• Toxicological Research
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• v.34 no.4
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• pp.333-341
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• 2018

Ferulate is a phenolic compound abundant in wheat germ and bran and has been investigated for its beneficial activities. The aim of the present study is to evaluate the efficacy of ferulate against the oxidative stress-induced imbalance of protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs), and serine/threonine protein phosphatase 2A (PP2A), in connection with our previous finding that oxidative stress-induced imbalance of PTKs and PTPs is linked with proinflammatory nuclear factor-kappa B $(NF-{\kappa}B)$ activation. To test the effects of ferulate on this process, we utilized two oxidative stress-induced inflammatory models. First, YPEN-1 cells were pretreated with ferulate for 1 hr prior to the administration of 2,2'-Azobis(2-methylpropionamidine) dihydrochloride (AAPH). Second, 20-month-old Sprague-Dawley rats were fed ferulate for 10 days. After ferulate treatment, the activities of PTKs, PTPs, and PP2A were measured because these proteins either directly or indirectly promote $NF-{\kappa}B$ activation. Our results revealed that in YPEN-1 cells, ferulate effectively suppressed AAPH-induced increases in reactive oxygen species (ROS) and $NF-{\kappa}B$ activity, as well as AAPH-induced PTK activation. Furthermore, ferulate also inhibited AAPH-induced PTP and PP2A inactivation. In the aged kidney model, ferulate suppressed aging-induced activation of PTKs and ameliorated aging-induced inactivation of PTPs and PP2A. Thus, herein we demonstrated that ferulate could modulate PTK/PTP balance against oxidative stress-induced inactivation of PTPs and PP2A, which is closely linked with $NF-{\kappa}B$ activation. Based on these results, the ability of ferulate to modulate oxidative stress-related inflammatory processes is established, which suggests that this compound could act as a novel therapeutic agent.

• YAKHAK HOEJI
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• v.54 no.4
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• pp.215-225
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• 2010

To investigate effects of pine essential oil isolated by steam distillation from Pinus densiflora needles (PN) and twigs (PT) on anti-oxidant and anti-aging activities, the experiments were carried out to determine anti-oxidant and antiaging activities on DPPH radical scavenging activity, NBT/xanthine oxidase-superoxide scavenging activity, silica-induced intracellular $H_2O_2$ and hydroxyl radical generation in RAW264.7 cells, hyaluronidase and elastase activities in vitro. Essential oil of PN and PT were contained 0.225 and 0.176 (w/v) %, respectively. PN was contained with 30 kinds of essential oil and its major constituent is $\alpha$-pinene (21.5%). Further PT was contained with 40 kinds of essential oil and its major constituent is $\beta$-pinene (22.4%) in GC/MS assay. Other essential oils of PN were $\beta$-pinene, camphene, myrcene, limonene, terpinolene, $\alpha$-terpineol, bornyl acetate, $\alpha$-copaene, caryophellene and humulene and PT were $\alpha$-pinene, camphene, phellandrene, limonene, terpinolene, $\alpha$-terpineol, bornyl acetate, $\alpha$-copaene, caryophellene and humulene. The essential oil of PT have more active than that of PN in anti-oxidant activity which has significant DPPH radical and superoxide scavenging activity, and significant inhibitory activities on silica-induced intracellular $H_2O_2$ and hydroxyl radical generation, as well as, significantly inhibited elastase and hyaluronidase activities. Further, phellandrene, myrcene and $\alpha$-pinene have DPPH radical and superoxide scavenging activities, $\beta$-pinene, terpinolene, myrcene and phellandrene inhibited silica-induced intracellular $H_2O_2$ and hydroxyl radical generations. And also phellandrene and $\beta$-pinene inhibited hyaluronidase and elastase activities. In conclusion, the essential oils isolated from PN and PT have anti-oxidant and anti-aging activities.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.4 s.59
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• pp.227-231
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• 2006

Wrinkle formation is mainly attributed to the environmental factors such as UV rays, air pollution, smoking and stress etc. Especially, UV rays induce premature skin aging which is characterized by deep wrinkle, leathery dryness etc. Recently, researches on the wrinkle formation and its prevention have been the main theme in cosmetics fields. We have studied the various plant extracts having anti-wrinkle effects and finally showed that Noni (Morinda citrifolia) extracts have the efficacy of promoting the type I collagen synthesis in normal human fibroblast, using PICP assay. We purified one active compound from Noni extracts and identified its structure. It was identified as 6,7-Dimethoxy-2H-1-Benzopyran-2-one; scopoletin by $^1H-NMR,\;^{13}C-NMR,$ IR, Mass analysis. Scopoletin increased collagen synthesis in a dose dependent manner (89.5% at $0.2{\mu}g/mL$). In order to verify the anti-aging effectiveness of the cream containing 3% noni extracsts, we performed the in vivo test with some female volunteers for 12 weeks. It reduced the signs of aging, especially face wrinkles. From these results, we conclude that the noni extracts could be used as an useful anti-wrinkle agent.

