• Journal of Periodontal and Implant Science
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• v.42 no.5
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• pp.151-157
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• 2012

Purpose: Cyclooxygenase (COX) enzyme catalyzes the production of prostaglandins, which are important mediators of tissue destruction in periodontitis. Single nucleotide polymorphisms of $COX_2$ enzyme have been associated with increasing susceptibility to inflammatory diseases. The present study evaluates the association of two single nucleotide polymorphisms in $COX_2$ gene (-1195G>A and $8_{473}$C>T) with chronic periodontitis in North Indians. Methods: Both SNPs and their haplotypes were used to explore the associations between $COX_2$ polymorphisms and chronic periodontitis in 56 patients and 60 controls. Genotyping was done by polymerase chain reaction followed by restriction fragment length polymorphism. Chi-square test and logistic regression analysis were performed for association analysis. Results: By the individual genotype analysis, mutant genotypes (GA and AA) of $COX_2$-1195 showed more than a two fold risk (odds ratio [OR]>2) and $COX_2$ $8_{473}$ (TC and CC) showed a reduced risk for the disease, but the findings were not statistically significant. Haplotype analysis showed that the frequency of the haplotype AT was higher in the case group and a significant association was found for haplotype AT (OR, 1.79; 95% confidence interval, 1.03 to 3.11; P=0.0370) indicating an association between the AT haplotype of $COX_2$ gene SNPs and chronic periodontitis. Conclusions: Individual genotypes of both the SNPs were not associated while haplotype AT was found to be associated with chronic periodontitis in North Indians.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.9 s.339
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• pp.49-56
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• 2005

Memory effect, which influence the performance of Doherty amplifier, become more significant and critical in designing these circuits as the modulation signal bandwidth and operation power level increase. This paper reports on an attempt to investigate, model and quantity the contribution of the electrical nonlinearity effects and the thermal memory effects to a Doherty amplifier's distortion generation. Also this raper reports on the development of an accurate dynamic expression of the instantaneous junction temperature as a function of the instantaneous dissipated power. This expression has been used in the construction of an electrothermal model for the Doherty amplifier. Parameters for the nelv proposed behavior model were determined from the Doherty amplifier measurements obtained under different excitation conditions. This study led us to conclude that the effects of the transistor self-heating phenomenon are important for signals with wideband modulation bandwidth(ex. W-CDMA or UMTS signal). Doherty amplifier with electrothermal memory effect compensator enhanced ACLR performance about 20 dB than without electrothemal memory effect compensator. Experiment results were mesured by 60W LDMOS Doherty amplifier and electrothermal memory effect compensator was simulated by ADS.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.10
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• pp.52-56
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• 2009

In this paper, we investigate the performance of the ARQ-aided downlink Time Switched Transmit Diversity (TSTD) in the WCDMA LCR-TDD system, when power ramping is applied. The proposed power ramping scheme ramps up the transmission power and then retransmits the data, when the receiver sends the response signal (ACK or NACK signal) to the transmitter and the response signal is NACK signal. Simulation results demonstrate that the proposed scheme yields about 0.7dB performance gain in terms of average Eb/N0, compared with the conventional ARQ-aided TSTD when a mobile speed is 3km/h and an frame error rate (FER) is 1%, respectively. In addition, 2.5% of throughput gain is shown when average Eb/N0 is equal to 0dB.

• Korean Journal of Agricultural Science
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• v.38 no.4
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• pp.689-693
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• 2011

The purpose of this study was to investigate the Cytochrome P450 (CYP2A6) gene as a candidate gene for the traits related with meat fatty acid composition traits in pigs. Porcine CYP2A6 polymorphisms were detected and PCR-RFLP was performed for genotyping of Korean native pig (n=14), Landrace (n=3), Duroc (n=3), Berkshire (n=3), Yorkshire (n=8) and F2 population composed of 202 individuals from an intercross between Korean Native pig and Yorkshire. PCR primer set amplified a 612 bp fragment of CYP2A6 and digestion of the PCR products was performed with the restriction enzymes SchI. The CYP2A6 SchI polymorphism was only found in the KNP breed. The genotype frequencies of TT, TC and CC genotypes were 0.36, 0.56 and 0.08 in the KNP respectively and the other pig breeds were fixed with CC genotype (Duroc, Landrace, Berkshire and Yorkshire). Statistical association between genotypes and fatty acid composition traits were tested in the Korean native pig and Yorkshire crossed F2 pigs. The CYP2A6 SchI polymorphism was associated with only fatty acid composition C20:3n3 level (cis11,14,17-Eicosatrienoic acid, p=0.0252). The 'T' allele was associated with lower C20:3n3 level. Further study is required to validate the genotypic association and biological consequence of the CYP2A6 gene polymorphism in pigs.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.6 s.360
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• pp.48-56
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• 2007

