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The Chemistry of Secondary Products from Acanthopanax Species and their Pharmacological Activities  

Shin, Kuk-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University)
Lee, Sang-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University)
Publication Information
Natural Product Sciences / v.8, no.4, 2002 , pp. 111-126 More about this Journal
Abstract
The chemistry of secondary products from Acanthopanax species and their pharmacological activities were reviewed. A nitrogenous compound, a furan compound, a quinoid, benzoids, coumarins, phenylpropanoids, lignans, flavonoids, terpenoids, phytosterols, polyacetylenes, a pyrimidine, cyclitols, monosaccharides and an aliphatic alcohol have been isolated from Acanthopanax species and have been shown to have various levels of activities such as anti-bacterial, anti-cancer, anti-gout, anti-hepatitis, anti-hyperglycemic, anti-inflammatory, anti-leishmanicidic, anti-oxidant, anti-pyretic, anti-xanthine oxidase, choleretic, hemostatic, hypocholesterolemic, immunostimulatory and radioprotectant effects, etc.
Keywords
Acanthopanax species; Araliaceae; secondary products; pharmacological activities;
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1 Awad, A. B., Von Holtz, R., Cone, J. P., Fink, C. S. and Chen, Y. C., \beta-Sitosterol inhibits growth of HT-29 human cancer cells by activating the sphingomyelin cyclA. Anticancer Res. 18, 471-479 (1998)   DOI   ScienceOn
2 Bladt, S., Wagner, H., Woo, W. S. and Taiga-Wurzel., DC- und HPLC-Analyse von Eleutherococcus- bzw. Acanthopanax-Extskten und diese enthaltenden Phytopr$\"a$paraten. DAZ 130, 1499-1508 (1990)
3 Bo, F., Matsumam, Y., Okada, Y., Qin, M., Xu, J-D. and Okuyama, T., Studies on constituents of Acanthopanax senticosus in China. Nat. Med. 52, 287 (1998)
4 Borris, R. P., Cordell, G. A. and Farnsworth, N. R., Isofraxidin, a cytotoxic coumarin from Micrandra elata (Euphorbiaceae). J. Nat. Prod. 43, 641-643 (1980)   DOI   PUBMED
5 Chang, S. Y., Yook, C. S. and Nohara, T., Lupane-triterpene glycosides from leaves of Acanthopanax koreanum. Phytochemistry 50, 1369-1374 (1999)   DOI   ScienceOn
6 Chang, S. Y., Yook, C. S. and Nohara, T., Two new lupanetriterpene glycosides from leaves of Acanthopanax koreanum. Chem. Pharm. BulI. 46, 163-165 (1998)   DOI   ScienceOn
7 Cho, H. K., Ham, I. and Whang, W. K., Constituents and quantitative analysis from the leaves of Acanthopanax divaricatus forma nambunensis. Yakhak Hoeji 43, 294-299 (1999)
8 Delioiman, D., Cali$\c{s}$, I.,Ergun,F., Dog$\u{a}$n, B. S., Buharaliog$\u{l}$u, C. K. and Kanzik, I., Studies on the vascular effects of the fractions and phenolic compounds isolated from Viscum album ssp. album. J. EthnopharmacoI. 72, 323-329 (2000)   DOI   ScienceOn
9 Hahn, D. R., Kasai, R., Kim, J. H., Taniyasu, S. and Tanaka, O., A new glycosyl ester of 3,4-seco-triterpene from a Korean medicinal plant, Acanthopanax chiisanensis (Araliaceae). Chem. Pharm. BuIl. 32, 1244-1247 (1984)   DOI
10 Heo, H-J., Cho, H-Y., Hong, B., Kim, H-K., Heo, T-R., Kim, E-K., Kim, S-K., Kim, C-J. and Shin, D-H., Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. Molecules and CelIs 13, 5-11 (2002)
