[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.13160/ricns.2016.9.3.185

Homology Modelling of Urotension-2 Receptor (UTS2R): Potential Target for Human Pharmacotherapy

B, Sathya. (Department of Genetic Engineering, School of Bioengineering, SRM University)

Publication Information

Journal of Integrative Natural Science / v.9, no.3, 2016 , pp. 185-189 More about this Journal

Abstract

Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. The crystal structure of Urotension-2 receptor has not yet been resolved. Hence, in the current study homology modelling of UTS2R was done utilizing the crystal structure of human delta opioid receptor as the template. Since the template has low sequence identity, we have incorporated both comparative modelling and threading approach to generate the three dimensional structure. 10 models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of UTS2R.

Keywords

UTS2R; Homology Modelling; Threading;

Citations & Related Records

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