Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
권호 표지
DOI QR코드

DOI QR Code

Cognitive Functions in Children Treated for Medulloblastoma

소아 수모세포종 환자의 인지 기능

  • Oh, Ju-Yong (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Ji-Hae (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Binna (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • An, Kyung-Jin (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sung, Ki-Woong (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Joung, Yoo-Sook (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 오주용 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 김지혜 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 김빛나 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 안경진 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
  • 성기웅 (성균관대학교 의과대학 삼성서울병원 소아청소년과학교실) ;
  • 정유숙 (성균관대학교 의과대학 삼성서울병원 정신과학교실)
  • Received : 2011.09.21
  • Accepted : 2011.11.14
  • Published : 2011.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : To investigate the cognitive functions of pediatric cancer patients and to test the hypotheses that the impairment of processing speed and working memory are more prevalent in children with medulloblastoma (MBL) compared to children with neuroblastoma (NBL). Methods : We gave the Korean version of the Wechsler Intelligent Scale for Children-III to 21 children with MBL and 24 children with NBL during outpatient follow-up after the treatment was completed. Results : Children with MBL showed below average performance across most of the sub-tests. The full scale IQ, verbal IQ, and performance IQ of children with MBL were significantly lower than those of children with NBL. There were significant differences between two groups in coding and Digit Span subtest scores. Children with MBL performed especially poorly in the coding subtest. Conclusion : These findings support previous reports of generally low IQ and the dysfunction of processing speed and working memory among children with MBL, a kind of central nervous system tumor. Further investigation is needed to determine how the deficit of processing speed and working memory affect neurocognitive development and general intelligent functions.

Keywords

References

  1. Yu ES. Psychological intervention of cancer patients. Proceedings of Korean psychology association annual conference; 2008 Aug 20-22;Seoul, Korea: Korean psychology association;2008. p.488-489.
  2. Fuemmeler BF, Elkin TD, Mullins LL. Survivors of childhood brain tumors: behavioral, emotional, and social adjustment. Clin Psychol Rev 2002;22:547-585. https://doi.org/10.1016/S0272-7358(01)00120-9
  3. Mulhern RK, Palmer SL. Neurocognitive late effects in pediatric cancer. Curr Probl Cancer 2003;27:177-197. https://doi.org/10.1016/S0147-0272(03)00026-6
  4. Moore BD 3rd. Neurocognitive outcomes in survivors of childhood cancer. J Pediatr Psychol 2005;30:51-63. https://doi.org/10.1093/jpepsy/jsi016
  5. Blaney SM, Kun LE, Hunter J, Rorke-Adams LB, Lau C, Strother D, et al. Tumors of the central nervous system. In: Piaao PA, Poplock DG, editors. Principles and practice of pediatric oncology. 5th ed. New York: Lippincott Williams & Wilkins Co;2006. p.786-864.
  6. Reeves CB, Palmer SL, Reddick WE, Merchant TE, Buchanan GM, Gajjar A, et al. Attention and memory functioning among pediatric patients with medulloblastoma. J Pediatr Psychol 2006;31:272-280. https://doi.org/10.1093/jpepsy/jsj019
  7. Kail R. Processing speed, speech rate, and memory. Dev Psychol 1992;28:899-904. https://doi.org/10.1037/0012-1649.28.5.899
  8. Palmer SL. Neurodevelopmental impact on children treated for medulloblastoma: a review and proposed conceptual model. Dev Disabil Res Rev 2008;14:203-210. https://doi.org/10.1002/ddrr.32
  9. Park HJ, Nam BH, Yun YH, Yang WJ, Kang HJ, Shin HY, et al. Establishment of Korean childhood cancer survivor cohort and long-term follow-up system. Clin Pediatr Hematol Oncol 2007;14:1-42.
  10. Choi JE, Shin HY, Kim IO, Yeon KM, Chae IY, Cho SC. Effects of central nervous system irradiation on neuropsychologic functioning in long-term survivors of childhood acute lymphoblastic leukemia. Cancer Res Treat 2007;50:182-189.
  11. Kim GH, Kook H, Baek HJ, Han DK, Song ES, Jo YK, et al. Comparison of growth and neuropsychological function after treatment for hematologic and oncologic diseases in monozygotic twins. Korean J Pediatr 2007;50:182-189. https://doi.org/10.3345/kjp.2007.50.2.182
  12. Mabbott DJ, Penkman L, Witol A, Strother D, Bouffet E. Core neurocognitive functions in children treated for posterior fossa tumors. Neuropsychology 2008;22:159-168. https://doi.org/10.1037/0894-4105.22.2.159
  13. Stargatt R, Rosenfeld JV, Maixner W, Ashley D. Multiple factors contribute to neuropsychological outcome in children with posterior fossa tumors. Dev Neuropsychol 2007;32:729-748. https://doi.org/10.1080/87565640701376151
  14. Briere ME, Scott JG, McNall-Knapp RY, Adams RL. Cognitive outcome in pediatric brain tumor survivors: delayed attention deficit at long-term follow-up. Pediatr Blood Cancer 2008;50:337-340. https://doi.org/10.1002/pbc.21223
  15. Mabbott DJ, Spiegler BJ, Greenberg ML, Rutka JT, Hyder DJ, Bouffet E. Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. J Clin Oncol 2005;23: 2256-2263. https://doi.org/10.1200/JCO.2005.01.158
  16. Fry AF, Hale S. Relationships among processing speed, working me-mory, and fluid intelligence in children. Biol Psychol 2000;54:1-34. https://doi.org/10.1016/S0301-0511(00)00051-X
  17. Kieffer-Renaux V, Bulteau C, Grill J, Kalifa C, Viguier D, Jamba-que I. Patterns of neuropsychological deficits in children with medulloblastoma according to craniospatial irradiation doses. Dev Med Child Neurol 2000;42:741-745. https://doi.org/10.1017/S0012162200001377
  18. Schatz J, Kramer JH, Ablin A, Matthay KK. Processing speed, working memory, and IQ: a developmental model of cognitive deficits following cranial radiation therapy. Neuropsychology 2000; 14:189-200. https://doi.org/10.1037/0894-4105.14.2.189
  19. Fry AF, Hale S. Processing speed, working memory, and fluid intelligence: evidence for a developmental cascade. Psychol Sci 1996; 7:237-241. https://doi.org/10.1111/j.1467-9280.1996.tb00366.x
  20. Palmer SL, Goloubeva O, Reddick WE, Glass JO, Gajjar A, Kun L, et al. Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. J Clin Oncol 2001; 19:2302-2308. https://doi.org/10.1200/JCO.2001.19.8.2302
  21. Leiper AD. Late effects of total body irradiation. Arch Dis Child 1995;72:382-385. https://doi.org/10.1136/adc.72.5.382