11 Hirose, N., Doi, F., Ueki, T., Akazawa, K., Chijiiwa, K., Sugano, M., Akimoto, K., Shimizu, S. and Yamada, H., Suppressive effect of sesamin against 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinogenesis. Anticancer Res. 12, 1259-1265 (1992)
12 Kim, J. H. and Hahn, D. R., Studies on the chemical constituents of Acanthopanax chiisanensis Nakai roots. Arch. Pharm. Res. 4, 59-62 (1981)   DOI   ScienceOn
13 Huh K., Park, J-M., Shin, U-S. and Lee, S-I., Effect of scoparone on the hepatic sulfotransferase activity in mice. Arch. Pharm. Res. 13, 51-54 (1990)   DOI   ScienceOn
14 Jang, S. H., A study on the chemical constituent of Acanthopanax chiisanensis. Daehan Hwahak Hwoejee 14, 277-279 (1970)
15 Kim, C. J. and Hahn, D. R., The biological activity of a new glycoside, chiisanoside from Acanthopanax chiisanensis Nakai leaves. Yakhak Hoeji 24, 123-34 (1980)
16 Kim, Y. H., Ryu, J. H. and Chung, B. S., Diterpene glycoside from Acanthopanax koreanum. Kor. J. Pharmacogn. 21, 49-51 (1990)
17 Kutschabsky, L., Pfeiffer, D., Lischewski, M., Ty, P. D. and Adam, G., Molecular and crystal structure of a new 24-nor-thterpenoid carboxylic acid from Acanthopanax trifoliatus. Croatica Chemica Acta 58, 427-434 (1985)
18 Lee, M. W., Chung, J. Y., Kim, Y. C. and Hahn, D. R., The primary investigation on physiological activity from Araliaceous glycoside. Chung Ang J. Pharm. Sci. 1, 1-3 (1987)
19 Lee, S., Ji, J., Shin, K. H. and Kim, B-K-., Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus. Planta Med. 68, 936-939 (2002a)   DOI   ScienceOn
20 Lee, S., Ban, H. S., Kim, Y. P., Kim, B-K., Cho, S. H., Ohuchi, K. and Shin, K.. H., Lignans from the roots of Acanthopanax chiisanensis having inhibitory activity on prostaglandin E_2 production. Phytother. Res (Accepted for publication, 2002c)
21 Miyakoshi, M., Shirasuna, K., Hirai, Y, Shingu, K., Isoda, S., Shoji, J., Ida, Y. and Shimizu, T., Thterpenoid saponins of Acanthopanax nipponicus leaves. J. Nat. Prod. 62, 445-448 (1999)   DOI   ScienceOn
22 Majester-Savornin, B., Elias, R., Diaz-Lanza, A. M., Balansard, G., Gasquet, M. and Delmas, F., Saponins of the ivy plant, Hedera helix, and their Leishmanicidic activity. Planta Med. 57, 260-262 (1991)   DOI   ScienceOn
23 Matsumoto, K., Kasai, R., Kanamaru, F., K-ohda, H. and Tanaka, 0., 3,4-Seco-Lupane-type triterpene glycosyl esters from leaves of Acanthopanax divaricatus Seem. Chem. Pharm. Bull. 35, 413-415 (1987)   DOI
24 Meyer, R. P., Hagemeyer, C. E., Knoth, R., Kurz, G. and Volk, B., Oxidative hydrolysis of scoparone by cytochrome P_4_5_0 CYP_2C_2_9reveals a novel metabolite. Biochem. Biophys. Res. Comm. 285, 32-39 (2001)   DOI   ScienceOn
25 Nakayama, T., Yamada, M., Osawa, T. and Kawakishi, S., Inhibitory effect of caffeic acid ethyl ester on H_2O_2-induced cytotoxicity and DNA single-stranded breaks in Chinese hamsters V79 cells. Biosci. Biotechnol. Biochem. 60, 316-318 (1996)   DOI   ScienceOn