OFDMA (Orthogonal Frequency Division Multiple Access) is widely used as multiple access techniques for next generation mobile communication systems. However, OFDMA has a disadvantage of high peak-to-average power ratio and SC-FDMA (Single-Carrier Frequency Division Multiple Access) was proposed for uplink systems to overcome the drawback. SC-FDMA also has several demerits including degraded performance with high-order modulations or with multiple antenna techniques, and less flexibility in resource allocation and pilot patterns. In order to achieve the best performance over a wide range of environments, each mobile station should select either of OFDMA and SC-FDMA according to the given condition and a pilot structure for SC-FDMA systems should be similar to that of OFDMA to maintain the same frame structure. While conventional SC-FDMA schemes require an entire SC-FDMA symbol or a separate short symbol for pilots, this paper proposes a method which supports the pilots included in SC-FDMA data parts and enables a SC-FDMA frame to hold the same structure as an OFDMA frame.

• The Journal of Information Technology
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• v.7 no.1
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• pp.43-56
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• 2004

The purpose of this paper is to study the send and receive of the message in the TEDI System. The TEDI System replaces a series of trade documents with electronic date, and it realizes secure and reliable transactions of data among parties by means of open networks, such as the Internet. The TEDI system is composed of Web browsers, TC Serves, a RSP Server, and Certification Servers. TEDI has development the system and legal frame work. Exporters, importers, carriers, banks insurance and companies those who engage in the trade releated business have tested TEDI system and evaluated the legal frame work from the practical point of view. TEDI is now refining the system and preparing for the service. A fundamental feature of the TEDI System is the attribution to participants of data messages through public key certificates issued by certification authorities that allow for verification of digital signatures. Access to servers maintained by such certification authorities also takes place through the internet. In principle, certificates used by any reputable certification authority may be employed as long as they are compatible with X.509 V3.

• Microbiology and Biotechnology Letters
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• v.49 no.1
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• pp.45-56
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• 2021

Improved amylases were developed from protoplast fusants of two amylase-producing Aspergillus species. Twenty regenerated fusants were screened for amylase production using Remazol Brilliant Blue agar. Crude enzyme extracts produced by solid state fermentation of rice bran were assayed for activity. Three variable factors (temperature, pH and enzyme type) were optimized to increase the amylase activity of the parents and selected fusants using rice bran medium and solid state fermentation. Analysis of this optimization was completed using the Central Composite Design (CCD) of the Response Surface Methodology (RSM). Amylase activity assays conducted at room temperature and 80℃ demonstrated that Aspergillus designates, T5 (920.21 U/ml, 966.67 U/ml), T13 (430 U/ml, 1011.11 U/ml) and T14 (500.63 U/ml, 1012.00 U/ml) all exhibited improved function making them the preferred fusants. Amylases produced from these fusants were observed to be active over the entire pH range evaluated in this study. Fusants T5 and T14 demonstrated optimal activity under acidic and alkaline conditions, respectively. Fusants T13 and T14 produced the most amylase at 72 h while parents TA, TC and fusant T5 produced the most amylase after 96 h of incubation. Response surface methodology examinations revealed that the enzyme from fusant T5 was the optimal enzyme demonstrating the highest activity (1055.17 U/ml) at pH 4 and a temperature of 40℃. This enzyme lost activity with further increases in temperature. Starch hydrolysis using fusant T5 gave the highest yield of glucose (1.6158 g/100 ml). The significant activities of the selected fusants at 28 ± 2℃ and 80℃ and the higher sugar yields from cassava starch hydrolysis over their parental strains indicate that it is possible to improve amylase activity using the protoplast fusion technique.

