• Title/Summary/Keyword: Vaccination Rate

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Efficacy of Concurrent Administration of Live and Killed Newcastle Disease Vaccines in Day - Old Broiler Chicks (육용계 초생추에 대한 뉴켓슬병 생독 및 사독 백신의 동시접종 효과)

  • 최정옥;박승주;위성하
    • Korean Journal of Poultry Science
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    • v.15 no.3
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    • pp.193-198
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    • 1988
  • In order to examine the efficacy of concurrent vaccination with live and killed Newcastle disease(ND) vaccines two types of each live($B_1$ and LaSota) and killed(gel and oil) vaccines of all commercial origin were administered either alone or simultaneously to day-old broiler chicks having maternal antibody. Live vaccines were given by conjuntival instillation in volumes of 25${\mu}\ell$ containing $10^{6.0}$ to $10^{6.3}$ median embroy infective dose(EH)) while killed vaccines were given in 0.3$m\ell$ volumes subcutaneously at the back of the neck Hemagglutination inhibition(HI) antibodies were determined at weekly intervals until 8 weeks of age and protection rate was determined at 4 and 8 week of age by challenge inoculation with virulent ND virus(NDV). During the 8 weeks experimental period concurrent administration of live and oil vaccine produced the highest level of HI antibody and the most satisfactory protection, whereas concurrent rent vaccination with live and gel vaccine induced poor immune responses. There was no noticeable difference in the efficacy between the live vaccines, Bl and LaSota when simultaneously administered with oil vaccine. Except for oil vaccine, single administration of either live or killed vaccine at day-old produced less than 50% protection at 4 and 8 weeks postvaccination(PV). Oil vaucine alone induced 80% and 70% protection at 4 and 8 week PV, respectively. Concurrent vaccination caused on visible side reaction like respiratory symptoms and did not negatively influence the growth rate of birds until the end of experiment.

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Effect of Timing of Vaccination on the Pregnancy Rate of Recipients and the Viability of Calves Derived from In Vitro Produced Hanwoo Embryos (한우 체외 수정란이 이식된 수란우에 백신 투여 시기가 임신과 송아지의 생존에 미치는 영향)

  • Park, Y.S.;Kim, S.S.;Jang, M.J.;Park, H.D.
    • Journal of Embryo Transfer
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    • v.21 no.4
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    • pp.307-313
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    • 2006
  • The present study was conducted to investigate the effects of time of vaccination in recipients on the pregnancy rate and the viability of calves derived from embryos produced in vitro. In experiment 1, control group was non-vaccinated, group 1-1 received vaccine (Pfizer, Exton, PA, USA) during 0$\sim$4 weeks and group 1-2 received vaccine during 4$\sim$8 weeks before embryo transfer. The pregnancy rates in the control (42.6%) and group 1-2 (45.3%) were significantly higher (p<0.05) than that in the group 1-1 (32.6%). However, the abortion rates were similar among groups (4.9 to 13.5%). In experiment 2, the recipients received embryos produced in vitro were non-vaccinated (control) or vaccinated. Vaccine was injected during 0$\sim$4 weeks (group 2-1) and 4$\sim$8 weeks (group 2-2) before parturition. The incidence of a disease in calves was significantly higher in the control (22.4%) than in other vaccinated groups (2.2% and 3.1%, p<0.05). The mortality of calves in the control is 27.6%, which was significantly higher than that of group 2-1 and group 2-2 (11.1% and 7.8%).

The immunogenicity and safety of three-component DTaP vaccine in Korean infants (우리나라 영아에서 3가 정제 백일해 항원 DTaP 백신의 면역원성 및 안전성)

