1 |
Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M.T., Michel, P.P., Marquez, J., Mouatt-Prigent, A., Ruberg, M., Hirsch, E.C., and Agid, Y. (1997). Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31.
|
2 |
Barmada, S.J., Serio, A., Arjun, A., Bilican, B., Daub, A., Ando, D.M., Tsvetkov, A., Pleiss, M., Li, X., Peisach, D., et al. (2014). Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat. Chem. Biol. 10, 677-685.
DOI
ScienceOn
|
3 |
Bonifati, V. (2006). Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics. Eur. J. Hum. Genet. 14, 1061-1062.
DOI
ScienceOn
|
4 |
Boya, P., Reggiori, F., and Codogno, P. (2013). Emerging regulation and functions of autophagy. Nat. Cell Biol. 15, 713-720.
DOI
ScienceOn
|
5 |
Burli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., et al. (2013). Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J. Med. Chem. 56, 9934-9954.
DOI
ScienceOn
|
6 |
Caccamo, A., Majumder, S., Richardson, A., Strong, R., and Oddo, S. (2010). Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285, 13107-13120.
DOI
ScienceOn
|
7 |
Chen, D., Fan, W., Lu, Y., Ding, X., Chen, S., and Zhong, Q. (2012). A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol. Cell. 45, 629-641.
DOI
ScienceOn
|
8 |
Cherra, S.J. 3rd, and Chu, C.T. (2008). Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol. 3, 309-323.
|
9 |
Ching, J.K., and Weihl, C.C. (2013). Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCPassociated myopathy. Autophagy 9, 799-800.
DOI
|
10 |
Cortes, C.J, and La Spada, A.R. (2014). The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov. Today 19, 963-971.
DOI
ScienceOn
|
11 |
Coune, P.G., Bensadoun, J.C., Aebischer, P., and Schneider, B.L. (2011). Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alphasynuclein based rat model of Parkinson's disease. J. Parkinsons Dis. 1, 373-387.
|
12 |
Crippa, V., Sau, D., Rusmini, P., Boncoraglio, A., Onesto, E., Bolzoni, E., Galbiati, M., Fontana ,E., Marino, M., Carra, S., et al. (2010). The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum. Mol. Genet. 19, 3440-3456.
DOI
ScienceOn
|
13 |
Decressac, M., Mattsson, B., Weikop, P., Lundblad, M., Jakobsson, J., and Bjorklund, A. (2013). TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity. Proc. Natl. Acad. Sci. USA 110, E1817-1826.
DOI
ScienceOn
|
14 |
Deng, Y.N., Shi, J., Liu, J., and Qu, Q.M. (2013). Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem. Int. 63, 1-9.
DOI
ScienceOn
|
15 |
Dolan, P.J., and Johnson, G.V. (2010). A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J. Biol. Chem. 285, 21978-21987.
DOI
ScienceOn
|
16 |
Filimonenko, M., Isakson, P., Finley, K.D., Anderson, M., Jeong, H., Melia, T.J., Bartlett, B.J., Myers, K.M., Birkeland, H.C., Lamark, T. et al. (2010). The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol. Cell 38, 265-279.
DOI
ScienceOn
|
17 |
Du, G., Liu, X., Chen, X., Song, M., Yan, Y., Jiao, R., and Wang, C.C. (2010). Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation. Mol. Biol. Cell 21, 2128-2137.
DOI
|
18 |
Duyao, M.P., Auerbach, A.B., Ryan, A., Persichetti, F., Barnes, G.T., McNeil, S.M., Ge, P., Vonsattel, J.P., Gusella, J.F., Joyner, A.L., et al. (1995). Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269, 407-410.
DOI
|
19 |
Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B.T., McLean, P.J., and Unni, V.K. (2011). Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of - synuclein. J. Neurosci. 31, 14508-14520.
DOI
ScienceOn
|
20 |
Filomeni, G., Graziani, I., De Zio, D., Dini, L., Centonze, D., Rotilio, G., and Ciriolo, M.R. (2012). Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol. Aging 33, 767-785.
DOI
ScienceOn
|
21 |
Forlenza, O.V., de Paula, V.J., Machado-Vieira, R., Diniz, B.S., and Gattaz, W.F. (2012). Does lithium prevent Alzheimer's disease? Drugs Aging 29, 335-342.
DOI
ScienceOn
|
22 |
Hadano, S., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Akatsuka, A., Koike, M., Aoki, M., Uchiyama, Y., Itoyama, Y., and Ikeda, J.E. (2010). Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One 5, e9805.
