• Genomics & Informatics
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• 제21권3호
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• pp.28.1-28.13
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• 2023

Mild cognitive impairment (MCI) is a clinical syndrome characterized by the onset and evolution of cognitive impairments, often considered a transitional stage to Alzheimer's disease (AD). The genetic traits of MCI patients who experience a rapid progression to AD can enhance early diagnosis capabilities and facilitate drug discovery for AD. While a genome-wide association study (GWAS) is a standard tool for identifying single nucleotide polymorphisms (SNPs) related to a disease, it fails to detect SNPs with small effect sizes due to stringent control for multiple testing. Additionally, the method does not consider the group structures of SNPs, such as genes or linkage disequilibrium blocks, which can provide valuable insights into the genetic architecture. To address the limitations, we propose a Bayesian bi-level variable selection method that detects SNPs associated with time of conversion from MCI to AD. Our approach integrates group inclusion indicators into an accelerated failure time model to identify important SNP groups. Additionally, we employ data augmentation techniques to impute censored time values using a predictive posterior. We adapt Dirichlet-Laplace shrinkage priors to incorporate the group structure for SNP-level variable selection. In the simulation study, our method outperformed other competing methods regarding variable selection. The analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) data revealed several genes directly or indirectly related to AD, whereas a classical GWAS did not identify any significant SNPs.

• 유통과학연구
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• 제12권6호
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• pp.67-79
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• 2014

Purpose - This study aims to accomplish three major research goals. First, it strives to change consumers' focus from peripheral routes to a central route of public service advertising related to the good health policy, without problematic effects, by influencing consumers' knowledge or involvement. Second, this study examines the elaboration likelihood model (ELM) and construal level theory (CLT). Specifically, we consider that the central route of ELM might correspond with the focal goal of CLT. Third, this study analyzes ELM through CLT. That is, ELM predicted that low involvement would take the peripheral route, and high involvement would take the central route. Research design, data, and methodology - This study consisted of three experiments. The first experiment had a 2×2 between-subject design. The subjects were university students and the research period was approximately one year. The first independent variable was the involvement of the overweight issue; this variable was measured and split by the median. The second independent variable was the temporal distance (near vs. distant future); this variable was manipulated. The second experiment also had a 2×2 between-subject design. The first variable was the involvement of cervical adenocarcinoma prevention, and was considered already manipulated by sex. Specifically, males had a low involvement of the disease, but females had high involvement. The second independent variable was priming (power vs. submissive). Power priming would induce abstract thinking, but submissive priming would take concrete processing. The third experiment had a 2×2×2 between-subject design. The first variable was cognitive depletion, and was manipulated by memorizing 9-digit numbers. The second and third independent variables were involvement and abstract thinking induction, such as prior experiments. Data were collected through questionnaires, and were analyzed by an SPSS program. Major hypotheses were tested by examining the interaction effects through ANOVA. Results - Major findings are as follows. First, even for low-involved consumers in the overweight category, distant future manipulation induced them to focus not on the peripheral route but on the central route of the public service advertisement. This result does not correspond to the typical ELM prediction. Second, under power priming, low-involved males of the cervical adenocarcinoma category focused on the peripheral route because of the induction to abstract thinking. This result replicated the first experiment, and confirmed the theoretical robustness. Third, high-involved females focused not on the central but on the peripheral route under the mixed condition of cognitive depletion and near future manipulation. Depletion consumed cognitive resources, and the processing mode of consumers changed from systematic to heuristic. Conclusions - ELM needs to be complemented through CLT in context of public service good health advertising. Specifically, the involvement of ELM may impact consumers' thinking mode (abstract vs. concrete), and the interaction effects may influence consumers' focus on advertising (central vs. peripheral route). This study's limitations were bounded subjects, limited stimuli, and somewhat weak external validity.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제7권2호
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• pp.233-246
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• 1996

성인의 스트레스에 관해서는 많은 연구가 존재하지만, 청소년의 스트레스에 관해서는 포괄적인 연구가 아직 부족한 단계이다. 성인과는 다른 발달과업을 가지고 있고, 더구나 학교라는 구조적 환경 내에서 생활의 대부분을 보내기 때문에. 청소년의 스트레스에 관한 연구는 더욱 필요하다. 따라서, 본 연구에서는 청소년들이 현재 느끼는 스트레스의 종류와, 그에 대한 대처 행동의 기제를 경험적 조사를 통해서 알아보고자 하였다. 기존의 스트레스 연구들이 구조적 변인에 관해서만 다루거나, 혹은 구조적 변인마저도 과정적 관점에서 다루려고 하는 경우가 많았기 때문에, 사회적 지지 정도에 관한 지각을 구조적 변인으로, 인지적 평가에 관한 부분을 과정적 변인으로 가정하여 대처 행동과 맺고 있는 관련을 측정하였다. 서울 시내 고교 2년생 519명에 대한 설문 조사 결과, 인지적 평가는 스트레스 상황에 따라서 달라지는 과정적 변인임이, 그리고 지각된 사회적 지지는 스트레스 유형에 대해서 독립적인 구조 변인인 것이 확증되었다. 인지적 평가는 대처 행동보다는 스트레스에 관한 질적 평가과정에 더 많은 관련을 가지고 있었고, 지각된 사회적 지지는 평가와 행동에 모두 영향을 미치는 중요한 구조 변인인 것으로 나타났다.

