Journal of Pharmaceutical Investigation
- Volume 21 Issue 2
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- Pages.73-78
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- 1991
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Study on the Design of Propranolol Rectal Suppository
푸로푸라놀롤 좌제 개발에 관한 연구
- Kim, Ga-Na (College of Pharmacy, Chosun University) ;
- Choi, Jun-Shik (College of Pharmacy, Chosun University) ;
- Lee, Jin-Hwan (College of Pharmacy, Chosun University)
- Published : 1991.06.20
Abstract
The influence of different suppository bases on the rectal absorption and the dissolution rate of propranolol was investigated. The bioavailability of propranolol in rectal suppository was determined by comparing the area under the concentration-time curves(AUC) for oral administration with rectal suppositories in rabbits. The dissolution
Keywords
- propranolol suppository;
- rectal absorption;
- Tween;
- Witepiol H-15;
- polyethylene glycol;
- dissolution;
- relative bioavailability;
- relationship