DOI
ScienceOn
|
23 |
Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M.L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008). Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 105, 2052-2057.
DOI
ScienceOn
|
24 |
Gamblin, T.C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A.L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., et al. (2003). Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 100, 10032-10037.
DOI
ScienceOn
|
25 |
Giordano, S., Darley-Usmar, V., and Zhang, J. (2014). Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol. 2, 82-90.
DOI
ScienceOn
|
26 |
Hamano, T., Gendron, T.F., Causevic, E., Yen, S.H., Lin, W.L., Isidoro, C., Deture, M., and Ko, L.W. (2008). Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. Eur. J. Neurosci. 27, 1119-1130.
DOI
ScienceOn
|
27 |
Han, H., Wei, W., Duan, W., Guo, Y., Li, Y., Wang, J., Bi, Y., and Li, C. (2014). Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). In Vitro Cell. Dev. Biol. Anim. [Epub ahead of print]
|
28 |
Jaeger, P.A., Pickford, F., Sun, C.H., Lucin, K.M., Masliah, E., and Wyss-Coray, T. (2010). Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One 5, e11102.
DOI
ScienceOn
|
29 |
Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A.M., Brown, R.H., and Glimcher, L.H. (2009). XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 23, 2294-2306.
DOI
ScienceOn
|
30 |
Hyttinen, J.M., Niittykoski, M., Salminen, A., and Kaarniranta, K. (2013). Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim. Biophys. Acta 1833, 503-510.
DOI
ScienceOn
|
31 |
Jia, H., Kast, R.J., Steffan, J.S., and Thomas, E.A. (2012). Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitinproteasomal and autophagy systems. Hum. Mol. Genet. 21, 5280-5293.
DOI
|
32 |
Jiang, T.F., Zhang, Y.J., Zhou, H.Y., Wang, H.M., Tian, L.P., Liu, J., Ding, J.Q., and Chen, S.D. (2013). Curcumin ameliorates the neurodegenerative pathology in A53T -synuclein cell model of Parkinson's disease through the downregulation of mTOR/ p70S6K signaling and the recovery of macroautophagy. J. Neuroimmune Pharmacol. 8, 356-669.
DOI
ScienceOn
|
33 |
Juenemann, K., Schipper-Krom, S., Wiemhoefer, A., Kloss, A., Sanz Sanz, A., and Reits, E.A. (2013). Expanded polyglutaminecontaining N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes. J. Biol. Chem. 288, 27068-27084.
DOI
ScienceOn
|
34 |
Kaushik, S., and Cuervo, A.M. (2012). Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 22, 407-417.
DOI
|
35 |
Koga, H., Martinez-Vicente, M., Arias, E., Kaushik, S., Sulzer, D., and Cuervo, A.M. (2011). Constitutive upregulation of chaperone- mediated autophagy in Huntington's disease. J. Neurosci. 31, 18492-18505.
DOI
|
36 |
Kesidou, E., Lagoudaki, R., Touloumi, O., Poulatsidou, K.N., and Simeonidou, C. (2013). Autophagy and neurodegenerative disorders. Neural Regen. Res. 8, 2275-2283.
|
37 |
Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Köhler, A., Glossmann, H., et al. (2010). Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc. Natl. Acad. Sci. USA 107, 21830-21835.
DOI
ScienceOn
|
38 |
Kiernan, M.C., Vucic, S., Cheah, B.C., Turner, M.R., Eisen, A., Hardiman, O., Burrell, J.R., and Zoing, M.C. (2011). Amyotrophic lateral sclerosis. Lancet 377, 942-955.
DOI
ScienceOn
|
39 |
Komatsu, M., and Ichimura, Y. (2010). Selective autophagy regulates various cellular functions. Genes Cells 15, 923-933.
DOI
ScienceOn
|
40 |
Lee, J.A. (2012). Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival? Exp. Neurobiol. 21, 1-8.
DOI
ScienceOn
|
41 |
Lee, J.H., Yu, W.H., Kumar, A., Lee, S., Mohan, P.S., Peterhoff, C.M., Wolfe, D.M., Martinez-Vicente, M., Massey, A.C., Sovak, G., et al. (2010). Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141, 1146-1158.
DOI
ScienceOn
|
42 |
Li, L., Zhang, X., and Le, W. (2008). Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 4, 290-293.
DOI
|
43 |
Lucin, K.M., O'Brien, C.E., Bieri, G., Czirr, E., Mosher, .KI., Abbey, R.J., Mastroeni, D.F., Rogers, J., Spencer, B., Masliah, E., et al. (2013). Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79, 873-886.