26 Nishiyama, N., Kamegaya, T., Iwai, A., Saito, H., Sanada, S., Ida, Y. and Shoji, J., Effect of Eleutherococcus senticosus and its components on sex- and learning-behaviour and tyrosine hydroxylase activities of adrenal gland and hypothalamic regions in chronic stressed mice. Shoyakugaku Zasshi 39, 238-242 (1985)
27 Novotn$\, L., Vach$\lkov$\, A., and Biggs, D., Ursolic acid: an antitumorigenic and chemopreventive activity, minireview. Neoplasma 48, 241-246 (2001)
28 Ro, H. S., Lee, S. Y. and Han, B. H., Studies on the lignan glycoside of Acanthopanax Cortex. J. Pharm. Soc. Kor. 21, 81-86 (1977)
29 Park, S. Y., Chang, S. Y., Yook. C. S. and Nohara, T., New 3,4-seco-lupane-type triterpene glycosides from Acanthopanax senticosus forma inermis. J. Nat. Prod. 63, 1630-1633 (2000a)   DOI   ScienceOn
30 Park, S. Y., Yook, C. S. and Nohara, T., A novel 3,4-seco-migrated-lupane glycoside with a seven-membered B-ring from Acanthopanax divaricatus var. sachunensis. tetrahedron Lett. 42, 2825-2828 (2001)   DOI   ScienceOn
31 Shirasuna, K., Miyakoshi, M., Mimoto, S., Isoda, S., Satoh, Y, Hirai, Y., Ida, Y. and Shoji, J., Lupane triterpenoid glycosyl esters from leaves of Acanthopanax divaricatus. Phytochemistry 45, 579-584 (1997)   DOI   ScienceOn
32 Soliman, K. F. A. and Mazzio, A. A., In vitro attenuation of nitric acid production in C_6 astrocyte cell culture by various dietary compounds. Proc. Soc. Exp. Biol. Med. 218, 390-397 (1998)
33 Srivastava, S., Gupta, M. M., Prajapati, V., Tripathi, A. K., and Kumar, S., Sesamin a potent anti-feedant principle from Piper mullesua. Phytother. Res. 15, 70-72 (2001)   DOI   ScienceOn
34 Takasugi, N., Mohguchi, T., Fuwa, T., Sanada, S., Ida, Y, Shoji, J. and Saito, H., Effect of Eleutherococcus senticosus and its components on rectal temperature, body and grip tones, motor coordination, and exploratory and spontaneous movements in acute stressed mice. Shoyakugaku Zasshi 39, 232-237 (1985)
35 Wielgorskaya, T. and Takhtajan, A., Dictionary of generic names of seed plants, Columbia University Press, NY (1995)
36 Yook, C. S., Rho, Y. S., Seo, S. H., Leem, J. Y. and Han, D. R., Chemical components of Acanthopanax divaricatus and anticancer effect in leaves. Yakhak Hoeji 40, 251-261 (1996)
37 Yasue, M., Kato, Y., Lin, Y. M. and Sakakibara, J., Studies on the constituents of Acanthopanax sciadophylloides Franch. et Sav. I. Isolation of cyclitols and flavonoid glycosides. Structure of antoside. Yakugaku Zasshi 88, 738-741 (1968)   DOI
38 Yat, P. N., Arnason, J. T. and Awang, D. V. C., An improved extraction procedure for the rapid, quantitative high-performance liquid chromatographic estimation of the main eleutherosides (B and E) in Eleutherococcus senticosus (Eleuthero). Phytochem. Anal. 9, 291-295 (1998)   DOI   ScienceOn
39 Yook, C. S., Kim, S. C., Kim, C. J. and Han, D. R., Phytoch$\u{e}$mical studies on the barks of Acanthopanax senticosus forma inermis. Yakhak Hoeji 35, 147-153 (1991)
40 Gupta, M. B., Nath, R., Srivastava, N., Kishor, K. and Bhargava, K. P., Anti-tnflammatory and anti-pyretic activities of \beta-sitosterol. Planta Med. 39, 157-163 (1980)   DOI   ScienceOn
41 Danielak, R., Popowska, A. and Borkowski, B., The preparation of vegetable products containing isofraxidin, silibin and Glaucium alkaloids and evaluation of their choleretic action, Polish J. Pharmacol Pharm. 25, 271-283 (1973)   DOI
