Browse > Article

Effect of Phellinus igniarius Quel Extract on the Anti-inflammatory, Anti allergy, Anti-oxidant, Anti-wrinkle  

Yun, Woo-Sik (대전대학교 한의과대학 한방안이비인후피부과교실)
Jung, Hyun-A (대전대학교 한의과대학 한방안이비인후피부과교실)
Roh, Seok-Seon (대전대학교 한의과대학 한방안이비인후피부과교실)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.23, no.1, 2010 , pp. 75-93 More about this Journal
Abstract
Objectives : This study was carried out to investigate the effects of Phellinus igniarius Quel extract on the Anti-inflammatory, Anti allergy, Anti-oxidant and Anti-wrinkle. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH method. In the next experiment, to investigate anti-inflammatory test, the RAW 264.7 macrophage cells was cultured using DMEM including the 10% FBS. To study anti-allergic effect, we blended cultured Human Mast Cells(HMC-1), and then observe TNF-$\alpha$, IL-8 by ELISA Results : Phellinus igniarius Quel extract has the effects of anti-inflammation and anti-allergy, which may be due to its inhibitory potential on the macrophage activation. Furthermore, Phellinus igniarius Quel extract has the anti-wrinkle effects through the inhibitory potential on the collagnease, elastase and gelatinase activities. Conclusions : The above results suggest that Phellinus igniarius Quel extract could be applicable for improvement of several skin functions.
Keywords
Phellinus igniarius Quel; Anti-oxidant; Anti-inflammation; Anti-allergy; Skin function;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Biosource, Manual for TNF-${\alpha}$ ELISA KAP-1751.
2 약품생화학분과위원회편. 분자약품생화학. 서울: 동명사. 2003:59-71.
3 Wadsworth T.L., Koop D.R., Effects of Ginkgo biloba extract and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem. Biol. Interact. 2001;137:43-58.   DOI   ScienceOn
4 Hinz B., Brune K., Rau T., Pahl A., Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages. Pharm. Res. 2001;18:151-6.   DOI   ScienceOn
5 Amersham, Manual for Prostaglandin E2 Biotrak Enzymeimmunoassay (EIA) system.
6 Chomczynski P., Sacchi N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-9.
7 Biosource, Manual for IL-6 ELISA KAP=1261.
8 Biosource, Manual for TNF-${\alpha}$ ELISA KAP-1751.
9 Kim C.D., Lee W.K., No K.O., Park S.K., Lee M.H., Lim S.R., Roh S.S., Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract. Int Immunopharmacol. 2003;3:129-136.   DOI   ScienceOn
10 Jung M.Y., Thapa N., Kim J.E., Yang J.D., Cho B.C., Kim I.S., Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing. Exp Mol Med. 2007;39:663-672.   DOI   ScienceOn
11 안덕균. 한국본초도감. 교학사. 2003:549.
12 盧石善. 原色皮膚科學. 서울: (주) 아이비씨기획. 2006:11-2, 111-21, 653, 739.
13 대한병리학회. 병리학. 서울: 고문사. 1995:71-104.
14 許 浚. 東醫寶鑑. 서울: 대한 형상 의학회. 2005:725-726.
15 서영준. 발암과정에 있어서 cyclooxigenase-2 의 역할 및 그 저해를 통한 화학 암예방. 분자세포생물학뉴스, 2001;13:8-17.
16 김륭규, 신경민, 천상국, 지사영, 서성훈, 박희준, 최종원, 이경태. 넙취 정유의 murine macrophage Raw 264.7 세포에서의 in vitro 항암효과. 약학회지. 2002;46(5):343-9.   과학기술학회마을
17 정해영역, Toshio Hirano편저. 생명과학과 분자의학을 위한 분자생물학. 서울; 월드 사이언스. 2002:73-85.
18 노민수, 하준용, 이창훈, 이우영, 이수환, 이정준. Inhibitory activities of natural products on lipopolysaccharide induced prostaglandin production in mouse macrophages. 약학회지, 1998;42(6):558-566.
19 張民慶. 中醫皮膚美容方劑大全. 北京; 중국중의약출판사. 2001:34.
20 강원형. 피부질환 아틀라스, 서울; 도서출판 한미의학. 2003:259-60,289-93,337-40,369-71,381-4.
21 김경동. 한방 천연식물의 항산화 및 자외선 흡수에 관한 연구. 한국미용학회지. 2004;10(2):145-53.
22 Jung JH., Photoaging. Photodermatol Photoimmunol Photomed. 2003;19:109-121.   DOI   ScienceOn
23 박광균. 구강생화학. 서울: 군자출판사. 1999:318-325.
24 王 燾. 外臺秘要. 北京: 人民衛生出版社. 1982:625-31,107.
25 嚴用和. 濟生方. 서울: 東洋醫藥大學. 1965:61-68.
26 危亦林. 得效方. 서울: 東洋醫藥大學. 1965:613.
27 Denizot F., Lang R., Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. Immunol.Methods. 1986;89: 271-7.   DOI   ScienceOn
28 Invitrogrogen, Manual for EnzChek${\circledR}$ Gelatinase/Collagenase Assay Kit E-12055.
29 Invitrogrogen, Manual for EnzChek${\circledR}$ Elastase Assay Kit E-12056.
30 Blos M.S., Antioxidant determination by the use of stable free radical. Nature. 1958;181:1199.   DOI   ScienceOn
31 주영승. 운곡본초학 각론. 서림재, 2004:50-7.
32 陳實功. 外科正宗. 서울: 天津科學技術出版社. 1993:47.
33 楊維傑. 黃帝內經解釋. 서울: 成輔社. 1997:147, 210, 299, 349, 456.
34 華 陀. 中藏經. 서울: 成輔社 1997:82.
35 李娟熹. 발아현미상황버섯의 피부면역질환에 대한 영향(Effects of Phellinus linteus grown in germinated brown rice on skin immune disorders). 서울: 建國大學校. 2006.
36 金泰勳. 상황버섯(Phellinus baumi)추출물의 항산화 작용과 자유라디칼의 소거효과. 진주:慶尙大學校. 2002.
37 孟垠鎬. 桑黃버섯(Phellinus linteus) 子實體分泌物의 免疫活性 및 항암효과. 서울: 단국대학교. 2001.
38 안성민. 상황버섯 균사체 인체 간암세포와 흰쥐의 간에서 염증관련 단백질에 미치는 효과. 부산대 대학원. 2005.
39 천순주. 상황버섯(Phellinus linteus)의 화장품 약리 활성검증과 한방화장품 응용에 관한 연구. 경산, 대구한의대학교. 2007.