• 한국정밀공학회지
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• 제24권8호통권197호
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• pp.50-57
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• 2007

In this paper, two types of novel planar Translational Parallel Manipulators (TPMs) by using parallelogram mechanism are conceived. One is made up of two Pa-P (Parallelogram-Prismatic) legs connecting the base to the moving platform. The other consists of two P-Pa legs, which is the kinematic inversion of the former. Since connecting links in a parallelogram mechanism are subject to only tensile/compressive load and all the heavy actuators are mounted at the base, the proposed manipulators can be applied for planar positioning/assembly tasks requiring high stiffness and high speed. The position, velocity, and statics are analyzed, and the design methodology using prescribed workspace and velocity transmission capability is presented. Finally, two types of prototype manipulators have been developed.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2002년도 봄 학술발표회 논문집
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• pp.717-724
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• 2002

To investigate the behavior of air-shaft and existing tunnel by excavating the small-diameter shaft into the existing tunnel, prototype air-shaft was constructed and analyzed in this study. Geotechnical characterization was conducted by boring and rock cores obtained were tested in the laboratory. Field monitoring including radial and tangential stresses and displacements was conducted with the 3-dimensional numerical analysis of prototype air-shaft. Results of field monitoring were compared with the numerical results. The results showed that maximum displacement of 2.11mm and maximum tangential stress of 54.0 kg/$\textrm{cm}^2$ were obtained during shaft excavation near the right shoulder of the existing tunnel. The comparison of these field measurements with 3-dimensional numerical analysis showed that much more higher stress was measured during excavation compared to the numerical results even though the trends of stress and displacement were similar.

• 생명과학회지
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• 제14권6호
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• pp.906-912
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• 2004

한국에서 분리한 Helicobacter pylori 균주가 위암 세포주에서 IL-8를 유도하는 유도능을 관찰하고자 하였으며, 특히 4형 분비구조의 주요 구성체인 cagE 유전자의 다형성에 따라 IL-8 유도능의 차이 및 각 질환에서 분리한 균주에서의 차이가 있는지 검토하고자 하였다. 강남성모병원 내시경검사를 받은 환자들 중 H. pylori 감염 양성으로 확인된 위암 23명 $(31.0\%)$, 위염 24명$(32.6\%)$, 십이지장궤양27명$(36.4\%)$ 총 74명을 대상으로 하여 H. pylori를 분리한 후 PCR-RFLP방법을 이용하여 cagE 다형성을 확인하였으며, PCR 및 Real-time PCR을 이용하여 ragA TPMs를 결정하였다, 또한 분리된 균주를 위암세포주에 감염시켜 상등액을 취하여 ELISA방법으로 IL-8을 정량화 하였다. 전체 74개의 분리 균주 중 59개의 균주$(79.7\%)$에서 IL-8 유도능이 있는 것으로 확인되었으며, cagE 다형성 중에서 가장 높은 빈도로 관찰되는 형태는 MboI/NlaIII B-C, A-C 및 C-C 타입 이었으며, 이중 A-C와 B-C 형태가 C-C 형태에 비해 유의적으로 높은 IL-8 유도능을 나타냈다. 그러나 cagA TPMs의 분류 및 vacA m-아형 분류와 IL-8 유도능과는 연관성이 없었다. 비록 본 연구에서 cagE 다형성과 IL-8 유도능과 아주 밀접한 연관성이 나타나지는 않았지만 vacA m-아형이나 cagA TPMs 보다는 cagE 다형성이 IL-8 유도능과 연관성이 클 것으로 생각된다.

• 접착 및 계면
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• 제11권4호
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• pp.137-143
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• 2010

Glass beads (GBs) were modified via plasma polymerization coatings in order to enhance the adsorption of polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke and activated carbons (ACs) were also utilized for comparative purposes. First, GBs and ACs were subjected to surface modification via plasma polymerization coating of acrylic acid, acrylonitrile, 1,3-diaminopropane, thiophene or dimethylphosphite with a RF plasma (13.56 MHz) generator. Next, their adsorption behavior was evaluated with a home-made 4-port smoking machine by collecting the total particulate matters (TPMs) on a Cambridge filter pad, followed by the separation of PAHs via solid phase extraction and analysis with GC/MS. Finally, the plasma polymerization coatings were analyzed by FT-IR/ATR to elucidate the adsorption mechanism, while the topology of the modified GBs and ACs were studied by FE-SEM.

• 시스템엔지니어링학술지
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• 제10권2호
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• pp.71-79
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• 2014

To enhance success probability of a system development project, its overall risk level should be minimized through systematically managing schedules, costs, and technical performances. However, Attempts to manage technical performance compared to numerous efforts to control costs and schedules in such projects are deficient. Particularly, a space launch vehicle, a large complex system, development project is much less likely to meet its technical performance objectives due to its technological difficulty, along with schedule delay and cost overrun. The technical performance management (TPM) is a method for tracking and managing technical progress in order to achieve technical performance targets within schedule and budget. In this paper, we investigate applications of the TPM in several space launch vehicle development projects. Then we propose and validate the TPM process to achieve a successful mission in such projects.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6305-6310
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• 2012