42 Medina, I., Tombo, I., Satu$\-Gracia, M. T, German, J. B. and Frankel, A. N., Effects of natural phenolic compounds on the anti-oxidant activity of lactoferrin in liposomes and oil-in-water emulsions. J. Agric. Food Chem. 50, 2392-2399 (2002)   DOI   ScienceOn
43 Nonaka, M., Yamashita, K., lizuka, Y., Namiki, M. and Sugano, M., Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol. Biosci. Biotechnol. Biochem. 61, 836-839 (1997)   DOI   ScienceOn
44 Yook, C. S., Chang, S. Y., Lai, J. H., Ko, S. K., Jeong, J. H. and Nohara, T., Lupane-glycoside of Acanthopanax trifoliatus forma tristigmatis leaves. Arch. Pharm. Res. 22, 629-632 (1999)   DOI   ScienceOn
45 Chen, F. C., Lin, Y. M. and Yu, P. L., Constituents of Acanthopanaxtrifoliatus. J. Am. Chem. Soc. 94, 4367 (1972b)   DOI
46 Nakamura, Y., Torikai, K., and Ohigashi, H., Toxic dose of a simple phenolic anti-oxidant, Protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney. J. Agiic. Food Chem. 49, 5674-5678 (2001)   DOI   ScienceOn
47 You, H. J., Choi, C. Y., Kim, J. Y., Park, S. J., Hahm, K. S., and Jeong, H. G., Ursolic acid enhances nitric oxide and tumor necrosis factor-\alpha production via nuclear factor-\kappaB activation in the resting macrophages. FEBS Lett. 509, 156-160 (2001)   DOI   PUBMED   ScienceOn
48 Kim, Y. H. and Chung, B. S., Pimaradiene diterpenes from Acanthopanax koreanum. J. Nat. Prod. 51, 1080-1083 (1988)   DOI
49 Kitajima, J., Takamori, Y. and Tanaka, Y., Studies on the constituents of Acanthopanax sciadophylloides Fr. et Sav. leaves. Yakugaku Zasshi 109, 188-191 (1989)   DOI
50 Chen, F. C., Lin, Y. M. and Lin, S., Constituents of three-leaved Acanthopanax. Phytochemistry 11, 1496-1497 (1972a)
51 Huh, K., Lee, S-I. and Park, J-M., Effect of scoparone on the hepatic microsomal UDP glucuronyltransferase activity in mice. Arch. Pharm. Res. 10, 165-168 (1987)   DOI   ScienceOn
52 Wagner, H. and Wurmb$\"o$ck, A., Chemie, Pharmakologie und D$\"u$nnschichtchromatographie der Ginsengund EIeutherococcus-Droge. DAZ 117, 743-748 (1977)
53 Kaul, A. and Khanduja, K. L., Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals. Nutr. Cancer 32, 81-85 (1998)   DOI   ScienceOn
54 Kwak, Y-S., Ryu, S-H., Baek, B-K., Lee, J-T. and Ahn, B-Z., The anthelmintic principle of'O-Mae', the roasted fruits of Prunus mume, against Clonorchis sinensis. Yakhak Hoeji 29, 32-38 (1985)
55 Wagner, H., Heur, Y. H., Obermeier, A., Tittel, G. and Bladt, S., Die DC- und HPLC-Analyse der Eleutherococcus Droge. Planta Med. 44, 193-8 (1982)   DOI   PUBMED   ScienceOn
56 Sirato-Yasumoto, S., Katsuta, M., Okuyama, Y., Takahashi, Y. and Ide T., Effect of sesame seeds rich in sesamm and sesamolin on fatty acid oxidation in rat liver. J. Agric. Food Chem. 49, 2647-2651 (2001)   DOI   ScienceOn
57 Kim, Y. H., Kim, H. S., Lee, S. W,, Uramoto, M. and Lee, J. J., Kaurane derivatives from Acanthopanax koreanum. Phytochemistry 39, 449-451 (1995)   DOI   ScienceOn
58 Lee, S., Kim, B-K., Cho, S. H. and Shin, K. H., Phytochemical constituents from the fruits of Acanthopanax sessiIiflorus. Arch. Pharm. Res. 25, 280-284 (2002b)   DOI   ScienceOn