  • Kang, Jin Han;Kim, Jong Hyun;Lee, Jung Hyun;Lee, Soo Young;Hong, Young Jin;Kim, Chang Hwi
    • Clinical and Experimental Pediatrics
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    • v.50 no.4
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    • pp.355-362
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    • 2007
  • Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine ($Infanrix^{(R)}$) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy infants aged 8-9 weeks. These infants were vaccinated at age 2, 4 and 6 months of age with three component DTaP vaccine. Solicited adverse events were actively monitored for 72 hours following each vaccination, and all adverse events after each vaccination were observed for three weeks. Anti-diphtheria toxoid Ab., anti-tetanus toxoid Ab., anti-pertussis toxin Ab., anti-filamentous hemagglutinin Ab., and anti-pertactin Ab. were measured using ELISA for assessing immunogenicity of study vaccine in 60 infants. Immunogenicity analysis of two component DTaP vaccine was performed with same methods in 14 infants as control. Results : The seroconversion rates of anti-diphtheria toxoid Ab, anti-tetanus toxoid Ab. anti-filamentous hemagglutinin Ab. were 100% in both group. Seroconversion rate of anti-pertactin Ab in study group was 100%, but the rate in control group was 50%. However, geometric mean concentration of anti-pertussis toxin Ab. was higher in control group. Mild local and systemic reactions were observed within three days after vaccination, and no serious adverse events related study vaccine were happened during study period. Conclusion : Our study results suggest that three component DTaP vaccine ($Infanrix^{(R)}$) is a well-tolerable and high immunogenic vaccine, especially anti-Pertactin Ab. of the study vaccine is very immunogenic. It can be available as routine DTaP vaccination in our infants.

THE ANALYSIS OF SEXUALLY TRANSMITTED DISEASES WITH DEMOGRAPHICS ON SCALE-FREE NETWORK

  • Liu, Maoxing;Zhang, Yunli
    • Journal of applied mathematics & informatics
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    • v.31 no.3_4
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    • pp.443-456
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    • 2013
  • In this paper we consider a model with demographics for sexually transmitted diseases (STDs) spread on scale-free networks. We derive the epidemic threshold, which is depend on the birth rate, the natural death rate and other parameters. The absence of a threshold in infinite scale-free network is proved. For a hard cut off scale-free network, we also analyze the stability of disease-free equilibrium and the persistence of STDs infection. Two immunization schemes, proportional scheme and targeted vaccination, are studied and compared. We find that targeted strategy is more effective on scale-free networks.

An overview and preparation of Korean pediatrician according to the expansion of national immunization program coverage (필수예방접종경비 국가부담 사업의 확대계획에 따른 소아청소년과의 준비)

  • Cho, In Sung
    • Clinical and Experimental Pediatrics
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    • v.51 no.12
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    • pp.1275-1281
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    • 2008
  • National Immunization Program (NIP) in korea is regulated by government for effective prevention of infectious diseases since 1954. But the program is only performed in public health center, so many people had various complaints such as inconvenience to use public center, high cost when vaccinated in private medical organization and lack of speciality and registration etc. In this reason, it was very difficult to raise the vaccination rate to 95 percent, infectious disease preventable rate. With this background national assembly and government try to expand the NIP coverage both public health center and private medical organization with increasing budget from 2009. So in this paper an overview and preparation of Korean pediatrician according to the expanding plan of NIP are described.

Problems in the field of maternal and child health care and its improvement in rural Korea (우리나라 농촌(農村)의 모자보건(母子保健)의 문제점(問題點)과 개선방안(改善方案))

