• Title/Summary/Keyword: age estimation

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A Significance of Estimation of Proliferating Cell Nuclear Antigen in Thyroid Nodule (갑상선 결절에서 PCNA 측정의 의의)

  • Kim Jung-Chul;Yoon Jung-Han;JeGal Young-Jong
    • Korean Journal of Head & Neck Oncology
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    • v.10 no.2
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    • pp.200-205
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    • 1994
  • Proliferating cell nuclear antgen(PCNA) plays an important role in DNA synthesis in nucleoli and is highly conserved non-histone nuclear protein composed of 261 amino acid. and is considered to correlated with the cells proliferative state, because it is synthesized particulary during the proliferative period of late Gland S-phase. Therefore, PCNA index meaningfully increases in the active or proliferative kinetic cells. By the use of recently developed monoclonal antibodies against PCNA, the immunohistochemical staining methods can make possible. These staining methods are the useful and productive one for ascertaining the cell's proliferating abillity. Moreover, immunohistochemical staining method with a antiPCNA antibody has particulrar advantages as follows. By means of these methods, we can stain the tissue that was already fixed in formalin or paraffin wax. We can see with naked eye that which cell is, where is differentiated through a microscope. Lastly, it maintains the whole tissue architecture and makes a search for the correlation. As we have seen above, the immunohistochemical staining methods for PCNA have been studied as an impotant factor that can find the cell proliferative kinetics in malignancy and biologic behavior of tumors. To investigate of the proliferative activity in thyroid nodule, Authors evaluated cell proliferative activity by immunostaing for PNCA in 45 pathologically confirmed solitary thyroid nodule. The results were as follows. 1) The benign nodules were 25 cases(Adenomatous Goiter: 20 cases, Follicular adenoma: 5 cases) and malignant nodules were 20 cases(Papillary Ca : 14 cases, Follicular Ca : 4 cases, Anaplastic Ca : 2 cases). 2) The Most prevalent age groups were 4th decade(11 cases), and the next group was 5th decade. 3) The average PCNA labelling indices were as follows. Adenomatous goiter(I6.9%), Follicular adenoma(37.6%), papillary Ca(26.3%), Follicular Ca(8.8%) and Anaplastic Ca(86.7%). There were no significant differences in benign(20.4) and malignant nodules (28.8%) except anaplastic Ca(p=0.3226). 4) When the average tumor size 2cm in papillary Ca, the PCNA indices were 26.0% (below 2cm) : 26.6% (above 2cm) (p=0.9642). The PCNA incidies were 23.9% (with lymphatic spread) : 28.7% (without lymphatic spread) (p=0.7056). There were no signlficant differences in the above cases. In conclusion, there were no significant differences in cell proliferative activity by staining for PCNA between benign and malignat nodules except anaplastic Ca.

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Estimation on Filling Performance of Thixotropic Grout for Increasing Front-Water Depth of Gravity-Type Quay Wall (중력식 안벽 구조물의 증심 시공을 위한 가소성 그라우트의 충진성능 평가)

  • Jang, Kyong-Pil;Ryu, Yong-Sun;Kwon, Seung-Hee;Han, Woon-Woo;Oh, Myong-Hak
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.21 no.6
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    • pp.169-177
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    • 2017
  • Recently, as the size of transportation vessels has increased, there is a growing need for securing the front-water depths of existing port facilities. The method of deepening front-water depth is securing the depth of the port facility, and it is reinforced by grouting after excavating the rubble-mound to the required depth. The purpose of this study is to investigate the reinforcing performance and filling performance of thixotropic grout as a grouting material for reinforcing rubble-mound. Compressive strength tests were carried out for two types of thixotropic grout, and 5 specimens with a diameter of 400 mm and a height of 530 mm were manufactured and evaluated for filling performance. The required strength of reinforced rubble-mound required to ensure the safety of the structure is 6 MPa. All the thixotropic grouts used in this study were found to satisfy the required strength over 9 MPa at 7 days of age. As a result of visual observation of filling state of the filling performance test specimens, it was confirmed that the thixotropic grout was well filled up to the desired fillet height.