59 Miyakoshi, M., Ida, Y., Isoda, S. and Shoji, J., 3\alpha-Hydroxy-oleanene type triterpene glycosyl esters from leaves of Acanthopanax spinosus. Phytochemistry 34, 1599-1602 (1993b)   DOI   ScienceOn
60 Yasue, M., Kato, Y., Lin, Y. M. and Sakakibara, J., Studies on the constituents of Acanthopanax sciadophylloides Franch. et Sav. 2. On the flavonoid and terpenoid constituents, Coincidence of hirsutrin and isoquercitrin. Yakugaku Zasshi 89, 872-876 (1969)   DOI
61 Yasue, M., Lin, Y. M. and Sakakibara, J., Studies on the constituents of Acanthopanax sciadophylloides Franch. et Sav. III. Yakugaku Zasshi 90, 341-343 (1970)   DOI
62 Segiet-K-ujawa, E. and Kaloga, M., Triterpenoid saponins of Eleutherococcus senticosus roots. J. Nat. Prod. 54, 1044-1048 (1991)   DOI
63 Ban, H. S., Lee, S. Kim, Y. P., Yamaki, K., Shin, K. H. and Ohuchi, K., Inhibition of prostaglandin E_2 Production by taiwanin C isolated from the root of Acanthovanax chiisanensis and the mechanism of action. Biochem. Pharmacol. 64,1345-1354 (2002)   DOI   ScienceOn
64 Janzowski, C., Glaab, V., Samimi, A., Schlatter, J. and Eisenbrand, G., 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food Chem. Toxicol. 38, 801-809 (2000)   DOI   ScienceOn
65 Lischewski, M., Ty, P. D., Kutschabsky, L., Pfeiffer, D., Phiet, H. V., Preiss, A., Sung, T. V. and Adam, G., Two 24-nor-triterpenoid carboxylic acids from Acanthopanax trifoliatus. Phytochemistry 24, 2355-2357 (1985)   DOI   ScienceOn
66 Miyakoshi, M., Shirasuna, K., Sawada, H., Isoda, S., Ida, Y. and Shoji, J., Constituents of Acanthopanax divaricatus and A. sieboldianus roots. Nat. Med. 49, 218 (1995)
67 Oh, O. J., Chang, S. Y., Kim, T. H., Yang, K. S., Yook, C. S., Park, S. Y. and Nohara, T., Constituents of Acanthopanax divaricatus var. aIbeofructus. Nat. Med. 54, 29-32 (2000)
68 Ivorra, M. D., D'Ocan, M. P., Paya, M. and Villar, A., Antihyperglycemic and insulin-releasing effect of b-sitosterol 3-\beta-D-glucoside and its aglycone, \beta-sitosterol. Arch. Int. Pharmacodyn. 296, 224-231 (1988)
69 D$\az Lanza, A. M., Abad Mart$\nez, M. J., Fem$\ndez Matellano, L., Recuero Carretero, C., Villaescusa Castillo, L., Silv$\n Sen, A. M. and Bermejo Benito, P., Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. PIanta Med. 67, 219-223 (2001)   DOI   ScienceOn
70 Kim, Y. H., Chung, B. S. and Kim, H. J., Studies on the constituents of Acanthopanax koreanum Nakai. Kor. J. Pharmacogn. 16, 151-154 (1985)
71 Yun-Choi, H. S., Kim, J. H,, Kim, S. O. and Lee, J. R., Platelet anti-aggregating plant materials. Kor. J. Pharmacogn. 17, 161-167 (1986)
72 Ruijim, Z., Jinkang, Q., Gnanghua, Y., Baozhen, W. and Xiulan, W., Medicinal protection with Chinese herb-compound against radiation damage. Avaition Space Environ. Med. 61, 729-731 (1990)
73 Ty, P. D., Lischewski, M., Phiet, H. V, Preiss, A., Nguyen, P. V. and Adam, G., 3\alpha,11\alpha-Dihydroxy-23-oxo-lup-20(29)-en-28-oic acid from Acanthopanax trifoliatus. Phytochemistry 24, 867-869 (1985)   DOI   ScienceOn
74 Kim, Y. H., Chung, B. S., Ko, Y. S. and Han, H. J., Studies on the chemical constituents of Acanthopanax koreanum. Arch. Pharm. Res. 11, 159-162 (1988)   DOI   ScienceOn
