Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 19 Issue 2
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- Pages.102-107
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- 1999
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- 1225-6307(pISSN)
Genotoxicity Studies of Occupationally Exposed Mixed Organic Solvents in Printers
혼합 유기용매 폭로 근로자의 유전독성에 관한 연구
Abstract
A population monitoring studies for assessing the genotoxicity of occupationally exposed mixed organic solvents to printers were performed by using the chromosome aberration assay and the cytokinesis-blocked micronucleus assay. The incidence of chromosome aberrations and micronuclei was studied in the peripheral blood lymphocytes of 51 male printers and their matched controls in Seoul area. Smoking habits and duration of employment were taken into account. The frequencies of micronucleus in peripheral lymphocytes of printers were significantly different in comparision with control subjects. Also there were significant increase in the frequencies of micronucleus by duration of exposure. The frequencies of chromosome aberrations showed no significant differences between printers and their matched controls.
Keywords
- Occupational exposure;
- Mixed organic solvents;
- Chromosome aberration;
- Cytokinesis-blocked micronucleus