• The Korean Journal of Pain
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• 제6권1호
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• pp.32-39
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• 1993

전북대학교 병원에 입원하여 하복부 수술을 받는 미국 마취과학회 전신상태 분류상 class I, II인 환자 40명을 대상으로 수술후 morphine(1군)과 ketorolac(2군)을 지속적으로 정주한 결과 다음과 같은 결론을 얻었다. 1) 1군과 2군 모두 수술후 통증에 의의 있는 감소를 보였으며 군 간의 차이는 없었다. 2) 1군에서 2군보다 부작용의 빈도가 많았다. 이상의 결과로 수술후 통증 관리에 있어서 morphine과 ketorolac의 지속적 정맥 주입 방법은 모두 효과적이었으며, ketorolac이 morphine보다 부작용의 발현 빈도가 더 적은것으로 보아 morphine을 대신할 수 있는 유용한 약물로 사료된다.

• 한국학교ㆍ지역보건교육학회지
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• 제21권1호
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• pp.15-31
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• 2020

Background and objectives: One-person households are the fastest growing family type in Korea. They bring social concerns such as weakened social integration, increasing poverty and social isolation. They are not homogeneous but heterogeneous groups depending on their socio-demographic characteristics including generation. This study compared the life satisfaction level as well as factors affecting it among the three one-person household generations Methods: The 13th wave of the Korea Welfare Panel dataset with 1,187 respondents was utilized. For data analysis Chi-square test, analysis of variance and hierarchical regression analysis were employed. Generations are divided into three, namely young adult (20-39), the middle-aged (40-64) and the elderly (65 and over). Result: The life satisfaction level was highest among the young adult one-person household generation, followed by the middle-aged and the elderly generation. The common factors affecting life satisfaction of the three generations were physical as well as mental health, including self-esteem and depression. However, there were more factors different from generation to generation. As for the young adult, age, religion, and smoking were significant. As for the middle aged and the elderly, gender (male) and income were significant. Additionally, age, home-ownership and drinking were significant to the elderly generation. Conclusions: As there are differences as well as similarities among the three generations, policies for one-person households need to be devised considering these findings. For all generations, both physical and mental health policies are needed. For young adult strengthening social relations, providing decent jobs, and promoting anti-smoking policy are major agenda, and for the middle-aged and the elderly, assisting in social capital accumulation (for male), providing stable jobs and diverse leisure activities, and securing income. Additionally, for the elderly, expanding the social security system and housing support are needed.

• 대한약침학회지
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• 제25권4호
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• pp.326-343
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• 2022

Neurological disorders represent a substantial healthcare burden worldwide due to population aging. Acorus gramineus Solander (AG) and Acorus tatarinowii Schott (AT), whose major component is asarone, have been shown to be effective in neurological disorders. This review summarized current information from preclinical and clinical studies regarding the effects of extracts and active components of AG and AT (e.g., α-asarone and β-asarone) on neurological disorders and biomedical targets, as well as the mechanisms involved. Databases, including PubMed, Embase, and RISS, were searched using the following keywords: asarone, AG, AT, and neurological disorders, including Alzheimer's disease, Parkinson's disease, depression and anxiety, epilepsy, and stroke. Meta-analyses and reviews were excluded. A total of 873 studies were collected. A total of 89 studies were selected after eliminating studies that did not meet the inclusion criteria. Research on neurological disorders widely reported that extracts or active components of AG and AT showed therapeutic efficacy in treating neurological disorders. These components also possessed a wide array of neuroprotective effects, including reduction of pathogenic protein aggregates, antiapoptotic activity, modulation of autophagy, anti-inflammatory and antioxidant activities, regulation of neurotransmitters, activation of neurogenesis, and stimulation of neurotrophic factors. Most of the included studies were preclinical studies that used in vitro and in vivo models, and only a few clinical studies have been performed. Therefore, this review summarizes the current knowledge on AG and AT therapeutic effects as a basis for further clinical studies, and clinical trials are required before these findings can be applied to human neurological disorders.