Estimation of Application on the Site of SRC Method for the Ground Reinforcement in Marine Clay (해성점토층에서 SRC 지반보강에 관한 현장적용성 평가)

  • Lee, Seungjun;Lee, Seogyoung;Chun, Byungsik
    • Journal of the Korean GEO-environmental Society
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    • v.14 no.1
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    • pp.23-32
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    • 2013
  • Currently, the west coast has focused on large-scale investment and development, such as harbor construction work and land reclamation projects, with soft ground grouting issues being the major concern. In addition, grouting for soft ground reinforcement is definitely considered that construction purpose, soil condition, construction situation, and construction costs. The SRC method, which is a high pressure injection method, can easily produce well-distributed strength regardless of soil characteristics and is environmentally friendly. Therefore in this study, the SRC method was applied to marine clay on the west coast where located Jeongok-ri, Seosin-myeon, Hwaseong-si, Gyeonggi-do, Korea as well as estimated of the ground reinforcement and the application on the site. The results of the application on the site by SRC method indicated age 28 day strength is $14,700{\sim}31,800kN/m^2$ which is satisfied the criterion of unconfined compressive strength that more than $5,333kN/m^2$. Therefore the result that the SRC method constructed marine clay on the west coast indicated the outstanding strength as well as excellent durability.

Mineral Contents in Bottled Natural Water and Estimation of Their Intake by Korean Adults (일부 무기질의 생수 중 함량 분석과 생수를 통한 섭취량 평가)

  • Kim, Moo-Kyung;Sim, Jin-Ah;Eom, Hee-Jung;Kim, Myung-Hee;Choi, Mi-Kyeong
    • Journal of the Korean Dietetic Association
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    • v.16 no.2
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    • pp.116-121
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    • 2010
  • Minerals play an important role in the body as essential nutrients. However, it is not easy to meet DRIs because food sources of minerals are limited. Recently, consumption of bottled natural water has been increasing in Korea due to water pollution and distrust of tap water. The present study was conducted to investigate mineral contents in bottled natural water and their intakes among Korean adults. We analyzed eight minerals in seven kinds of bottled natural water by ICP-spectrometry and conducted a survey on the intake status of water and bottled natural water with 400 Korean young adults. The mean contents of Ca, Mg, Fe, Zn, Cu, Mn, Se, and Mo in bottled natural water were 22.45${\pm}$22.48 mg/L, 10.59${\pm}$9.97 mg/L, 0.27${\pm}$0.18 ${\mu}g/L$, 2.06${\pm}$1.48 ${\mu}g/L$, 5.47${\pm}$0.70 ${\mu}g/L$, 1.43${\pm}$0.37 ${\mu}g/L$, 1.90${\pm}$0.96 ${\mu}g/L$, and 3.34${\pm}$0.79 ${\mu}g/L$, respectively. The mean age, height, weight, and BMI were 22.76 years, 174.94 cm, 68.64 kg, and 22.41 $kg/m^2$ for males (n=150) and 21.25 years, 162.04 cm, 51.05 kg, and 19.46 $kg/m^2$ for females (n=250), respectively. The respective daily intakes of total water and bottled natural water as water itself were 670.30 ml and 212.20 ml for males and 488.04 ml and 132.72 ml for females. The daily intakes of Ca, Mg, Fe, Zn, Cu, Mn, Se, and Mo from bottled natural water were 4.76 mg, 2.25 mg, 0.06 ${\mu}g$, 0.44 ${\mu}g$, 1.16 ${\mu}g$, 0.30 ${\mu}g$, 0.40 ${\mu}g$, and 0.71 ${\mu}g$ for males and 2.98 ${\mu}g$, 1.41 mg, 0.04 ${\mu}g$, 0.27 ${\mu}g$,0.73 ${\mu}g$, 0.19 ${\mu}g$,0.25 ${\mu}g$, and 0.44 ${\mu}g$ for females, respectively. Overall, the contents of Ca, Mg, and Se in bottled natural water were relatively high and the daily intakes of these minerals were 0.4~1.0% of the DRIs.

