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http://dx.doi.org/10.5352/JLS.2013.23.9.1073

Antioxidant and Anti-inflammatory Effects of Bletilla striata Reichenbach fil. Fractions as Cosmetic  

Yoon, Ji-Hun (Department of Cosmeceutical Science, Daegu Haany University)
Park, Seong-Geun (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Mi-Ji (Department of Cosmeceutical Science, Daegu Haany University)
Park, Jin-Young (Skin science R&D Center, Cosmelab Co. Ltd.)
Seo, Kyo-Seong (Small and Medium Business Administration)
Woo, Kyung-Chul (Korean Research institute for Skin science, Newlife Cosmetics Ltd.)
Lee, Chang-Eon (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Journal of Life Science / v.23, no.9, 2013 , pp. 1073-1078 More about this Journal
Abstract
The antioxidant and anti-inflammatory effects of active ingredients in cosmetics are very important. The effects are closely related to the prevention of skin aging. Among medicinal plants, Bletilla striata Reichenbach fil. has well-known pharmacological activity. Extracted samples were prepared using sequential fractionation of ethyl acetate, butanol, and water. The antioxidant effect of the fractions was confirmed by DPPH and ABTS+ radical scavenging. Among the various fractions of B. striata Reichenbach fil., ethyl acetate was associated with a reduction in nitric oxide production, which was induced by LPS (lipopolysaccharide) treatment in a dose-dependent manner. In addition, the production of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2), which are upstream regulators of nitric oxide production, was also inhibited. Thus, the ethyl acetate fraction of B. striata Reichenbach fil. appears to be a potential active ingredient for use in cosmetics.
Keywords
Anti-oxidant; Induced-Nitric oxide synthase (iNOS); cyclooxygenase-2 (COX-2); fraction; Bletilla striata Reichenbach fil.;
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