• 운동영양학회지
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• 제23권3호
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• pp.13-21
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• 2019

[Purpose] Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis. [Methods] Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Protein levels were assessed using western blot analysis and newborn cells were detected using 5-bromo-2'-deoxyuridine (BrdU). [Results] Three weeks of treadmill running ameliorated the behavioral depression caused by 14 days of continuous restraint stress. The exercise regimen enhanced BrdU-labeled cells and class III β-tubulin levels in the hippocampal dentate gyrus, as well as those of thioredoxin-1 (TRX-1) and synaptosomal β2-adrenergic receptors (β2-AR) under stress. In vitro experiments involving treatment with recombinant human TRX-1 (rhTRX-1) augmented the levels of phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2), nuclear β-catenin, and proliferating cell nuclear antigens, which were previously inhibited by U0216 and FH535 (inhibitors of ERK1/2 and β-catenin/T cell factor-mediated transcription, respectively). The hippocampal neurogenesis elicited by a 7-day exercise regimen was abolished by a selective inhibitor of β2-AR, butoxamine. [Conclusion] These results suggest that TRX-1-mediated hippocampal neurogenesis by β2-AR function is a potential mechanism underlying the psychotropic effect of exercise.

• 한국사회복지학
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• 제64권4호
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• pp.209-231
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• 2012

일반적으로 정신장애에 대한 반낙인 프로그램들은 '정신장애가 다른 신체질환과 마찬가지로 생물학적 장애'임을 강조한다. 이는 귀인정서이론에 근거한 것이다. 그러나 본 연구는 선행연구들을 바탕으로 정신장애 원인을 생물학적 원인과 같은 통제 불가능한 것으로 귀인 하는 경우, 통제 가능한 것으로 귀인하는 경우와 마찬가지로 분노와 두려움이라는 정서를 매개로 사회적 거리감을 증가시킬 것이라는 수정된 귀인정서 모형을 제안하였다. 모형의 적합도를 높이기 위해 모형수정 작업을 통해 최종 수정된 귀인정서모형을 선택하였다. 최종모형의 경로를 분석한 결과 모든 경로는 통계적으로 유의하여 정신장애의 원인을 통제 가능한 것으로 보는 경우와 통제 불가능한 것으로 보는 경우 모두 두려움과 분노를 매개로 사회적 거리감을 증가시키는 것으로 나타났다. 이러한 모형이 정신분열, 알코올중독, 우울증 사례에 동일하게 적용되는지를 알아보기 위해 다집단분석을 실시한 결과 세 집단 모두에 동일하게 적용된다는 전제가 적합한 것으로 나타났고 경로계수의 강도와 크기 역시 유사하게 적용되는 것으로 나타났다. 그러나 전체 모형과 달리 정신장애를 통제 가능한 것으로 인식하는 경우 두려움을 매개로 사회적 거리감을 증가시키는 경로는 통계적으로 유의하지 않았다. 따라서 통제 가능한 원인으로 보는 경우 분노를 매개로 사회적 거리감을 증가시키지만 통제 불가능한 원인으로 보는 경우 두려움을 매개로 사회적 거리감을 증가시키는 것을 알 수 있다. 이를 바탕으로 연구자들은 의료적 모델로 대중을 교육하는 편견극복방법에 수정이 필요함을 지적하였다.

• 한국산학기술학회논문지
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• 제12권2호
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• pp.653-664
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• 2011

