Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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ENHANCEMENT OF FREQUENCY OF RADIATION-INDUCED CHROMOSOME ABERRATIONS AND MICRONUCLEI BY ARA C AND 3AB

  • Chung, Hai-Won (School of Public Health, Seoul National University) ;
  • Cho, Yoon-Hee (School of Public Health, Seoul National University) ;
  • Kim, Su-Young (School of Public Health, Seoul National University) ;
  • Kim, Tae yeon (School of Public Health, Seoul National University) ;
  • Kim, Yang-Ji (School of Public Health, Seoul National University) ;
  • Lee, Ra-Mi (School of Public Health, Seoul National University) ;
  • Seo, Soo-Ra (School of Public Health, Seoul National University) ;
  • Kim, Tae-Hwan (Korea Cancer Center Hospital) ;
  • Ha, Sung-Hwan (College of Medicine, Seoul National University)
  • Published : 2002.05.01
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Abstract

In order to determine the effect of the DNA repair inhibitors, cytosine arabinoside(Ara C)and 3-aminobenzamide(3AB) on the frequenceis of chromosomal aberrations and micronuclei induced by radiation. After in vitro exposure of human lymphocytes to x-ray(1-3Gy) DNA repair inhibitors, Ara C and 3AB were treated and the frequencies of micronuclei, translocation and dicentric chromosomes were analysed using FISH technique with DNA probe for chromosome 4.(omitted)

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