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The Chemistry of Secondary Products from Acanthopanax Species and their Pharmacological Activities

  • Shin, Kuk-Hyun;Lee, Sang-Hyun
    • Natural Product Sciences
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    • v.8 no.4
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    • pp.111-126
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    • 2002
  • The chemistry of secondary products from Acanthopanax species and their pharmacological activities were reviewed. A nitrogenous compound, a furan compound, a quinoid, benzoids, coumarins, phenylpropanoids, lignans, flavonoids, terpenoids, phytosterols, polyacetylenes, a pyrimidine, cyclitols, monosaccharides and an aliphatic alcohol have been isolated from Acanthopanax species and have been shown to have various levels of activities such as anti-bacterial, anti-cancer, anti-gout, anti-hepatitis, anti-hyperglycemic, anti-inflammatory, anti-leishmanicidic, anti-oxidant, anti-pyretic, anti-xanthine oxidase, choleretic, hemostatic, hypocholesterolemic, immunostimulatory and radioprotectant effects, etc.

Effect of Phellinus igniarius Quel Extract on the Anti-inflammatory, Anti allergy, Anti-oxidant, Anti-wrinkle (상황버섯 추출물이 항염증 및 항알레르기, 항산화, 주름제거에 미치는 실험적 연구)

  • Yun, Woo-Sik;Jung, Hyun-A;Roh, Seok-Seon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.23 no.1
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    • pp.75-93
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    • 2010
  • Objectives : This study was carried out to investigate the effects of Phellinus igniarius Quel extract on the Anti-inflammatory, Anti allergy, Anti-oxidant and Anti-wrinkle. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH method. In the next experiment, to investigate anti-inflammatory test, the RAW 264.7 macrophage cells was cultured using DMEM including the 10% FBS. To study anti-allergic effect, we blended cultured Human Mast Cells(HMC-1), and then observe TNF-$\alpha$, IL-8 by ELISA Results : Phellinus igniarius Quel extract has the effects of anti-inflammation and anti-allergy, which may be due to its inhibitory potential on the macrophage activation. Furthermore, Phellinus igniarius Quel extract has the anti-wrinkle effects through the inhibitory potential on the collagnease, elastase and gelatinase activities. Conclusions : The above results suggest that Phellinus igniarius Quel extract could be applicable for improvement of several skin functions.

Consumers' Activity on the Consumers' Voluntary Anti-sites on On-line and Its Evaluation (온라인상의 소비자 자발적 안티 사이트의 활동과 평가)

  • Choi, Young-Won;Lee, Eun-Hee
    • Journal of Families and Better Life
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    • v.25 no.4
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    • pp.113-137
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    • 2007
  • This study examined the characteristics of total consumers' anti-sites on on-line and their changes according to the establishment year of consumers' anti-sites, the activities and the evaluation of consumers' anti-sites and their differences according to the characteristics of consumers' anti-sites. Total 649 consumers' anti sites were analyzed for examining the characteristics of total consumers' anti-sites and 18 anti sites were selected for examining the activities and the evaluations of consumers' anti site. The anti sites were evaluated by the index of using in preceding research. The result showed that about 90% of total consumers' anti-site were not activated, only a few consumers participated even in the activated sites, most activity of the anti-site were operated only on on-line not off-line, over half of anti-sites targeted to the company in the type of the subject of anti-site, and the majority of the external shape of anti-site were cafe. On the change of characteristics according to the opening year, the proportion of cafe and the sites acting on both on-line and off-line were increased year by year. The number of anti-sites was decreased since 2005 and the proportion of highly activated sites was lowest in 2005. On the activity of anti-sites, the number of providing the information were more than the number of presenting the complaint among the bulletin writings. The number of the bulletin writing were more in highly activated sites than in low activated sites. most of highly activated sites were problem solving type compared to the low activated sites. The number of the bulletin writings in company anti-sites were the most among three type of subject of anti-site. The number of the bulletin writings in cafe type were more than in home-page type. On the evaluation of consumers' anti-sites, most of the sites didn't update the notices and provided incomplete information how consumers participated in the protesting movements. The highly activated sites functioned better in most parts in providing a information, connection with other consumer and site manager, management of the site.

