Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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The Sister Chromatid Exchange Frequencies and Chromosome Aberrations in Mouse Lymphocyte by X-Ray Irradiation

X-선 조사에 의한 마우스 淋巴球의 SCE 경도와 염색체이상

  • 황인담 (전북대학교 의과대학 예방의학교실) ;
  • 기노석 (전북대학교 의과대학 예방의학교실) ;
  • 이정상 (전북대학교 의과대학 예방의학교실) ;
  • 김남송 (전북대학교 의과대학 예방의학교실) ;
  • 이재형 (전북대학교 의과대학 예방의학교실) ;
  • 이준배 (전북대학교 의과대학 방사선과교실)
  • Published : 1990.04.01
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Abstract

This study was carried out to investigate the effects on sister chromatid exchanges (SCEs) and chromosome aberrations in PHA or LPS stimulated mouse spleen and bone marrow lymphocytes after an acute whole body irradiation. Frequencies of sister chromatid exchanges were significantly increased with the increased dose(from zero to 400tad) but there was no differences between B-cell and T-cell. By times, the maximum induced SCE levels was observed at 12 hours after irradiation and then returned to base level at one day in 100rad group and three day in 400rad group. There was a significant difference in chromosome aberration with increasing exposure. X-ray irradiated chromosome aberration was long lived relative to SCE. This results show that counting the incidence of SCE may not provide a sensitive system for detecting X-ray exposure.

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