  • Lee, Sung-Kwan
    • Journal of agricultural medicine and community health
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    • v.1 no.1
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    • pp.29-36
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    • 1976
  • Introduction Recently, changes in the patterns and concepts of maternity care, in both developing and developed countries have been accelerating. An outstanding development in this field is the number of deliveries taking place in hospitals or maternity centers. In Korea, however, more than 90% of deliveries are carried out at home with the help of untrained relatives or even without helpers. It is estimated that less than 10% of deliveries are assisted by professional persons such as a physician or a midwife. Taking into account the shortage of professional person i11 rural Korea, it is difficult to expect widespread prenatal, postnatal, and delivery care by professional persons in the near future, It is unrealistic, therefore, to expect rapid development of MCH care by professional persons in rural Korea due to economic and sociological reasons. Given these conditions. it is reasonable that an educated village women could used as a "maternity aid", serving simple and technically easy roles in the MCH field, if we could give such a women incentive to do so. The midwife and physician are assigned difficult problems in the MCH field which could not be solved by the village worker. However, with the application of the village worker system, we could expect to improve maternal and child hoalth through the replacement of untrained relatives as birth attendants with educated and trained maternity aides. We hope that this system will be a way of improving MCH care, which is only one part of the general health services offered at the local health centre level. Problems of MCH in rural Korea The field of MCH is not only the weakest point in the medical field in our country hut it has also dropped behind other developing countries. Regarding the knowledge about pregnancy and delivery, a large proportion of our respondents reported having only a little knowledge, while 29% reported that they had "sufficient" knowledge. The average number of pregnancies among women residing in rural areas was 4.3 while the rate of women with 5 or more pregnancies among general women and women who terminated childbearing were 43 and 80% respectively. The rate of unwanted pregnancy among general women was 19.7%. The total rate for complications during pregnancy was 15.4%, toxemia being the major complication. The rate of pregnant women with chronic disease was 7%. Regarding the interval of pregnancy, the rates of pregnancy within 12 months and within 36 months after last delivery were 9 and 49% respectively. Induced abortion has been increasing in rural areas, being as high as 30-50% in some locations. The maternal death rate was shown 10 times higher than in developed countries (35/10,000 live births). Prenatal care Most women had no consultation with a physician during the prenatal period. Of those women who did have prenatal care, the majority (63%) received such care only 1 or 2 times throughout the entire period of pregnancy. Also, in 80% of these women the first visit Game after 4 months of gestation. Delivery conditions This field is lagging behind other public health problems in our country. Namely, more than 95% of the women deliveried their baby at home, and delivery attendance by a professional person occurred only 11% of the time. Attendance rate by laymen was 78% while those receiving no care at all was 16%. For instruments used to cut the umbilical corn, sterilized scissors were used by 19%, non-sterilized scissors by 63% and 16% used sickles. Regarding delivery sheets, the rate of use of clean sheets was only 10%, unclean sheets, vinyl and papers 72%, and without sheets, 18%. The main reason for not using a hospital as a place of delivery was that the women felt they did not need it as they had previously experience easy deliveries outside hospitals. Difficult delivery composed about 5% of the total. Child health The main food for infants (95%) was breast milk. Regarding weaning time, the rates within one year, up to one and half, two, three and more than three years were 28,43,60,81 and 91% respectively, and even after the next pregnancy still continued lactation. The vaccination of children is the only service for child health in rural Korea. As shown in the Table, the rates of all kinds of vaccination were very low and insufficient. Infant death rate was 42 per 1,000 live births. Most of the deaths were caused by preventable diseases. Death of infants within the neonatal period was 83% meaning that deaths from communicable diseases decreased remarkably after that time. Infant deaths which occurred without medical care was 52%. Methods of improvement in the MCH field 1. Through the activities of village health workers (VHW) to detect pregnant women by home visiting and. after registration. visiting once a month to observe any abnormalities in pregnant women. If they find warning signs of abnormalities. they refer them to the public health nurse or midwife. Sterilized delivery kits were distributed to the expected mother 2 weeks prior to expected date of delivery by the VHW. If a delivery was expected to be difficult, then the VHW took the mother to a physician or call a physician to help after birth, the VHW visits the mother and baby to confirm health and to recommend the baby be given proper vaccination. 2. Through the midwife or public health nurse (aid nurse) Examination of pregnant women who are referred by the VHW to confirm abnormalities and to treat them. If the midwife or aid nurse could not solve the problems, they refer the pregnant women to the OB-GY specialist. The midwife and PHN will attend in the cases of normal deliveries and they help in the birth. The PHN will conduct vaccination for all infants and children under 5, years old. 3. The Physician will help only in those cases referred to him by the PHN or VHW. However, the physician should examine all pregnant women at least three times during their pregnancy. First, the physician will identify the pregnancy and conduct general physical examination to confirm any chronic disease that might disturb the continuity of the pregnancy. Second, if the pregnant woman shows any abnormalities the physician must examine and treat. Third, at 9 or 10 months of gestation (after sitting of the baby) the physician should examine the position of the fetus and measure the pelvis to recommend institutional delivery of those who are expected to have a difficult delivery. And of course. the medical care of both the mother and the infants are responsible of the physician. Overall, large areas of the field of MCH would be served by the VHW, PHN, or midwife so the physician is needed only as a parttime worker.