Frequencies and Distributions of Unexpected Antibodies at a General Hospital in the Daejeon of Korea (대전지역 일개 종합병원에서의 비예기 항체 발생현황과 분포)

  • Kim, Jae-Jung
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.3
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    • pp.354-358
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    • 2018
  • When preparing for a blood transfusion, the presence and types of unexpected antibodies should be identified through screening tests. Using the DiaMed-ID system, antibody identification among unexpected antibody screening tests performed at a university hospital in Daejeon area for two years from January 2016 to December 2017 were limited to 55 patients and were predominantly women. A total of 36 patients (65.5%) belonged to the Rh group, 7 (12.7%) patients to the Lewis group, 4 (7.3%) patients to the Kidd and Duffy groups, 3 patients (5.5%) to the MNS group, and 1 (1.8%) to the Rh+Kidd combined group. In the Rh group, 19 (34.5%) patients had Anti-E single antibody, 5 (9.1%) patients had Anti-D single antibody, 4 (7.3%) patients had Anti-E/-c, 4 (7.3%) patients had Anti-C/-e, and 1 (1.8%) patient had $Anti-E/-c/-Jk^b$. In the Lewis group, three (5.5%) patients had both $Anti-Le^a$ and $Anti-Le^b$. In the Kidd group, one (1.8%) patient had $Anti-Jk^a$ and three (5.5%) patients had $Anti-Jk^b$. In the Duffy and MNS groups, only single antibody was found: one (1.8%) patient with $Anti-Fy^a$, three (5.5%) patients with $Anti-Fy^b$, two (3.6%) patients with Anti-M, and one (1.8%) patient with Anti-S. This study reflects the recent frequencies and distributions of unexpected antibodies in Daejeon, which would be helpful for the efficient preparation for transfusions.

Study on the Anti-inflammatory Effect of Polysaccharide Extract from Acyranthes bidentata (우슬 다당 추출물의 항염 효과에 관한 연구)

  • Lee, Dae-Woo;Kim, Young-Jin;Kim, Young-Sil;Eom, Sang-Yong;Kim, Jong-Heon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.34 no.1
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    • pp.37-42
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    • 2008
  • Acyranthes bidentata has been used as anti-arrthritic, aphrodisiac, anti-viral, anti-spasmodic, anti-hypertensive, anti-coagulant and anti-tumor agent. In this study, we evaluated anti-inflammatory effect of polysaccharide extract from Acyranthes bidentata. Acyranthes bidentata polysaccaride decreased $IL-1{\alpha}$, IL-6, COX-2, and total NO synthesis. Our results point to the potential use of Acyranthes bidentata polysaccaride as a cosmeceutical agent for inflammatory cutaneous symptoms.

Experimental Study on Anti-body effects of Anti-BV on the Bee Venom Herbal Acupuncture (Anti-BV의 봉약침 항체 효능에 관한 실험적 연구)

  • Kwon, Ki-Rok;Lee, Kwang-Ho;Park, Won-Pil
    • Journal of Pharmacopuncture
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    • v.8 no.1
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    • pp.21-30
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    • 2005
  • Objectives : To observe physiological anti-body effects of anti-BV, acute toxic response, measurement of $LD_{50}$, and the effects of anti-body were evaluated. Methods : $LD_{50}$ of Anti-Bee Venom were measured, and to analyze acute toxic responses, weight, and the anti-body effects various concentrations of Anti-BV were diluted and the survival rate was measured. Cell blood count (CBC), liver, spleen, and kidney pathologies were observed from the histological aspects. Results : Experiment was conducted to observe Anti-BV as the anti-body to the bee venom and the following results were obtained : 1.anti-BV was injected intraperitoneally and no toxic responses were witnessed. All of the experiment subjects stayed alive during the experiment, making $LD_{50}$ analysis impossible. 2.Anti-BV was injected intraperitoneally in mice and no significant weight changes were measured between the control group and the experiment groups. 3. Measuring the concentration dependent survival rate, the highest survival rate was at the concentration of $1.25{\times}10^2mg/kg$(1/2.000) for Anti-BV. 4. No particular results were shown in the CBC test. 5. Observation of changes in the organ tissues, Anti-BV was found to suppress blood stasis in the liver and inhibit necrosis of the cells. Conclusion : Above results suggest that Anti-BV doesn't cause any toxic responses in the body and works as an anti-body to the bee venom. Further studies must be followed to secure the findings.

A study on analyzing the terms describing anti-aging effects in Dongeuibogam to propose the methodology for selecting medicinal herbs related to anti-aging effects (『東醫寶鑑』에 수록된 항노화 효능어와 이에 근거한 항노화 한약재 선별 방법론 연구)

