• Clinical and Experimental Reproductive Medicine
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• 제48권1호
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• pp.27-33
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• 2021

Objective: The chief outcome of testicular torsion in clinical and experimental contexts is testicular ischemia. Curcumin, a compound with anti-inflammatory and antioxidant properties, has fascinated researchers and clinicians for its promise in the treatment of fertility diseases. Methods: Thirty-five fully grown male mice were randomly classified into five groups: control, sham, testicular torsion, treatment group 1 (testicular torsion+short-term curcumin), and treatment group 2 (testicular torsion+long-term curcumin). Thirty-five days later, spermatozoa from the right cauda epididymis were analyzed with regard to count and motility. Toluidine blue (TB), aniline blue (AB), and chromomycin A3 (CMA3) staining assays were used to evaluate the sperm chromatin integrity. In addition, the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) test was used to assess apoptosis. Results: Treatment group 1 exhibited a remarkably elevated sperm count compared to the testicular torsion group. Additionally, notably lower sperm motility was found in the testicular torsion group compared to the control, treatment 1, and treatment 2 groups. Staining (CMA3, AB, and TB) and the TUNEL test indicated significantly greater testicular torsion in the torsion group compared to the control group (p<0.05). The data also revealed notably lower results of all sperm chromatin assays and lower apoptosis in both treatment groups relative to the testicular torsion group (p<0.05). Significantly elevated (p<0.05) AB and TB results were noted in treatment group 1 compared to treatment group 2. Conclusion: Curcumin can compensate for the harmful effects of testicular ischemia and improve sperm chromatin quality in mice.

• Clinical and Experimental Reproductive Medicine
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• 제50권4호
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• pp.292-298
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• 2023

Objective: Ovarian torsion is a gynecological disorder that causes ischemia-reperfusion injuries in the ovary. Our study investigated berberine's short- and long-term effects on ovarian ischemia-reperfusion injuries. Methods: This study included 28 Wistar albino female rats weighing 180 to 220 g, which were divided into four groups: sham (S), torsion/detorsion (T/D), torsion/ detorsion+single dose berberine (T/D+Bb), and torsion/detorsion+15 days berberine (T/D+15Bb). The torsion and detorsion model was applied in all non-sham groups. In the T/D+Bb group, a single dose of berberine was administered, while in the T/D+15Bb group, berberine was administered over a period of 15 days. After the rats were euthanized, their ovaries were excised. The left ovaries were used for histopathologic evaluation, which included ovarian injury scoring and follicle count, while the right ovaries were used for biochemical analyses (tissue transforming growth factor-β [TGF-β] and alpha-smooth muscle actin [α-SMA] levels). Results: The histopathologic evaluation scores for the ovaries were significantly lower in the T/D+B group (p<0.05) and the T/D+15B group (p<0.005) than in the T/D group. The follicle counts in the T/D group were lower than those in both the sham and treated groups (p<0.005). The TGF-β levels were significantly lower in the T/D+15B group (p<0.005), whereas the α-SMA levels did not show a significant difference. Conclusion: Both short- and long-term berberine use could potentially have therapeutic effects on ovarian torsion. Long-term berberine use exhibited anti-inflammatory effects by reducing TGF-β levels, thereby preventing ischemia-reperfusion injuries. Therefore, we suggest that long-term berberine use could be beneficial for ovarian torsion.

• The Korean Journal of Physiology and Pharmacology
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• 제18권4호
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• pp.321-326
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• 2014

Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-${\kappa}B$) activation. In this study, we aimed to investigate the effects of PDTC to testicular torsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four groups. A sham operation was performed in group I. In group II, torsion is performed 2 hours by 720 degree extravaginally testis. In group III, 4 h reperfusion of the testis was performed after 2 h of testicular torsion. In group IV, after performing the same surgical procedures as in group III, PDTC (100 mg/kg, intravenous's) was administered before 30 min of detorsion. The testes tissue malondialdehyde (MDA), superoxide dismutase (SOD) catalase (CAT) level was evaluated. Histological evaluations were performed after hematoxylin and eosin staining. Testicular tissue MDA levels were the highest in the T/D groups compared with treatment group. Administration of PDTC prevented a further increase in MDA levels. Significant decrease occurred in CAT and SOD levels in treatment group compared with the control group. The rats in the treatment group had normal testicular architecture. The results suggest that PDTC can be a potential protective agent for preventing the biochemical and histological changes related to oxidative stress in testicular injury caused by testis torsion.

