• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권3호
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• pp.93-98
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• 2021

Electroencephalography (EEG) measures neural activation due to various cognitive processes. EEG and event-related potentials (ERPs) are widely used in studies investigating psychopathology and neural substrates of psychiatric diseases in children and adolescents. The present study aimed to review recent ERP studies in child and adolescent psychiatry. ERPs are non-invasive methods for studying synaptic functions in the brain. ERP might be a candidate biomarker in child-adolescent psychiatry, considering its ability to reflect cognitive and behavioral functions in humans. For the EEG study of psychiatric diseases in children and adolescents, several ERP components have been used, such as mismatch negativity, P300, error-related negativity (ERN), and reward positivity (RewP). Regarding executive functions and inhibition in patients with attention-deficit/hyperactivity disorder (ADHD), P300 latency, and ERN were significantly different in patients with ADHD compared to those in the healthy population. ERN showed meaningful changes in patients with anxiety disorders, such as generalized anxiety disorder, separation anxiety disorder, and obsessive-compulsive disorder. Patients with depression showed significantly attenuated RewP compared to the healthy population, which was related to the symptoms of anhedonia.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.2946-2952
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• 2014

본 연구는 고령사회를 앞두고 증가하고 있는 노인들의 자동차 운전에 대한 실태를 확인하고 향후 노인들의 안전한 자동차 운전에 대한 연구를 하는데 기초적인 자료로 사용하고자 하는 목적을 가지고 있다. P시에 소재하고 있는 노인복지관을 이용하고 있는 노인 128명을 대상으로 설문조사를 실시하였다. 설문조사를 통해서 노인들의 자가운전 현황을 파악하고, 자가운전을 하고 있다고 응답한 41명의 노인들을 대상으로 인지기능을 확인할 수 있는 한국판 몬트리올 인지기능평가(Montreal Cognitive Assessment Korean Version; MoCA-K)와 신경행동학적 인지상태 검사(neurobehavioral cognitive status examination; NCSE)를 실시하였다. 연구결과 대상 노인의 32%가 자동차운전을 하고 있었으며 매일 운전을 하는 경우(56.1%)가 가장 많고, 운전시간은 하루 1-2시간 정도(56.1%) 운전을 하는 경우가 가장 많았다. 차량사용목적으로는 여가활동(46.3%)에 많이 이용을 하였으며, 사고경험이 있는 노인은 31.7%였다. 인지기능검사 결과 개인에 따라서 특정항목에서 평균이하의 점수를 획득하는 경우가 있어 안전한 자동차 운전에 영향을 줄 수 있다는 것을 알 수 있었다. 그러므로 노인들의 안전한 자동차 운전을 위해서는 노인의 감소된 능력을 정확하게 측정할 수 있는 체계적인 평가시스템과 부족한 부분에 대해서 보완할 수 있는 운전재교육시스템의 의무화가 필요할 것으로 생각된다. 또한 향후 운전면허관리제도 및 갱신과 같은 노인의 운전을 위한 정부차원의 제도적 접근도 필요할 것이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제24권4호
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• pp.220-227
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• 2013

Objectives : This study aims to investigate the clinical characteristics and neuropsychological profiles of children with attention-deficit hyperactivity disorder (ADHD) and their siblings. Methods : Eighteen children (age $8.2{\pm}1.7$ years, 12 boys) with ADHD and their 18 siblings (age $7.8{\pm}1.6$ years, 8 boys) completed Continuous Performance (CPT), Stroop, Children's Trail Making, Rey-Kim Memory, and Kim's Frontal Executive Function tasks. The parents of these subjects underwent the Attention-Deficit/Hyperactivity Disorder Rating Scale (ARS), 10-item Parent General Behavior Inventory (P-GBI), and the Social Responsiveness Scale (SRS). Paired t-tests were used. Results : The inattention (p=.020), and hyperactivity-impulsivity (p=.001), scores of the ARS and the P-GBI score (p=.004) were significantly higher in children with ADHD than in their siblings. Deficits in social communication and motivation on SRS were higher in children with ADHD than in their siblings (p=.017 and p=.011, respectively). Z-scores of omission and commission errors as well as response time variability on visual CPT and omission errors on auditory CPT were in clinically significant range, and z-score of omission errors on auditory CPT was in borderline range in siblings. Omission (p=.018) and commission errors on Visual CPT (p=.007) were significantly higher in children with ADHD compared to their siblings. Recognition efficiency on Kim's Frontal Executive Function Task was lower in children with ADHD compared to their siblings, but in normal range in both groups. Stroop interference and figure fluency on Kims Frontal Executive Function Task were in borderline range in ADHD group, and figure fluency was in borderline range in siblings. Conclusion : Our results support a preliminary evidence for mild degree of attention deficit in ADHD siblings. Further studies are needed to examine the cognitive functions of siblings with ADHD in larger samples.