  • Lee, Dong-Woo;Baek, Jin-Ung
    • Journal of Korean Medical classics
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    • v.27 no.2
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    • pp.25-48
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    • 2014
  • Objectives : This study aims to analyze the terms describing anti-aging effects in Dongeuibogam, and to propose the methodology for selecting medicinal herbs related to anti-aging effects. Methods : We considered aging or anti-aging theories by reviewing the major literature in korean medicine or traditional chinese medicine, and then we deduced the concepts describing anti-aging effects and the medicinal herbs for anti-aging effects. We investigated the medicinal herbs based on the terms describing anti-aging effects in Dongeuibogam and drew the methodology for selecting and classifying the medicinal herbs related to anti-aging. Results & Conclusions : The following conclusions could be drawn. 1. A set of causes and signs of aging in Dongeuibogam and a set of therapies for alleviating the aging signs in Chengumikbang, Yanglobongchinseo, and Nolohangeon was found. 2. Anti-aging effects should not be confused with disease treatments. Therefore, we defined the medical terms of anti-aging effects as "the terms expressing the effect of delaying or alleviating the subjective or objective signs of aging concretely". Based upon the terms of anti-aging effects, we defined the medicinal herbs for anti-aging effects as "the medicinal herbs whose effects are described in medical terms expressing the effects of delaying or alleviating the subjective or objective signs of aging concretely". 3. We considered Lycii Fructus, Asparagi Tuber in Dongeuibogam as examples of medicinal herbs whose effects are described in medical terms expressing anti-aging effects. It shows that we can select medicinal herbs for anti-aging effects by comparing the effects of 937 single therapies in Dongeuibogam to the terms describing anti-aging effects defined in this study. Futhermore, the results could be utilized as the basic materials of experimental study on anti-aging.

Contrasting Correlation in the Inhibition Response of ADP-induced Platelet Aggregation and the Anti-coagulant Activities of Algal fucoidans Derived from Eisenia bicyclis and Undaria pinnatifida sporophylls (Mekabu)

  • Jeong, Eui-Sook;Yoon, Yeon-Hee;Kim, Jong-Ki
    • Fisheries and Aquatic Sciences
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    • v.12 no.3
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    • pp.194-202
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    • 2009
  • Sulfated fucans are known to have both anti-thrombotic and anti-coagulant activities. In this study, the variation in platelet aggregation and anti-coagulant activities was investigated in vitro with regard to administered dose, molecular weight distribution, sulfate content, and sugar composition in two algal fucoidans from Eisenia bicyclis and Undaria pinnatifida sporophylls (Mekabu). The anti-coagulant activity largely correlated with sulfate content and with molecular weight distribution in a dose-dependent manner. However, both fucoidans demonstrated inhibitory responses to ADP-induced platelet aggregation in dose- and structure-dependent manners that contrasted with the anti-coagulant activity. Neither molecular weight distribution nor sulfate content greatly affected platelet-aggregation inhibition (PA-inhibition) by the fucoidan fractions, whereas anti-coagulant activity was sensitive to these structural factors. Interestingly, an E. bicyclis fucoidan fraction exhibited almost complete PA-inhibition at a treatment dose of 500 mg/mL while retaining weak anti-coagulant activity. In conclusion, these observations suggest that fucoidan may be a useful anti-thrombotic or anti-platelet agent in various arterial thrombotic disorders, including post-vascular intervention with controlled bleeding complications, due to its anti-coagulant modulating activity.

The Problems and Solutions in the Laws and Regulations regarding Anti-Dumping in China (중국 반덤핑법제상의 문제점과 해결방안)

  • Choi, Seok-Beom
    • International Commerce and Information Review
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    • v.12 no.3
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    • pp.361-387
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    • 2010
  • China has been the number one target of anti-dumping cases. In the middle of 1990s, China began to make anti-dumping rules to protect its domestic markets. The first anti-dumping regulation was mentioned in 1994 and the anti-dumping and anti-subsidy regulation was published in 1997. In 2001, China entered into the WTO and as a member of WTO, China is obliged to revise its anti-dumping rules in accordance with WTO's requirements. After that China amended anti-dumping rules in 2004 and it is still valid. Even though China makes considerable efforts to make the rules to be consistent with WTO Rules, China is still facing various difficulties such as lack of transparency, absence of definite deadlines, mismatch between rules, lack of clear interest criteria, overly hard questionnaires and inadequacy of judicial review and non-market economy. This paper deals with the current situation of anti-dumping system in China and the scheme of antidumping law and regulations and the main contents of that law and regulations. The purpose of this paper is to contribute to the enhancement of China's anti-dumping rules by studying the problems and solutions of the anti-dumping rules in China.

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Isolation of Quercetin and Isorhamnetin Derivatives and Evaluation of Anti-microbial and Anti-inflammatory Activities of Persicaria glabra

  • Manivannan, R.;Shopna, R.
    • Natural Product Sciences
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    • v.21 no.3
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    • pp.170-175
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    • 2015
  • The present study aims to detect the rare flavonoids isolated from the leaves of Persicaria glabra. The known flavonoids: quercetin (1), isorhamnetin (2), avicularin (3) and new one isorhamnetin-3-O-α-L-(6''-E-p-coumaroyl)-rhamnoside (4) were identified by HPLC, UV, IR and NMR. P. glabra has used traditionally for its analgesic, anti-inflammatory and anti-rheumatic properties. To find out the ingredients responsible for the efficiency of this plant, we have used to study the anti-microbial and anti-inflammatory activities of different extracts.