DOI
ScienceOn
|
44 |
Li, W.W., Li, J., and Bao, J.K. (2012). Microautophagy: lesserknown self-eating. Cell. Mol. Life Sci. 69, 1125-1136.
DOI
|
45 |
Lin, T.K., Chen, S.D., Chuang, Y.C., Lin, H.Y., Huang, C.R., Chuang, J.H., Wang, P.W., Huang, S.T., Tiao, M.M., Chen, J.B., et al. (2014). Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. Int. J. Mol. Sci. 15, 1625-1646.
DOI
|
46 |
Liu, D., Pitta, M., Jiang, H., Lee, J.H., Zhang, G., Chen, X., Kawamoto, E.M., and Mattson, M.P. (2013). Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol. Aging 34, 1564-1580.
DOI
ScienceOn
|
47 |
Manzoni, C., Mamais, A., Dihanich, S., Abeti, R., Soutar, M.P., Plun- Favreau, H., Giunti, P., Tooze, S.A., Bandopadhyay, R., and Lewis, P.A. (2013). Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochim. Biophys. Acta 1833, 2900-2910.
DOI
ScienceOn
|
48 |
Martin, D.D., Ladha, S., Ehrnhoefer, D.E., and Hayden, M.R. (2015). Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci. 38, 26-35.
DOI
ScienceOn
|
49 |
Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A.C., Mazzulli, J., Mosharov, E.V., Hodara, R., Fredenburg R., Wu, D.C., Follenzi, A., et al. (2008). Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777-788.
|
50 |
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010). Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat. Neurosci. 13, 567-576.
DOI
ScienceOn
|
51 |
Millecamps, S., and Julien, J.P. (2013). Axonal transport deficits and neurodegenerative diseases. Nat. Rev. Neurosci. 14, 161-176.
DOI
ScienceOn
|
52 |
Mizushima, N., Yoshimori, T., and Ohsumi, Y. (2011). The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132.
DOI
ScienceOn
|
53 |
Mizushima, N. (2010). The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 22, 132-139.
DOI
ScienceOn
|
54 |
Morimoto, N., Nagai, M., Ohta, Y., Miyazaki, K., Kurata, T., Morimoto, M., Murakami, T., Takehisa, Y., Ikeda, Y., Kamiya, T., et al. (2007). Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 1167, 112-117.
DOI
ScienceOn
|
55 |
Nagata, E., Sawa, A., Ross, C.A., and Snyder, SH. (2004). Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport 15, 1325-1328.
DOI
ScienceOn
|
56 |
Nah, J., Pyo, J.O., Jung, S., Yoo, S.M., Kam, T.I., Chang, J., Han, J., Soo A An, S., Onodera, T., and Jung, Y.K. (2013). BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid 42. Autophagy 9, 2009-2021.
DOI
ScienceOn
|
57 |
Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W.L., Griffith, J., Nag, S., Wang, K., Moss, T., et al. (2011). SNARE proteins are required for macroautophagy. Cell 146, 290-302.
DOI
ScienceOn
|
58 |
Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., and Hetz, C. (2014). Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy 10, 1256-1271.
DOI
ScienceOn
|
59 |
Nakatogawa, H., Suzuki, K., Kamada, Y., and Ohsumi, Y. (2009). Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol. 10, 458-467.
DOI
ScienceOn
|
60 |
Narendra, D., Tanaka, A., Suen, D.F., and Youle, R.J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803.
DOI
ScienceOn
|
61 |
Nixon, R.A., Wegiel, J., Kumar, A., Yu, W.H., Peterhoff, C., Cataldo, A., and Cuervo, A.M. (2005). Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 64, 113-122.
DOI
|
62 |
Orenstein, S.J., Kuo, S.H., Tasset, I., Arias, E., Koga, H., Fernandez- Carasa, I., Cortes, E., Honig, L.S., Dauer, W., Consiglio, A., et al. (2013). Interplay of LRRK2 with chaperone-mediated autophagy. Nat. Neurosci. 16, 394-406.
DOI
ScienceOn
|
63 |
Pan, P.Y., and Yue, Z. (2014). Genetic causes of Parkinson's disease and their links to autophagy regulation. Parkinsonism Relat. Disord. 20 Suppl 1, S154-157.
DOI
ScienceOn
|
64 |
Pandey, U.B., Nie, Z., Batlevi, Y., McCray, B.A., Ritson, G.P., Nedelsky, N.B., Schwartz, S.L., DiProspero, N.A., Knight, M.A., Schuldiner, O., et al. (2007). HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863.
|
65 |
Querfurth, H.W., and LaFerla, F.M. (2010). Alzheimer's disease. N. Engl. J. Med. 362, 329-344.
