficiency and overload. From these observations, it was suggested that adequate levels of zinc may promote the immune function of obese individuals. The relationship and its functional role of the zinc in obesity remains to be further studied.

• 동아시아식생활학회지
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• 제24권5호
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• pp.604-613
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• 2014

This study was carried out to investigate consumption patterns of health functional foods (HFF) and analyze their related factors in male workers in order to provide basic data for appropriate understanding and optimal use of HFF. The subjects were 325 shipbuilding workers aged 20~50 in the Geoje area. About 84% of subjects reported that they were currently consuming or had experience of consuming HFF. The most commonly used type of HFF was vitamins (53.5%), followed by red ginseng (28.9%) and vegetable extract (15.4%). The major reasons for consuming and not-consuming HFF were 'to recovery from fatigue' (49.5%) and 'can not trust the effects' (39.4%), respectively. The intake period was 'less than 3 months' (35.5%), average monthly expense was 'less than 50,000 won' (49.1%), and purchase place was 'store of health functional foods' (32.2%) as the most common answers. The effects after consuming HFF were 'moderate' (51.3%) as the most common answer, and 16.1% of subjects experienced side effects, such as diarrhea, indigestion and nausea. Contributing factors for selecting and desire for future use of HFF were 'effectiveness' (52.2%) and 'when necessary' (67.8%) as the most common answers. Experience of using HFF was positively correlated with age (p<0.05), marital status (p<0.05), unbalanced diet (p<0.01), concern about health (p<0.05), and fear for disease (p<0.05). Purchase of HFF was positively correlated with fear of disease (p<0.01), whereas it was negatively correlated with frequency of exercise (p<0.05). The desire for future use of HFF was positively correlated with concern about health (p<0.05), fear of disease (p<0.01) and drinking (p<0.05). In conclusion, factors affecting consumption patterns of health functional foods (HFF) were age, marital status, unbalanced diet, concern about health, fear of disease and drinking.

• 한국식품영양과학회지
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• 제43권7호
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• pp.1112-1121
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• 2014

본 연구는 대도시 폐경기 중년 여성의 건강기능성식품에 대한 인지도 및 섭취 실태를 파악하여 향후 폐경기 전후 여성들을 위해 필요한 정보 제공 및 교육에 기초 자료를 제공하고자 실시되었으며 중요한 연구 결과는 다음과 같다. 폐경기 전후 중년 여성들은 자신의 건강 상태를 비교적 양호한 것으로 지각하고 있으며, 폐경 및 건강기능성식품에 대한 인식문항에서는 임신가능성 여부 및 폐경기 증상에 대해서는 높은 지식수준을 보였지만 폐경의 정의 및 건강 관련 사항에 대해서는 대부분 잘 모르는 것으로 나타났다. 또한 건강기능성식품에 대한 지식의 정답률은 48.7%로 지식수준이 높지 않은 것으로 나타났다. 그러나 건강기능성식품을 구매 또는 섭취한 경험이 있는 사람은 83.7%로 나타났고 구입처는 타인의 소개(35.0%)와 약국 병원(27.8%)이 가장 많았으며 건강기능성식품의 주요 섭취 이유는 질병 예방(29.6%), 영양소 보충(20.3%), 피로 회복(16.0%) 순으로 나타났다. 본 연구의 조사대상자인 폐경기 전후의 중년 여성들은 건강기능성식품을 구매할 때 효과를 가장 중요하게 생각하고 있으며, 일반 건강기능성식품의 경우 구매 또는 섭취한 경험이 있는 사람이 83.7%로 높게 나타났지만 폐경기 증상 완화를 위한 건강기능성식품의 경우 구입한 경험이 없는 대상자가 65.9%로 더 많았다. 또한 섭취한 건강기능성식품의 성분을 조금 알고 있는 대상자(56.4%)가 가장 많았고 모르는 대상자(25.5%)가 그 뒤를 이어 건강기능의 성분에 대한 지식이 매우 부족한 것으로 나타났다. 그러나 건강관심도에 따라서 건강기능식품의 구매빈도 및 섭취빈도, 폐경기 증상 완화를 위한 건강기능성식품 구매 및 섭취 여부에 유의한 차이를 보였다. 또한 폐경 증상 완화를 위해 콩 제품에 대한 인지도가 가장 높았으며 실제 섭취도 가장 많이 하는 것으로 나타났다. 폐경기 전후의 중년 여성들을 대상으로 실시한 본 연구 결과를 종합해 보면 이제는 사회에서 폐경을 맞는 여성들을 대상으로 교육을 실시하여 폐경에 대한 정확한 정보를 전달하고 폐경 후의 생활을 건강하게 보낼 수 있도록 정보제공 및 교육적 지원이 필요한 것으로 사료된다.

