• Nutrition Research and Practice
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• 제9권1호
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• pp.30-36
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• 2015

BACKGROUD/OBEJECTIVES: The mechanism of how black garlic effects lipid metabolism remains unsolved. Therefore, the objectives of this study were to determine the effects of black garlic on lipid profiles and the expression of related genes in rats fed a high fat diet. MATERIALS/METHODS: Thirty-two male Sqrague-Dawley rats aged 4 weeks were randomly divided into four groups (n=8) and fed the following diets for 5 weeks: normal food diet, (NF); a high-fat diet (HF); and a high-fat diet + 0.5% or 1.5% black garlic extract (HFBG0.5 or HFBG1.5). Body weights and blood biochemical parameters, including lipid profiles, and expressions of genes related to lipid metabolism were determined. RESULTS: Significant differences were observed in the final weights between the HFBG1.5 and HF groups. All blood biochemical parameters measured in the HFBG1.5 group showed significantly lower values than those in the HF group. Significant improvements of the plasama lipid profiles as well as fecal excretions of total lipids and triglyceride (TG) were also observed in the HFBG1.5 group, when compared to the HF diet group. There were significant differences in the levels of mRNA of sterol regulatory element binding protein-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and glucose-6-phosphate dehydrogenase (G6PDH) in the HFBG1.5 group compared to the HF group. In addition, the hepatic expression of (HMG-CoA) reductase and Acyl-CoA cholesterol acyltransferase (ACAT) mRNA was also significantly lower than the HF group. CONCLUSIONS: Consumption of black garlic extract lowers SREBP-1C mRNA expression, which causes downregulation of lipid and cholestrol metahbolism. As a result, the blood levels of total lipids, TG, and cholesterol were decreased.

• 한국식생활문화학회지
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• 제21권2호
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• pp.216-224
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• 2006

This study was conducted to examine the correlation among meals variety, obesity index, blood pressure, and lipid profiles of Korean adults. A total of 308 adults(men 124, women 184) measured the anthropometric characteristics, blood pressure, dietary intake using 24-hour recall method, and serum lipid profile. The average ages of the study subjects were 50.9 yrs in men and 51.4 yrs in women. The average height, weight and BMI were 166.3 cm, 68.4 kg, $24.7\;kg/cm^2$ in men and 154.3 cm, 59.8 kg, $25.0\;kg/cm^2$ in women, respectively. The numbers of food items in meal of men and women were 14.1, 15.9 for breakfast, 15.7, 15.9 for lunch, 14.7, 14.1 for dinner, respectively. The numbers of dish items in meal of men and women were 4.0, 4.3 for breakfast, 4.3, 4.3 for lunch, 4.2, 3.9 for dinner, respectively. The average blood pressure, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and atherogenic index were 126.6/76.0 mmHg, 181.0 mg/dL, 157.7 mg/dL, 40.9 mg/dL, 108.6 mg/dL, 3.5 in men and 123.2/73.6 mmHg, 185.0 mg/dL, 137.3 mg/dL, 44.8 mg/dL, 112.7 mg/dL, 3.2 in women, respectively. The total cholesterol was negatively correlated to the number of food item for lunch(p<0.05). Therefore, more systematic studies to investigate the meal variety roles of blood lipids in meals of adults were required.

• 대한지역사회영양학회지
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• 제7권6호
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• pp.803-813
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• 2002