• Nuclear Engineering and Technology
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• v.56 no.10
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• pp.4423-4436
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• 2024

The development and assessment of pharmaceutical dosage forms make considerable use of gamma-scintigraphy. Gamma scintigraphy is an imaging technique that is integrated with CT to assess and evaluate the targeting of drugs to various delivery sites, the impact of treatment, and the severity of the disease. A small number of radioisotopes were tagged with the delivery system and emitted radiation can be visualized by the gamma camera which forms a 2-D image displaying the tissue-specific distribution of radioactivity. The isotopes that are used widely include Technetium-99 m (99Tc), Iodine (131I), Fluorodeoxyglucose (18F-FDG), Fluoromisonidazole (18F-FMISO) and Gallium (Ga67), Indium (111In). This review mainly covers different applications of gamma scintigraphy for the assessment of drug targeting via different routes to different organs and their visualization by gamma scintigraphy. The review mainly focuses assessment of drug targeting in the tumor tissue, thyroid gland, brain, pulmonary pathway, skin deposition, detection of renal impairment as well as cardiac diseases, drug release from formulations, drug deposition in arthritis, drug retention in the scalp, and behavior of formulation when administered via intra-vaginal route. Various pre-clinical and clinical studies were included in the review that demonstrates the importance and future of gamma scintigraphy in sensing drug delivery.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.1
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• pp.107-127
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• 2018

Objectives : The present study investigated the anti-obese and blood flow improvement activities of aqueous extracts of ginseng berry (GBe) on the mild diabetic obese mice as compared with metformin. Methods : After end of 56 days of continuous oral administrations of GBe 150, 100 and 50 mg/kg, or metformin 250 mg/kg, anti-obese and blood flow improvement effects - the changes of body weights, body and abdominal fat density by in live dual-energy x-ray absorptionmetry (DEXA), tail bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) levels, aorta and serum cyclic guanosine monophosphate (cGMP), nitric oxide (NO) and endothelin (ET)-1 levels, aorta phosphorylated PI3K (pPI3K), phosphorylated Akt (pAkt) and phosphorylated p38 MAPK (pp38 MAPK) levels were systemically analyzed. In addition, aorta vascular dilation and constriction related gene mRNA expressions - PI3K, Akt, eNOS, p38 MAPK and ET-1 were also analyzed by realtime RT-PCR. Results : The obesity and related blood flow impairment, induced by 84 days of continuous HFD supply, were significantly inhibited by 56 days of continuous oral treatment of GBe 150, 100 and 50mg/kg, dose-dependently, and they also dramatically normalized the changes of the aorta vascular dilation and constriction related gene mRNA expressions, also dose-dependently. Especially, GBe 150 mg/kg constantly showed favorable inhibitory activities against type II diabetes related obesity and vascular disorders through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities, as comparable to those of metformin 250 mg/kg in HFD mice. Conclusion : By assessing the key parameters for anti-obese and blood flow improvement activities on the HFD-induced mild diabetic obese mice, the present work demonstrated that GBe 150, 100 and 50 mg/kg showed favorable anti-obese and blood flow improvement effects in HFD-induced type II diabetic mice, through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.1 s.343
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• pp.1-8
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• 2006

In this paper, we suggested a new antenna structure for the RFID(Radio Frequency IDentification) reader. The conventional RFID reader uses a loop antenna. The central area of a loop antenna shows a low magnetic field strength, especially for the case of a large loop antenna diameter. We proposed a parallel-fed multiple loop antenna. Simulation and measurement were carried out for a single loop antenna, series-fed and parallel-fed multiple loop antennas. Simulation results show that we can obtain 0.40A/m, 0.68A/m, 1.98A/m of magnetic field strengths at the central point of a reader antenna for a single loop antenna, series-fed and parallel-fed multiple loop antennas, respectively. We measured the $79mm{\time}48mm$ tag area averaged induced voltages with applying 20Vp-p same source signals to reader antennas through the resistors. Measured tag area averaged induced voltages at the central point of a reader antennas were 0.76V, 1.45V, 4.04V for a single loop antenna series-fed and parallel-fed multiple loop antennas, respectively. The results show that we can get high induced voltage which can grantee a longer reading distance with a proposed parallel-fed multiple loop antenna.