• Environmental Mutagens and Carcinogens
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• v.19 no.2
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• pp.102-107
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• 1999

A population monitoring studies for assessing the genotoxicity of occupationally exposed mixed organic solvents to printers were performed by using the chromosome aberration assay and the cytokinesis-blocked micronucleus assay. The incidence of chromosome aberrations and micronuclei was studied in the peripheral blood lymphocytes of 51 male printers and their matched controls in Seoul area. Smoking habits and duration of employment were taken into account. The frequencies of micronucleus in peripheral lymphocytes of printers were significantly different in comparision with control subjects. Also there were significant increase in the frequencies of micronucleus by duration of exposure. The frequencies of chromosome aberrations showed no significant differences between printers and their matched controls.

• Environmental Mutagens and Carcinogens
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• v.19 no.1
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• pp.14-19
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• 1999

Chromosome rearrangements induced in human lymphocyte after in vitro exposure to chromium were analysed by the use of fluorescence in situ hybridization(FISH) with triple combination of composite whole chromosome-specific probe for chromosome 1, 2 and 4. Chromosome aberrations was scored by the Protocol for Aberration Identification and Nomenclature Terminology (PAINT). Stable translocation was the most frequent type of aberrations and dicentrics and insertions were also observed. Chromium treatment enhanced the frequencies of stable translocations and color junctions in a dose-dependent manners, but no distinct increase of dicentrics and insertions was seen. The ratio of the yields of translocation to the yields of dicentric varied between 13 to 27. The presents results demonstrate fluorescent in situ hybridization (FISH) is useful for detecting chromosomal rearrangements induced by chromium.

• BMB Reports
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• v.47 no.5
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• pp.280-285
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• 2014

Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochondria are unclear. In this study, we assessed mitochondrial changes accompanying TRAP1 overexpression, in a mouse cell line, NIH/3T3. We found that overexpression of TRAP1 leads to a series of mitochondrial aberrations, including increase in basal ROS levels, and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma coactivator-$1{\alpha}$ (PGC-$1{\alpha}$) mRNA levels. We also observed increased extracellular signal-regulated kinase (ERK) phosphorylation, and enhanced proliferation of TRAP1 overexpressing cells. This study suggests that overexpression of TRAP1 might be a critical link between mitochondrial disturbances and carcinogenesis.

• Journal of the Optical Society of Korea
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• v.20 no.4
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• pp.481-487
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• 2016

This study presents a new optical system for a combiner-type head-up display (HUD) with a cylindrical lens as an asymmetrical aberration corrector, instead of a freeform mirror. In the initial design process based on off-axial aberration analysis, we obtain an off-axis two-mirror system corrected for linear astigmatism and spherical aberration by adding a conic secondary mirror to an off-axis paraboloidal mirror. Thus, since the starting optical system for an HUD is corrected for dominant aberrations, it enables us to balance the residual asymmetrical aberrations with a simple optical surface such as a cylinder, not a complex freeform surface. From this design process, an optical system for an HUD having good performance is finally obtained. The size of the virtual image is 10 inches at 2 meters away from a combiner, and the area of the eye box is 130×50 mm².

• Journal of the Optical Society of Korea
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• v.20 no.1
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• pp.64-69
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• 2016

A new compact conformal dome optical system was established, and the aberration characteristics of the dome were investigated using Zernike aberration theory. The aberrations induced by the dome at different fields of regard (FORs) from 30° to 100° were effectively balanced by a rotating cylindrical lens. This kind of optical system can be widely used in top-view optical searching devices. A design method was introduced and the optimization results analyzed in detail. The results showed that the Zernike aberrations produced by the conformal dome were decreased dramatically. Also, a complete conformal optical system was designed, to further illustrate the aberration correction effect of the rotating cylindrical lens. Using a cylindrical lens not only provided a large FOR, but also simplified enormously the structure of the conformal optical system.

• Journal of the Optical Society of Korea
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• v.20 no.1
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• pp.13-21
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• 2016

Since the direct-gradient (DG) method uses the Shack-Hartmann wave front sensor (SH-WFS), based on the phase-conjugation principle, for atmospheric compensation in free-space optical (FSO) communication, it cannot effectively correct high-order aberrations. While the stochastic parallel gradient descent (SPGD) can compensate the distorted wave front, it requires more calculations, which is sometimes undesirable for an FSO system. A hybrid compensation (HC) method is proposed by properly using the DG method and SPGD algorithm to improve the performance of FSO communication. Simulations show that this method can well compensate wave-front aberrations and upgrade the coupling efficiency with few computations, preferable correction results, and rapid convergence rate.

• Journal of the Optical Society of Korea
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• v.13 no.2
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• pp.184-192
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• 2009

There are total eight degrees of freedom in designing a three-mirror system. If we correct four kinds of third order aberrations and the system should have the specified effective focal length, the remaining three degrees of freedom can be used for selecting a suitable configuration for a specific application. We suggest an analytic design procedure for a three-mirror telescope system which has a suitably sized secondary mirror and proper separations between mirrors, and is corrected for four kinds of third order aberrations, spherical aberration, coma, astigmatism, and field curvature. Two design examples are shown. One has a compact configuration with off-axial field, the other has relatively long configuration with annular ring field.

• 한국가시화정보학회:학술대회논문집
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• 2001.12a
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• pp.123-137
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• 2001

PIV (particle image velocimetry) systems use a camera to take snapshots of particles carried by a fluid at some precise instants. Signal processing methods are then used to compute the flow velocity field. In this paper, the design of the camera objective (optics) is addressed. The optimization is done in order to maximize the signal-to-noise ratio of in-focus particles. Four different kinds of noise are considered: photon shot noise, thermal and read noise, background glow shot noise, and noise made by the other particles. A semi-empirical model for the lens aberrations of a two-doublet objective is first addressed, since further, it is shown that lens aberrations (low f-value $f_{\#}$) should be used instead of the Fraunhofer diffraction (high f-value) for the fitting of the particle image size with the pixel size. Other important conclusions of the paper include the expression of optimum values for the magnification M, for the exposure period $\tau$ and for the pixel size $\xi$.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.124-124
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• 2002

In order to determine the effect of the DNA repair inhibitors, cytosine arabinoside(Ara C)and 3-aminobenzamide(3AB) on the frequenceis of chromosomal aberrations and micronuclei induced by radiation. After in vitro exposure of human lymphocytes to x-ray(1-3Gy) DNA repair inhibitors, Ara C and 3AB were treated and the frequencies of micronuclei, translocation and dicentric chromosomes were analysed using FISH technique with DNA probe for chromosome 4.(omitted)

• Journal of Environmental Health Sciences
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• v.16 no.1
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• pp.55-65
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• 1990

This study was carried out to investigate the effects on sister chromatid exchanges (SCEs) and chromosome aberrations in PHA or LPS stimulated mouse spleen and bone marrow lymphocytes after an acute whole body irradiation. Frequencies of sister chromatid exchanges were significantly increased with the increased dose(from zero to 400tad) but there was no differences between B-cell and T-cell. By times, the maximum induced SCE levels was observed at 12 hours after irradiation and then returned to base level at one day in 100rad group and three day in 400rad group. There was a significant difference in chromosome aberration with increasing exposure. X-ray irradiated chromosome aberration was long lived relative to SCE. This results show that counting the incidence of SCE may not provide a sensitive system for detecting X-ray exposure.