Objectives: This study aimed to demonstrate the tyrosine phosphorylation motif (TPM) and 3' region structure of the Helicobacter pylori CagA gene as well as its SHP-2 binding activity in AGS cells and relation to gastric carcinogenesis. Methods: Sixteen clinical isolate H. pylori strains from eight duodenal ulcer and eight gastric adenocarcinoma patients were studied for CagA repeat sequence EPIYA motifs, C-terminal structure, and western blot analysis of CagA protein expression, translocation, and SHP-2 binding in AGS cells. Results: Except for strain 547, all strains from the gastric adenocarcinoma patients were positive for CagA by PCR and had three EPIYA copy motifs. Western blotting showed that all strains were positive for CagA protein expression (100%), CagA protein translocation (100%), and SHP-2 binding (100%). CagA protein expression was significantly higher in the gastric adenocarcinoma patients than in the duodenal ulcer patients (P=0.0023). CagA protein translocation and SHP-2 binding in the gastric adenocarcinoma patients were higher than those in the duodenal ulcer patients, but no significant differences were found between the two groups (P=0.59, P=0.21, respectively). Conclusions: The TPMs and 3' region structures of the H. pylori CagA gene in the duodenal ulcer and gastric adenocarcinoma patients have no significant differences.

• 대한기계학회논문집A
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• 제41권8호
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• pp.737-744
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• 2017

최근 Shellular라는 새로운 극저밀도 재료가 소개되었다. Shellular는 주기적 구조를 가지면서도 한장의 부드러운 곡면의 쉘로 구성되어 있다. 최초의 Shellular는 리쏘그래피를 이용하여 제조되며 3주기최소곡면의 일종인 P-곡면과 유사한 형태를 갖는다. 본 연구에서는 와이어 직조에 기반하여 D-곡면과 유사한 Shellular를 제작하는 새로운 방법을 제시한다. 실험과 유한요소해석을 통하여 압축하중 하의 재료물성을 평가하고 종래의 극저밀도 재료와 비교하였다.

• 대한전자공학회논문지TC
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• 제46권1호
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• pp.121-132
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• 2009

운영체제는 사용자 암호의 유출을 막고 안전한 로그온 과정을 보장하기 위해 다양한 보안 기법을 적용하고 있다. 그러나 공격자가 서버에 물리적인 접근을 하거나 관리자 권한을 가지고 있다면 공격자는 암호에 관한 정보를(예를 들어, 유닉스의 Shadow file, 또는 윈도우의 SAM 파일) 얻을 수 있다. 그리고 Brute Force Attack과 Dictionary Attack을 통하여 암호 정보들로부터 사용자의 암호를 분석해 낼 수 있다. 따라서 이러한 공격을 방지하려면 사용자에게 복잡한 암호를 사용하도록 강제해야 한다. 하지만 그것은 한계가 있으며 알아내기 쉬운 간단한 암호를 사용하는 사용자들은 항상 존재하기 마련이다. 따라서 보다 근본적인 보안 대책이 요구된다. 본 논문에서는 사용자 암호의 복잡도와 상관없이 Brute Force Attack과 Dictionary Attack으로부터 안전한 전자서명(Digital Signature) 및 TPM(Trusted Platform Module) 암호 전용칩 기반의 인증 기법을 제시하고 그 성능을 분석한다.

• 대한전자공학회논문지SD
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• 제45권11호
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• pp.63-70
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• 2008

본 논문에서는 MEMS 압력 센서의 스마트 센서 시스템을 구현하였다. 피에조 압력센서의 온도 드리프트 문제를 해결하기 위해 외부 환경에 맞춰 시스템이 스스로 발생 오차를 제거하는 보상 알고리즘과 이에 의해 제어되는 프로그래머블한 보정 회로를 제안하였다. 시스템은 신호처리부, 보정 회로, 온도 감지부, 그리고 마이크로프로세서 및 통신부가 SOC으로 구현되었으며, RS-232 인터페이스가 시스템의 모니터링 및 제어를 위해 사용되었다. 구현된 IC의 면적은 $4.38{\times}3.78\;mm^2$이며 $0.35{\mu}m$ CMOS 공정으로 제작되었다. $-40^{\circ}C{\sim}150^{\circ}C$ 온도 범위에서 50 KPa급 MEMS 압력센서의 온도 드리프트 보상 오차는 ${\pm}0.48%$로 측정되었다. 구현된 시스템의 전력소모는 30.5mW로 측정되었다.

• 한국연초학회지
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• 제30권1호
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• pp.14-24
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• 2008

The objective of this study was to determine the effect of smoking conditions on the in vitro toxicological activity of mainstream smoke. The 2R4F reference cigarette was machine-smoked by International Organization for Standardization(ISO) and Canadian Intense(CI) conditions. Smoke was analysed for chemical composition and in vitro toxicity. The cytotoxic potencies of both the total particulate matter(TPM), which were collected in Cambridge filter pad, and gas/vapor phase(GVP), which was bubbled through in phosphate-buffer saline in a gas-washing bottle, were assessed neutral red up take assay with chinese hamster ovary(CHO) cells. The assessment for genotoxicity of TPMs generated under ISO and CI conditions was determined using Salmonella mutagenicity assay and in vitro micronucleus assay. When calculated on an equal TPM basis, in vitro toxicity of TPM obtained under CI condition was decreased compared to TPM generated under ISO condition. The results of chemical composition analyses revealed that the lower toxicological activity under CI condition than that of ISO condition could be explained by the decreased in the contents of phenols, N-nitrosoamines and aromatic amines of TPM on an equal TPM basis.