• 유통과학연구
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• 제12권10호
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• pp.99-108
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• 2014

Purpose - The goals of this study are the following. First, this study focused on customer satisfaction of in-flight service. Specifically, in-flight duty free items were considered because of their potential value related with the differentiated strategy of airline companies. Second, this study analyzed feasible strategies that would fence off the aversive attitudes of consumers toward innovation regarding in-flight duty free items. Third, this study strived to discover implicit routes related with the reactions of of consumers to innovation. Fourth, the construal level theory was applied to the context of in-flight service. Psychological distance is expected to promote acceptance of innovation for duty free items. Research design, data, and methodology - This study consisted of three experiments. All data were collected through the participation of university students. First, the experiment employed a 2×2 between-subject design. The first independent variable was temporal distance (long vs. short of navigation time). The second independent variable was innovativeness (innovative duty free items vs. typical items). Further, experiment 2 involved a 2×2 between-subject design. The first independent variable was social distance (typical vs. atypical stewardess image). The second was innovativeness that was based on a pattern similar to that of the prior experiment. The third experiment involved a 2×2×2 design. The first and second independent variables were temporal distance and item innovation, respectively, based on the method of experiment 1. The third independent variable was cognitive depletion (depletion vs. control condition). Results - Experiment 1 demonstrated that the innovation of duty free items would need to consider the journey time of the airline. Specifically, innovative items were preferred in case of a long journey; typical items, however, were liked in a short journey. Further, experiment 2 demonstrated that, in spite of a short journey, innovative items would be preferred if an atypical stewardess was serving. An atypical stewardess was linked with social distance, and the psychological effects would activate a creative and flexible mindset that would fit with innovative duty free items. The final experiment was accomplished for the examination of cognitive processing of psychological distance on innovation-acceptance. Specifically, if the effects were related with systematic processing, then cognitive effort would be needed. In contrast, if they were related with heuristic processing, then such efforts would not be required. The same pattern appeared under both cognitive depletion and control condition; therefore, the effects of psychological distance were implied to be heuristic processing. Conclusions - Managers need to consider the navigation time, stewardess concepts, and depletion of consumers as important factors for innovative strategy regarding in-flight service. Longer journeys are more successful for innovative trials. Further, a more atypical stewardess image is more successful for atypical service. Long navigation and unfamiliar stewardesses may activate creative and flexible thinking. Further, cognitive depletion of consumers is not a dominant factor of psychological distance effects, because the effects are not related with systematic processing, but with heuristic processing.

• 한국항행학회논문지
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• 제10권1호
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• pp.79-85
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• 2006

무선통신 및 방송 기술의 발달과 함께 주파수 자원의 효율적 활용에 대한 관심이 더욱 높아지고 있다. 또한 향후 유비쿼터스 센서 네트워크, 이동 및 고정 무선통신, 무선방송 등 다양한 무선 응용 기술들이 혼재된 상황은 주파수 자원의 효율적 이용에 대한 요구를 강화할 것으로 예상된다. 본 논문에서는 다양한 무선자원을 능동적으로 인지하여 동적으로 변화하는 사용자의 요구 및 상황에 적합하도록 유휴 무선자원을 지능적으로 활용하는 제반 기술인 Cognitive Radio의 필요성 및 발전 방향과 IEEE 802.22 표준화 진행에 대하여 알아본다.

• 디지털콘텐츠학회 논문지
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• 제6권3호
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• pp.179-184
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• 2005

무선통신 및 방송 기술의 발달과 함께 주파수 자원의 효율적 활용에 대한 관심이 더욱 높아지고 있다. 또한 향후 유비쿼터스센서 네트워크 이동 및 고정 무선통산 무선방송 등 다양한 무선 응용 기술들이 혼재된 상황은 주파수 자원의 효율적 이용에 대한 요구를 강화할 것으로 예상된다. 본 논문에서는 다양한 무선자원을 능동적으로 인지하여 동적으로 변화하는 사용자의 요구 및 상황에 적합하도록 유휴 무선자원을 지능적으로 활용하는 제반 기술인 Cognitive Radio의 필요성 및 발전 방향과 IEEE 802.22 표준화 진행에 대하여 알아본다.

• 디지털산업정보학회논문지
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• 제16권2호
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• pp.83-93
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• 2020

The purpose of this study was to verify the effect on learning using YouTube. The relationship between expectations, cognitive attitudes, emotional attitudes, and reuse intentions was explored. The results are as follows. First, the factors affecting the intention to reuse YouTube were emotional attitude and expectation. cognitive attitude did not show any significant effect. Second, cognitive attitude and expectation agreement were significant variables in emotional attitude. cognitive attitude was identified as a major factor affecting emotional attitude. Third, expectation agreement was found to have a significant influence on cognitive attitude. Therefore, expectancy is an important factor in identifying cognitive attitudes. In particular, the satisfaction of expectations after experiencing a new technology or system, such as YouTube, affects the cognitive attitude. Finally, the main findings of this study were that cognitive attitude was not a variable affecting the intention to reuse YouTube. The reason for this is that YouTube is used as a medium of interest, and it is not used as a medium for searching the main data source for learning. Therefore, in order to activate YouTube learning, it is necessary to convert recognition into YouTube for learning rather than YouTube for play.

