• 생약학회지
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• 제21권2호
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• pp.126-129
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• 1990

Platelet anti-aggregating activities were evaluated with three combined crude drug preparations which have been used for 'eahyul'-one of the pathological concept in oriental medicine presumably concerning blood stasis or stagnant syndrome. The water extract of each combined preparation and each component plant was tested for their effects against ADP, arachidonic acid (AA) or collagen induced rat platelet aggregations. Mild inhibitory activities were observed with all the three tested preparations, Kaechibokryung-Hwan, Dangkqijakyak-San and Ohnkyung-Tang, and the component plants which are included in at least two of the above preparations.

• 한국분말재료학회지
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• 제24권3호
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• pp.229-234
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• 2017

We report on a simple and robust route to the spontaneous assembly of well-ordered magnetic nanoparticle superstructures by irreversible evaporation of a sessile single droplet of a mixture of a ferrofluid (FF) and a nonmagnetic fluid (NF). The resulting assembled superstructures are seen to form well-packed, vertically arranged columns with diameters of $5{\sim}0.7{\mu}m$, interparticle spacings of $9{\sim}2{\mu}m$, and heights of $1.3{\sim}3{\mu}m$ The assembled superstructures are strongly dependent on both the magnitude of magnetic field and the mixing ratio of the mixture. As the magnitude of the externally applied magnetic field and the mixing ratio of the mixture increase gradually, the size and interspacing of the magnetic nanoparticle aggregations decrease. Without an externally applied magnetic field, featureless patterns are observed for the ${\gamma}-Fe_3O_4$ nanoparticle aggregations. The proposed approach may lead to a versatile, cost-effective, fast, and scalable fabrication process based on the field-induced self-assembly of magnetic nanoparticles.

• Journal of Ginseng Research
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• 제17권2호
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• pp.127-130
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• 1993

Lipophilic Fraction (LF) from Panax ginseng C.A. Meyer strongly inhibited human platelet aggregations induced by thrombin. When platelets were prelabeled with 5-hydroxy[G-$^3$H]-tryptamine (serotonin) and then stimulated by thrombin, LF inhibited the release of serotonin in a dose-dependent manner. From this result, we suggest that LF have antiplatelet and antimigraine functions by inhibiting the release of serotonin.

• Journal of Ginseng Research
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• 제18권1호
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• pp.44-48
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• 1994

In adrenaline-stimulated human platelets, panaxadiol (PD) and panaxatriol (PT) from Panax ginseng C.A. Meyer did not inhibit the $Ca^{2+}$-innux, but inhibited the formation of thromboxane $A_2$ and the platelet aggregations. It seems that PD and PT block a pathyway interconvefing arachidonic acids (20:4) to thromboxane $A_2$ (TX $A_2$), because the amount of $Ca^{2+}$ which phospholipase C or phospholipase $A_2$ requires to liberate 20 : 4 from membrane phospholipids was increased by PD and PT. These results mean that PH and PT have an antiplatelet effect by Inhibiting the formation of TX $A_2$.

• 한국통신학회논문지
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• 제33권12B호
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• pp.1097-1102
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• 2008

An effective method for calculating delay bounds of flows through flow aggregations and deaggregations is given. Based on this calculation, it is suggested a simple criteria for flow aggregation whether the aggregation will induce an increased delay bound. The criteria is evaluated in a few realistic scenarios.

• 동의생리병리학회지
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• 제18권6호
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• pp.1860-1868
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• 2004

Geijibokryunghwan has a wide range of therapeutic applications, and some reports have indicated that it has protective activity against atherosclerosis, and more specifically stroke and myocardial infarction. A recent report showed that atherosclerotic plaque volume can be reduced by supplying Geijibokryunghwan extracts for several years. In this study, we used a component of Geijibokryunghwan, which has been used for the prevention of atherosclerosis in Korea for several years, and has proven to be useful in lowering the occurrence of cerebral infarction. In a preliminary study, we found that Geijibokryunghwan potently suppressed platelet aggregation induced by various agonists. In this study, we sought to explore the mechanism by which Geijibokryunghwan inhibits platelet aggregations.

• 한국수산과학회지
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• 제48권6호
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• pp.960-968
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• 2015

This study examined the spatiotemporal distribution of demersal fish aggregations in the Northern East China Sea by conducting a trawl survey with hydroacoustic devices. A bottom trawl was used for this survey and fish density was determined from the catch data. Acoustic data were collected at frequencies of 38 and 200 kHz from November to December 2014 and converted into the nautical area scattering coefficient (NASC, $m^2/n{\cdot}mile^2$). In the catch data analysis, the range of catch per unit area by station was $26-8,055kg/km^2$ and for the acoustic data, that of the NASC was $0.45-34.80m^2/n{\cdot}mile^2$. The values were significantly correlated. The combined results of both surveys found that the density was highest at St. 5 ($33^{\circ}$ 10.3', $126^{\circ}$ 23.3') and lowest at St. 8 ($33^{\circ}$ 20.7', $127^{\circ}$ 36.3'). The application of hydroacoustic methods offers a new approach for estimating the biomass of demersal fish aggregations.

