• 보건행정학회지
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• 제26권4호
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• pp.333-342
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• 2016

Background: The use of therapeutic materials based on new health technology has increased in recent years in the field of medicine, raising concerns for medical practitioners regarding increased spending on the new therapeutic materials amid the rapid population ageing and increase of chronic diseases in Korea. While therapeutic materials have significant importance in the health care system, they have not been given appropriate attention in the academic world of Korea. The purpose of this study is to identify factors that affect the growth of expenditure on therapeutic materials and to derive implications for an effective management considering the diversity of therapeutic materials. Methods: Using the claims data of the National Health Insurance Services, specific utilization patterns of groups of therapeutic materials in the middle classification level of Health Insurance Review and Assessment Service from 2007 to 2014 were analyzed. Four categories (J5083: drug eluting coronary stent, D0302: nonmetallic anchor, K6014: gauze, K6023: gauze) that exhibit unique patterns with respect to price and volume were selected. Then, decomposition analysis was performed to identify the largest contributor to the spending growth by dividing the products into existing, new, and abandoned products for the period between 2010 and 2013. Results: The effect of new products had larger impact on spending growth than the effect of core items in drug eluting coronary stent (J5083) and nonmetallic anchor (D0302). In addition, existing products in general included items priced relatively lower when compared with another item manufactured by the same company. In the gauze category, however, existing products had the largest impact on expenditure and the effect of volume was greater than that in other categories. Conclusion: This study provides evidence that appropriate management measures classified by the characteristics of therapeutic materials are required for therapeutic materials pricing and reassessment in Korea.

• 보건행정학회지
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• 제30권3호
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• pp.409-417
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• 2020

Background: It is well known that the distribution of therapeutic materials is very complex. However, it is not easy to demonstrate the concrete problems caused by distribution channels empirically. The purpose of this study was to investigate the differences in the price of therapeutic materials according to the type of purchasing agency and the way in which medical institutions purchase therapeutic materials. Methods: This study compared the claimed prices and the maximum allowable prices for the items of therapeutic material used for general spinal surgery. Results: Ilsan Hospital, which purchased directly without a purchasing agent, had the lowest claimed prices, followed by a large professional purchasing agency, a foundation-related purchasing agency, and a general purchasing agency. In addition, the difference between the claimed prices and the maximum allowable prices according to the purchase type was larger in the expensive treatment materials, and in the case of the lower price treatment materials, it tended to converge to the maximum allowable prices. Conclusion: National health insurance spending for therapeutic materials are to be affected by the distribution channels of them. We proposed several ideas to rationalize the expenditure such as classification of therapeutic materials on the basis of price or other criteria.

• Applied Science and Convergence Technology
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• 제25권6호
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• pp.103-107
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• 2016

The use of nanovesicles (NVs) has contributed to nanotechnology in the development of new concept medicine to compete with diseases of deleterious and infectious to human health. Due to their properties of size, morphology, and biocompatibility NVs have great impact on public health especially in the development of new therapeutic and prophylaxis approaches in addition to the device for biosensors to diagnose human diseases. Recent data also strongly suggest that NVs are regarded as innovative materials in developing for vaccines and diagnostic tools. In this review, we focus on the basic concepts and recent applications of NVs to utilize or engineer them as therapeutic materials.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 춘계학술발표대회
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• pp.7.2-7.2
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• 2009

Polyvalent nanoparticle-DNA conjugates exhibit a variety of unique features such as programmable assembly and disassembly, sharp melting transitons, intense optical properties, high stability, enhanced binding properties, and easy fabrication of the surface nature by chemical and physical modification. The unique properties of nanoparticle-DNA conjugates enable one to build up a number of versatile assay schemes for the detection of various targets. In addition, nanoparticle-RNA conjugates also demonstrate great promise of therapeutic applications in the context of RNA interference when combined with polymeric materials. In this presentation, representative examples of each aspect of nanoparticle-oligonucleotide conjugates will be discussed.

• 한국융합학회논문지
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• 제12권12호
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• pp.371-388
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• 2021

본 연구는 미술치료사들의 실제 임상 경험을 통해 치료적 동맹을 촉진하는 미술치료사의 개입 과정 및 전문적 역량 요소들을 탐색하여 미술치료 교육과 미술치료사 수련에 도움이 되는 자료를 제공하려는 목적으로 실시되었다. 이를 위해 9명의 미술치료사를 대상으로 심층 면담을 실시하였고, 자료 분석은 합의적 질적 분석(CQR)을 사용하여 5개 영역과 41개 범주로 정리되었다. 연구 결과, 치료적 동맹 촉진을 위한 미술치료사의 개입 과정은 치료적 동맹을 위해 기본적으로 고려할 사항과 치료적 동맹을 구성하는 세 가지 차원을 토대로 안전한 환경으로 구조화하는 것을 의미하며, 미술치료사의 전문적인 역량은 치료적 동맹을 위한 미술치료사의 개입 요인들과 상호작용하여 치료적 동맹 효과에 직·간접적으로 영향을 미치는 것으로 나타났다. 따라서 미술치료사는 치료적 동맹을 촉진하기 위해 임상적인 문제를 가진 독특한 개별 사례를 개념화할 수 있는 능력, 풍부한 임상경험, 미술을 치료적으로 활용할 수 있는 능력, 치료적 대상으로 존재하기 위한 노력 등과 관련된 전문적인 역량 강화가 필요하다고 본다. 본 연구는 미술치료에서 치료적 동맹을 촉진시키기 위한 구조화와 미술치료사의 전문성 강화에 필요한 발달과제들을 도출하여 미술치료사의 교육과 훈련에 활용될 자료를 제시했다는데 의의가 있다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2002년도 추계학술대회
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• pp.118-120
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• 2002

