• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.10
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• pp.239-244
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• 2013

This paper presents a design of the CMOS LDO regulator with a UVLO protection function for a high speed PMIC. Proposed LDO regulator circuit consists of a BGR reference circuit, an error amplifier and a power transistor and so on. UVLO block between the power transistor and the power supply is added for a low input protection function. Also, UVLO block showed normal operation with turn-off voltage of 2.7V and turn-on voltage of 4 V in condition of 5 V power supply. Proposed circuit generated fixed 3.3 V from a supply of 5V. From SPICE simulation results using a $1{\mu}m$ high voltage CMOS technology, simulation results were 5.88 mV/V line regulation and 27.5 uV/mA load regulation with load current 0 mA to 200 mA.

• Journal of Microbiology
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• v.43 no.spc1
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• pp.110-117
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• 2005

Salmonella enterica serovar Typhimurium causes human gastroenteritis and a systemic typhoid-like infection in mice. A critical virulence determinant of Salmonella is the ability to invade mammalian cells. The expression of genes required for invasion is tightly regulated by environmental conditions and a variety of regulatory genes. The hilA regulator encodes an OmpR/ToxR family transcriptional regulator that activates the expression of invasion genes in response to both environmental and genetic regulatory factors. Work from several laboratories has highlighted that regulation of hilA expression is a key point for controlling expression of the invasive phenotype. A number of positive regulators of hilA expression have been identified including csrAB, sirA/barA, pstS, hilC/sirC/sprA, fis, and hilD. HilD, an AraC/XylS type transcriptional regulator, is of particular importance as a mutation in hilD results in a 14-fold decrease in chromosomal hilA::Tn5lacZY-080 expression and a 53-fold decrease in invasion of HEp-2 cells. It is believed that HilD directly regulates hilA expression as it has been shown to bind to hilA promoter sequences. In addition, our research group, and others, have identified genes (hilE, hha, pag, and lon) that negatively affect hilA transcription. HilE appears to be an important Salmonella-specific regulator that plays a critical role in inactivating hilA expression. Recent work in our lab has been directed at understanding how environmental signals that affect hilA expression may be processed through a hilE pathway to modulate expression of hilA and the invasive phenotype. The current understanding of this complex regulatory system is reviewed.

• Journal of Power Electronics
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• v.14 no.2
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• pp.217-225
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• 2014

This paper deals with the optimization of the driving techniques for the ZVT synchronous buck converter proposed in [1]. Two new gate drive circuits are proposed to allow this converter to operate by only one control signal as a 12V voltage regulator module (VRM). Voltage-driven method is applied for the synchronous rectifier. In addition, the control signal drives the main and auxiliary switches by one driving circuit. Both of the circuits are supplied by the input voltage. As a result, no supply voltage is required. This approach decreases both the complexity and cost in converter hardware implementation and is suitable for practical applications. In addition, the proposed SR driving scheme can also be used for many high frequency resonant converters and some high frequency discontinuous current mode PWM circuits. The ZVT synchronous buck converter with new gate drive circuits is analyzed and the presented experimental results confirm the theoretical analysis.

• Journal of Power Electronics
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• v.14 no.6
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• pp.1217-1223
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• 2014

A novel half load-cycle worked dual input single output (DISO) DC/AC inverter is presented. The basic circuit consists of a dual buck regulator, which works in continuous current mode. The working principle of DISO DC/AC inverter has been used. The control method applied for half load-cycle worked DISO DC/AC inverter has been studied. The control effects of the open-loop proportional control and closed-loop proportional-integral control are compared by using PSIM software. The parameters are adopted in the realistic simulation and experiment test. Moreover, the waveforms, such as voltage of modulation reference signal and output voltage, were given. The simulation and experiment results proved that the half load-cycle worked DISO DC/AC inverter could achieve good performance, gain a line frequency of 50 Hz, and verify the correctness of theoretical analysis.

• 제어로봇시스템학회:학술대회논문집
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• 1989.10a
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• pp.877-880
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• 1989

Described is a DC voltage regulator of new type where an optical fiber is used as a sense line to transmit the PFM signal, which represents the load voltage and its change, from the load to the controller so as to make the equivalent sense-line length short. The prototype version provides a load voltage change rate of 2.3% over the current range of 0A to 5A at 15V DC, with an output impedance of 0.06ohm.