DOI
ScienceOn
|
66 |
Pickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P.A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008). The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 118, 2190-2199.
|
67 |
Pizzasegola, C., Caron, I., Daleno, C., Ronchi, A., Minoia, C., Carrì, M.T., and Bendotti, C. (2009). Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice. Amyotroph. Lateral Scler. 10, 221-228.
DOI
ScienceOn
|
68 |
Qi, L., and Zhang, X.D. (2014). Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein. Acta Biochim. Biophys. Sin. (Shanghai) 46, 83-91.
DOI
ScienceOn
|
69 |
Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J., et al. (2004). Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595.
DOI
ScienceOn
|
70 |
Rodriguez-Martín, T., Cuchillo-Ibanez, I., Noble, W., Nyenya, F., Anderton, B.H., and Hanger, D.P. (2013). Tau phosphorylation affects its axonal transport and degradation. Neurobiol. Aging 34, 2146-2157.
DOI
ScienceOn
|
71 |
Rohn, T.T., Wirawan, E., Brown, R.J., Harris, J.R., Masliah, E., and Vandenabeele, P. (2011). Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain. Neurobiol. Dis. 43, 68-78.
DOI
ScienceOn
|
72 |
Sasaki, S. (2011). Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 70, 349-359.
DOI
|
73 |
Rose, C., Menzies, F.M., Renna, M., Acevedo-Arozena, A., Corrochano, S., Sadiq, O., Brown, S.D., and Rubinsztein, D.C. (2010). Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum. Mol. Genet. 19, 2144-2153.
DOI
ScienceOn
|
74 |
Russell, R.C., Tian, Y., Yuan, H., Park, H.W., Chang, Y.Y., Kim, J., Kim, H., Neufeld, T.P., Dillin, A., and Guan, K.L. (2013). ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741-750.
DOI
ScienceOn
|
75 |
Sala, G., Stefanoni, G., Arosio, A., Riva, C., Melchionda, L., Saracchi, E., Fermi, S., Brighina, L., and Ferrarese, C. (2014). Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease. Brain Res. 1546, 46-52.
DOI
ScienceOn
|
76 |
Scarffe, L.A., Stevens, D.A., Dawson, V.L., and Dawson, T.M. (2014). Parkin and PINK1: much more than mitophagy. Trends Neurosci. 37, 315-324.
DOI
ScienceOn
|
77 |
Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., and Yuan, J. (2006). Regulation of intracellular accumulation of mutant Huntingtin by Beclin1. J. Biol. Chem. 281, 14474-14485.
DOI
ScienceOn
|
78 |
Shibutani, S.T., and Yoshimori, T. (2014) A current perspective of autophagosome biogenesis. Cell Res. 24, 58-68.
DOI
ScienceOn
|
79 |
Shintani, T., and Klionsky, D.J. (2004). utophagy in health and disease: a double-edged sword. Science 306, 990-995.
DOI
ScienceOn
|
80 |
Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G.R., Zou, Z., Kinch, L., Wilkins, A.D., Sun, Q., Pallauf, K., MacDuff, D., et al. (2013). Identification of a candidate therapeutic autophagyinducing peptide. Nature 494, 201-206.
DOI
ScienceOn
|
81 |
Shpilka, T., Mizushima, N., and Elazar, Z. (2012). Ubiquitin-like proteins and autophagy at a glance. J. Cell Sci. 125, 2343-2348.
DOI
|
82 |
Son, S.M., Jung, E.S., Shin, H.J., Byun, J., and Mook-Jung, I. (2012). -induced formation of autophagosomes is mediated by RAGE--AMPK signaling. Neurobiol. Aging 33, 1006.e11-23.
|
83 |
Song, C.Y., Guo, J.F., Liu, Y., and Tang, B.S. (2012). Autophagy and Its Comprehensive Impact on ALS. Int. J. Neurosci. 122, 695-703.
DOI
ScienceOn
|
84 |
Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., and Masliah, E. (2009). Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 29, 13578-13588.
DOI
ScienceOn
|
85 |
Staats, K.A., Hernandez, S., Schönefeldt, S., Bento-Abreu, A., Dooley, J., Van Damme P., Liston, A., Robberecht, W., and Van Den Bosch, L. (2013). Rapamycin increases survival in ALS mice lacking mature lymphocytes. Mol. Neurodegener 8, 31.