Estimation of Uplift Rate Based on Morphostratigraphy and Chronology of Coastal Terraces in the SE Part of Korean Peninsula (한반도 남동부에 분포하는 해안단구의 지형층서 및 연대자료를 이용한 융기율 평가)

  • Kim, Ju-Yong;Yang, Dong-Yoon;Choi, Won-Hak;Kim, Jeong-Chan
    • The Korean Journal of Quaternary Research
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    • v.20 no.2
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    • pp.51-57
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    • 2006
  • Terrace stratigraphy of the southeastern coastal areas of Korea is reappraised on the basis of terrace mapping and geochronology. Coastal terraces are divided into uHT ($90{\sim}130\;m$), HT ($63{\sim}86m$), MT ($36{\sim}55\;m$), and LT ($8{\sim}25\;m$) according to altitude. Among these, the Lower Terrace I is interpreted to have formed during MIS 5e based on Tephras Aso-4 (MIS 5c), Ata(MIS 5d or 5e) and OSL data. The age of Lower Terrace II is thought to be MIS 5a based on tephras and OSL data. The uplift rate in the SE part of Korea during the formation of the Lower Terrace (i.e. the MIS 5) ranges from 0.08 to 0.25 mm/yr and averages as 0.15 mm/yr. Such value is quite small in comparison to that of Japan, Taiwan or many other tectonically active areas in the world.

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The Distribution, Ages and Uplift Ratio ofmarine Terraces in SE coast of Korea: Review (동해안 해성단구 분포, 형성시기 및 융기율 검토)

  • Kim, Ju-Yong;Yang, Dong-Yoon;Kim, Jin-Kwan;Lee, Jin-Young;Kim, Jeong-Chan;Hong, Sei-Sun;Oh, Keun-Chang;Choi, Don-Won
    • The Korean Journal of Quaternary Research
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    • v.19 no.1
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    • pp.27-40
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    • 2005
  • Researches onmarine terrace in Korea have been drastically progressed during the last two decades.main themes of researches include vertical and horizontal distribution of paleo-shoreline, sedimentary facies ofmarine terrace deposits, OSL dating of terrace deposits and estimation of uplift rate. At present, it is noted thatmarine terraces distributed at the same altitude do not always show the same sedimentary facies, nor have the same ages.marine terraces are generally divided into five terrace systems, of which ages increase in ascending order. There are some arguments about discrimination between 2nd and 3rd terrace systems and their age. The core discrepancy lies on the question of whether the level of the last interglacial terrace is on the level of about 20m or on the 30~35m(~40m) in altitude. The uplift rate based on the paleoshoreline distribution ranges between 0.10 and 0.20m/ka.

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Development of the PDA Based Mobile System for Body Fat Measurement and Diagnosis Using Bioelectrical Impedance Method (체임피던스 방법을 이용한 PDA 기반의 휴대용 체지방 측정 및 진단 시스템 개발)

  • 권세윤;이상민;김재환;우지환;김인영;이형기;방석원;김선일
    • Journal of Biomedical Engineering Research
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    • v.25 no.1
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    • pp.21-26
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    • 2004
  • Recently, many people want to know their state of health, such as a body fat rate, anywhere and anytime. The Personal Digital Assistance(PDA) is the portable wireless apparatus that has become widely popular. There are many application areas of the IDA to be in mobile care devices. In this study, we developed the PDA based body fat measurement system, composed of a cradle type measurement module and a WindowCE operated software module, a regression equation for predicting lean body mass (LBM). Sixty-three weight-stable subjects (53 men, 10 women) aged 20∼32yr participated in this study. A regression model, LBM = (0.0005*Height2 - 0.0160*Impedance + 0.3920*Weight - 0.0684*Age - 5.8141*Sex + 25.984, was found. The correlation coefficient( r) of body fat rate between developed system and HTM1000plus(BionetTM) was 0.928. HTM1000plus is a commercially available and approved by KFDA. These results indicated that developed system is reliable for estimation of body fat rate. Although developed system is the PDA based miniaturized, it shows good performance comparing with other commercial product.

