• BMB Reports
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• 제51권3호
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• pp.151-156
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• 2018

The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actin-mediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain.

• BMB Reports
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• 제54권6호
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• pp.285-294
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• 2021

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.

• 대한공간정보학회지
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• 제3권1호
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• pp.91-104
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• 1995

교통 및 기타 공간계획 과정에 있어서 분석을 위한 공간분할은 필수적이다. 공간 분할에 있어서 두 가지의 중요한 변수는 scale과 aggregation이라고 할 수 있는바 이들 2가지의 조합에 따라서 분할된 공간상의 계획결과물은 실로 엄청난 차이를 보일 때도 있다. 본고에서는 이들 공간 zone 분항 및 재구성 체계의 과정 및 결정기법을 살펴 보는데 우선 목적이 있고, 또한 vector형 GIS의 위상관계자료를 이용한 교통 zone체계의 재설정 방법을 제시해 봄으로써 경직된 교통계획상의 zone체계 구성에의 변화를 창출해 보았다. 시범연구로서는 남한을 132개의 세부 zone으로 구분한 뒤 사회경제적 지표에 의한 동질적인 zone체계를 구축하여 교통계획에 응용하였으나 애초에 macro된 세부 zone체계를 사용한 나머지 aggregate된 zone이 concave한 문제점 또한 발견되었다.

• 한국ITS학회 논문지
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• 제22권3호
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• pp.51-61
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• 2023

정확한 전동킥보드 중장기수요예측은 지역별 수요공급 불균형 문제해결 및 MaaS 등 연계교통체계 마련을 위해 필요하다. 공유 전동킥보드의 지역별 발생-유입량을 예측하는 연구는 많지만, 공유 전동킥보드의 존간 통행분포를 예측하는 연구는 전무한 실정이다. 본 연구에서는 공유 전동킥보드의 통행분포모형 추정을 위한 적정 존단위를 선정하고자 하였다. 분석 대상 존단위는 250m, 500m, 750m, 1,000m 정사각형 그리드로 설정하였다. 공유 전동킥보드 이용 이력 데이터는 각 공간 단위별 통행거리, 통행시간 계산 및 중력모형 도출을 위해 활용되었다. 평균제곱오차는 각 중력모형의 적정성을 검증하는데 활용되었다. 분석 결과, 250m 그리드가 실제 공유킥보드 통행분포를 가장 잘 묘사하는 것으로 나타났다.

• Parasites, Hosts and Diseases
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• 제54권5호
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• pp.617-623
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• 2016

An excavation of the Vesakoyakha II-IV and Nyamboyto I burial grounds was conducted during the 2014 field season, and soil samples from intact burials dating from the 19th and 20th centuries, respectively, were analyzed to determine interactions between parasites and host/vectors. Considering the discovery of Diphyllobothrium sp. and Taenia sp. eggs in soil samples from the pelvic region, diphyllobothriasis was the most frequent helminthic infection among the Taz Nenets. The Nyamboyto Nenets mainly consumed uncooked fish, while the Vesakoyakha Nenets had a bigger variety in food choices, including reindeer meat. Nenets children were given raw fish from early childhood. The paleoparasitological results corroborate rare ethnographic records about the consumption of uncooked reindeer cerebrum which led to beef tapeworm helminthiases. This is the first parasitological report of helminthic diseases among the Taz Nenets, and, as such, it provides insight into their subsistence activities and food patterns and broadens our understanding of their health condition.

• BMB Reports
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• 제56권8호
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• pp.417-425
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• 2023

In various organisms, the Hippo signaling pathway has been identified as a master regulator of organ size determination and tissue homeostasis. The Hippo signaling coordinates embryonic development, tissue regeneration and differentiation, through regulating cell proliferation and survival. The YAP and TAZ (YAP/TAZ) act as core transducers of the Hippo pathway, and they are tightly and exquisitely regulated in response to various intrinsic and extrinsic stimuli. Abnormal regulation or genetic variation of the Hippo pathway causes a wide range of human diseases, including cancer. Recent studies have revealed that Hippo signaling plays a pivotal role in the immune system and cancer immunity. Due to pathophysiological importance, the emerging role of Hippo signaling in blood cell differentiation, known as hematopoiesis, is receiving much attention. A number of elegant studies using a genetically engineered mouse (GEM) model have shed light on the mechanistic and physiological insights into the Hippo pathway in the regulation of hematopoiesis. Here, we briefly review the function of Hippo signaling in the regulation of hematopoiesis and immune cell differentiation.

• BMB Reports
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• 제50권2호
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• pp.71-78
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• 2017

The Hippo signaling pathway plays an essential role in adult-tissue homeostasis and organ-size control. In Drosophila and vertebrates, it consists of a highly conserved kinase cascade, which involves MST and Lats that negatively regulate the activity of the downstream transcription coactivators, YAP and TAZ. By interacting with TEADs and other transcription factors, they mediate both proliferative and antiapoptotic gene expression and thus regulate tissue repair and regeneration. Dysregulation or mutation of the Hippo pathway is linked to tumorigenesis and cancer development. Recent studies have uncovered multiple upstream inputs, including cell density, mechanical stress, G-protein-coupled receptor (GPCR) signaling, and nutrients, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway as effector of these biophysical cues and its potential implications in tissue homeostasis and cancer.

• 소성∙가공
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• 제25권3호
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• pp.155-160
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• 2016

Magnesium(Mg) alloys have been evaluated as replacements for steel or aluminum parts in the automobile industry because of the fuel economy they can provide through reducing weight. The application of Mg alloys has been limited due to its low formability at room temperature, which results from a small number of active slip systems. In the current study, an extruded TAZ711(Mg-7Sn-1Al-1Zn) alloy was warm forged into an automotive control arm to evaluate its formability at various forging temperature. Warm forging was conducted at temperatures of 200, 250, 350 and 450℃. Static strength evaluation was performed on the as-forged specimen at 250℃. The results showed good static strength.

• BMB Reports
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• 제51권3호
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• pp.106-118
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• 2018

How the organ size is adjusted to the proper size during development and how organs know that they reach the original size during regeneration remain long-standing questions. Based on studies using multiple model organisms and approaches for over 20 years, a consensus has been established that the Hippo pathway plays crucial roles in controlling organ size and maintaining tissue homeostasis. Given the significance of these processes, the dysregulation of the Hippo pathway has also implicated various diseases, such as tissue degeneration and cancer. By regulating the downstream transcriptional coactivators YAP and TAZ, the Hippo pathway coordinates cell proliferation and apoptosis in response to a variety of signals including cell contact inhibition, polarity, mechanical sensation and soluble factors. Since the core components and their functions of the Hippo pathway are evolutionarily conserved, this pathway serves as a global regulator of organ size control. Therefore, further investigation of the regulatory mechanisms will provide physiological insights to better understand tissue homeostasis. In this review, the historical developments and current understandings of the regulatory mechanism of Hippo signaling pathway are discussed.

• Molecules and Cells
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• 제41권2호
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• pp.83-92
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• 2018

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.