• 정신신체의학
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• 제25권1호
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• pp.63-72
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• 2017

연구목적 본 연구는 주의력결핍 과잉행동장애(attention-deficit/hyperactivity disorder, ADHD) 환자들을 대상으로 다양한 실행기능과 정량화 뇌파간의 상관성을 알아보고자 하였다. 방법 31명의 소아청소년 ADHD 환자를 대상으로 정량화 뇌파를 측정하였다. 종합주의력검사(Comprehensive Attention Test, CAT), 스트룹 색-단어 추론 검사(Color-Word Inference Test, CWIT), 선추적 검사(Trail Making Test, TMT), 카드분류검사(Card Sorting Test, CST)가 시행되었고 한국어판 주의력결핍 과잉행동장애 평정척도(Korean version of the ADHD Rating Scale, K-ARS)가 측정되었다. 결과 CAT 검사 점수와 알파, 베타 파워가 양적 상관이 있는 반면, 델타 파워와는 부적 상관이 있었다. CWIT 검사에서는 감소된 델타 파워와 증가된 베타 파워가 높은 수행수준과 관련 있었다. 높은 TMT 검사 점수는 증가된 알파 대역 파워와 관련이 있었으며, CST 검사에서 델타 파워는 높은 수행수준과 부적 상관이 있는 반면 알파, 하이 감마파의 파워와는 양적 상관을 보였다. K-ARS 점수는 알파 파워와 부적 상관을 보였다. 결론 정량화 뇌파는 ADHD 환자들의 실행기능과 상관성을 보이며 신경생리학적 지표로서의 유용성이 시사된다.

• 생물정신의학
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• 제21권2호
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• pp.65-73
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• 2014

Objectives This study aimed to identify the differences and the profiles of cognitive deficits in remitted patients with schizophrenia and first-degree relatives of schizophrenic probands. Methods A total of 26 remitted states of schizophrenia patients were included in the study and the same number of unaffected first-degree relatives of schizophrenic probands and healthy controls were matched for age, sex, years of education. Cognitive function of all participants was measured by using the Digit span test, the Continuous performance test, the Rey auditory & visual learning test, the Complex figure test, the Verbal fluency test, the Wisconsin card sorting test and the Finger tapping test. The effects of subsyndromal symptomatology and general intelligence score were controlled. Results Schizophrenia patients' group showed more significant impairment than other groups in verbal memory (learning, immediate recall, delayed recall), visual memory (copy, immediate recall, delayed recall) and cognitive flexibility domains. The family group and the patient group commonly performed significantly worse than healthy controls in working memory and verbal fluency (category) tests. There were no differences in sustained attention, psychomotor performance. Conclusions Our research shows that the deficit in working memory and verbal fluency could be strong candidates of endophenotypic marker in schizophrenia.

• 동의생리병리학회지
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• 제25권3호
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• pp.406-416
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• 2011

In this study, we have verified the memory and cognitive enhancing effect of Longanae Arillus, the fruit of Euphoria longana Lamarck, which has been used as a tonic and for the treatment of amnesia, insomnia, and palpitations in oriental medicine. To investigate the effect of Longanae Arillus water extract(LAE) on the memory and cognitive dysfunction, scopolamine (1 mg/kg, i.p.) was injected in C57BL/6 mice and several behavior tests including Y-maze, Morris water-maze, passive avoidance and fear conditioning tests were conducted. Administration of LAE (100 or 200 mg/kg/day, p.o.) effectively improved scopolamine-induced memory impairment and dysfunction. To further determine the possible molecule mechanism of LAE, we have examined the activity and/or mRNA expression of diverse proteins involved in the acetylcholine metabolism. LAE particularly increased the amount of acetylcholine in the cortex which was mediated by suppression of acetylcholine esterase (AchE) activity. In addition, LAE elevated the mRNA expression of muscarinic acetylcholine receptors (mAchRs) without affecting the mRNA levels of choline acetyltransferase (ChAT) and acetylcholine esterase (AchE). In another experiment, LAE effectively inhibited mRNA expression of pro-inflammatory cytokines such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-$1{\beta}$ (IL1-${\beta}$), which seemed to be mediated by inhibition of upstream transcription factor NF-${\kappa}B$ and extracellular-regulated kinase 1/2 (ERK1/2). These results demonstrate that Longanae Arillus can increase acetylcholine amount the cortex via regulation of AchE activity as well as mAchRs expression and decrease pro-inflammatory responses via inhibition of NF-${\kappa}B$ signaling pathway, thereby having therapeutic potential to improve memory and cognitive deficit in amnesia.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.302-306
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• 2011

Objectives : To investigate the cognitive functions of pediatric cancer patients and to test the hypotheses that the impairment of processing speed and working memory are more prevalent in children with medulloblastoma (MBL) compared to children with neuroblastoma (NBL). Methods : We gave the Korean version of the Wechsler Intelligent Scale for Children-III to 21 children with MBL and 24 children with NBL during outpatient follow-up after the treatment was completed. Results : Children with MBL showed below average performance across most of the sub-tests. The full scale IQ, verbal IQ, and performance IQ of children with MBL were significantly lower than those of children with NBL. There were significant differences between two groups in coding and Digit Span subtest scores. Children with MBL performed especially poorly in the coding subtest. Conclusion : These findings support previous reports of generally low IQ and the dysfunction of processing speed and working memory among children with MBL, a kind of central nervous system tumor. Further investigation is needed to determine how the deficit of processing speed and working memory affect neurocognitive development and general intelligent functions.