• 한국식품영양학회지
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• 제27권5호
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• pp.940-955
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• 2014

The purpose of this study was to compare the degree nutrient intake, health status and other characteristics of females aged 65 years and over in a longevity area according to family arrangement. For analysis, 585 female elderly were recruited from the Kugoksoondam area (Kurye, Goksung, Soonchang and Damyang counties), known as the longevity-belt region in Jeonla province, Korea. The subjects were categorized into three groups according to family arrangement (living alone, living with spouse only and living with family). Demographic characteristics were collected, as well as information on physical measurements, blood tests for biochemical indicators, health status and health-related life style, dietary behavior, favorite food groups, consumption frequency of food groups, nutrient intake and mini nutrition assessment. In the group living with their spouse only, the highest education, physical activity, diverse food intake, frequency of eating meats and fish, energy and nutrients intake, and score on the mininutrient status assessment (MNA) were found to be significantly favorable factors. Taken together, these results demonstrated that the group living with their spouse only had relatively superior nutrient intake and the quality of diet. In contrast, the group living alone showed the lowest self-rated economic status, diversity of food intake, and physical activity, with the highest frequency of drinking, smoking and regular exercise for almost everyday compared with the other groups. On the other hand, those living with family demonstrated the lowest intake of supplements or functional foods, and levels of hemoglobin hematocrit MCH, but the highest HBA1c and blood sugar. Therefore, the group living with family was assumed to be at risk of anemia and diabetes. These results could be useful to plan effective strategies to increase the health-life expectancy of Korean elderly people living in rural areas, according to family arrangement.

• 대한영양사협회학술지
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• 제18권1호
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• pp.16-29
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• 2012

The purpose of this study was to investigate the changes in nutritional status of gastrectomy patients. The anthropometric and biochemical data were measured at pre-operation, at discharge, 1 month after discharge, and 3 months after discharge. Nutrient intake levels, nutrients adequacy ratio (NAR), mean adequacy ratio (MAR), and the proportion of patients with intake levels inferior to those of dietary reference intakes (DRIs) were analyzed at discharge, 1 month after discharge, and 3 months after discharge. Finally, the data on 23 patients (15 male and 8 female) were collected and used for statistical analysis. Fifteen patients underwent subtotal gastrectomy, and 8 patients underwent total gastrectomy. Compared to pre-operation, body weight and body mass index of subjects significantly decreased at discharge, 1 month after discharge, and 3 months after discharge (P<0.001). Serum albumin (P<0.001), total lympocyte count (P<0.001), total cholesterol (P<0.001), hemoglobin (P<0.001), hematocrit (P<0.001), and mean corpuscular hemoglobin concentration (P<0.05) were significantly different between pre-operation, at discharge, 1 month after discharge, and 3 months after discharge. The proportions of patients with lower nutrient intake levels than DRIs were substantial. MAR at discharge, 1 month after discharge, and 3 months after discharge were 0.70, 0.80 and 0.91, respectively. Especially, the NARs of folate, niacin, vitamin $B_2$, vitamin C, and zinc were all low. Considering the various nutritional problems of gastrectomy patients, systematic medical nutrition therapy is needed after gastrectomy.

• Journal of Nutrition and Health
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• 제55권1호
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• pp.1-9
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• 2022

In the past few decades, great progress has been made on understanding the interaction between nutrition and health status. But despite this wealth of knowledge, health problems related to nutrition continue to increase. This leads us to postulate that the continuing trend may result from a lack of consideration for intra-individual biological variation on dietary responses. Precision nutrition utilizes personal information such as age, gender, lifestyle, diet intake, environmental exposure, genetic variants, microbiome, and epigenetics to provide better dietary advices and interventions. Recent technological advances in the artificial intelligence, big data analytics, cloud computing, and machine learning, have made it possible to process data on a scale and in ways that were previously impossible. A big data platform is built by collecting numerous parameters such as meal features, medical metadata, lifestyle variation, genome diversity and microbiome composition. Sophisticated techniques based on machine learning algorithm can be used to integrate and interpret multiple factors and provide dietary guidance at a personalized or stratified level. The development of a suitable machine learning algorithm would make it possible to suggest a personalized diet or functional food based on analysis of intra-individual metabolic variation. This novel precision nutrition might become one of the most exciting and promising approaches of improving health conditions, especially in the context of non-communicable disease prevention.

• BMB Reports
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• 제45권11호
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• pp.671-676
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• 2012

Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our results demonstrate that CR induced an increase in protein carbonylation in the heart without changing the content of sulfhydryl groups or the activities of superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney. Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney.