• Korean Security Journal
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• no.51
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• pp.11-35
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• 2017

The third industrial revolution, characterized by factory automation and informatization, are moving toward the fourth industrial revolution which is the era of superintelligence and supernetworking through rapid technology innovation. The most important resources in the fourth industrial revolution are information or data since the most of industrial and economic activities will be affected by information in the fourth industrial revolution. Therefore we can expect that more information will be utilized, shared and transfered through the networks or systems in real time than before so the significance of information management and security will also increase. As the importance of information resource management and security which is the core of the fourth industrial revolution increases, the threats on information security are also growing so security incidents such as data breeches and accidents take place more often. Various and thorough solutions are highly needed to protect information resources from security risks because information accidents or breaches seriously damage brand image and cause huge financial damage to organization. The purpose of this study is to research general trends on data breaches and accident that can be serious threat of information security. Also, we will provide resonable solutions to protect data from nine attack patterns or other risk factors after figuring out each characteristic of nin attack patterns in data breaches and accidents.

• Research in Plant Disease
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• v.23 no.2
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• pp.99-113
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• 2017

Recently, global warming and drastic climate change are the greatest threat to the world. The climate change can affect plant productivity by reducing plant adaptation to diverse environments including frequent high temperature; worsen drought condition and increased pathogen transmission and infection. Plants have to survive in this condition with a variety of biotic (pathogen/pest attack) and abiotic stress (salt, high/low temperature, drought). Plants can interact with beneficial microbes including plant growth-promoting rhizobacteria, which help plant mitigate biotic and abiotic stress. This overview presents that rhizobacteria plays an important role in induced systemic resistance (ISR) to biotic stress or induced systemic tolerance (IST) to abiotic stress condition; bacterial determinants related to ISR and/or IST. In addition, we describe effects of rhizobacteria on defense/tolerance related signal pathway in plants. We also review recent information including plant resistance or tolerance against multiple stresses ($biotic{\times}abiotic$). We desire that this review contribute to expand understanding and knowledge on the microbial application in a constantly varying agroecosystem, and suggest beneficial microbes as one of alternative environment-friendly application to alleviate multiple stresses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.4
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• pp.106-121
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• 2016

While economic crises are happening internationally due to the global financial crisis and the long-term recession of the domestic economy, South Korea is also experiencing an aging society with the retirement of the baby-boomers and a low birth-rate. The rapid retirement of baby-boomers, which is one of the essential parts of the Korean economy, is ongoing. Consequently, the number of seniors showing interest in entrepreneurship, as a way to avoid the economic threat, is increasing. Therefore, this study examined the correlation between two factors and its success, which can be stated as the influence of decision making in entrepreneurship and the influence of promotion policies to entrepreneurship. A survey was taken from 393 people, who received academic and managerial assistance from the Senior-Founded Support Center of Small Business Market Corporation and Adults Incubators of Seoul-Business Agency. and 'Hypothesis 1-1' and 'Hypothesis 2-2' were selected, because a positive effect was derived at each verification process. As a result, under the decision making types of entrepreneurship, only a reasonable type showed a positive effect at both the financial outcome and non-financial outcome of success, and the intuitive type was affected positively by the non-financial outcome. In addition, under the entrepreneur supporting business, among financial support, managerial support and educational support only managerial support had a positive effect.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2000.04a
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• pp.3-6
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• 2000

Antimicrobial resistance has been a well-recognized problem ever since the introduction of penicillin into clinical use. History of antimicrobial development can be categorized based on the major antibiotics that had been developed against emerging resistant $pathogens^1$. In the first period from 1940 to 1960, penicillin was a dominating antibiotic called as a "magic bullet", although S.aureus armed with penicillinase led antimicrobial era to the second period in 1960s and 1970s. The second stage was characterized by broad-spectrum penicillins and early generation cephalosporins. During this period, nosocomial infections due to gram-negative bacilli became more prevalent, while those caused by S.aureus declined. A variety of new antimicrobial agents with distinct mechanism of action including new generation cephalosporins, monobactams, carbapenems, ${\beta}$-lactamase inhibitors, and quinolones characterized the third period from 1980s to 1990s. However, extensive use of wide variety of antibiotics in the community and hospitals has fueled the crisis in emerging antimicrobial resistance. Newly appeared drug-resistant Streptococcus pneumoniae (DRSP), vancomycin-resistant enterococci (VRE), extended-spectrum ${\beta}$-lactamase-producing Klebsiella, and VRSA have posed a serious threat in many parts of the world. Given the recent epidemiology of antimicrobial resistance and its clinical impact, there is no greater challenge related to emerging infections than the emergence of antibiotic resistance. Problems of antimicrobial resistance can be amplified by the fact that resistant clones or genes can spread within or between the species as well as to geographically distant areas which leads to a global concern$^2$. Antimicrobial resistance is primarily generated and promoted by increased use of antimicrobial agents. Unfortunately, as many as 50 % of prescriptions for antibiotics are reported to be inappropriate$^3$. Injudicious use of antibiotics even for viral upper respiratory infections is a universal phenomenon in every part of the world. The use of large quantities of antibiotics in the animal health industry and farming is another major factor contributing to selection of antibiotic resistance. In addition to these background factors, the tremendous increase in the immunocompromised hosts, popular use of invasive medical interventions, and increase in travel and mixing of human populations are contributing to the resurgence and spread of antimicrobial resistance$^4$. Antimicrobial resistance has critical impact on modem medicine both in clinical and economic aspect. Patients with previously treatable infections may have fatal outcome due to therapeutic failure that is unusual event no more. The potential economic impact of antimicrobial resistance is actually uncountable. With the increase in the problems of resistant organisms in the 21st century, however, additional health care costs for this problem must be enormously increasing.