• 재활치료과학
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• 제1권1호
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• pp.29-38
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• 2012

서론 : 본 연구는 인지재활의 주요영역인 실행 장애, 기억력 장애, 지각 장애, 주의력 장애, 일상생활활동 영역에서의 가상현실의 적용 사례를 문헌고찰 함으로써, 작업치료 적용을 위한 기초자료로 활용하고자 한다. 본론 : 가상현실을 바탕으로 한 인지프로그램은 평가 뿐 만이 아니라 전반적인 인지 요소의 훈련용으로 사용되어지고 있다. 가상현실을 이용한 인지 프로그램은 실제 환경에서의 평가이자 훈련이기에 기존 컴퓨터에 기초한 평가 및 훈련과 비교하여 실제 환경으로 전이효과가 큰 것으로 밝혀지고 있다. 가상현실의 재활 프로그램에 적용은 최신 기술의 발전과 더불어 보다 큰 발전을 가져올 것으로 예상되며, 이는 곧 혁신적인 치료 기술의 발전을 가져 올 수 있다. 이 과정에 가상현실은 미래에 보다 많이 연구 되어질 것으로 예상되며, 특히 인지영역에서 가상현실은 기존의 평가들 보다 향상된 실제 환경으로의 전이효과에 주목할 필요가 있다. 결론 : 인지영역에서 가상현실의 적용은 무한한 잠재력을 가지고 있으며, 평가 뿐 만 아니라 훈련이 통합된 재활 프로그램으로 활용도가 광범위 할 것으로 기대된다.

• Nutrition Research and Practice
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• 제12권3호
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• pp.191-198
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• 2018

BACKGROUD/OBJECTIVES: Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a mouse model of inflammation-induced memory and cognitive deficit. MATERIALS/METHODS: C57BL/6 mice were injected with lipopolysaccharide (LPS; 2.5 mg/kg, intraperitoneally) and orally administrated G. uralensis, G. glabra, and SW extract (150 mg/kg/day). SW, a new species of licorice in Korea, was combined with G. uralensis and G. glabra. Behavioral tests, including the T-maze, novel object recognition and Morris water maze, were carried out to assess learning and memory. In addition, the expressions of inflammation-related proteins in brain tissue were measured by western blotting. RESULTS: There was a significant decrease in spatial and objective recognition memory in LPS-induced cognitive impairment group, as measured by the T-maze and novel object recognition test; however, the administration of licorice ameliorated these deficits. In addition, licorice-treated groups exhibited improved learning and memory ability in the Morris water maze. Furthermore, LPS-injected mice had up-regulated pro-inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2, interleukin-6, via activation of toll like receptor 4 (TLR4) and nuclear factor-kappa B ($NF{\kappa}B$) pathways in the brain. However, these were attenuated by following administration of the three licorice varieties. Interestingly, the SW-administered group showed greater inhibition of iNOS and TLR4 when compared with the other licorice varieties. Furthermore, there was a significant increase in the expression of brain-derived neurotrophic factor (BDNF) in the brain of LPS-induced cognitively impaired mice that were administered licorice, with the greatest effect following SW treatment. CONCLUSIONS: The three licorice varieties ameliorated the inflammation-induced cognitive dysfunction by down-regulating inflammatory proteins and up-regulating BDNF. These results suggest that licorice, in particular SW, could be potential therapeutic agents against cognitive impairment.

• 디지털융복합연구
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• 제17권11호
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• pp.327-337
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• 2019

본 연구의 목적은 성인의 스마트폰 중독이 주관적 안녕감에 영향을 미치는 과정에서 실행기능 결함과 적응적 인지적 정서조절전략의 이중매개효과를 검증하고, 성인 스마트폰 중독 치료에 대한 시사점을 파악하는 것이었다. 성인 148명(남성 71명, 여성 77명)을 대상으로 자기보고식 설문을 실시하고 회귀분석을 통해 매개효과를 검증하였다. 핵심연구결과는 다음과 같다. 첫째, 스마트폰 중독과 적응적 인지적 정서조절전략 간의 관계에서 실행기능 결함은 매개역할을 했다. 둘째, 스마트폰 중독과 주관적 안녕감 간의 관계에서 적응적 인지적 정서조절전략의 매개효과는 유의미하지 않았다. 셋째, 스마트폰 중독과 주관적 안녕감 간의 관계에서 실행기능 결함과 적응적 인지적 정서조절전략은 이중매개 및 완전매개 효과를 나타냈다. 본 연구결과는 성인 스마트폰 중독군의 치료적 개입에 있어 실행기능 훈련과 적절한 인지적 정서조절전략의 함양이 도움이 될 수 있음을 시사하였다. 마지막으로 본 연구의 제한점과 전체 성인 연령층을 대상으로 한 향후연구의 필요성이 논의되었다.