• Journal of Sasang Constitutional Medicine
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• v.24 no.1
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• pp.54-65
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• 2012

1. Objective : The purpose of this study is to investigate the effects of TAM (Taraxacum mongolicum) on Th2 cytokine production in MC/9 mast cells. 2. Methods : The effects of TAM was analyzed by ELISA and Real-time PCR in MC/9 mast cells. Levels of IL-5, IL-13 were measured using enzyme-linked immunosorbent assays(ELISA). mRNA levels of IL-4, IL-5, IL-6, IL-13 were analyzed with Real-time PCR. 3. Results : 1) TAM inhibited the IL-4 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 2) TAM inhibited the IL-13 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 3) TAM inhibited the IL-4 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4) TAM inhibited the IL-5 mRNA expression significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$. 5) TAM inhibited the IL-6 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 6) TAM inhibited the IL-13 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4. Conclusions : These results indicate that TAM (Taraxacum mongolicum) has the effect of decreasing the Th2 cytokine production in the MC/9 mast cell.

• Restorative Dentistry and Endodontics
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• v.30 no.5
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• pp.372-384
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• 2005

The purpose of this study was to monitor the secretion of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) by human periodontal ligament (PDL) fibroblasts stimulated with Prevotella nigrescens lipopolysaccharide (LPS), and to examine the effect of calcium hydroxide treatment on P. nigrescens LPS. LPS was extracted and purified from anaerobically cultured P. nigrescens. PDL fibroblasts were stimulated by the LPS (0, 0.1, 1, 10 ${\mu}g/ml$) or LPS (10 ${\mu}g/ml$) pretreated with 12.5 mg/ml of $Ca(OH)_2$ for 3 days, for various periods of time (12, 24, 48 h). Immunoprecipitation were performed for protein level analysis of MMP-1 MMP-2 and TIMP-1. Total RNA was isolated and real-time quantitative polymerase chain reaction (PCR) was performed for quantification of MMP-1 mRNA. According to this study, the results were as follows: 1. The p개duction of MMP-1 by stimulation with P. nigrescens LPS increased in time-dependent manner, and showed maximum value at 48 h in both protein and mRNA level. But there was no dose-dependent increas. 2. MMP-2 production time-dependently increased when stimulated with 1 and 10 ${\mu}g/ml$LPS, but there was no dose-dependent increase. 3. TIMP-1 p개duction increased to 24 h, but decreased at 48 h. It increased when stimulated with 0.1 and 1${\mu}g/ml$, but suppressed at 10 ${\mu}g/ml$ .4. P. nigrescens LPS pretreated with $Ca(OH)_2$ markedly downregulated MMP-1 gene expression.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.10a
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• pp.83-86
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• 2007

In the blind Maximum-likelihood (ML) detection for Orthogonal Space-Time Block Codes (OSTBC), the problem of ambiguity in determining the symbols has been a great concern. A solution to this problem is to apply semi-blind ML detection, i.e., the blind ML decoding with pilot symbols or training sequence. In order to increase the performance, the number of pilot symbols or length of training sequence should be increased. Unfortunately, this leads to a significant decrease in system spectral efficiency. This work presents an approach to resolve the aforementioned issue by introducing a new method for constructing transmitted information symbol. Thus, by transmitting information symbols drawn from different modulation constellation, the ambiguity can be easily eliminated in blind detection. Also, computer simulations are implemented to verify the performance of the proposed approach.

• Korean Chemical Engineering Research
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• v.59 no.2
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• pp.209-218
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• 2021

First principle-based modeling studies have been performed to improve the heat exchange efficiency of ORV and optimize operation, but the heat transfer coefficient of ORV is an irregular system according to time and location, and it undergoes a complex modeling process. In this study, FNN, LSTM, and AutoML-based modeling were performed to confirm the effectiveness of data-based modeling for complex systems. The prediction accuracy indicated high performance in the order of LSTM > AutoML > FNN in MSE. The performance of AutoML, an automatic design method for machine learning models, was superior to developed FNN, and the total time required for model development was 1/15 compared to LSTM, showing the possibility of using AutoML. The prediction of NG and seawater discharged temperatures using LSTM and AutoML showed an error of less than 0.5K. Using the predictive model, real-time optimization of the amount of LNG vaporized that can be processed using ORV in winter is performed, confirming that up to 23.5% of LNG can be additionally processed, and an ORV optimal operation guideline based on the developed dynamic prediction model was presented.