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5 Years Follow up Study of Anti HBs Titer After Basic Immunization by Recombinant HBV Vaccine (유전자재조합 B형간염 백신의 기본접종 5년후 추적항체역가에 관한 연구)

  • Kim, Hyun Jung;Lee, Chang Yeun;Hwang, Kwang Soo
    • Pediatric Infection and Vaccine
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    • v.7 no.1
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    • pp.136-142
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    • 2000
  • Purpose : Although there are a lot of the reports about the persistence of anti HBs titer of plasma derives HBV vaccine, it is difficult to find the follow up studies of the recombinant HBV vaccine. We performed this study to compare the persistence of anti HBs titer by vaccination schedule and the seronegative rate of 5 years later according to Anti HBs titer after basic immunization in neonatal period by recombinant HBV vaccination. Methods : This study was performed on 420 neonates at Pusan Moon Hwa Hospital from April to December 1993, followed up for 5 years after basic immunization by recombinant HBV vaccine. The anti HBs titer test was done by radioimmunoassay(RIAAUSAB, Abbott laboratories). The positive anti HBs level that would protect against HBV infection was defined as a level equal to or greater than 10mIU/mL. Results : In this study the seronegative rate after 5 years was 5% in 2 month schedule group, 25.5% in 6 month schedule group(P>0.05). In 2 month schedule group the seronegative rate was 20% when anti HBs titer is lower than 200mIU/mL, 0% when more than 200mIU/mL(P>0.05). In 6 month schedule group the seronegative rate was 66.7% when anti HBs titer was lower than 200mIU/mL, 40% when 200~499.9mIU/mL, 23.9% when 500~999.9mIU/mL, 22.5% when more than 1000mIU/mL. Conclusion : In this study the seronegative rate after 5 years of recombinant HBV vaccination was 5~25.5%. The persistence of anti HBs titer was statistically irrelevant to schedule. The seronegative rate after 5 years was statistically irrelevant to anti HBs titer after basic immunization.

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Lymphadenitis following intradermal BCG vaccination (피내용 BCG 접종 후 발생한 국소 림프절염)

  • Baek, Hey Sung;Chang, Ji Young;Moon, Su Ji;Oh, Sung Hee
    • Clinical and Experimental Pediatrics
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    • v.49 no.1
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    • pp.46-50
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    • 2006
  • Purpose : Intradermal BCG vaccine has not well been accepted by pediatric practitioners due to BCG lymphadenitis. Therefore, this study was undertaken to find out the incidence of lymphadenitis following intradermal BCG vaccination and its clinical outcome. Methods : One thousand and fifty infants, who received intradermal BCG(French 1173 P2, Korea Tuberculosis Association) vaccination in the Well Baby Clinic of Hanyang University Hospital from July 2001 to January 2004, were included in the study. Severe local reactions at the injection site and any mass noted on surrounding areas were reported to, and evaluated by, pediatricians. Surgical procedures, either surgical resection or needle aspiration, were recommended when lymph nodes progressed to suppurate without regression. Results : Twenty infants(1.9 percent) developed lymphadenitis 2 to 8 months following vaccination. The incidence of BCG lymphadenitis was significantly higher in infants born with intrauterine period of <38 weeks and birth weight of <2,700 g. The lymph nodes became suppurative in 7/17 infants (41.2 percent) and four infants required surgical procedures with which the rate for the requirement of surgical procedures among intradermal BCG vaccinnes approximated to be 0.45 percent. There was no correlation between the size of lymph nodes and suppuration, however surgical procedures were required significantly more often for lymph nodes of greater than 3 cm in diameter. Conclusion : The incidence of BCG lymphadenitis following intradermal BCG(French 1173 P2, Korea Tuberculosis Association) vaccinations would be more than 1.9 percent, when considering cases of lymphadenits not reported. More efforts need to be paid to decrease the incidence of BCG lymphadenitis in order to promote intradermal BCG vaccination in Korea.

