• Title/Summary/Keyword: cross-regulation

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Proposals for New Regulations Concerning Consumer ADR and ODR and their Implications in the EU (EU의 소비자 ADR 및 ODR에 관한 새로운 규정 논의와 국내에의 시사점)

  • Son, Hyun
    • Journal of Arbitration Studies
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    • v.23 no.1
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    • pp.107-131
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    • 2013
  • Online-ADR (Alternative Dispute Resolution) has been receiving attention from the international community as a means of alternative dispute resolution for consumer disputes in both small and mass international e-commerce. The EU Parliament and the Council proposed the Online Dispute Resolution Regulation for Consumer Disputes (hereafter, "EU Consumer ODR Regulation") and the Directive on Alternative Dispute Resolution of Consumer Disputes (hereafter, "EU Consumer ADR Directive") as a legislative package, now scheduled to be adopted. Those efforts strengthen consumer protection by enhancing ODR in international e-commerce and improving of the functions of the e-commerce market. The EU Consumer ADR and ODR regulation package will operate in conjunction with the ODR platform as a single point across Europe, abandoning the ADR system of each member. Consumers and traders who need dispute resolution apply on the EU ODR platform linked website, and the applications are distributed to individual ADR institutions in accordance with the Rules and Procedure of ADR institutions in the respective country. Although there has been partial progress in Korea for ODR programs such as the establishment of the Online Administrative Trial and the procedures of individual ADR agencies operating through the website, existing norms do not fully support the system. At this point, we see many implications of the EU Consumer ADR and ODR regulation package on the direction chosen for domestic ADR and ODR policy and legislation. This study introduces the main features and content of the EU Consumer ADR Directive (draft) and ODR Regulation provisions, and describes the direction of domestic policy and legislation regarding Online-ADR.

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A Study on DEM-based Automatic Calculation of Earthwork Volume for BIM Application

  • Cho, Sun Il;Lim, Jae Hyoung;Lim, Soo Bong;Yun, Hee Cheon
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.38 no.2
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    • pp.131-140
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    • 2020
  • Recently the importance of BIM (Building Information Modeling) that enables 3D location-based design and construction work is being highlighted around the world. In Korea, the road map has been established to settle the design based on BIM using drone survey results by 2025. As the first step, BIM would be applied to road construction projects worth more than 50 billion Korean Won from 2020. On the other hand, drone survey regulation has been enacted and the data for drone survey cost were also included on Standard of construction estimate in 2020. However, more careful improvement is required to reflect drone survey results in BIM design and construction. Currently, Engineering instructions and Standard of construction estimate specifies that earthwork volume must be calculated by cross section method only. So it is required to add the method of DEM (Digital Elevation Model) based volume calculation on these regulations to realize BIM application. In order for that, this study verified the method of DEM based earthwork volume calculation. To get an accurate DEM for accurate volume computation, drone survey was carried out according to the drone survey regulation and then could get an accurate DEM data which have errors less than 3cm in X, Y and 6.8cm in H. As each DEM cell has 3D coordinate component, the volume of each cell can be calculated by obtaining the height of area of the cell then total volume is calculated by multiplying total number of cells by volume of each cell for the construction area. Verification for the new calculation method compare with existing method was carried out. The difference between DEM based volume by drone survey and cross section based volume by traditional survey was less than 1.33% and it can be seen that new DEM method will be able to be applied to BIM design and construction instead of cross section method.

A Fermented Ginseng Extract, BST204, Inhibits Proliferation and Motility of Human Colon Cancer Cells

  • Park, Jong-Woo;Lee, Jae-Cheol;Ann, So-Ra;Seo, Dong-Wan;Choi, Wahn-Soo;Yoo, Young-Hyo;Park, Sun-Kyu;Choi, Jung-Young;Um, Sung-Hee;Ahn, Seong-Hoon;Han, Jeung-Whan
    • Biomolecules & Therapeutics
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    • v.19 no.2
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    • pp.211-217
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    • 2011
  • Panax ginseng CA Meyer, a herb from the Araliaceae, has traditionally been used as a medicinal plant in Asian countries. Ginseng extract fermented by ginsenoside-${\beta}$-glucosidase treatment is enriched in ginsenosides such as Rh2 and Rg3. Here we show that a fermented ginseng extract, BST204, has anti-proliferative and anti-invasive effects on HT-29 human colon cancer cells. Treatment of HT-29 cells with BST204 induced cell cycle arrest at $G_1$ phase without progression to apoptosis. This cell cycle arrest was accompanied by up-regulation of tumor suppressor proteins, p53 and p21$^{WAF1/Cip1}$, down-regulation of the cyclin-dependent kinase/cyclins, Cdk2, cyclin E, and cyclin D1 involved in $G_1$ or $G_1/S$ transition, and decrease in the phosphorylated form of retinoblastoma protein. In addition, BST204 suppressed the migration of HT-29 cells induced by 12-O-tetradecanoylphorbol-13-acetate, which correlated with the inhibition of metalloproteinase-9 activity and extracellular signal-regulated kinase activity. The effects of BST204 on the proliferation and the invasiveness of HT-29 cells were similar to those of Rh2. Taken together, the results suggest that fermentation of ginseng extract with ginsenoside-${\beta}$-glucosidase enhanced the anti-proliferative and the anti-invasive activity against human colon cancer cells and these anti-tumor effects of BST204 might be mediated in part by enriched Rh2.