• 한국균학회소식:학술대회논문집
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• 2015.11a
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• pp.41-41
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• 2015

Oomycetes belong to the kingdom Straminipila, a remarkably diverse group which includes brown algae and planktonic diatoms, although they have previously been classified under the kingdom Fungi. These organisms have evolved both saprophytic and pathogenic lifestyles, and more than 60% of the known species are pathogens on plants, the majority of which are classified into the order Peronosporales (includes downy mildews, Phytophthora, and Pythium). Recent phylogenetic investigations based on DNA sequences have revealed that the diversity of oomycetes has been largely underestimated. Although morphology is the most valuable criterion for their identification and diversity, morphological species identification is time-consuming and in some groups very difficult, especially for non-taxonomists. DNA barcoding is a fast and reliable tool for identification of species, enabling us to unravel the diversity and distribution of oomycetes. Accurate species determination of plant pathogens is a prerequisite for their control and quarantine, and further for assessing their potential threat to crops. The mitochondrial cox2 gene has been widely used for identification, taxonomy and phylogeny of various oomycete groups. However, recently the cox1 gene was proposed as a DNA barcode marker instead, together with ITS rDNA. To determine which out of cox1 or cox2 is best suited as universal oomycete barcode, we compared these two genes in terms of (1) PCR efficiency for 31 representative genera, as well as for historic herbarium specimens, and (2) in terms of sequence polymorphism, intra- and interspecific divergence. The primer sets for cox2 successfully amplified all oomycete genera tested, while cox1 failed to amplify three genera. In addition, cox2 exhibited higher PCR efficiency for historic herbarium specimens, providing easier access to barcoding type material. In addition, cox2 yielded higher species identification success, with higher interspecific and lower intraspecific divergences than cox1. Therefore, cox2 is suggested as a partner DNA barcode along with ITS rDNA instead of cox1. Including the two barcoding markers, ITS rDNA and cox2 mtDNA, the multi-locus phylogenetic analyses were performed to resolve two complex clades, Bremia lactucae (lettuce downy mildew) and Peronospora effuse (spinach downy mildew) at the species level and to infer evolutionary relationships within them. The approaches discriminated all currently accepted species and revealed several previously unrecognized lineages, which are specific to a host genus or species. The sequence polymorphisms were useful to develop a real-time quantitative PCR (qPCR) assay for detection of airborne inoculum of B. lactucae and P. effusa. Specificity tests revealed that the qPCR assay is specific for detection of each species. This assay is sensitive, enabling detection of very low levels of inoculum that may be present in the field. Early detection of the pathogen, coupled with knowledge of other factors that favor downy mildew outbreaks, may enable disease forecasting for judicious timing of fungicide applications.

• 한국균학회소식:학술대회논문집
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• 2014.10a
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• pp.11-11
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• 2014

Fungal pathogens have huge impact on health and economic wellbeing of human by causing life-threatening mycoses in immune-compromised patients or by destroying crop plants. A key determinant of fungal pathogenesis is their ability to undergo developmental change in response to host or environmental factors. Genetic pathways that regulate such morphological transitions and adaptation are therefore extensively studied during the last few decades. Given that epigenetic as well as genetic components play pivotal roles in development of plants and mammals, contribution of microbial epigenetic counterparts to this morphogenetic process is intriguing yet nearly unappreciated question to date. To bridge this gap in our knowledge, we set out to investigate histone modifications among epigenetic mechanisms that possibly regulate fungal adaptation and processes involved in pathogenesis of a model plant pathogenic fungus, Magnaporthe oryzae. M. oryzae is a causal agent of rice blast disease, which destroys 10 to 30% of the rice crop annually. Since the rice is the staple food for more than half of human population, the disease is a major threat to global food security. In addition to the socioeconomic impact of the disease it causes, the fungus is genetically tractable and can undergo well-defined morphological transitions including asexual spore production and appressorium (a specialized infection structure) formation in vitro, making it a model to study fungal development and pathogenicity. For functional and comparative analysis of histone modifications, a web-based database (dbHiMo) was constructed to archive and analyze histone modifying enzymes from eukaryotic species whose genome sequences are available. Histone modifying enzymes were identified applying a search pipeline built upon profile hidden Markov model (HMM) to proteomes. The database incorporates 22,169 histone-modifying enzymes identified from 342 species including 214 fungal, 33 plants, and 77 metazoan species. The dbHiMo provides users with web-based personalized data browsing and analysis tools, supporting comparative and evolutionary genomics. Based on the database entries, functional analysis of genes encoding histone acetyltransferases and histone demethylases is under way. Here I provide examples of such analyses that show how histone acetylation and methylation is implicated in regulating important aspects of fungal pathogenesis. Current analysis of histone modifying enzymes will be followed by ChIP-Seq and RNA-seq experiments to pinpoint the genes that are controlled by particular histone modifications. We anticipate that our work will provide not only the significant advances in our understanding of epigenetic mechanisms operating in microbial eukaryotes but also basis to expand our perspective on regulation of development in fungal pathogens.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.7
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• pp.504-515
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• 2012

