Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Anti-tumour Efficiency of Chitosan Hydrogel Containing Anionic Liposomes as a Depot System

음이온성 리포솜이 결합된 키토산 겔의 항암효과

  • Choi, Min-Soo (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Han, Hee-Dong (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Tae-Woo (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Song, Chung-Kil (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Park, Eun-Seok (College of Pharmacy, Sung Kyun Kwan University) ;
  • Shin, Byung-Cheol (Advanced Materials Division, Korea Research Institute of Chemical Technology)
  • 최민수 (한국화학연구원 나노생체재료팀) ;
  • 한희동 (한국화학연구원 나노생체재료팀) ;
  • 김태우 (한국화학연구원 나노생체재료팀) ;
  • 송충길 (한국화학연구원 나노생체재료팀) ;
  • 박은석 (성균관대학교 제약학과) ;
  • 신병철 (한국화학연구원 나노생체재료팀)
  • Published : 2005.02.20
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Abstract

Depot system for local drug delivery using chitosan hydrogel has been developed to enhance the therapeutic efficacy and to prevent the severe side effect in whole body. Thus, we have prepared an injectable chitosan hydrogel containing liposomes to treat cancers clinically. Anionic liposomes incorporated to improve sustained release efficiency within chitosan hydrogel. The chitosan solution containing liposomes was designed to form a hydrogel complex at body temperature. The released behavior of doxorubicin from liposomes in chitosan hydrogel showed sustained-release caused by diffusion of doxorubicin from temperature responsive liposome into chitosan hydrogel. The chitosan hydorgel containing liposomes enhanced the therapeutic potency for the solid tumor in vivo system. Our results indicate that the liposomes in chitosan hydrogel represent a depot system for local drug delivery.

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References

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