75 Nishibe, S., Kinoshita, H., Takeda, H. and Okano, G., Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem. Pharm. Bull. 38, 1763-1765 (1990)   DOI   ScienceOn
76 Park, S. Y., Chang, S. Y., Oh, 0. J., Yook, C. S. and Nohara, T., nor-Oleanene type triterpene glycosides from the leaves of Acanthopanax japonicus. Phytochemistry 59, 379-384 (2002)   DOI   ScienceOn
77 Miyakoshi, M., Isoda, S., Sato, H., Hira,i Y., Shoji, J. and Ida, Y., 3\alpha-Hydroxy-oleanene type triterpene glycosyl esters from leaves of Acanthopamx spinosus. Phytochemistry 46, 1255-1259 (1997a)   DOI
78 Noguchi, T., Ikeda, K., Sasaki, Y., Yamamoto, J., Seki, J., Yamagata, K., Nara, Y., Hara, H., Kalnita, H. and Yamori, Y., Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Hypertension Research: Official Journal of the Japanese Society of Hypertension 24, 735-742 (2001)   DOI   ScienceOn
79 Taherzadeh, M. J., Gustafsson, L., Niklasson, C. and Lid$\n, G., Physiological effects of 5-hydroxymethylfurfural on Saccharomyces cerevisiae. AppI. Microbiol. Biotechnol. 53, 701-708 (2000)   DOI   ScienceOn
80 Yook, C. S., Lee, D. H., Seo, Y. K. and Ryu, K. S., Study on the constituents m the root bark of Acanthopanax sessiliflorum Seemann (II). Kor. J. Pharmacogn. 8, 31-34 (1977)
81 Ide, T., Ashakumary, L, Takahashi, Y., Kushiro, M., Fukuda, N. and Sugano, M., Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1, Biochim. Biophys. Acta 1534, 1-13 (2001)   DOI   ScienceOn
82 Chen, Z. W. and Ma, C. G., Effects of hyperin on free intracellular calcium in dissociated neonatal rat brain cells. Acta Pharmac. Sin. 20, 27-30 (1999)
83 Fujikawa, T., Yamaguchi, A., Morita, I., Takeda, H. and Nishibe, S., Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol. Pharm. BuII. 19, 1227-1230 (1996)   DOI   ScienceOn
84 Chung, J. Y. and Hahn, D. R., Constituents of Acanthopanax koreanum leaves. Yakhak Hoeji 35, 240-244 (1991)
85 Kapil, A. and Sharma, S., Immunopotentiating compounds from Tinospora cordifolia. J. Ethnopharmacol. 58, 89-95 (1997)   DOI   ScienceOn
86 Slacanin, I., Marston, A., Hostettmann, K., Gu$\don, D. and Abbe, P., The isolation of Eleutherococcus senticosus constituents by centrifugal partition chromatography and their quantitative determination by high performance liquid chromatography. Phytochem. Anal. 2, 137-142 (1991)   DOI
87 Taira, J., Ikemoto, T., Yoneya, T., Hagi, A., Murakami, A. and Makino, K., Essential oil phenyl propanoids: useful as OH scavengers? Free Rad. Res. Commun. 16, 197-204(1992)   DOI
88 Akimoto, K., Kitagawa, Y., Akamatsu, T., Hirose, N., Sugano, M., Shimazu, S. and Yamada, H., Protective effect of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann. Nutr. Metabol. 37, 218-224 (1993)   DOI   ScienceOn
89 Alvarez, M. A., Mar$\a, A. O. M. and Saad, J. R., Diuretic activity of Fabiana patagonica in rats. Phytother. Res. 16, 71-73 (2002)
90 Aziz, N. H., Farag, S. A., Mousa, L. A. and Abo-Zaid, M. A., Comparative anti-bacterial and anti-fungal effects of some phenolic compounds. Microbios 93, 43-54 (1998)