• 한국노년학
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• v.29 no.1
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• pp.21-35
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• 2009

The aim of this study is to make clear the characteristics of elderly comsumer behaviors and to provide information for the organ and company preparing aging friendly industry. This information is actual data which analyzed elderly consumer behaviors according to sociology of Population criterion. The first survey was conducted to 600 elderly about the degree of products preference, the criterion of products selection, actual purchaser, the preferring medium. To compare elderly consumer behaviors to young consumer behaviors, the second survey was conducted to 400 elderly and young persons. The results are in following. First, the crucial factors of elderly consumers making select products is the function of products. Second, when planning marketing for elderly consumers, company needs to investigate factors affecting elderly consumers behaviors, for instance the educational level, a monthly income level, age, sex, and so on. Third, elderly consumers were the most interested in health products. Specially, male elderly consumers in leisure sports and tour products. Fourth, elderly consumers is active for economic respect and independent for social respect.

• Journal of Life Science
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• v.34 no.9
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• pp.656-665
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• 2024

Enzymes, as proteins that regulate various metabolic processes within the human body, play a crucial role in maintaining health. However, the overexpression of certain enzymes can disrupt metabolic balance, leading to various diseases. Enzyme inhibitors are vital in treating these diseases or conditions by inhibiting the action of these enzymes, making them indispensable in the development of effective therapies for a wide array of diseases. Quercetin, a natural product derived from plants, is a type of flavonoid that belongs to the polyphenol family. Quercetin, a natural flavonoid from the polyphenol family, has emerged as a potent enzyme inhibitor. This low-molecular-weight secondary metabolite is known for its inhibitory effects on enzymes such as α-glucosidase, acetylcholinesterase, bacterial neuraminidase, and xanthine oxidase due to its structural advantages. Quercetin is isolated from biomaterials and can be classified into glycosylated, methoxylated, and alkylated derivatives based on its structural variations. These natural quercetin derivatives possess unique substituents that enable specific binding patterns with catalytic residues in enzyme active sites. Therefore, quercetin derivatives can be expected to have better enzyme inhibitory activity than basic quercetin. Due to their specificity and enhanced activity, quercetin and its derivatives hold promise as candidates for developing potent enzyme inhibitors to treat diseases resulting from enzyme imbalances.

• Journal of muscle and joint health
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• v.19 no.1
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• pp.57-70
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• 2012

Purpose: This study aimed to investigate the level of physical activity and to identify factors related with physical activity for the elderly with Diabetes Mellitus (DM). Methods: The subjects were 154 diabetic outpatient at 3 hospitals located in J city. Data were collected from February 1 to 17 in 2012. Data were analysed using Chi-square test, ANOVA, and logistic regression by SPSS/WIN 18.0. Results: Mean physical activity level per week measured by International Physical Activity Questionnaire (IPAQ) was $2247.01{\pm}2533.73$ MET-minutes (minimally active). There were significant differences in the level of physical activity by age, spouse, education, job, admission, duration of DM, and DM therapy. There were significant differences in subjective health status, objective and subjective obesity, satisfaction with physical body, perception of aging, self-efficacy, perceived benefits, perceived barriers, and social support among the inactive, minimally active, and health enhancing physical activity groups. Factors influencing the level of health enhancing physical activity were spouse (OR=10.192), self-efficacy (OR=5.351), subjective obesity (OR=.114), and perceived barriers (OR=.069). Conclusions: The level of physical activity of elderly patients with DM was minimally inactive. Physical activity program enhancing self-efficacy and decreasing perceived barriers, as well as improving the correct perception of subjective obesity is recommended as a nursing intervention.

