Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Gamma scintigraphy in sensing drug delivery systems

  • Arif Nadaf (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard) ;
  • Umme Jiba (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard) ;
  • Arshi Chaudhary (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard) ;
  • Nazeer Hasan (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard) ;
  • Mohammad Adil (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard) ;
  • Yousuf Hussain Mohammed (Therapeutics Research Group, Frazer Institute, Faculty of Medicine, University of Queensland) ;
  • Prashant Kesharwani (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard) ;
  • Gaurav Kumar jain (Department of Pharmaceutics, Delhi Pharmaceutical Science and Research University) ;
  • Farhan Jalees Ahmad (Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard)
  • Received : 2023.03.30
  • Accepted : 2024.06.02
  • Published : 2024.10.25
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Abstract

The development and assessment of pharmaceutical dosage forms make considerable use of gamma-scintigraphy. Gamma scintigraphy is an imaging technique that is integrated with CT to assess and evaluate the targeting of drugs to various delivery sites, the impact of treatment, and the severity of the disease. A small number of radioisotopes were tagged with the delivery system and emitted radiation can be visualized by the gamma camera which forms a 2-D image displaying the tissue-specific distribution of radioactivity. The isotopes that are used widely include Technetium-99 m (99Tc), Iodine (131I), Fluorodeoxyglucose (18F-FDG), Fluoromisonidazole (18F-FMISO) and Gallium (Ga67), Indium (111In). This review mainly covers different applications of gamma scintigraphy for the assessment of drug targeting via different routes to different organs and their visualization by gamma scintigraphy. The review mainly focuses assessment of drug targeting in the tumor tissue, thyroid gland, brain, pulmonary pathway, skin deposition, detection of renal impairment as well as cardiac diseases, drug release from formulations, drug deposition in arthritis, drug retention in the scalp, and behavior of formulation when administered via intra-vaginal route. Various pre-clinical and clinical studies were included in the review that demonstrates the importance and future of gamma scintigraphy in sensing drug delivery.

Keywords

References

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