Design of Single-Inductor Dual-Output Boost-Boost DC-DC Converter with Dual Feedback Loop Based on Relative Sawtooth Generator (Dead-time을 갖는 톱니파 발생기를 이용한 이중 피드백 루프 기반 단일 인덕터 이중 출력 승압형 변압기 설계)

  • Yun, Dam;Kim, Dong-Young;Lee, Kang-Yoon
    • Journal of IKEEE
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    • v.18 no.2
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    • pp.220-227
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    • 2014
  • This paper presents a control method of Single-Inductor Dual-Output DC-DC Converter using Common mode feedback and differential feedback loops. To generate duty used for differential mode feedback loop, this paper propose relative sawtooth circuit using current divider circuit which makes ramp signal with variable dead-time. Two outputs of the Single-Inductor Dual-Output DC-DC Converter are specified for 2.8 V and 4.2 V with input voltage 2.5 V. The maximum conversion efficiency of designed SIDO DC-DC Converter is 95% at total output power of 539mW. Cross regulations of Boost1 and Boost2 are 3.57% and 4% each, when increasing twice times output current.

The Cross-talk Mechanisms of Constitutive Androstane Receptor (CAR) in the Regulation of its Activity, Energy Metabolism, Cellular Proliferation and Apoptosis (Constitutive Androstane Receptor (CAR)의 활성, 에너지 대사 및 세포의 증식과 사멸의 조절에 대한 CAR의 cross-talk 기전)

  • Min, Gyesik
    • Journal of Life Science
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    • v.30 no.2
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    • pp.211-220
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    • 2020
  • The activity of CAR can be regulated not only by ligand binding but also by phosphorylation of regulatory factors involved in extracellular signaling pathways, cross-talk interactions with transcription factors, and the recruitment, degradation, and expression of coactivators and corepressors. This regulation of CAR activity can in turn have effects on the control of diverse physiological homeostasis, including xenobiotic and energy metabolism, cellular proliferation, and apoptosis. CAR is phosphorylated by the ERK1/2 signaling pathway, which causes formation of a complex with Hsp-90 and CCRP, leading to its cytoplasmic retention, whereas phenobarbital inhibits ERK1/2, which causes dephosphorylation of the downstream signaling molecules, leading to the recruitment to CAR of the activated RACK-1/PP2A components for the dephosphorylation, nuclear translocation, and the transcriptional activation of CAR. Activated CAR cross-talks with FoxO1 to induce inhibition of its transcriptional activity and with PGC-1α to induce protein degradation by ubiquitination, resulting in the transcriptional suppression of PEPCK and G6Pase involved in gluconeogenesis. Regulation by CAR of lipid synthesis and oxidation is achieved by its functional cross-talks, respectively, with PPARγ through the degradation of PGC-1α to inhibit expression of the lipogenic genes and with PPARα through either the suppression of CPT-1 expression or the interaction with PGC-1α each to induce tissue-specific inhibition or stimulation of β-oxidation. Whereas CAR stimulates cellular proliferation by suppressing p21 expression through the inhibition of FoxO1 transcriptional activity and inducing cyclin D1 expression, it suppresses apoptosis by inhibiting the activities of MKK7 and JNK-1 through the expression of GADD45B. In conclusion, CAR is involved in the maintenance of homeostasis by regulating not only xenobiotic metabolism but also energy metabolism, cellular proliferation, and apoptosis through diverse cross-talk interactions with extracellular signaling pathways and intracellular regulatory factors.