• Journal of Life Science
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• v.23 no.9
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• pp.1073-1078
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• 2013

The antioxidant and anti-inflammatory effects of active ingredients in cosmetics are very important. The effects are closely related to the prevention of skin aging. Among medicinal plants, Bletilla striata Reichenbach fil. has well-known pharmacological activity. Extracted samples were prepared using sequential fractionation of ethyl acetate, butanol, and water. The antioxidant effect of the fractions was confirmed by DPPH and ABTS+ radical scavenging. Among the various fractions of B. striata Reichenbach fil., ethyl acetate was associated with a reduction in nitric oxide production, which was induced by LPS (lipopolysaccharide) treatment in a dose-dependent manner. In addition, the production of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2), which are upstream regulators of nitric oxide production, was also inhibited. Thus, the ethyl acetate fraction of B. striata Reichenbach fil. appears to be a potential active ingredient for use in cosmetics.

• The Journal of the Acoustical Society of Korea
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• v.30 no.4
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• pp.207-214
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• 2011

Human auditory acuity decreases naturally due to aging. But recently cases of impaired hearing at a young age are increasing greatly. The biggest reason for such an increase of population with impaired hearing is popularization of various kinds of portable multimedia appliances. Many studies on impaired hearing due to noises caused by the earphone and headphone are being made, but there are few studies on noise-impaired hearing caused directly by mobile phone communication. Based on a precedent inquiry, this study proposes a technique for preventing noise-impaired hearing applying to an active noise reduction technique onto bone conduction speaker. This technique is a method for reducing noises by antiphase oscillation through bone conduction speaker with ambient noises. If the proposed system is applied, the noise level that is actually introduced to audition decreases by more than 12 dB, and such a decreased amount of sound volume fundamentally prevents the factors of noise-caused hearing difficulty due to mobile phone communication. Sensibility test results showed that adequate communication was possible even in such a situation where communication volume was decreased like this.

• Korean Journal of Plant Resources
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• v.21 no.1
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• pp.5-11
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• 2008

This study examined the characteristics of Pinus thunbergii community that forms a windbreak forest around the coast of Gwanmaedo located in Jodo-myeon, Jindo-gun, Jeollanamdo which is located in the south-western areas of Korea from December 2005 to April 2007 and to suggeste the ecological management methods of coastal windbreak areas. P. thunbergii community, a coastal windbreak forest of Gwanmaedo, was classified into disturbance, growth, mixture, stability, and back mountain vegetation according to major companions species and vegetation types. P. thunbergii community of disturbance and growth vegetation needs active management through tree thinning, mowing, weeding out, use of rest space, and felling sick pine trees. P. thunbergii community of mixture, stability, and back mountain vegetation needs active preservation of a coastal windbreak to restore natural vegetation by making a windbreak walk and a forest buffer zone and inducing vegetation succession. Accordingly, in this study, ecological management methods were suggested according to the actual state of distribution by habitat characteristics of coastal windbreak areas such as management of beaches and surrounding area of idle lands, restoration of back wetlands, inhibition of foreign plants, maintenance of diversity of species and habitats, and prevention of aging and spread of damage from insects.

• Journal of the Korean housing association
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• v.17 no.3
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• pp.143-155
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• 2006

The purpose of the study was to examine the housing needs of the elderly who lived in rural area and suggest the planning directions of the housing for the rural elderly. The subjects were 192 elderlies who lived in the rural area in Gyeongnam and Chonbuk. They were selected by using the stratified sampling method. Also the interview method was used for collecting the data. The results were as follows: 1) Most of the rural elderly had some problems in their health. Thus, the housing for them should be planned on the basis of their health conditions. 2) The rural elderly had active interaction with their neighborhoods. Therefore, the housing for them should be planned for maintaining this active relation. 3) The rural elderly has lived in their housing for long time and wanted to live there as long as possible. This implies that the concept of 'aging in place' should be considered as one of the Important design issues in the rural housing for the elderly. 4) Even though many rural elderlies didn't know about the planned housing facilities for the elderly, they had intentions to live in there if they were provided in rural area. 5) The rural elderly preferred the monthly payment system or the life long payment system as the payment system of the planned housing facilities for the elderly. Also, they wanted that facility to be maintained by the government. 6) The detached housing type or three story townhouse type which is located in each rural village as small size would be desirable as the housing for the rural elderly. 7) The 10-30 pyung would be desirable as the size of housing unit. Also, 2-6 persons per room in case of sharing a bedroom. 8) Ondol-bang would be desirable however the size of the bedroom should be determined by considering using the bed.