본 연구에서는 전문계 고등학생의 학교 적응유연성에 영향을 미치는 위험요인과 보호요인이 무엇인지 알아보기 위해 서울, 경기 지역의 전문계 고등학교 학생 573명과 인문계 고등학생 512명을 대상으로 설문조사를 통해 자료를 수집하였다. 연구 결과는 다음과 같다. 첫째, 학교 적응유연성과 위험요인과의 상관관계를 분석한 결과 위험요인이 높을수록 학교 적응유연성은 낮게 나타났다. 둘째, 위험요인이 학교 적응유연성에 미치는 영향을 검증한 결과, 전문계고 학생들에게는 교사차별, 비행유대, 반사회성이 영향을 미쳤고, 인문계고 학생들에게는 교사차별, 비행유대, 우울이 영향을 미쳤다. 셋째, 학교 적응유연성과 보호요인과의 상관관계를 분석한 결과 보호요인이 높을수록 학교 적응유연성은 높게 나타났다. 넷째, 보호요인이 학교 적응유연성에 미치는 영향을 검증한 결과, 전문계고 학생들에게는 교사지지, 학교의 민주적 분위기, 책임감, 가족응집력, 자아존중감, 합리적 부양태도로 나타났고, 인문계고 학생들에게는 교사지지, 민주적 학교 분위기, 책임감, 가족 응집력이 영향을 미쳤다. 다섯째, 학교계열과 학교 적응유연성 수준에 따른 위험요인과 보호요인의 차이를 분석한 결과 반사회성, 우울, 비행유대, 자아존중감의 변인에서 상호작용이 나타났다.

• 대한불안의학회지
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• 제7권1호
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• pp.48-53
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• 2011

본 연구는 주요우울증 환자군과 정상 대조군을 대상으로, 한국어판 Beck 우울설문지 2판(Beck Depression Inventory-II)에 대한 신뢰도와 타당도를 검증하여 실제적이고 표준화된 규준을 제시하고, 분할점(cut-off score)을 설정하여 우울증의 유무를 나타내는 기준을 마련하고자 하였다. 주요한 연구결과는 다음과 같다. 첫째, 한국판 BDI-II의 문항-총점 상관의 범위는 .51에서 .74이고, 전체 문항들이 .60 이상의 문항-총점 상관을 보여 한국어판 Beck 우울설문지 2판의 신뢰도가 '보통' 이상이라는 것이 검증되었다. 둘째, 집단별 BDI-II의 내적 일치도를 알아보기 위한 Cronbach' alpha 값은 .94 이상인 것으로 나타났다. 셋째, 주성분 분석 방식으로 요인을 추출하여 합치성을 검사한 결과 3개의 하위 요인이 추출되었고, 설명되는 변량은 총 47.3%였다. 넷째, 한국어판 BDI-II의 분할점수 산출을 위하여 ROC(Receiver operator characteristic) 분석을 실시한 결과 18점일 때 가장 높은 민감도와 특이도를 보인 것으로 나타났다. 따라서 본 연구결과를 바탕으로, 한국어판 BDI-II의 분할점은 18점으로 정하는 것이 타당할 것으로 여겨진다. 그러나 본 연구에서는 연구에 사용된 환자군이 우울증상을 가진 모든 정신질환자를 대상으로 한 것이 아니라 주요우울증 환자들만을 대상으로 하여 결과를 일반화 하는데 일부 제약이 따를 수 있을 것으로 판단되며, 증상의 중증도(severity)에 따라 군을 나눠 분할점을 산출하지는 못하여 추후에는 이를 고려한 추가적인 연구가 필요할 것이다.

• 대한본초학회지
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• 제38권6호
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• pp.1-27
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• 2023