• 수산해양기술연구
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• 제32권3호
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• pp.257-265
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• 1996

The combined hydroacoustic and bottom trawl surveys were conducted in the Cheju southeastern area by the training ship "KAYA" belong to Pukyong National University in July 1995 and the traning ship "NAGASAKI MARl]" belong to Nagasaki University in April 1994, respectively. The main purpose of the investigations was to provide the basic data for the management and the biomass estimation of commercially important demersal fish stocks in this area. Fish samples were collected by bottom trawling from 10 trawl stations randomly selected in the survey area, and the species and length compositions of trawl catches were examined. The fish school target strength for demersal fish aggregations was related to the catchability of trawl net with a 90 mm mesh codend. The most abundant species in the 1995 trawl stations were Japanese flying squid, sword tip squid and red horsehead and that of the 1994 trawl stations Japanese flying squid and blackmouth goosefish. The average weight per cubic meter of trawl catches collected by bottom trawling in the Cheju southeastern area were $1.0791{\times}lO^-4$kg/$m^3$ in the 1994 survey area and $1.3636{\times}lO^-4$kg/$m^3$ in the 1995 survey area, respectively. The catch data by cover net suggest that the efficiency of trawl net could affect the weight normalized target strength values for demersal fish aggregations. That is, the average target strength per unit of weight dropped from - 33.1 dB/kg using the total catch by codend and cover net to - 30.5 dB/kg using only the catch data by codend, and a change of2.6 dB/kg was observed.ange of2.6 dB/kg was observed.

• 대한본초학회지
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• 제28권3호
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• pp.39-44
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• 2013

Objectives : The purpose of this study was to identify active fraction and components from antiplatelet Ulmi cortex extract. Methods : The 70% ethanol extract of Ulmi cortex was subjected to column chromatography over D101 resin and eluted with an 20% (W1), 30% (W2), 40% (W3), 50%(W4), 70% (W5), and 100% ethanol (W6) to yield 6 fractions. W6 was further fractioned and its active components were purified using semi-preparative HPLC. The isolated compounds were identified by MS and NMR, and their contents were simultaneously analyzed using HPLC/UV. Antiplatelet aggregation activities of the fractions and the compounds were evaluated using rat platelet-rich plasma in presence of collagen ($5{\mu}g/ml$), arachidonic acid (0.05 U/ml), or thrombin ($100{\mu}M$). Results : Among six fractions, W3 prominently inhibited platelet aggregation. At the concentration of $200{\mu}g/ml$, W3 strongly inhibited arachidonic acid- and collagen-induced platelet aggregations by 78.2% and 65.9%, respectivley, and weakly inhibited thrombin-inducded platelet aggregation by 32.6%. Catechin, epicatehin, and catechin-7-O-${\beta}$-D-glucopyranoside were isolated from W3 and their contents were revealed to be 15.1%, 0.87%, and 0.32%. Catechin and epicatechin at the concentrations of $100{\mu}M$ strongly inhibited collagen-induced platelet aggregation by 79.9% and 86.6%, respectively, but weakly inhibited arachidonic acid- and thrombin-induced platelet aggregations. Conclusions : A main active principle of anitplatelet Ulmi Cortex extract is W3 fraction, of which main active component is catechin considering its antiplatelet activity and content.

• Natural Product Sciences
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• 제10권3호
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• pp.109-113
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• 2004

The possibility of Chungpesagantang, which has been recommended for stroke patients in Korean Sasang Constitutional Clinics, and its ingredients as a novel antithrombotic agent was evaluated. Chungpesagantang potently inhibited ADP and collagen-induced rat platelet aggregation in vitro as well as ex vivo in a dose-dependent manner. Puerariae Radix and Rhei Rhizoma potently inhibited ADP-induced rat platelet aggregation ex vivo. However, Puerariae Radix did not inhibit both in vitro ADP and collagen-induced rat platelet aggregations. Chungpesagnatang and its ingredients except Rhei Rhizoma did not affect certain plasma clotting times, such as APTT, PT, and TT. Chungpesagantang and its ingredients Raphani semen and Scutellariae Radix showed significant protection against death due to pulmonary thrombosis in mice.