The purpose of this study was to investigate the anthropometric and blood biochemical characteristics, the dietary behaviors and health-related lifestyles of obese children in Incheon. A cross-sectional survey was conducted using anthropometric measurements, biochemical assessments and questionnaire analysis. The subjects included 7,055 obese children residing in the Incheon area (from 106 elementary schools). The degree of obesity was classified using the Obesity Index (OI) as light 20% ＜ OI ＜ 30% ; Medium 30% ＜ OI ＜ 50% ; Severe 50% ＞ OI. The statistical analysis was conducted using SPSS 10.0 program. Most subjects fell within the medium range of obesity. Most subjects had dietary problems such as overeating, unbalanced meals and skipping breakfast. The ratio of boy subjects eating green and yellow vegetables was lowe. when compared to that of the girl subjects. The boy subjects exercised more frequently and longer than the girls. As the Obesity Index increased, hypercholesterolemia significantly increased. The blood cholesterol levels of the subjects were positively correlated with body fat, waist/hip ratio and BMI; HDL cholesterol levels of the subjects were negatively correlated with the anthropometric data and the LDL cholesterol levels of the subjects were positively correlated with body fat. The blood triglycerides levels of the subjects were positively correlated with body weight, body fat, waist/hip ratio and BMI. Therefore, proper nutritional education and intervention are required for an improvement of obese children＇s dietary behavior, heath-related factors and blood lipid profiles.

• Nutrition Research and Practice
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• 제3권1호
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• pp.31-37
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• 2009

Recently, Korean people are consuming seaweeds almost 3.5 times more now than three decades ago. It is well known that seaweeds contain lots of soluble dietary fiber in addition to micronutrients such as ${\beta}$-carotene, iodine and some bioactive components. Seaweeds are considered to be effective for preventing chronic diseases including obesity, diabetes mellitus, atherosclerosis, cancer or constipation. This study was conducted to investigate the effect of seamustard intake on body weight gain, blood glucose level and lipid profiles in rats fed diets with different energy nutrient composition. Male Sprague-Dawley rats (average initial weight 103.7g) were divided into groups for two experiments as follows; Control, M2.5 & M5 groups (Exp. I) and M5, M10, HCM5, HCM10, HFM5 & HFM10 groups (Exp. II). The rats were fed diet and water ad libitum for 4 weeks. In general, there was no significant difference in blood glucose and triglyceride concentration among groups. In Exp. I, serum LDL-cholesterol level of rats fed diet with 5% seamustard powder (M5) was significantly lower than that of control group, while HDL-cholesterol level, TC/LDL ratio and weight of adrenal gland were higher. In Exp. II, food intake, body weight gain and EER of high fat diet with 10% seamustard group (HFM10) were the lowest among groups. Except gastrocnemius muscle, all organ weights of HFM10 group were the lowest. Fecal cholesterol excretion and serum LDL-cholesterol concentration of HFM10 group were the highest, while serum HDL-cholesterol level was the lowest among groups. Interestingly, HDL-cholesterol concentration was the highest in HCM5 group among groups. From these results, it was suggested that seamustard intake might be more effective for body weight control, but not for improving blood lipid profiles in high fat diet than in high carbohydrate diet.

• 한국응용과학기술학회지
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• 제35권4호
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• pp.1145-1155
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• 2018

본 연구는 비만여대생을 대상으로 섭식제한(DG), 유산소운동(EG), 섭식제한과 유산소운동(DEG) 그룹으로 나누어 체중, 비만의 개선, 혈중지질성분 및 대사성위험요인에 미치는 영향을 분석하였다. 실험은 8주간 주 5회 실시하였으며, DG는 1일 에너지 섭취열량을 300kcal를 제한하였고, EG는 런닝머신을 이용하여 300kcal를 소비시켰으며, DEG는 각각 150kcal를 제한과 소비시켰다. 결과, 신체조성의 경우 DG에서는 체중(p<.011), BMI(p<.008)가 감소하였고, EG와 DEG에서는 체중(p<.044, p<.017), 체지방량(p<.047, p<.018), BMI(p<.03, p<.008), 체지방률(p<.036, p<.015), WHR(p<.049, p<.027)이 유의하게 감소하였다. 혈중지질성분은 DG에서 HDL-C(p<.028), EG에서 TG(p<.038), DEG에서는 TC(p<.014), LDL-C(p<.007)에서 유의하게 감소하였다. 대사성위험요인은 DG에서 HOMA-IR(p<.035), leptin(p<.007), EG에서 FBG(p<.043), leptin(p<.003), DEG에서 FBG(p<.014), insulin(p<.005), HOMA-IR(p<.005), leptin(p<.016), resistin(p<.040)에서 유의한 차이가 나타났다. 따라서 본 연구의 결과로부터 비만여대생들이 섭식제한, 유산소운동의 단독처치보다 섭식제한과 유산소운동을 병행하는 것이 신체조성, 혈중지질성분, 대사성위험요인의 개선에 가장 효과가 있을 것으로 판단된다.

• Journal of Nutrition and Health
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• 제42권6호
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• pp.547-558
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• 2009

This study was carried out to compare the effect of smoking on dietary habits, nutrient intakes and blood lipid profiles in 173 adult male drinkers. Subjects were classified by two groups, alcohol-only and alcohol-smoking, based on their alcohol or smoking habits. The BMI of the alcohol-smoking group was significantly lower than those of alcohol-only group. In dietary habits, the alcohol-smoking group had higher irregular breakfast and dinner intakes than alcoholonly group (p < 0.05). Plant lipid intake of the alcohol-smoking group was higher than those of alcohol-only group (p < 0.05) and the vitamin C intake of the alcohol-smoking group was lower than those of alcohol-only group (p < 0.05). With regard to the diet quality evaluation of subjects, the alcohol-smoking group showed significantly lower values than alcohol-only group in the nutrient density of carbohydrate, dietary fiber, sodium, potassium, vitamin $B_6$, and vitamin C. Also, with regard to the index of nutrition quality (INQ) and the nutrient adequacy ratio (NAR), the alcohol-smoking group showed significantly lower value than alcohol-only group in vitamin C. With these results, we found that the alcohol-smoking group had lower diet quality evaluation. The results of blood analysis showed that HDL-cholesterol in the alcohol-smoking group was significantly lower than that in the alcohol-only group. In conclusion, the alcohol-smoking group had greater health risk than the alcohol-only group. Particularly, alcohol-smoking caused irregular eating patterns and unbalanced nutrition intakes compared to alcohol-only and also changed blood composition as shown in the decrease of HDL-cholesterol. Besides, the index of coronary heart disease such as AI was higher in both groups suggesting that alcohol-only or alcohol-smoking cause health problems. Since there is the limiting point in which the comparative analysis of non-drinkers and non-smokers is unable to be performed in this study, further wide research is needed on that matter.

• 한국보건간호학회지
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• 제24권1호
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• pp.39-48
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• 2010

Purpose: To examine the effects of a 36-week resistance training program on body composition, fitness and blood lipid profiles in the obese elderly. Method: fourteen subjects were assigned into the resistance training group. The 12-16 exercise sessions were performed for 60min with 15-25 repetitions twice per week for 36 weeks. Data were analyzed by paired t-test with SPSS version 12.0 for Windows. Results: Significant changes were evident in weight (t=5.983, p<.001), body mass index (t=5.922, p<.001), % body fat (t=3.480, p=.004), and fat free mass (t=-2.592, p=.022). Concerning exercises, no significance was noted for back scratch (t=-1.814, p=.093), but were for 2-min step (t=-3.075, p=.009), arm curl (t=-2.223, p=.045), chair stand (t=-3.671, p=.003), chair sit and reach (t=-2.508, p=.026), and 8-ft up and go (t=5.545, p<.001). No significant changes were evident in total cholesterol (t=1.189, p=.279), and total glucose (t=0.689, p=.517), while the change in high-density lipoprotein was significant (t=3.535, p=.012). Conclusion: The 36-week resistance training program enhanced body composition and physical fitness, but not blood lipid profiles in obese elderly subjects.

• 동아시아식생활학회지
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• 제15권5
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• pp.549-557
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• 2005

Effects of Acanthopanax senticosus extract (AS) on blood sugar content and serum lipid profiles of streptozotocin-induced diabetic rats were investigated. Experimental groups were classified into four groups, that is, normal control (NC) group, diabetic mellitus (DM) group, AS-fed group and DMAS-fed group. The AS group showed lower feed efficiency than the NC group, but the efficiency of DMAS group was higher than DM group. DMAS group showed the decreased water intake and urine by $45.5\%$ and $23.7\%$ respectively, compared with DM group. Compared with DM group, DMAS group decreased blood sugar by $46.9\%$ and triglyceride by $17.8\%$, total cholesterol by $10.0\%$ and LDL cholesterol by $22.0\%$ in serum, but increased serum HDL cholesterol by $14.4\%$ The relative percentage of liver or kidney per body weight, and the serum ALT activity in DMAS group were lower than those of DM group. There were no significant differences in hepatic glutathione(GSH) contents and total xanthine oxidase(XOD) activities among experimental groups. The hepatic lipid peroxide(LPO) content in DMAS group decreased by $54.6\%$ compared with that in DM group. The XOD (O type) and the ratio of O type to total type of both STZ-treated groups (DM and DMAS) were higher than those of NC group, but less conversion of D to O type was observed in DMAS group than in DM group. There was no significant difference in GST activity between NC and AS, but STZ-treated groups showed lower glutathione S-transferase(GST) activity than NC. In conclusion, it seems that AS reduces blood sugar by inhibiting the activity of xanthine oxidase type O as an oxygen-free radical generating system which induces the tissue damage. Antidiabetic effect of AS may regulate diabetes-induced high lipid profiles in blood.

• 대한영양사협회학술지
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• 제19권2호
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• pp.124-139
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• 2013

Unlike studies of Europeans and Americans, many epidemiological studies of the Korean population have indicated that their risk for cardiovascular disease does not decrease with a vegetable-rich diet. The different dietary practices of Koreans, who consume salted vegetables instead of fresh vegetables (common in the Western diet), has been suggested as a reason for this observation. Korea is in a period of rapid epidemiologic transition, which includes dietary and disease patterns; therefore, this study investigated differences in the food consumption pattern and blood lipid profiles of Koreans compared to Europeans and Americans. The identification of dietary patterns related to blood lipid abnormalities was carried out using the 2007~2009 Korean National Health and Nutrition Survey data from 14,056 subjects. Dietary patterns were analyzed according to food group and nutrient intake. Blood lipid abnormalities were classified into three groups: hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia (hypo-HDL-cholesterolemia). The prevalence of hypercholesterolemia, hypertriglyceridemia, and hypo-HDL-cholesterolemia was 12.4%, 16.2%, and 27.7% respectively. In our analysis, the low consumption of all food groups was related to hypercholesterolemia. The high consumption of vegetable-containing foods, alcoholic beverages, and the low consumption of milk products were associated with hypertriglyceridemia and hypo-HDL-cholesterolemia. Thus, unlike Europeans and Americans, the low consumption of all food groups is related to hypercholesterolemia and a low consumption of milk products is related to hypertriglyceridemia and hypo-HDL-cholesterolemia. Dietary pattern might play a role in epidemiologic transition of Korean. Also, this study implies necessity of further research using longitudinal data.

• Nutritional Sciences
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• 제8권1호
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• pp.35-41
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• 2005

Controlling dietary behaviors and health-related lifestyle habits is important to manage non-insulin dependent diabetes mellitus (NIDDM). If NIDDM is not treated properly, the prevalence of macro-vascular complications (MC) may increase. The goal of NIDDM therapy is to maintain normal concentrations of blood glucose and lipid profiles by having regular meals, controlling alcohol drinking, quitting smoking, and performing physical exercise regularly. This study was performed to investigate the dietary and health-related lifestyle habits and blood parameters of NIDDM patients of both genders and compared these characteristics between the patients with and without MC. Our results show that the subjects with MC compared to without MC and the female patients than the males controlled their diets more regularly, tended to regulate the number of meals better, and smoke less than those without MC. Although plasma lipid profiles were not significantly different between the genders and between the subjects with and without MC, the men had higher blood glucose and plasma tHcy concentrations than the women and plasma tHcy concentration was higher in the female subjects without MC. These results imply that the male patients of NIDDM without MC might have more problems in maintaining their blood glucose. In addition, smoking may be the most important life-style factor influencing some blood parameters like blood glucose, HbAlc, and total cholesterol in the NIDDM patients.