91 Ty, P. D., Lischewski, M., Phiet, H. V., Preiss, A., Sung, T. V., Schmidt, J. and Adam, G., Two triterpenoid carboxylic acids from Acanthopanax trifoliatus. Phytochemistry 23, 2889-2891 (1984)   DOI   ScienceOn
92 Yook, C. S., Kim, I. H., Hahn, D. R., Nohara, T. and Chang, S. Y., A lupane-triterpene glycoside from leaves of two Acanthopanax. Phytochemistry 49, 839-843 (1998)   DOI   ScienceOn
93 Chan, W. S., Wen, P. C. and Chiang, H. C., Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition. Anticancer Res. 15, 703-707 (1995)
94 Cho, H. R., Choi, D. H., Ko, B. K., Nam, C. W., Park, K. M., Lee, Y. J., Lee, S. G., Lee, J. S., Lee, K. A., Lee, A. A., Ju, S. A. and Kim, B. S., Cold preservation of rat cultured hepatocytes: the scoparone effect. Transplantation Proceedings 32, 2325-2327 (2000)   DOI   ScienceOn
95 Shao, C-J., Kasai, R., Xu, J-D. and Tanaka, O., Saponins from leaves of Acanthopanax senticosus HARMS., Ciwujia: Structures of Ciwujianosides B, C_1, C_2, C_3, C_4, D_1, D_2 and E. Chem. Pharm. Bull. 36, 601-608 (1988)   DOI
96 Umeyama, A., Shoji, N., Takei, M., Endo, K. and Arihara, S., Ciwujianosides C_1 and D_1: Powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast dells. J. Pharm. Sci. 81, 661-662 (1992)   DOI   PUBMED
97 Chen, F. C., Lin, Y. M. and Yu, P. L., Constituents of Acanthopanax trifoliatus. Phytochemistry 12, 467 (1973)   DOI   ScienceOn
98 Hahn, D. R., Kim, C. J. and Kim, J. H., A study on the chemical constituents of Acanthopanax koreanum Nakai and its Pharmaco-biological activities. Yakhak Hoeji 29, 357-361 (1985)
99 Haznedaroglu, M. Z., Karabay, N. U. and Zeybek, U., Anti-bacterial activity of Sclvia tomentosa essendal oil. Fitoterapia 72, 829-831 (2001)   DOI   ScienceOn
100 Miyakoshi, M., Terajima, Y., Isoda, S., Hirai, Y. and Ida, Y., Constituents of leaves of Acanthopanax trichodon. Nat. Med. 51, 494 (1997b)
101 Sugiyama, M. and Seki, J., In viva application of lipoproteins as drug carriers: pharmacological evaluation of Sterylgiucoside-lipoprotein complexes. Targ. Diagn. Ther. 5, 315-350 (1991)
102 Ishikura, N., Anthocyanin of Acanthopanax divaricatus. Phytochemistry 14, 1439 (1975)   DOI   ScienceOn
103 Shimizu, M., Zenko, Y., Tanaka, R., Matsuzawa, T., and Mohta, N. Studies on aldose reductase inhibitors from natural products. V. Active components of Hachimi-jio-gan (Kampo medicine). Chem. Pharm. BulI. 41, 1469-1471 (1993)   DOI   ScienceOn
104 Shao C-J., K-asai, R., Xu, J-D. and Tanaka, O., Saponins from leaves of Acanthopanax senticosus HARMS., Ciwujia. II. Structures of Ciwujianosides A_1, A_2, A_3, A_4and D_3. Chem. Pharm. Bull. 37, 42-45 (1989)   DOI
105 Yun-Choi, H. S., Kim, J. H. and Lee, J. R., Potential inhibitors of platelet aggregation from plant sources,.J. Nat. Prod. 50, 1059-1064 (1987)   DOI   PUBMED
106 Hirata, F., Fujita, K., Ishikura, Y., Hosoda, K. and Ishikawa, H., Hypocholesterolemic effect of sesamin lignan in humans. AtheroscIerosis 122, 135-136 (1996)   DOI   ScienceOn
107 Miyakoshi, M., Ida, Y, Isoda, S. and Shoji, J., 3-epi-Oleanene type triterpene glycosyl esters from leaves of Acanthopanax spinosus. Phytochemistry 33, 891-895 (1993a)   DOI   ScienceOn