• The Journal of the Korea Contents Association
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• v.22 no.4
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• pp.706-713
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• 2022

The study is to observe the time trend variation in the blood lead concentration of Korean teenage groups and to examine the changes in the daily lead intake from intake amount(g) by food groups as an influencing factor. A total of 1,540 subjects are participants in the Korea National Health and Nutrition Examination Survey (KNHANES) in 2011, 2012, 2014, 2016, and 2017. The blood lead concentrations were 1.25㎍/100ml in 2011 survey, 1.16㎍/100ml in 2012, 1.17㎍/100ml in 2013, 1.05㎍/100ml in 2016, and 0.84㎍/100ml in 2017. The time trend decrease in food intake amount appeared mainly in the plant food groups such as grains, potatoes and starch, pulses, mushrooms, vegetables, and fruits. And the milk and dairy products of the animal food group also showed a decreased trend. The decrease in the intake amount of these food groups can be an influencing factor in the decrease in lead concentration in the blood.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.54 no.4
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• pp.458-463
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• 2009

In this study, white ginseng water extract (WGWE) solutions were analyzed to set up the functional saponin content and quality optimization condition. The highest saponin content among the total white ginseng extracts was 8.32 mg/10 ml which was extracted at $75^{\circ}C$ for 18 hours. In addition, the saponin content decreased according to the increased extraction temperature and time. The highest content of $Rb_2$ and Re was 0.89 mg/10 ml, 0.82 mg/10 ml at $75^{\circ}C$ for 18 hours which decreased according to the increased extracted temperature and time. The highest content of $Rg_3$ was 1.67 mg/10 ml at $95^{\circ}C$ for 24 hours which decreased according to the increased time. The turbidity, sweetness and reducing sugar content were increased according to the increased extracted time at $75^{\circ}C$, $85^{\circ}C$, $95^{\circ}C$, but pH were decreased according to the increased extracted time. Therefore, the most appropriate white ginseng extracting method have to extracted the proper temperature for saponin content at first time in combination with raise the temperature for taste at second time.

• Proceedings of the IEEK Conference
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• 2001.06a
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• pp.9-12
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• 2001

In this paper, the natural space-time coding is applied for a DS-CDMA system with multiple transmit/receive antennas in a Rayleigh fading channel. With difference of arrival times from transmit antennas a modified maximum likelihood (ML) decoding algorithm is proposed for the space-time coded DS-CDMA system. The proposed decoding algorithm performs ML decoding over the transition of two consecutive branches by using a modified branch metric with the partial autocorrelation. By simulation, it is shown that the proposed decoding algorithm achieves significant performance improvement over the ML decoding algorithm without the modified branch metric.

• Journal of Pharmaceutical Investigation
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• v.21 no.2
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• pp.73-78
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• 1991

The influence of different suppository bases on the rectal absorption and the dissolution rate of propranolol was investigated. The bioavailability of propranolol in rectal suppository was determined by comparing the area under the concentration-time curves(AUC) for oral administration with rectal suppositories in rabbits. The dissolution $rates(D_{20min})$ were higher in such order as tween (TWE), witepsol H-15(WIT), polyethylene glycol(PEG) suppository. The maximum blood concentrations $(C_{max})$ were 803.9 ng/ml for TWE suppository, 770.2 ng/ml for WIT suppository, 281.2 ng/ml for PEG suppository and 177.1 ng/ml for oral administration. The relative bioavailabilities were 233.5% for TWE suppository, 218.1% for TWE suppository, 191.3% for PEG suppository. The correlation between $D_{20min}$ and AUC, the time for dissolution in 75% and $C_{max}$, the mean dissolution time and the mean residence time showed significant linear relationship respectively.

• The Korean Journal of Food And Nutrition
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• v.1 no.2
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• pp.64-67
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• 1988

Cadmium resistant cocobacillus B-17 from soil was tolerated up to 1600ug/ml of cadmium at agar plate and the strain B-17 was able to grow at 600ug/ml of cadmium at liquid medium after the lag phase being prolonged with lengthening culture time. Optimal pH of the strain was shown at pH7.0. The elimination frequency of cadmium resistance by 10ug/ml of acriflavin was 28%, and by 20ug/ml of ethidium bromide was 47%, respectively.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.265-268
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• 2004

In this paper. we propose an adaptive step-size algorithm for the adaptive interference canceller (AIC) in the space-time trellis coded DS-CDMA system. In the AIC, the performance of the blind LMS algorithms that updates the tap-weight vector of the AIC is heavily dependent on the choice of step-size. To improve the performance of the fixed step-size AIC (FS-AIC), the regular adaptive step-size algorithm is extended in complex domain and applied to the joint AIC and ML decoder scheme. Simulation results show that the joint adaptive step-size AIC (AS-AIC) and ML decoder scheme using the proposed algorithm has boner performance than not only the conventional ML decoder but also the joint FS-AIC and ML decoder scheme without much increase of the decoding delay and complexity.