DOI
ScienceOn
|
86 |
Steele, J.W., and Gandy, S. (2013). Latrepirdine (Dimebon), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy 9, 617-618.
DOI
|
87 |
Surendran, S., and Rajasankar, S. (2010). Parkinson's disease: oxidative stress and therapeutic approaches. Neurol. Sci. 31, 531-540.
DOI
|
88 |
Thompson, L,M., Aiken, C,T., Kaltenbach, L.S., Agrawal, N., Illes, K., Khoshnan, A., Martinez-Vincente, M., Arrasate, M., O'Rourke, J.G., Khashwji, H., et al. (2009). IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J. Cell Biol. 187, 1083-1099.
DOI
ScienceOn
|
89 |
Tan, C.C., Yu, J.T., Tan, M.S., Jiang, T., Zhu, X.C., and Tan, L. (2014). Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. Neurobiol. Aging 35, 941-957.
DOI
ScienceOn
|
90 |
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nekooki, M., and Nukina, N. (2004). Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat. Med. 10, 148-154.
DOI
ScienceOn
|
91 |
Tian, Y., Bustos, V., Flajolet, M., and Greengard, P. (2011). A smallmolecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 25, 1934-1942.
DOI
ScienceOn
|
92 |
Tsvetkov, A.S., Miller, J., Arrasate, M., Wong, J.S., Pleiss, M.A., and Finkbeiner, S. (2010). A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc. Natl. Acad. Sci. USA. 107, 16982-16987.
DOI
ScienceOn
|
93 |
Ulamek-Kozio, M., Furmaga-Jablonska, W., Januszewski, S., Brzozowska, J., Scislewska, M., Jablonski, M., and Pluta, R. (2013). Neuronal autophagy: self-eating or self-cannibalism in Alzheimer's disease. Neurochem. Res. 38, 1769-1773.
DOI
ScienceOn
|
94 |
Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J.E., Janle, E.M., Lobo, J., Ferruzzi. M.G., Davies. P., et al. (2010). AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J. Biol. Chem. 285, 9100-9113.
DOI
ScienceOn
|
95 |
Weidberg, H., Shvets, E., and Elazar, Z. (2011). Biogenesis and cargo selectivity of autophagosomes. Annu. Rev. Biochem. 80, 125-156.
DOI
ScienceOn
|
96 |
Wacker, J.L., Zareie, M.H., Fong, H., Sarikaya, M., and Muchowski, P.J. (2004). Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nat. Struct. Mol. Biol. 11, 1215-1222.
DOI
ScienceOn
|
97 |
Waldemar, G., Dubois, B., Emre, M., Georges, J., McKeith, I.G., Rossor, M., Scheltens, P., Tariska, P., and Winblad, B. (2007). Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline. Eur. J. Neurol. 14, e1-26.
|
98 |
Wang, J.Z., Xia, Y.Y., Grundke-Iqbal, I., and Iqbal, K. (2013). Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J. Alzheimers Dis. 33 Suppl 1, S123-139.
|
99 |
Yu, W.H., Cuervo, A.M., Kumar, A., Peterhoff, C.M., Schmidt, S.D., Lee, J.H., Mohan, P.S., Mercken, M., Farmery, M.R., Tjernberg, L.O., et al. (2005). Macroautophagy--a novel Beta-amyloid peptide- generating pathway activated in Alzheimer's disease. J. Cell Biol. 171, 87-98.
DOI
ScienceOn
|
100 |
Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., and Le, W. (2011). Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 7, 412-425.
DOI
|
101 |
Zhang ,X., Chen, S., Song, L., Tang, Y., Shen, Y., Jia, L., and Le, W. (2014). MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy 10, 588-602.
DOI
ScienceOn
|
102 |
Andersen, P.M., and Al-Chalabi, A. (2011). Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat. Rev. Neurol. 7, 603-615.
DOI
ScienceOn
|
103 |
Abrahamsen, H., Stenmark, H., and Platta, H.W. (2012). Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett. 586, 1584-1591.
DOI
ScienceOn
|
104 |
Alcalay, R.N., Caccappolo, E., Mejia-Santana, H., Tang, M.X., Rosado, L., Ross, B.M., Verbitsky, M., Kisselev, S., Louis, E.D., Comella, C., et al. (2010). Frequency of known mutations in early- onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch. Neurol. 67, 1116-1122.
|
105 |
Alegre-Abarrategui, J., Christian, H., Lufino, M.M., Mutihac, R., Venda, L.L., Ansorge, O., and Wade-Martins, R. (2009). LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022-4034.
DOI
ScienceOn
|