108 Park, S. Y., Chang, S. Y., Yook, C. S. and Nohara, T, Tnterpene glycosides from leaves of Acanthopanax senticosus forma inermis. Nat. Med. 54, 43 (2000b)
109 Lee, I., Lee, J., Lee, Y. H., and Leonard, J., Ursolic acid-induced changes in tumor growth, O_2 consumption, and tumor interstitial Quid pressure. Anticancer Res. 21, 2827-2833 (2001)
110 Shin, A. T., Kim, C. J. and Yook, C. S., Studies on the chemical constituents of Acanthopanax fruits. Bull. K. H. Pharm. Sci. 20, 63-73 (1992)
111 Kang, H. S., Kim, Y. H., Lee, C. S., Lee, J. J., Choi, I. and Pyun, K. H., Suppression of interleukin-1 and tumor necrosis factor-\alpha production by acanthoic acid, (-)-pimara-9(11),15-diene-19-oic acid, and its anti-fibrotic effects in vivo. CelI. ImmunoI. 170, 212-221 (1996)   DOI   ScienceOn
112 Brekhman, I.I. and Dardymov, I. V, Pharmacological investigation of glycosides from Ginseng and Eleutherococcus. J. Nat. Prod. 32, 46-51 (1969)
113 Hibasami, H., Fujikawa, T., Takeda, H., Nishibe, S., Satoh, T., Fujisawa, T. and Nakashima, K., Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO cells. Oncology Reports 7, 1213-1216 (2000)
114 Chung, B. S. and Kim, Y. H., Studies on the constituents of Acanthopanax koreanum. Kor. J. Pharmacogn. 17, 62-66 (1986)
115 Heinemann, T., Axtmann, G. and Von Bergmarm, K., Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest. 23, 827-831 (1993)   DOI   ScienceOn
116 Liu, C-L., Wang, J-M., Chu, C-Y., Cheng, M-T, and Tseng, T-H., In vivo protective effect of protocatechuic acid on tert-butyI hydroperoxide-induced rat hepatotoxicity. Food Chem. ToxicoI. 41, 635-641 (2002)
117 Umeda-Sawada, R., Ogawa, M., Nakamura, M. and Igarashi, O., Effect of sesamin on mitochodhal and peroxisomal \beta-oxidadon of arachidonic and eicosapentaenoic acids in rat liver. Lipids 36, 483-489 (2001)   DOI   ScienceOn
118 Atm, J. S., Kwon, Y. S. and Kim, C. M., Anti-inflammatory constituents of PoIygonum bistorta. Kor. J. Pharmacogn. 30, 345-349 (1999)
119 Kohda, H., Tanaka, S. and Yamaoka, Y., Saponins from leaves of Acanthopanax hypoleucus Makino. Chem. Phann. Bull. 38, 3380-3383 (1990)   DOI   ScienceOn
120 Nissanka, A. P., Karunaratne, V., Bandara, B. M., Kumar, V., Nakanishi, T., Nishi, M., Inada, A., Tillekeratne, L. M., Wijesundaia, D. S. and Gunatilaka, A. A., Anti-microbial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry 56, 857-861 (2001)   DOI   ScienceOn
121 Kasai, R., Matsumoto, K., Taniyasu, S., Tanaka, 0., Kim, J. H. and Hahn, D. R., 3,4-Seco-lupane triterpene glycosyl esters from a Korean medicinal plant, Acanthopanax chiisanensis (Araliaceae). Chem. Pharm. Bull. 34, 3284-3289 (1986)   DOI
122 Li, X-C., Barnes, D. L. and Khan, I. A., A new lignan glycoside from Eteutherococcus senticosus. Planta Med. 67, 776-778 (2001)   DOI   ScienceOn
123 Sawada H., Miyakoshi, M., Isoda, S., Ida, Y. and Shoji, J., Saponins from leaves of Acanthopanax sieboldianus. Phytochemistry 34, 1117-1121 (1993)   DOI   ScienceOn
124 Zhao, W. M., Qin, G. W., Xu, R. S., Li, X. Y, Liu, J. S., Wang, Y. and Feng, M., Constituents from the roots of Acanthopanax setchuenensis. Fitoterapia 70, 529-531 (1999)   DOI   ScienceOn