• 호남수학학술지
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• 제20권1호
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• pp.121-133
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• 1998

We find some properties of the pro-torsion products. Under the suitable conditions, we also show that the map ${\bar{H}}_P({\chi};G){\rightarrow}{\bar{H}}_p^{s(r)}({\chi};G)$ is an isomorphism and the n-th homotopy group of X is isomorphic to the n-th ${\check{C}}ECH$ homology group.

• 통합자연과학논문집
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• 제14권3호
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• pp.139-146
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• 2021

The purpose of this paper is to classify the torsion-free extensions 1→ℤ³→𝛱→ℤ_𝜱→1 with injective abstract kernel 𝜙 : ℤ_𝜱→Aut(ℤ³). From this classification, we handle the sufficient conditions so as to classify the crystallographic groups of Sol⁴_m,n.

• 대한수학회논문집
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• 제22권2호
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• pp.157-161
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• 2007

Let G be a p-mixed abelian group with semi-complete torsion subgroup $G_t$ such that G is splitting or is of torsion-free rank one, and let R be a commutative unitary ring of prime characteristic p. It is proved that the group algebras RG and RH are R-isomorphic for any group H if and only if G and H are isomorphic. This isomorphism relationship extends our earlier results in (Southeast Asian Bull. Math., 2002), (Proc. Amer. Math. Soc., 2002) and (Bull. Korean Math. Soc., 2005) as well as completely settles a problem posed by W. May in (Proc. Amer. Math. Soc., 1979).

• The Korean Journal of Physiology and Pharmacology
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• 제21권5호
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• pp.457-464
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• 2017

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to $720^{\circ}$ degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta ($IL-1{\beta}$) and tumor necrosis factor alpha ($TNF-{\alpha}$) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion.

• 대한수학회보
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• 제60권1호
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• pp.203-223
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• 2023

A generalized torsion element is an obstruction for a group to admit a bi-ordering. Only a few classes of hyperbolic knots are known to admit such an element in their knot groups. Among twisted torus knots, the known ones have their extra twists on two adjacent strands of torus knots. In this paper, we give several new families of hyperbolic twisted torus knots whose knot groups have generalized torsion. They have extra twists on arbitrarily large numbers of adjacent strands of torus knots.

• 대한수학회보
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• 제50권1호
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• pp.83-96
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• 2013

Let K be a number field and fix a prime number $p$. For any set S of primes of K, we here say that an elliptic curve E over K has S-reduction if E has bad reduction only at the primes of S. There exists the set $B_{K,p}$ of primes of K satisfying that any elliptic curve over K with $B_{K,p}$-reduction has no $p$-torsion points under certain conditions. The first aim of this paper is to construct elliptic curves over K with $B_{K,p}$-reduction and a $p$-torsion point. The action of the absolute Galois group on the $p$-torsion subgroup of E gives its associated Galois representation $\bar{\rho}_{E,p}$ modulo $p$. We also study the irreducibility and surjectivity of $\bar{\rho}_{E,p}$ for semistable elliptic curves with $B_{K,p}$-reduction.

• 충청수학회지
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• 제33권2호
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• pp.227-236
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• 2020

A set {a₁, a₂,_…, a_m} of positive integers is called Diophantine m-tuple if a_ia_j+1 is a perfect square for all 1 ≤ i < j ≤ m. In this paper, we find the structure of torsion group of elliptic curve E_k constructed by Diophantine triple, and find all integer points on E_k under assumption that rank(E_k(ℚ)) = 1.