• Journal of Animal Science and Technology
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• v.55 no.6
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• pp.509-513
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• 2013

We identified molecular markers associated with meat-quality traits in the porcine RPL27A (ribosomal protein L27a) gene. Three single nucleotide polymorphisms (SNPs) were discovered in the porcine RPL27A gene: g.920T>C, g.1013T>C, and g.1046T>C. The g.920 T>C SNP was significantly associated with pH24 (P < 0.05) and collagen (P < 0.05), while the g.1013T>C and g.1046T>C SNPs were significantly associated with moisture (P < 0.05). Either the TTT or CCC haplotype was significantly associated with moisture, pH24 and collagen (P < 0.05, respectively). The genotypes of RPL27A associated with meat-quality traits were all located in intron 2. The three SNPs of the RPL27A found in this study will provide useful information for genetic characterization or association studies of meat-quality traits in other populations. Additionally, these markers could potentially be applied in pig breeding programs to improve meat-quality traits after validation in other populations.

• Membrane and Water Treatment
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• v.13 no.1
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• pp.29-37
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• 2022

To verify the fate and transport of engineered nanoparticles (ENP), it is essential to understand its interactions with organic matter. Previous research has shown that dissolved organic matter (DOM) can increase particle stability through steric repulsion. However, the majority of the research has been focused on model organic matter such as humic or fulvic acids, lacking the understanding of organic matter found in field conditions. In the current study, organic matter was sampled from wastewater treatment plants to verify the stability of engineered nanoparticles (ENP) under field conditions. To understand how different types of organic matter may affect the fate of ENP, wastewater was sampled and separated based on their size; as small organic particular matter (SOPM) and large organic particular matter (LOPM), and dissolved organic matter (DOM). Each size fraction of organic matter was tested to verify their effects on nano-zinc oxide (nZnO) and nano-titanium oxide (nTiO₂) stability. For DOM, critical coagulation concentration (CCC) experiments were conducted, while sorption experiments were conducted for organic particulates. Results showed that under field conditions, the surface charge of the particles did not influence the stability. On the contrary, surface charge of the particles influenced the amount of sorption onto particulate forms of organic matter. Results of the current research show how the size of organic matter influences the fate and transport of different ENPs under field conditions.

• Archives of Pharmacal Research
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• v.23 no.5
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• pp.507-512
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• 2000

This study set out to improve the physical and pharmaceutical characteristics of the present formulation using an appropriate experimental design. The work described here concerns the formulation of the dispersible tablet applying direct compression method containing roxithromycin in the form of coated granules. In this study $2^3$ factorial design was used as screening test model and Central Composite Design (CCC) associated with response surface methodology was used as optimization study model to develop and to optimize the proper formulation of roxithromycin dispersible tablet. The three independent variables investigated were functional excipients like binder (X1), disintegrant (X2) and lubricant (X3). The effects of these variables were investigated on the following responses: hardness (Y1), friability (Y2) and disintegration time (Y3) of tablet. Three replicates at the center levels of the each design were used to independently calculate the experimental error and to detect any curvature in the response surface. This enabled the best formulations to be selected objectively. The effect order of each term to all response variable was X3> X2> Xl> X1＊X2> X2＊X2> X2＊X3> X3＊X3> Xl＊X3> Xl＊Xl and model equations on each response variables were generated. Optimized compositions of formula were accordingly computed using those model equations and confirmed by following demonstration study. As a result, this study has demonstrated the efficiency and effectiveness of using a systematic formulation optimization process to develop the tablet formulation of roxithromycin dispersible tablet with limited experiment.

• Proceedings of the KSR Conference
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• 2003.10c
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• pp.322-326
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• 2003

Dae-gu subway accident raise whole points in connection with safety facilities and operating of national urban transit system like rolling stocks, facilities, management of human. Rolling stock is made every effort for improvement of performance, guarantee of comfortableness, insurance of economical efficiency. But Security like safety of fire is not thoroughgoing enough. Especially, interior material has used although it is not prove its degree of safety. it is a main cause of Dae-gu subway accident. Safety regulation of urban transit vehicle that legislate for security in March 2000 does not applied manufacturing vehicles before in 2000. It has be prescribed in the regulations that incombustibles must be used. But detailed test standard related with incombustibles is not prescribe. Thus that regulation be required reinforcement of detailed test standard. Main cause of Dae-Gu subway accident is a fire in vehicle. However, many defects are found in infrastructure and operating vehicle of urban transit, such as inexperienced disposal of driver and CCC in early stage of the fire accident, unskilled opening and closing doors, insufficient escape facilities and safety facilities of a station house and tunnel, and incomplete communication system between vehicle and CTC, extraordinary step. Thus the aims of this study are prevention of urban transit accident, improvement plan of safety driving, and proposal of quick action plan through analysis of total faculty of vehicle.

• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.293-302
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• 2002

The classical concept for iron uptake into mammalian cells has been the endocytosis of transferrin( $T_{f}$ )-bound F $e^{3+}$ via the $T_{f}$ - $T_{f}$ receptor cycle. In this case, we could not explain the uptake of F $e^{2＋}$ ion and the export of iron from endosome. Studies on iron transport revealed that other transport system exists in epithelial cells of the intestine. One of non- $T_{f}$ -receptor-mediated transport systems is Nramp2/DMT1/DCT1 which transports M $n^{＋＋}$, $Mg^{＋＋}$, Z $n^{＋＋}$, $Co^{＋＋}$, N $i^{＋＋}$ or C $u^{＋＋}$ ion as well as F $e^{+2}$ ion. DMT1 was cloned from intestines of iron-deficient rats and shown to be a hydrogen ion-coupled iron transporter and a protein regulated by absorbed dietary iron. DMT1 is founded in other cells such as cortical and hippocampal glial cells as well as endothelial cells in duodenum. Two F $e^{3+}$ ion bound to transferrin( $T_{f}$ ) are taken up via the $T_{f}$ - $T_{f}$ receptor cycle in the intestinal epithelial cell. F $e^{3+}$ in endosome was converted to F $e^{2＋}$ ion, and then exported to cytosol via DMT1. F $e^{2＋}$ ion is taken up into cytosol via DMT1. Several other transporters such as FET, FRE, CCC2, AFT1, SMF, FTR, ZER, ZIP, ZnT and CTR have been reported recently and dysfunction of the transporters are related with diseases containing Wilson's disease, Menkes disease and hemochromatosis. Evidences from several studies strongly suggest that DMT1 is the major transporter of iron in the intestine and functions critically in transport of other metal ions.

• The Korean Journal of Applied Statistics
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• v.22 no.2
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• pp.261-270
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• 2009

Current financial crisis triggered by shaky U.S. banking system adds to the emphasis on the importance of the volatility in controlling and understanding financial time series data. The ARCH and GARCH models have been useful in analyzing economic time series volatilities. In particular, multivariate GARCH(MGARCH, for short) provides both volatilities and conditional correlations between several time series and these are in turn applied to computations of hedge-ratio and VaR. In this short article, we try to assess various MGARCH models with respect to the back-testing performances in VaR study. To this end, 14 korean stock prices are analyzed and it is found that MGARCH outperforms rolling window, and BEKK and CCC are relatively conservative in back-testing performance.

• Child Health Nursing Research
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• v.24 no.4
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• pp.527-536
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• 2018

Purpose: The purpose of this study was to investigate the needs for pediatric palliative care (PPC) among parents of children with complex chronic conditions (CCCs) and to investigate differences in the needs for PPC according to their general characteristics. Methods: A cross-sectional survey was conducted between March 28 and May 18, 2018. Parents (N=96) who had a child under 18 years with a CCC were recruited. Data were analyzed using descriptive statistics, independent t-test, and one-way ANOVA. Results: The overall average need for PPC was $3.58{\pm}0.33$ out of 4.00. In terms of care for the subjects' children, the highest need was physical care, followed by psychosocial and spiritual care. In the sub-dimensions, preservation of physical function received the highest score. Of the items, the highest need was for seizure control. In terms of care for the subjects themselves, the highest need was for psychosocial care, followed by bereavement and spiritual care. In the sub-dimensions, communication received the highest score. Of the items, the highest need was for smooth communication with medical staff. Differences in needs for PPC according to participants' general characteristics were not statistically significant. Conclusion: Medical staff should provide PPC according to the priorities of parents' perceived needs.

• The Journal of the Korea Contents Association
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• v.15 no.7
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• pp.436-448
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• 2015

This study examined one of the contemporary financial aspects, the level of corporate cash holdings for the firms belonging to the chaebols in the Korean capital markets. Being accompanied by various alternative econometric methodologies such as static and dynamic panel data model, stepwise OLS, and Fama-Macbeth modelm this research extended the preceding Kim's study (2015) in anticipation of validating the results to identify any financial factors which may significantly affect the chaebol firms' cash reserves. Several financial characteristics such as CASHFLOW, MVBV, REINVEST, and AGENCY, were found to be statistically significant factors on the level corporate liquidity, along with CCC as cash conversion cycle in the models. It may be plausible that any outcomes of this study may be applied to enhance the efficiency of financial strategies of the chaebol firms on cash holdings, thereby expediting the development of the domestic capital markets status quo toward the advanced one in the market classification.

• Journal of the Korean Society of Propulsion Engineers
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• v.16 no.1
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• pp.72-78
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• 2012

The position effect of the solid propellant in the combustion chamber on the decrease of the differential pressure has been investigated using the IBcode. Generally the metallic cartridge or CCC (combustible cartridge case) are used to load the propellant of the gun propulsion system. The position of the cartridge(propellant) is, therefore, a major factor for the interior ballistics in case the combustion chamber is larger than the cartridge. In this study, three different positions in the empty space of the chamber have been considered. As results, the case of the propellant located in the region near the base and breech has shown that the negative differential pressure and the difference between the breech pressure and the base pressure are much higher than those of the case of the propellant located in the center of the chamber. The case of the propellant in the center of the chamber is, therefore, more profitable to improve the performance of the interior ballistics.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.04a
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• pp.236-241
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• 2011

The position effect of the solid propellant in the combustion chamber on the decrease of the differential pressure has been investigated using the IBcode. Generally the metallic cartridge or CCC (combustible cartridge case) as the propellant for the cannon has been loaded. The position of the propellant(cartridge) is, therefore, a major factor for the interior ballistics in case the combustion chamber is larger than the cartridge. In this study, three cases of the existence of empty space in the chamber has been considered. As results, the case of the propellant located in the region near the base and breech has shown that the negative differential pressure and the difference between the breech pressure and the base pressure are much higher than those of the case of the propellant located in the center of the chamber. The case of the propellant in the center of the chamber is, therefore, more profitable to improve the performance of the interior ballistics.