The Status, Problem and Improvement Method for Cross-ownership between Agency and Production (매니지먼트사와 외주제작사간 상호겸영 실태와 문제점 및 개선 방안)

  • Kim, Jeong-Seob
    • The Journal of the Korea Contents Association
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    • v.16 no.12
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    • pp.60-69
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    • 2016
  • Korean management agency and production's size is bigger than ever applying diversification strategy since the Korean Wave started in 2000. Thus, the cross-ownership between two sectors is widespread and it's side effect such as unfair trading occurred among them. Came up with this problem, this study has focused on the analysis of the cross-ownership status of the entire Korean listed agencies and productions and the quest of the alternatives to solve the problem through in-depth interviews of the stakeholders and experts. Results showed that the horizontal regulation and American regulatory systems should be applied considering the previous law because the cross-ownership level was so high. In conclusion, it was proposed three regulatory models as follows : first, accept the cross-ownership and prohibit casting their contracted actors in their art, second, ban on the cross-ownership and allow mutual investment within a 10 to 20 percent stake, third, blanket ban on the cross-ownership and investment.

Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review

  • Kim, Minseong;Jho, Eek-hoon
    • BMB Reports
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    • v.47 no.10
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    • pp.540-545
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    • 2014
  • Balanced cell growth is crucial in animal development as well as tissue homeostasis. Concerted cross-regulation of multiple signaling pathways is essential for those purposes, and the dysregulation of signaling may lead to a variety of human diseases such as cancer. The time-honored Wnt/${\beta}$-catenin and recently identified Hippo signaling pathways are evolutionarily conserved in both Drosophila and mammals, and are generally considered as having positive and negative roles in cell proliferation, respectively. While most mainstream regulators of the Wnt/${\beta}$-catenin signaling pathway have been fairly well identified, the regulators of the Hippo pathway need to be more defined. The Hippo pathway controls organ size primarily by regulating cell contact inhibition. Recently, several cross-regulations occurring between the Wnt/${\beta}$-catenin and Hippo signaling pathways were determined through biochemical and genetic approaches. In the present mini-review, we mainly discuss the signal transduction mechanism of the Hippo signaling pathway, along with cross-talk between the regulators of the Wnt/${\beta}$-catenin and Hippo signaling pathways.

Influence of Interpersonal Problems on Sleep Quality in College Students: The Mediating Role of Mental Health and Moderated Mediating Role of Cognitive Emotional Regulation (대학생의 대인관계 문제가 수면의 질에 미치는 영향 : 정신건강의 매개효과와 인지적 정서조절전략의 조절된 매개효과)

  • Won, Mi Hwa;Shin, Sun-Hwa
    • Journal of the Korea Convergence Society
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    • v.10 no.12
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    • pp.525-534
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    • 2019
  • The purpose of this convergence study was to evaluate the influence of interpersonal problems on sleep quality in college students and to analyze the mediating role of mental health and the moderated mediating role of emotional regulation. This was a cross-sectional study of 307 students at a college in Seoul. The results of hierarchical linear regression showed that interpersonal problems and mental health were statistically significant predictors of sleep quality in college students. A mediation analysis further revealed that students' mental health mediates the relationship between interpersonal problems and sleep quality. Additionally, there was a moderated mediating role of dysfunctional emotional regulation in this process. Our findings suggest that supportive and adaptive cognitive emotional regulation educational programs should be designed based on college students' maladaptive emotional regulation experiences and individual characteristics.

The Evaluation on EU′s Info-Communication Regulatory Policy in Preparation for Media Convergence (미디어 융합에 대응한 EU의 통신규제정책에 대한 평가)

  • Kim Pang-Ryong
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.11B
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    • pp.1001-1011
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    • 2004
  • The structure of info-communications industry has been changing from vertical integration to horizontal layered disintegration as the Internet technology has been rapidly developed. Considering with this background, EU has decided to introduce new regulatory framework called 2003 framework and asked member states to shift to new framework by July 2003. The key words of the new framework is to be denoted by the following three characteristics: Introduction of cross-media regulatory framework Alleviation of entry regulation by general authorization, Transition from ex ante regulation to ex post regulation.

The Prediction of Allowable Limit Distance about Human Body by Vibration Regulation (진동 규제기준에 따른 인체의 허용 한계거리 예측)

  • Song, Jeong-Un;Hong, Woong-Ki;Kim, Seung-Kon
    • Journal of Environmental Impact Assessment
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    • v.21 no.2
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    • pp.289-296
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    • 2012
  • The shock vibration such as machine vibration, blasting vibration etc. has effect on nearby structure as well as human body. The purpose of this study is to predict allowable limit distance of vibration about human body. First of all, vibration velocity such as PPV, PVS was measured by shock vibration experiment, and vibration level was calculated by conversion formula of vibration velocity. And then, allowable limit distance was analyzed by converted vibration level. The results are as follows : Firstly, the correlation coefficient of converted vibration level was over R=0.94, and vibration level caused by PVS was usually represented to high curve line. Secondly, the cross point of vibration level between ground and concrete condition was represented to 66.68dB(V), and allowable limit distance was represented to difference over three times when vibration regulation was raised from 65dB(V) to 80dB(V).