• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.14 no.2
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• pp.69-76
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• 2018

The paper presents preliminary investigation results for the effect of the baseline correction in the acceleration excitation method on finite element seismic analysis results (such as accumulated equivalent plastic strain, equivalent plastic strain considering cyclic plasticity, von Mises effective stress, etc) of nuclear safety Class I components. For investigation, finite element elastic-plastic time-history seismic analysis is performed for a surge line including a pressurizer lower head, a pressurizer surge nozzle, a surge piping, and a hot leg surge nozzle using the Chaboche hardening model. Analysis is performed for various seismic loading methods such as acceleration excitation methods with and without the baseline correction, and a displacement excitation method. Comparing finite element analysis results, the effect of the baseline correction is investigated. As a result of the investigation, it is identified that finite element analysis results using the three methods do not show significant difference.

• Transactions of Materials Processing
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• v.15 no.9 s.90
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• pp.667-672
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• 2006

Agglutination is one of the most commonly employed reactions in clinical diagnosis. In this paper, we have designed and fabricated nickel mold insert for injection molding of a microfluidic lab-on-a-chip for the purpose of the efficient detection of agglutination. In the presented microfluidic lab-on-a-chip, two inlets for sample blood and reagent, flow guiding microchannels, improved serpentine laminating micromixer(ISLM) and reaction microwells are fully integrated. The ISLM, recently developed by our group, can highly improve mixing of the sample blood and reagent in the microchannel, thereby enhancing reaction of agglutinogens and agglutinins. The reaction microwell was designed to contain large volume of about $25{\mu}l$ of the mixture of sample blood and reagent. The result of agglutination in the reaction microwell could be determined by means of the level of the light transmission. To achieve the cost-effectiveness, the microfluidic lab-on-a-chip was realized by the injection molding of COC(cyclic olefin copolymer) and thermal bonding of two injection molded COC substrates. To define microfeatures in the microfluidic lab-on-a-chip precisely, the nickel mold inserts of lab-on-a-chip for the injection molding were fabricated by combining the UV photolithography with a negative photoresist SU-8 and the nickel electroplating process. The microfluidic lab-on-a-chip developed in this study could be applied to various clinical diagnosis based on agglutination.

• Steel and Composite Structures
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• v.34 no.6
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• pp.891-907
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• 2020

Many studies reveal that during destructive earthquakes, most of the structures enter the inelastic phase. The amount of hysteretic energy in a structure is considered as an important criterion in structure design and an important indicator for the degree of its damage or vulnerability. The hysteretic energy value wasted after the structure yields is the most important component of the energy equation that affects the structures system damage thereof. Controlling this value of energy leads to controlling the structure behavior. Here, for the first time, the hysteretic behavior and energy dissipation capacity are assessed at presence of elliptical braced resisting frames (ELBRFs), through an experimental study and numerical analysis of FEM. The ELBRFs are of lateral load systems, when located in the middle bay of the frame and connected properly to the beams and columns, in addition to improving the structural behavior, do not have the problem of architectural space in the bracing systems. The energy dissipation capacity is assessed in four frames of small single-story single-bay ELBRFs at ½ scale with different accessories, and compared with SMRF and X-bracing systems. The frames are analyzed through a nonlinear FEM and a quasi-static cyclic loading. The performance features here consist of hysteresis behavior, plasticity factor, energy dissipation, resistance and stiffness variation, shear strength and Von-Mises stress distribution. The test results indicate that the good behavior of the elliptical bracing resisting frame improves strength, stiffness, ductility and dissipated energy capacity in a significant manner.

• Journal of the Society of Naval Architects of Korea
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• v.30 no.4
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• pp.136-152
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• 1993

This study is intended to develop an accurate and efficient, analytical thin-walled beam model, and to analyze overall behavior of SWATH ship under repeated overloads. SWATH ship is idealized to a simple thin-walled beam of channel type. An analytical beam model is formulated by the stress component with geometrically(fully) nonlinear thin-walled beam and treated numerically by the Finite Element Method. An efficient cyclic plasticity model is also included, suitable for material nonlinear behavior under complex loading conditions. The local stress distribution can be very exactly represented and the material yielding propagation, easily traced. In addition, the local treatment of the effect of shear deformation improves the representation of deformation and shear stress distribution along the section contour. It is desirable to use the analytical thin-walled beam at initial design stage, and is needed to improve the practical thin-walled beam model advancing the current approach.

• Advances in materials Research
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• v.3 no.3
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• pp.163-174
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• 2014

In this study, fatigue properties and crack growth characteristics of a polycarbonate (PC) were examined during cyclic loading at various mean stress (${\sigma}_{amp}$) and stress amplitude (${\sigma}_{mean}$) conditions. Different S vs. N and da/dN vs. ${\Delta}K$ relations were obtained depending on the loading condition. The higher fatigue strength and the higher resistance of crack growth are seen for the PC samples cyclically loaded at the higher mean stress and lower stress amplitude due to the low crack driving force. Non-linear S - N relationship was detected in the examination of the fatigue properties with changing the mean stress. This is attributed to the different crack growth rate (longer fatigue life): the sample loaded at the high mean stress with lower stress amplitude. Even if the higher stress amplitude, the low fatigue properties are obtained for the sample loaded at the higher mean stress. This was due to the accumulated strain energy to the sample, where severe plastic deformation occurs instead of crack growth (plasticity-induced crack closure). Shear bands and discontinuous crack growth band (DGB) are observed clearly on the fracture surfaces of the sample cyclically loaded at the high stress amplitude, where the lower the ${\sigma}_{mean}$, the narrower the shear band and DGB. On the other hand, final fracture occurred instantly immediately after the short crack growth occurs in the PC sample loaded at the high mean with the low ${\sigma}_{amp}$, i.e., tear fracture, in which the shear bands and DGB are not seen clearly.