Groundwater is widely used as drinking water supplies around the world. However, microbial contamination of groundwater is a serious environmental problem that degrades drinking water quality and poses a great threat to human health. Among the pathogenic microorganisms such as viruses, bacteria, and protozoa, viruses are not readily removed during transport through soils, having high mobility in groundwater environment due to their smaller size compared to bacteria and protozoa. Studies regarding the fate and transport of viruses in soils and aquifers are necessary to determine the vulnerability of groundwater to microbial contamination and to secure safe drinking water sources. Also, these studies provide important information to establish the regulations and policies related to public health. This review paper presented the field and laboratory studies conducted for the fate and transport of viruses in subsurface environments. Also, the paper provided the factors affecting the fate and transport of viruses, the characteristics of bacteriophages used for virus studies, and virus transport model/colloid filtration theory. Based on this review work, future researches should be performed actively to set up the viral protection zone for the protection of groundwater from viral contamination sources. Especially, the researches should be focused on the development of mathematical models to calculate the setback distance and travel time for the viral protection zone along with the accumulation of information related to the model parameters.

• Journal of the Korean Recycled Construction Resources Institute
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• v.6 no.1
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• pp.63-71
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• 2011

Portland cement production is under critical review due to high amount of $CO_2$ gas released to the atmosphere. Attempts to increase the utilization of a by-products such as fly ash and ground granulated blast-furnace slag to partially replace the cement in concrete are gathering momentum. But most of by-products is currently dumped in landfills, thus creating a threat to the environment. Many researches on alkali-activated concrete that does not need the presence of cement as a binder have been carried out recently. In this study, we investigated the influence of alkali activator and superplasticizer on the flowability and compressive strength of the alkali-activated mortar in oder to develop cementless alkali-activated concrete using blast furnace slag. In view of the results, we found out that the type and mixture ratio of alkali activator, the type and adding order of superplasticizer results to be significant factors. When cementless alkali-activated mortar using blast furnace slag manufactured with 1:1 the mass ratio of 9M NaOH and sodium silicate, and added superplasticizer before alkali activator in the mixer, we can be secured workability with 180 mm of flow during 1 hours and compressive strength of about 50 MPa under $20^{\circ}C$ curing condition at age of 28days.

• Journal of Korean Home Economics Education Association
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• v.32 no.1
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• pp.127-143
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• 2020

The purpose of this study is to develop the clothing safety teaching/learning plan in Home Economics based on the health belief model and to examine the effects of the course using the developed teaching/learning plan on the health belief. Based on ADDIE model, 6 clothing safety teaching/learning plans were developed by applying the health belief model. They consisted of three learning factors of 'harmful substances that can be exposed during the production, wear, wash, and storage of clothes and textile products', 'environment friendly fibers' and 'natural detergents'. Then they were implemented on 7 classes in middle school located in Gyeonggi-do Province from August 20 to September 7 in 2018. The health beliefs data collected before and after the course were analyzed with paired t-test with SPSS/win. As a result, the perceived threat(combination of perceived severity and perceived susceptibility), the perceived benefit, and the self-efficacy were significantly improved. And the perceived barrier was significantly reduced. In conclusion, the home economics clothing safety education course using the health belief model was meaningful as the safety education to enable middle school students to practice safe clothing life from harmful substances. The results of this study are expected to be helpful for activating safety education in home economics.

• Journal of Environmental Policy
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• v.7 no.4
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• pp.75-103
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• 2008

It is widely recognized that destruction of the eco-system with the counter-effect from the rapid industrialization threatens the life of human species. Furthermore, the extinction of some wild species keeps sending a warning message on the threat to human lives in the sense that both the human and wild lives have coexisted for a long time before the industrialization. Therefore, this study will shed a light on the importance of a natural ecology protection, focusing on wild-life conservation. This will provide an opportunity to consider the economic value of biodiversity through conservation of diverse wild lives and a natural ecology. Also, the irreversible damage to natural resources and extinction of certain species represent the urgency of this issue. This paper will perform a theoretical examination on the concept of wild plants and animals, an analysis of factors influencing their survivals, as well as the theory of natural ecology protections. This also examine the problems arising out of current domestic legislation of a natural ecology protection, comparing it with case studies of foreign countries. Through these analysis, this paper will seek for a maintenance of the currently enforcing natural ecology protection law to overcome its limits and will ultimately find alternatives to current system.