Genetic materials including DNA plasmid are effective delivery vehicle to express interesting gene efficiently and safely not to generate replication competent virus. Moreover, it has advantages to design a better vector and to simplify manufacturing and storage condition. To understand a possible pathogenic mechanism by a flavivirus, West Nile virus (WNV), WNV genome sequence was aligned to other pathogenic viral genome. Interestingly, WNV capsid (Cp) amino acid sequence has some homology to HIV-l Vpr protein. These proteins induce apoptosis in human cell lines as well as in vivo and cell cycle arrest. Therefore, DNA plasmid carrying apoptosis-inducing and cell cycle arresting viral proteins including a HIV-1 Vpr and a WNV Cp protein can be useful for anti-cancer therapeutic applications. This WNV Cp protein is an early expressed protein which can be a reasonable target antigen (Ag) for vaccine design. Immunization of a DNA construct encoding WNV Cp protein induces a strong Ag-specific humoral and Th1-type immune responses in animal. Therefore, DNA plasmid encoding apoptotic viral proteins can be useful tool for therapeutic and prophylactic applications.

• Molecules and Cells
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• 제38권5호
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• pp.381-389
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• 2015

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of autophagy is particularly important in various stress conditions, perturbation of autophagy can lead to cellular dysfunction and diseases. Accumulation of abnormal protein aggregates, a common cause of neurodegenerative diseases, can be reduced through autophagic degradation. Recent studies have revealed defects in autophagy in most cases of neurodegenerative disorders. Moreover, deregulated excessive autophagy can also cause neurodegeneration. Thus, healthy activation of autophagy is essential for therapeutic approaches in neurodegenerative diseases and many autophagy-regulating compounds are under development for therapeutic purposes. This review describes the overall role of autophagy in neurodegeneration, focusing on various therapeutic strategies for modulating specific stages of autophagy and on the current status of drug development.

• Journal of Pharmaceutical Investigation
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• 제35권1호
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• pp.25-31
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• 2005

Depot system for local drug delivery using chitosan hydrogel has been developed to enhance the therapeutic efficacy and to prevent the severe side effect in whole body. Thus, we have prepared an injectable chitosan hydrogel containing liposomes to treat cancers clinically. Anionic liposomes incorporated to improve sustained release efficiency within chitosan hydrogel. The chitosan solution containing liposomes was designed to form a hydrogel complex at body temperature. The released behavior of doxorubicin from liposomes in chitosan hydrogel showed sustained-release caused by diffusion of doxorubicin from temperature responsive liposome into chitosan hydrogel. The chitosan hydorgel containing liposomes enhanced the therapeutic potency for the solid tumor in vivo system. Our results indicate that the liposomes in chitosan hydrogel represent a depot system for local drug delivery.

• 한국실내디자인학회논문집
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• 제20권4호
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• pp.21-28
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• 2011

As people have paid much attention to their health along with increased interest in high quality of living, they have managed their health in organized manners. Space is a physical field which directly and indirectly interacts with human life, there is a little research on its therapeutic aspect and it is only negatively applied for development of products and alternative medicine. This study aims to identify research trends and flows targeting previous research on therapeutic approaches in domestic space design and present basic materials on space design approaches in a therapeutic view, which will be helpful in ultimate development of space design in theories and practices. As a result, it was discovered that there were only a few papers which were searched with direct key words on curative environment, which indicates that specific studies as therapeutic approaches are insufficient. When the studies were analysed according to annual publications, research on residential welfare and medical space was active, and research on design methodology, design techniques, and design plans was active, but research on psychology, behaviors, laws and institutions was relatively insufficient, which indicates studies on physical and psychological aspects of space design are necessary. In conclusion, it is suggested that further studies on therapeutic environment for direct and specific persons should be defined and classified although there have been relevant studies in various fields.

• 대한족부족관절학회지
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• 제8권1호
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• pp.16-21
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• 2004

Purpose: To investigate the characteristics of the patients and therapeutic shoes for diabetic patients. Materials and Methods: Forty two diabetic patients who had their own therapeutic shoes which were prescribed somewhere else were studied from March 2003 to December 2003. There were 27 males and 15 females, and the mean age was 62.1 years (range, 49-72 years). Duration of diabetes was average 14 years (range, $6{\sim}30$ years), all had type 2 diabetes. Sensation was examined with 5.07 nylon monofilament. The route of purchasing the shoes, compliance to the prescribed shoes were investigated by interview. The shape of shoe, stiffness of upper, conformity of insole to the shape of the foot were recorded. In-shoe plantar pressure was measured in 15 patients. Results: Eighteen patients were insensate to the monofilament. Seven patients did not wear the therapeutic shoes, and only 18 of 35 patients were wearing the therapeutic shoes more than 6 hours a day. The shoes of 17 patients were prescribed by medical doctor and the rest were purchased by the recommendation of acquaintances or advertisement. Ulcer recurred in four of five patients to whom the shoe was prescribed by medical doctor and the cause of three recurrences were evident by just observing the foot and shoe. The therapeutic shoes were made from 11 different makers. Eight shoes were adequate for diabetic patients with respect to the material, shape of insole, type of shoe. In-shoe plantar pressure was examined in 15 patients and was less than 300 kPa in all patients. Conclusion: The therapeutic shoes for the diabetic patients need to be prescribed by medical doctor for selective patients with neuropathy or previous history of ulcer and follow-up examination is important to monitor the compliance of the patients and adequacy of the shoes.