• Steel and Composite Structures
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• v.37 no.2
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• pp.175-191
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• 2020

In this article, for the first time, the seismic behavior of elliptic-braced moment resisting frame (ELBRF) is assessed through a laboratory program and numerical analyses of FEM specifically focused on the development of global- and local-type failure mechanisms. The ELBRF as a new lateral braced system, when installed in the middle bay of the frames in the facade of a building, not only causes no problem to the opening space of the facade, but also improves the structural behavior. Quantitative and qualitative investigations were pursued to find out how elliptic braces would affect the failure mechanism of ELBRF structures exposed to seismic action as a nonlinear process. To this aim, an experimental test of a ½ scale single-story single-bay ELBRF specimen under cyclic quasi-static loading was run and the results were compared with those for X-bracing, knee-bracing, K-bracing, and diamond-bracing systems in a story base model. Nonlinear FEM analyses were carried out to evaluate failure mechanism, yield order of components, distribution of plasticity, degradation of structural nonlinear stiffness, distribution of internal forces, and energy dissipation capacity. The test results indicated that the yield of elliptic braces would delay the failure mode of adjacent elliptic columns and thus, help tolerate a significant nonlinear deformation to the point of ultimate failure. Symmetrical behavior, high energy absorption, appropriate stiffness, and high ductility in comparison with the conventional systems are some of the advantages of the proposed system.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2A
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• pp.233-242
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• 2008

This study presents a non-prismatic beam element for modeling the elastic and inelastic behavior of steel beams, which have the post-Northridge(cover plate) connections in steel moment frames that are subjected to earthquake ground motions. The elastic stiffness matrix for non-prismatric members with increased beam section (IBS) connection is in the closed-form. The plasticity model is of a discrete type and is composed of a series of nonlinear hinges connected by rigid links. The hardening rules can model the inelastic behavior for monotonic and random cyclic loading, and the effects of local buckling. Moreover the determination of yield surfaces, stiffness parameters, and hardening (or softening) rule parameters for IBS beam element were described. Analytical results of the IBS beam element show good correlation with test data and FEM results.

• Earthquakes and Structures
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• v.25 no.1
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• pp.27-41
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• 2023

This study focused on nonlinear effective stress site response analysis using two coupled constitutive models, that is, the DM model (Dafalias and Manzari 2004), which incorporated a simple plasticity sand model accounting for fabric change effects, and the PMDY03 model (Khosravifar et al. 2018), that is, a 3D model for earthquake-induced liquefaction triggering and postliquefaction response. A detailed parametric study was conducted to validate the effectiveness of nonlinear site response analysis and porewater pressure (PWP) generation through a true coupled formulation for assessing the initiation of liquefaction at ground level. The coupled models demonstrated accurate prediction of liquefaction triggering, which was in line with established empirical liquefaction triggering relations in published databases. Several limitations were identified in the evaluation of liquefaction using the cyclic stress method, despite its widespread implementation for calculating liquefaction triggering. Variations in shear stiffness, represented by changes in shear wave velocity (Vs1), exerted the most significant influence on site response. The study further indicated that substantial differences in response spectra between nonlinear total stress and nonlinear effective stress analyses primarily occurred when liquefaction was triggered or on the verge of being triggered, as shown by excess PWP ratios approaching unity. These differences diminished when liquefaction occurred towards the later stages of intense shaking. The soil response was predominantly influenced by the higher stiffness values present prior to liquefaction. A key contribution of this study was to validate the criteria used to assess the triggering of level-ground liquefaction using true coupled effective-stress constitutive models, while also confirming the reliability of numerical approximations including the PDMY03 and DM models. These models effectively captured the principal characteristics of liquefaction observed in field tests and laboratory experiments.

• Korean Journal of Biological Psychiatry
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• v.16 no.1
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• pp.5-14
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• 2009

Objectives : Most of the mechanisms reported for antidepressant drugs are the enhancement of neurite outgrowth and neuronal survival in the rat hippocampus. Neural cell adhesion molecule 140(NCAM140) has been implicated as having a role in cell-cell adhesion, neurite outgrowth, and synaptic plasticity. In this report, we have performed to elucidate a correlation among chronic antidepressant treatments, NCAM140 expression, and activation of phosphorylated cyclicAMP responsive element binding protein(pCREB) which is a downstream molecule of NCAM140-mediated intracellular signaling pathway in the rat hippocampus. Methods : Fluoxetine(10mg/kg) was injected acutely(daily injection for 5days) or chronically(daily injection for 14days) in adult rats. RNA and protein were extracted from the rat hippocampus, respectively. Real-time RT-PCR was performed to analyze the expression pattern of NCAM140 gene and western blot analyses for the activation of the phosphorylation ratio of CREB. Results : Chronic fluoxetine treatments increased NCAM140 expression 1.3 times higher than control in rat hippocampus. pCREB immunoreactivity in the rat hippocampus with chronic fluoxetine treatment was increased 4.0 times higher than that of control. Conclusion : Chronic fluoxetine treatment increased NCAM140 expression and pCREB activity in the rat hippocampus. Our data suggest that NCAM140 and pCREB may play a role in the clinical efficacy of antidepressants promoting the neurite outgrowth and neuronal survival.