• Molecules and Cells
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• v.40 no.9
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• pp.607-612
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• 2017

When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. These seemingly opposite roles of autophagy may reflect a complex picture of autophagic regulation on cellular senescence, including different types of autophagy or a unique spatiotemporal activation of autophagy. Thus, a better understanding of autophagy process will lead us to not only elucidate the conundrum how autophagy plays dual roles in the regulation of cellular senescence but also helps the development of new therapeutic strategies for many human diseases associated with cellular senescence. We address the pro-senescence and anti-senescence roles of autophagy while focusing on the potential mechanistic aspects of this complex relationship between autophagy and cellular senescence.

• Biomolecules & Therapeutics
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• v.26 no.3
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• pp.255-267
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• 2018

Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links between inflammatory signals and pain-mediating neuronal signals is essential for understanding the mechanisms behind pain exacerbation. Some inflammatory mediators directly modulate the excitability of pain-mediating neurons by contacting the receptor molecules expressed in those neurons. For decades, many discoveries have accumulated regarding intraneuronal signals from receptor activation through electrical depolarization for bradykinin, a major inflammatory mediator that is able to both excite and sensitize pain-mediating nociceptor neurons. Here, we focus on the final effectors of depolarization, the neuronal ion channels, whose functionalities are specifically affected by bradykinin stimulation. Particular G-protein coupled signaling cascades specialized for each specific depolarizer ion channels are summarized. Some of these ion channels not only serve as downstream effectors but also play critical roles in relaying specific pain modalities such as thermal or mechanical pain. Accordingly, specific pain phenotypes altered by bradykinin stimulation are also discussed. Some members of the effector ion channels are both activated and sensitized by bradykinin-induced neuronal signaling, while others only sensitized or inhibited, which are also introduced. The present overview of the effect of bradykinin on nociceptor neuronal excitability at the molecular level may contribute to better understanding of an important aspect of inflammatory pain and help future design of further research on the components involved and pain modulating strategies.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.905-910
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• 2016

Breast cancer is one of the major threats to female health, and its incidence is rapidly increasing in many countries. Currently, breast cancer is treated with surgery, followed by chemotherapy or radiation therapy, or both. However, a substantial proportion of breast cancer patients might have a risk for local relapse that leads to recurrence of their disease and/or metastatic breast cancer. Therefore searching for new and potential strategies for breast cancer treatment remains necessary. Immunotherapy is an attractive and promising approach that can exploit the ability of the immune system to identify and destroy tumors and thus prevent recurrence and metastatic lesions. The most promising and attractive approach of immunotherapeutic research in cancer is the blockade of immune checkpoints. In this review, we discuss the potential of certain inhibitors of immune checkpoints, such as antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death 1 (PD-1) and lymphocyte activation gene-3 (LAG-3), in breast cancer therapeutics. Immune checkpoint inhibitors may represent future standards of care for breast cancer as monotherapy or combined with standard therapies.

• Journal of Korea Society of Digital Industry and Information Management
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• v.11 no.1
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• pp.197-207
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• 2015

A new communication revolution such as social networking service (SNS) has been transforming the way of interaction between people in both of individual level and organizational level. Recently many people have switched to closed type SNS such as Naver Band and Kakao group due to the several reasons. The purpose of this study is to investigate the usage motivation and satisfaction of closed type SNS based on use and gratifications perspectives. Based on prior studies on use and gratifications of Internet-related media and SNS, information motivation, relationship motivation, pleasure/entertainment motivation, self-expression motivation, work motivation were identified as usage motivation of closed type SNS. According to the results, relationship motivation and work motivation were found to be significantly related to the satisfaction. But other motivation factors(information motivation, pleasure/entertainment motivation, self-expression motivation) are not significantly related to the satisfaction. Then satisfaction was found to be significantly related to the intention to use. This study contributes to give companies providing closed type SNS and using it as a marketing tool with the base of activation strategies and practical implications.

• Journal of environmental and Sanitary engineering
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• v.21 no.2 s.60
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• pp.69-83
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• 2006

This research aims to improve the environmental education for elementary student's education program. That let environmental education be connected to other curriculum with a compunction enhancement plan to the internal volume side of environmental education, and grope for activation of compunction environmental education with curriculum necessary paradigm conversion of education for continuance possibility in green education. In case of legal and system, improving of legal and system by establishment of the environmental education act for system repair and source of revenue preparation of environmental education is needed. Based on importance of teaching-education and evaluation, it must be developed various teaching-education ways of environmental education in case of curriculum and an improvement of teaching-education ways and evaluation must be performed. After teaching-education about environmental education has been executed, a teaching-education improvement must be performed by evaluation.

• Tuberculosis and Respiratory Diseases
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• v.68 no.3
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• pp.125-139
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• 2010

Patients with chronic obstructive pulmonary disease (COPD) frequently complain of dyspnea on exertion and reduced exercise capacity, which has been attributed to an increase in the work of breathing and in impaired of gas exchange. Although COPD primarily affects the pulmonary system, patients with COPD exhibit significant systemic manifestations of disease progression. These manifestations include weight loss, nutritional abnormalities, skeletal muscle dysfunction (SMD), cardiovascular problems, and psychosocial complications. It has been documented that SMD significantly contributes to a reduced exercise capacity in patients with COPD. Ventilatory and limb muscle in these patients show structural and functional alteration, which are influenced by several factors, including physical inactivity, hypoxia, smoking, aging, corticosteroid, malnutrition, systemic inflammation, oxidative stress, apoptosis, and ubiquitin-proteasome pathway activation. This article summarizes briefly the evidence and the clinical consequences of SMD in patients with COPD. In addition, it reviews contributing factors and therapeutic strategies.