Immunization Practices in Children with Renal Disease : A Survey of the Members of Korean Society of Pediatric Nephrology (신질환 소아의 예방접종 현황 : 대한소아신장학회 회원들의 접종 방식에 대한 조사)

  • Park Seong-Shik;Ahn Sung-Ryou;Lee Ju-Suk;Kim Su-Yung
    • Childhood Kidney Diseases
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    • v.6 no.2
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    • pp.198-208
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    • 2002
  • Purpose : There is no scientific basis for an immunization policy for children with renal disease who have increased risk of infection in Korea. As an initial step in approaching this problem, this survey of pediatric nephrologists was undertaken to determine the current recommendations of practicing pediatric nephrologists Methods : Questionnaires were sent to the members of Korean Society of Pediatric Nephrology via mail and E-mail. The questionnaire was designed to obtain information about the immunization practice of basic vaccination schedule for nephrotic syndrome, the side effects after vaccination and the immunization practice about recommended vaccines for children with renal disease. Results : Questionnaires were sent to 56 pediatric nephrologists. 35 replies were received (response rate: 62.5%). Almost of the respondents (82.8%) reported practicing at university hospital. All respondents reported modified vaccination schedule. 65.7% of the respondents immunized nephrotic children with live vaccines some time later after discontinuation of corticosteroids treatment and 57.1% of respondents immunized them with killed vaccines during medication of low doses of corticosteroids. Respondents experienced relapse of nephrotic syndrome after vaccination are nine, lack of vaccine efficacy are three and infection by organisms of live vaccines are two. 71.4% of respondents reported vaccinating children with renal disease for hepatitis B, pneumococcus and influenza during medication of low doses of corticosteroids. But There is few difference of the rates of respondents vaccinating them for Hemophilus influenzae type b between during medication of low doses of corticosteroids and after discontinuation of corticosteroids treatment (45.7% us 42.9%). Almost of respondents reported vaccinating renal failure children without immunosuppression for hepatitis B, pneumococcus, influenza and H. influenzae type b ($54.3{\sim}77.1%$). Conclusion : Pediatric nephrologists practiced modifying vaccination schedules for children with renal disease in Korea and there was variation according to the progression of disease and the doses of corticosteroids. It is necessary to establish the immunization guideline for children with renal disease through the prospective studies.

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The Incidence Rate of Lymphadenitis after Bacille Calmette-Guérin (BCG) Vaccination (Bacille Calmette-Guérin (BCG) 백신 접종 후 림프절염의 발생 빈도)

  • Kim, Jaehong;Lee, Kyujin;Kim, Jong-Hyun;Kim, Seong Joon;Lee, Soo Young;Lee, Hye Jin;Cho, Kyung Soon;Kwon, Young Joo;Lee, Byoung Chan;Jo, Sang Min;Ha, Jeong Hun;Lee, Yoon Kyung;Seung, So Jin
    • Pediatric Infection and Vaccine
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    • v.23 no.1
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    • pp.54-61
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    • 2016
  • Purpose: Bacille Calmette-$Gu{\acute{e}}rin$ (BCG) lymphadenitis is a relatively frequent local adverse reactions after BCG vaccination. Its incidence rate is usually <1%. However, this rate may be different according to BCG strain, vaccination method or skill, etc. In the Republic of Korea, two BCG strains are used: intradermal Danish-1331 or percutaneous Tokyo-172. We surveyed the incidence rates of BCG lymphadenitis. Methods: This survey was performed in total 25 centers (5 general hospitals, 20 private pediatric clinics). Immunized type of BCG strain in study subjects was verified by directly observing the scar. The occurrence of BCG lymphadenitis was asked to their parent. In cases of BCG lymphadenitis, location, diameter size, progression of suppuration, and treatment method were investigated, as well. Results: The total number of study subjects was 3,342. Among these, the subjects suitable for enrollment criteria (total 3,222; Tokyo strain 2,501, Danish strain 721) were analyzed. BCG lymphadenitis regardless of its size developed in each five of subjects per strains, therefore, its incidence rate was 0.20% in Tokyo and 0.69% in Danish strain, respectively (P=0.086). However, when applying the WHO criteria - the development of lymph node swelling with diameter 1.5 cm or more, the incidence rate of BCG lymphadenitis was 0.16% (4 cases) in Tokyo and 0.42% (3 cases) in Danish strain, respectively. Conclusions: The incidence rate of lymphadenitis in two BCG types, percutaneous Tokyo and intradermal Danish strain BCG, is 0.20% and 0.69%, respectively. Both rates are acceptable.