Objectives : To investigate the modern research achievements of agarwood and its association with the efficacy of herbal medicine based on the in vivo and in vitro activities of volatile compounds detected in agarwood. Methods : Databases such as PubMed and ScienceOn were searched for medicinal in vivo and in vitro activity studies on agarwood. They were categorized into "medicine and pharmacy" and "others not related to medicine and pharmacy," and the studies on medicine and pharmacy were organized according to active efficacy. The efficacy and virtue of agarwood as identified in the book (or herbal medicine/herbology) corresponded to modern medical terms and diseases in reference to the . Separately, the Gas Chromatography & Mass spectrometer (GC-MS) analysis results of agarwood from a total of 5 production areas of Aquilaria crassna from Vietnam, Indonesia, Malaysia, Myanmar, and Cambodia as identified in previous studies were consulted to search for research papers on the medicinal activity of the 13 compounds of the aromatic sesquiterpene family detected in agarwood, and they were categorized according to topic. Results : There were 123 studies on the medicinal activity of agarwood. Overall, 46 studies on single extracts of agarwood reported activities such as improving mental health, including anti-anxiety and stability, and antiallergic, antioxidant, antibacterial, and digestive system protective effects. In total, 59 papers on the activities of single compounds isolated from agarwood reported anti-inflammatory and mental health benefits. Separately, 13 compounds detected in agarwood, such as α-agarofuran and β-caryophyllene, were reported by 110 studies to have anticancer, stabilizing, antibacterial, and anti-inflammatory activities. There were also papers on the cultivation methods and resin formation conditions of agarwood trees unrelated to the efficacy of herbal medicine. Conclusion : Among the pharmacological papers, a total of 57 papers corresponded to the effects of agarwood in traditional herbal medicine, including 33 papers related to agarwood extracts and 24 papers analyzing 8 types of sesquiterpenes, such as β-caryophyllene and cedrol, from previous studies. Based on the research findings of each paper, it was possible to correlate the effects of agarwood in traditional herbal medicine with the achievements of modern pharmacological research. In addition, further research is anticipated in new areas related to traditional herbal medicine, including the improvement of mental health such as anti-depression, as well as activities related to anticancer, antioxidant, and hair growth.

• 한국환경과학회지
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• 제24권5호
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• pp.633-639
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• 2015

The experience of natural dyeing is expected to be effective in promoting health through good exercise, in giving emotional stability based on the functional aromatic components of the dyeing material, and in improving self-esteem and increasing positive experiences through the behavior of creation. A natural dyeing material easily found around us, artemisia has long been used in food and Oriental medicine and was recently found to contain antioxidative, anticancer, deodorizing, antibacterial, anti-obesity, and anti-diabetes substances through chemical analysis. It has also been reported that group reminiscence therapy using the fragrance of artemisia is effective in relieving pain and depression and in promoting ego integrity in the elderly population. This study aimed to make a comparative analysis of dyeability, washing fastness, and deodorization between Artemisia princeps, Artemisia iwayomogi, and Artemisia annua, all of which are considered to be healthful and functional dyeing materials, among about thirty domestic plants in the genus of Artemisia and to provide basic data concerning natural dyeing in mind-peace education for the silver generation. The fabric dyed and post-mordanted at $80^{\circ}C$ for 40 minutes showed the greatest surface color variation; in this condition, artemisia princes (32.29) gave the greatest color difference, followed by artemisia iwayomogi (31.07) and artemisia annua (26.17). While all the types of artemisia were excellent in washing fastness, dry-cleaning fastness, and rubbing fastness at the fourth- or fifth-grade, light fastness was at the third grade for artemisia princes, at the second to third grade for artemisia annua, and at the second grade for artemisia iwayomogi; therefore, artemisia princes was found to give better fastness than the other two types of artemisia. In determining functionality of the fabric dyed with artemisia, deodorization test also found that the fabric dyed with artemisia princes had 20% higher deodorization.

• 동의신경정신과학회지
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• 제13권1호
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• pp.3-18
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• 2002

Hypertension excessively affects national health is the basic disease that causes death and disablement after the middle-aged. Therefore, The detection and control of hypertension is essential to health care. In general, It is known that the systolic blood pressure should be below 140mmHg, the diastolic blood pressure should be below 90mmHg. Presently, the treatment of hypertension is mostly taking anti-hypertension drug, diet and stability. but Taking anti-hypertension drug has such side effects as depression. and that, We were making a study of various treatments of hypertension. In a course of hypertension study, We applied aromatherapy to the control of hypertension. Aromatherapy is the practice of using of volate plant oils including essential oils, for psychological and physical well-being. Essential oils are drawn into the body by the sense smell not only does the aroma of the true plant stimulate the brain to the trigger a positive effect, but supply physical benefits also. In Europe and North America, The study and development of aromatherapy is lively in progress. In the control of hypertension, We applied Lavender, Majoram, Ylang-Ylang to forty-two hypertensive patients. After aromatherapy for controlling hypertension. We measured the changes of the systolic blood pressure & the diastolic blood pressure of patients by time. As the result of above study, We identified the significance of blood pressure down by aromatherapy.