• Proceedings of the KIEE Conference
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• 1999.11b
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• pp.364-368
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• 1999

This paper suggests switching regulator technique to overcome the drawback of conventional variable linear power supply. Switching regulator technique can eliminate the extremely lossy operation and reduce the size and weight of variable linear power supply and provide nearly constant output power over the majority of output voltage range. The topology of variable switched mode power supply is employed active clamp forward converter with a current doubler rectifier and by using control of variable-frequency together with control of fixed-frequency, output voltage can be controled. Equivalent circuits pertinent to each operational mode of converter are derived, and an experimental 20V, 50A converter was designed and built. The converter operates from an output voltage of zero to 25 V, under 100 kHz switching frequency.

• Transactions on Electrical and Electronic Materials
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• v.11 no.4
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• pp.178-181
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• 2010

An automotive IC voltage regulator which consists of one-chip based on a metal-oxide semiconductor field effect transistor (MOSFET) is investigated experimentally with three types of packaging. The closed type is filled with thermal silicone gel and covered with a plastic lid on the MOSFET. The half-closed type is covered with a plastic case but without thermal silicone gel on the MOSFET. Opened type is no lid without thermal silicone gel. In order to simulate the high temperature condition in engine bay, the operating circuit of the MOSFET is constructed and the surrounding temperature is maintained at $100^{\circ}C$. In the overshoot the maximum was mainly found at the half-closed packaging and the magnitude is dependent on the packaging type and the surrounding temperature. Also the impressed current decreased exponentially during the MOSFET operation.

• Molecules and Cells
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• v.46 no.1
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• pp.10-20
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• 2023

Antisense oligonucleotide (ASO) technology has become an attractive therapeutic modality for various diseases, including Mendelian disorders. ASOs can modulate the expression of a target gene by promoting mRNA degradation or changing pre-mRNA splicing, nonsense-mediated mRNA decay, or translation. Advances in medicinal chemistry and a deeper understanding of post-transcriptional mechanisms have led to the approval of several ASO drugs for diseases that had long lacked therapeutic options. For instance, an ASO drug called nusinersen became the first approved drug for spinal muscular atrophy, improving survival and the overall disease course. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Although Trikafta and other CFTR-modulation therapies benefit most CF patients, there is a significant unmet therapeutic need for a subset of CF patients. In this review, we introduce ASO therapies and their mechanisms of action, describe the opportunities and challenges for ASO therapeutics for CF, and discuss the current state and prospects of ASO therapies for CF.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.21 no.3
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• pp.96-106
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• 2007

The terminal voltage of a synchronous generator is maintained by the field current control of excitation system. Generally AC/DC converter which is component of AVR(Automatic Voltage Regulator) system for excitation current control is connected to diode rectifier and DC/DC converter system. In the case of diode rectifier system of phase controlled converter as AC/DC converter have low power factor and harmonics of lower order in the line current. In this paper, two stage three phase PWM AC/DC converter is studied to solve these problems. The characteristics of a proposed converter reduces the harmonics and reactive power of the distribution line and has fast dynamic response in transient period using boost converter and current control mode buck converts. The proposed method is verified by the computer simulation and experimental results in prototype generation system.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.12
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• pp.63-70
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• 2013

This paper describes a high PSRR low-dropout(LDO) linear regulator for wide frequency range without output-capacitor. Owing to both of the cascode compensation technique and the current buffer compensation technique in nested Miller compensation loop, the proposed LDO not only maintaines high stability but also achieves high PSRR over wide frequency range with reasonable on-chip capacitances. Since the external capacitor is removed by the proposed compensation techniques, the cost for pad is eliminated. The designed LDO works under the input voltage range from 2.5V to 4.5V and provides up to 10mA load current with the output voltage of 1.8V. The LDO was implemented with 0.18um CMOS technology and the area is 300um X 120 um. The measured power supply rejection ratio(PSRR) is -76dB and -43dB at DC and 1MHz, respectively. The operating current is 25uA.