• Annals of Clinical Neurophysiology
• /
• v.15 no.2
• /
• pp.37-41
• /
• 2013

Saccades are rapid eye movements that shift the line of sight between successive points of fixation. The cerebellum calibrates saccadic amplitude (dorsal vermis and fastigial nucleus) and the saccadic pulse-step match (flocculus) for optimal visuo-ocular motor behavior. Based on electrophysiology and the pharmacological inactivation studies, early activity in one fastigial nucleus could be important for accelerating the eyes at the beginning of a saccade, and the later activity in the other fastigial nucleus could be critical for stopping the eye on target, which is controlled by inhibitory projection from the dorsal vermis. The cerebellum could monitor a corollary discharge of the saccadic command and terminate the eye movement when it is calculated to be on target. The fastigial nucleus and dorsal vermis also participate in the adaptive control of saccadic accuracy.

• Journal of Integrative Natural Science
• /
• v.9 no.3
• /
• pp.185-189
• /
• 2016

Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. The crystal structure of Urotension-2 receptor has not yet been resolved. Hence, in the current study homology modelling of UTS2R was done utilizing the crystal structure of human delta opioid receptor as the template. Since the template has low sequence identity, we have incorporated both comparative modelling and threading approach to generate the three dimensional structure. 10 models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of UTS2R.

• Molecules and Cells
• /
• v.43 no.3
• /
• pp.203-214
• /
• 2020

Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.7 no.8
• /
• pp.1840-1847
• /
• 2003

In this paper, we have developed the MHDA scheme for data association. This scheme is important in providing a computationally feasible alternative to complete enumeration of JPDA which is intractable. We have proved that given an artificial measurement and track's configuration, MHDA scheme converges to a proper plot in a finite number of iterations. Also, a proper plot which is not the global solution can be corrected by re­initializing one or more times. In this light, even if the performance is enhanced by using the MHDA, we also note that the difficulty in tuning the parameters of the MHDA is critical aspect of this scheme. The difficulty cat however, be overcome by developing suitable automatic instruments that will iteratively verify convergence as the network parameters vary.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.14 no.6
• /
• pp.1138-1143
• /
• 2011

One of the critical items in radar testing is the ability to evaluate the performance of radar systems under real operational environments. But it takes lots of time and cost to operate real targets and analyze the test results due to a large amount of data based on these complicated environments. In this paper, the Radar Simulative T&E Lab. is introduced, and the test and analysis results of the developing radar for predicting the radar system performance are described in the Radar Simulative T&E Lab. This laboratory could be used to test the far-field characteristics of antenna radiation pattern and to perform an effective radar system test and evaluation using a simulative target generator under a low cost repeating test situation.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2013.10a
• /
• pp.769-772
• /
• 2013

When developing engine mount, interm mount bracket 1st resonance is critical to make sound quality better or worse. So, at the initial stage of development, we need to consider some design parameter to setup the target of interm bracket 1st resonance. Especially, 3cylinder interm bracket guideline is not well known. So, this paper deals with some important sensitivity which should be considered during the development of vehicle. From source to interior side, we should know the component sensitivity like body sensitivity p/F or bracket gain etc. Through this paper, we could get the knowledge of design guideline and key consideration points.

• Molecules and Cells
• /
• v.37 no.3
• /
• pp.196-201
• /
• 2014

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by the vascular remodeling of the pulmonary arterioles, including formation of plexiform and concentric lesions comprised of proliferative vascular cells. Clinically, PAH leads to increased pulmonary arterial pressure and subsequent right ventricular failure. Existing therapies have improved the outcome but mortality still remains exceedingly high. There is emerging evidence that the seven-transmembrane G-protein coupled receptor APJ and its cognate endogenous ligand apelin are important in the maintenance of pulmonary vascular homeostasis through the targeting of critical mediators, such as Kr$\ddot{u}$ppel-like factor 2 (KLF2), endothelial nitric oxide synthase (eNOS), and microRNAs (miRNAs). Disruption of this pathway plays a major part in the pathogenesis of PAH. Given its role in the maintenance of pulmonary vascular homeostasis, the apelin-APJ pathway is a potential target for PAH therapy. This review highlights the current state in the understanding of the apelin-APJ axis related to PAH and discusses the therapeutic potential of this signaling pathway as a novel paradigm of PAH therapy.

• Electronics and Telecommunications Trends
• /
• v.36 no.5
• /
• pp.21-31
• /
• 2021

Ransomware attacks, such as Conti, Ryuk, Petya, and Sodinokibi, that target medical institutions are increasing rapidly. In 2020, in the United States., ransomware attacks affected over 600 separate clinics, hospitals, and organizations, and more than 18 million patient records. The cost of these attacks is estimated to be almost $21 billion USD. The first death associated with a ransomware attack was reported in 2020 by the University Hospital of Düesseldorf in Germany. In the case of medical institutions, as introduced in the Medjack report issued by TrapX Labs, in many cases, attackers target medical devices that are relatively insecure and then penetrate deep into more critical network infrastructure, such as EMR servers. This paper introduces security vulnerabilities of hospital medical devices, considerations for ransomware response by medical institutions, and related technology trends.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.34 no.1
• /
• pp.33-38
• /
• 2021

Using facing target magnetron sputtering (FTMS) with a graphite target source, carbon nitride thin films were deposited on silicon and glass substrates at different substrate temperatures to confirm the tribological, electrical, and structural properties of thin films. The substrate temperatures were room temperature, 150℃, and 300℃. The tribology and electrical properties of the carbon nitride thin films were measured as the substrate temperature increased, and a study on the relation between these results and structural properties was conducted. The results show that the increase in the substrate temperature during the fabrication of the carbon nitride thin films increased the hardness and elastic modulus values, the critical load value was increased, and the residual stress value was reduced. Moreover, the increase in the substrate temperature during thin-film deposition was attributed to the improvement in the electrical properties of carbon nitride thin film.

• IMMUNE NETWORK
• /
• v.16 no.4
• /
• pp.201-210
• /
• 2016

Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.