Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Influence of Geijibokryunghwan on Platelet Aggregation, Cyclic AMP, Cyclic GMP, TXA2, $Ca^{2+}$ Mobilization, Tyrosine Phosphorylation of PLC-$\gamma$2 and IP3 in Activated Platelets

  • Kim Han Geu (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Jong Gu (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Seog Ha (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Sa Eun-Ho (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Jae-Woo (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Moon Jin Young (Department of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Park Sun Dong (Department of Prescription, College of Oriental Medicine, Dongguk University) ;
  • Choi Dall Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim Cherl Ho (Department of Biochemistry, College of Oriental Medicine, Dongguk University) ;
  • Park Won Hwan (Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • Published : 2004.12.01
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Abstract

Geijibokryunghwan has a wide range of therapeutic applications, and some reports have indicated that it has protective activity against atherosclerosis, and more specifically stroke and myocardial infarction. A recent report showed that atherosclerotic plaque volume can be reduced by supplying Geijibokryunghwan extracts for several years. In this study, we used a component of Geijibokryunghwan, which has been used for the prevention of atherosclerosis in Korea for several years, and has proven to be useful in lowering the occurrence of cerebral infarction. In a preliminary study, we found that Geijibokryunghwan potently suppressed platelet aggregation induced by various agonists. In this study, we sought to explore the mechanism by which Geijibokryunghwan inhibits platelet aggregations.

Keywords

References

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