Comparative Analysis of Calculation Methods on Willingness to Pay for Introduction of Emergency-call System (교통사고 긴급통보시스템 도입을 위한 지불의사액 산정방안 비교분석)

  • Lee, Yoonjung;Do, Myungsik;Jang, Taek young;Han, Daeseok
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.14 no.6
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    • pp.50-59
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    • 2015
  • This study aimed at suggesting Willingness To Pay (WTP) for introduction of the Traffic Accident emergency Call (TAC) system by using Contingent Valuation Method (CVM) which is a general valuation method. As the method, this study suggested a WTP estimation method of the TAC system with the double-bound dichotomous choice model. In previous studies, the data are processed differently according to the type of questions and analysis models used for the calculation of willingness to pay. Therefore, we re-organized the model by the cases using the truncated data sets, and showed the difference in WTPs. The dataset was developed by more than 500 questionnaire obtained from online and offline survey with the consideration of composition ratio by age group referring housing census in 2010 to mitigate regional bias of samples. At last, this study applied various statistical methods, survival analysis, multiple regression, and Tobit model for better interpretation of the questionnaires.

Comparison of Test Methods for Evaluation of Chloride Diffusion Coefficient in Concrete (콘크리트의 염소이온 확산계수 평가를 위한 시험방법 비교)

  • Lee, Chan-Young;Kim, Hong-Sam;Kim, Jin-Cheol;Cheong, Hai-Moon;Ahn, Tae-Song
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.04a
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    • pp.581-584
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    • 2008
  • Generally, durability of concrete structures under marine environment is grossly declined by detrimental ions such as chlorides, which penetrate concrete and was diffused to corrode reinforcing rod. Therefore, chloride diffusion properties in concrete are important for durability evaluation and design of concrete structure. For estimation of chloride diffusion coefficient in concrete, both evaluation methods are used for steady state and non-steady state derived from Fick's 1st and 2nd law, respectively. However, as it is very difficult to evaluate diffusion coefficient for non-steady state like service environment where concrete is actually exposed, indirect evaluation method by laboratory accelerated test is generally used. In this study, comparison of chloride diffusion behavior was investigated for fixed mix proportion and age of concrete using four accelerated test methods based on domestic and foreign standards. From test results, only relative comparison between concrete mixtures was possible using ASTM C 1202 test, and diffusion coefficient for steady state was estimated as low as 1/10 of that for non-steady state. In addition, diffusion coefficient estimated by immersion test was similar to result by NT build 492 test.

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The Relationship between Stand Mean DBH and Temperature at a Watershed Scale: The Case of Andong-dam Basin (유역단위에서의 임목평균흉고직경과 기온 간의 관계: 안동댐 유역을 중심으로)

  • Moon, Jooyeon;Kim, Moonil;Lim, Yoonjin;Piao, Dongfan;Lim, Chul-Hee;Kim, Seajin;Song, Cholho;Lee, Woo-Kyun
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.18 no.4
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    • pp.287-297
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    • 2016
  • This study aims to identify the relationship between climatic factors and stand mean Diameter at Breast Height (DBH) for two major tree species; Pinus densiflora and Quercus mongolica in Andong-dam basin. Forest variables such as age, diameter distribution and number of trees per hectare from the $5^{th}$ and $6^{th}$ National Forest Inventory data were used to develop a DBH estimation model. Climate data were collected from six meteorological observatory station and twelve Automatic Weather System provided by Korea Meteorological Administration to produce interpolated daily average temperature map with Inverse Distance Weighting (IDW) method. Andong-dam basin reflects rugged mountainous terrain, so temperature were adjusted by lapse rate based correction. As a result, predictions of model were consistent with the previous studies; that the rising temperature is negatively related to the growth of Pinus densiflora whereas opposing trend is observed for Quercus mongolica.