• 대한간호학회지
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• 제46권1호
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• pp.1-18
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• 2016

Purpose: This study was conducted to synthesis the results of research on relationships of cognitive impairment with multi-dimensional correlates of rheumatic disease through a systematic literature review and meta-analysis. Methods: For the study purpose, 23 studies were selected through a systematic process of searching the literature. Results: The study results showed that among general characteristics, age and education were the variables having a significant relationship with cognitive impairment. Among health risk factors, obesity appeared to have a significant positive relationship with cognitive impairment. For past history, diabetes and hypertension were shown to have a significant positive relationship with cognitive impairment. It was noted also that aPL, one of the physiological factor, had significant association with cognitive impairment. None of the medication related factors had a significant relationship with cognitive impairment. Results showed that among disease related factors, disease activity had the highest relationship with cognitive impairment. Depression, among psychological factors, was the only variable having a significant relationship with cognitive impairment. Conclusion: The findings indicate that the variables strongly impacting on cognitive impairment in rheumatic disease are depression and disease activity.

• 재활치료과학
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• 제12권3호
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• pp.61-77
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• 2023

목적 : 본 연구는 노인들의 인지기능과 구강건강관련 삶의 질 사이의 연관성을 분석하기 위해 수행되었다. 연구방법 : 2020년에 수집된 제8차 고령화연구패널조사에 참여한 지역에 거주하는 45세 이상의 중고령자를 대상으로 인구통계학적 및 임상적 특성을 추출하여 활용하였다. 독립변수는 한국형 간이정신상태검사 점수를 기준으로 분류한 인지기능, 종속변수는 구강건강관련 삶의 질을 측정하기 위한 노인구강건강평가지수이다. 인지기능 그룹 간 공변량의 차이를 보정하기 위해 성향점수 활용법 중 역확률가중치를 적용 후 인지기능과 구강건강관련 삶의 질의 연관성을 분석하기 위해 역확률가중치 적용 전의 다중회귀분석과 적용 후의 다중회귀분석 결과에 차이가 있는지 결과를 비교하였다. 결과 : 연구 대상자는 총 6,116명으로 인지정상군 4,367명, 경도 인지손상군 1,155명, 중증 인지손상군 594명으로 구성되었다. 성향점수 역확률가중치 적용 결과로 표준화된 평균 차이(standardized mean difference)를 확인하여 0.2 이상인 변수를 다시 통제하고 분석한 다중회귀모델에서 인지기능 그룹과 구강건강관련 삶의 질 간의 부정적인 연관성이 있었다(정상 vs. 경도: β = -2.534, p < .0001; 정상 vs. 중증: β = -2.452, p < .0001). 결론 : 본 연구 결과에서 인지손상과 구강건강관련 삶의 질은 음의 연관성을 나타내었다. 성향점수 활용 후 중증 인지손상보다 경도 인지손상에서 더 부정적인 연관성을 나타낸 결과는 인지손상은 저하된 정도와 관계없이 구강건강관련 삶의 질에 부정적인 영향을 미치는 것을 의미한다. 따라서 인지기능의 감퇴가 나타난 모든 환자들은 구강관리의 중요성과 교육이 필요하다는 것을 시사한다.

• 복식문화연구
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• 제23권6호
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• pp.940-954
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• 2015

The purpose of this study is to identify the antecedents of repurchase intention toward fast fashion brands. Perceived quality, perceived price, deindividuation, and overly trendy styles, which are product characteristic variables, and fashion innovativeness, which is a consumer characteristic variable, were considered as antecedents. It was hypothesized that product and consumer characteristics influence repurchase intention toward fast fashion brands not only directly, but also indirectly through cognitive dissonance. Data were gathered by surveying university students in Seoul using convenience sampling. Three hundred and fifty-two questionnaires were used in the statistical analysis. SPSS was used for exploratory factor analysis, and AMOS was used for confirmatory factor analysis and path analysis. The factor analysis of product characteristics revealed four dimensions: "perceived quality", "perceived price", "deindividuation", and "overly trendy styles", and the factor analysis of consumer characteristics revealed one dimension. The factor analysis of cognitive dissonance revealed two dimensions, "regrets" and "perceived uncertainty." The hypothesized path test proved that perceived quality, deindividuation, overly trendy styles, and fashion innovativeness influence repurchase intention directly. Perceived price and deindividuation influence repurchase intention indirectly through the factor of cognitive dissonance, which is the perceived uncertainty, indicating the importance of cognitive dissonance. The results indicate effective marketing strategies should be used to decrease consumers' cognitive dissonance, and suggestions for future study are provided.