• Journal of Information Technology Services
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• v.9 no.1
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• pp.141-156
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• 2010

Service industry has become the integral part of economy. And the activation of industry requires a scientific and systematic approach. As one of these kinds of efforts, IBM presented a service model which consisted of strategies, processes, technology, manpower and so on through Service Science. And IBM raised the needs of considering the main issue and methodology of service model's scientific approach. On that account, this study worked out factorial definitions and measurable items by the four components of service model presented by Service Science in order for it to be measured through studies on related literature and interviews of specialists. In order to prepare an opportunity of categorizing the conception of the service model of which character was strongly intangible and of systematically approaching to it, the investigator examined related literature and applied it QFD methodology. Through this kind of redefinition, the investigator concretely conceptualized the service model which was standstill at the level of theoretical approach so far and presented guidelines with which researchers could classify it more concretely. In addition, the investigator tried to present a systematic frame which could be applied to business by working-level officials or decision-makers. Therefore, the investigator expects that study findings will be used as references for the design or implementation of service-oriented business model.

• Journal of Oriental Neuropsychiatry
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• v.20 no.2
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• pp.31-46
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• 2009

Objectives : This experiment was designed to investigate the effect of Gojineumja(Guzhenyinzi, GJEJ) on damaged neural tissue in cultured glial cells and in the mouse brain tissue. Methods : The effects of the GJEJ on activation of astrocytes and caspase 3-positive cell counts in cultured glial cells administered with ${\beta}$-amyloid peptide were investigated. The effects of the GJEJ on levels of glial fibrillary acidic protein(GFAP)-positive reactive astrocyets and caspase 3-positive cells in the hippocampal subfields in the rats administered with scopolamine were investigated. Results : 1. GJEJ reduced levels of activated astrocytes and caspase 3-positive cell counts in cultured glial cells administered with ${\beta}$-amyloid peptide. 2. GJEJ reduced levels of GFAP-positive reactive astrocyets and caspase 3-positive cells in the hippocampal subfields in the rats administered with scopolamine. Conclusions : The present data. suggest that GJEJ may have a protective function of neuronal and non-neuronal cells in damaged neural tissue caused by AD-like stimulations. Further studies on identification of effective molecular components of GJEJ and their interactions with damaged neural cells would be important for understanding molecular mechanism and may be further applicable for the development of therapeutic strategies.

• International Journal of Highway Engineering
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• v.17 no.3
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• pp.59-68
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• 2015

PURPOSES : This study suggests the application of glow line marking technology for reducing traffic accidents at nighttime. METHODS : In this study, using a statistical analysis, we analyzed the characteristics of traffic accidents occurring at nighttime. Next, the strength, weakness, opportunity, and threat (SWOT) factors were derived based on a current-status analysis of glow line marking technology and road environments. An SO strategy, ST strategy, WO strategy, and WT strategy were established in accordance with the four SWOT factors. RESULTS : This study suggests that the following strategies should be promoted to apply glow line marking technology to a road environment: 1) an activation strategy for the technological development of glow line markings for a new paradigm in reducing traffic accidents, 2) a benefit enhancement strategy applying glow line marking technology in places where nighttime traffic accidents frequently occur, 3) a strategy for the expansion of glow line marking by replacing streetlights, and 4) a strategy for enhancing road applications through the development of various line marking methods in consideration of both performance and costs. CONCLUSIONS : The application of glow line markings in a road environment can contribute to a reduction of traffic accidents at nighttime, and aid energy savings from the replacement of streetlights.

• Biomolecules & Therapeutics
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• v.20 no.2
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• pp.133-143
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• 2012

Matrix metalloproteinases (MMPs) are a subfamily of zinc-dependent proteases that are re-sponsible for degradation and remodeling of extracellular matrix proteins. The activity of MMPs is tightly regulated at several levels including cleavage of prodomain, allosteric activation, com-partmentalization and complex formation with tissue inhibitor of metalloproteinases (TIMPs). In the central nervous system (CNS), MMPs play a wide variety of roles ranging from brain devel-opment, synaptic plasticity and repair after injury to the pathogenesis of various brain disorders. Following general discussion on the domain structure and the regulation of activity of MMPs, we emphasize their implication in various brain disorder conditions such as Alzheimer's disease, multiple sclerosis, ischemia/reperfusion and Parkinson's disease. We further highlight accumu-lating evidence that MMPs might be the culprit in Parkinson's disease (PD). Among them, MMP-3 appears to be involved in a range of pathogenesis processes in PD including neuroinflamma-tion, apoptosis and degradation of ${\alpha}$-synuclein and DJ-1. MMP inhibitors could represent poten-tial novel therapeutic strategies for treatments of neurodegenerative diseases.