• Genomics & Informatics
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• v.19 no.4
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• pp.39.1-39.8
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• 2021

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)-positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To achieve a better understanding of the ER-independent antifungal action mechanisms of TAM, we systematically identified TAM-sensitive genes through microarray screening of the heterozygous gene deletion library in fission yeast (Schizosaccharomyces pombe). Secondary confirmation was followed by a spotting assay, finally yielding 13 TAM-sensitive genes under the drug-induced haploinsufficient condition. For these 13 TAM-sensitive genes, we conducted a comparative analysis of their Gene Ontology (GO) 'biological process' terms identified from other genome-wide screenings of the budding yeast deletion library and the MCF7 breast cancer cell line. Several TAM-sensitive genes overlapped between the yeast strains and MCF7 in GO terms including 'cell cycle' (cdc2, rik1, pas1, and leo1), 'signaling' (sck2, oga1, and cki3), and 'vesicle-mediated transport' (SPCC126.08c, vps54, sec72, and tvp15), suggesting their roles in the ER-independent cytotoxic effects of TAM. We recently reported that the cki3 gene with the 'signaling' GO term was related to the ER-independent antifungal action mechanisms of TAM in yeast. In this study, we report that haploinsufficiency of the essential vps54 gene, which encodes the GARP complex subunit, significantly aggravated TAM sensitivity and led to an enlarged vesicle structure in comparison with the SP286 control strain. These results strongly suggest that the vesicle-mediated transport process might be another action mechanism of the ER-independent antifungal or cytotoxic effects of TAM.

• Journal of the Korean Home Economics Association
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• v.47 no.4
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• pp.99-110
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• 2009

The Technology Acceptance Model(TAM) proposed by Davis(1989) has been applied as a reliable and robust model in the study of user’s adoption of different technologies. However it is necessary to incorporate additional constructs to the original model in the quest for increased predictive power. This study investigate consumer’s acceptance of smart clothing applied by the extended TAM. Besides perceived ease of use and perceived usefulness, clothing involvement is included in the extended TAM. Data were collected from the adults over 20 years old living in Seoul and other metropolitan areas from March 2 to March 12, 2009. 815 copies of data were analyzed to examine a structural model and test research hypotheses using AMOS package. The study showed the extended TAM for smart clothing was validated empirically in predicting the individual’s acceptance of smart clothing and 5 hypotheses among 7 hypotheses were supported. Specifically, perceived ease of use, perceived usefulness, and clothing involvement were the factors affecting attitude toward smart clothing. Attitude toward smart clothing was influenced directly by perceived usefulness and clothing involvement but influenced indirectly by perceived ease of use. Acceptance intention toward smart clothing was influenced strongly by attitude. From a theoretical point of view, the study extended the TAM for smart clothing. Moreover, this study would be beneficial for those who would develop smart clothing by providing information about attitude and acceptance intention of smart clothing consumers.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.31 no.1
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• pp.11-20
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• 2008

The purpose of this study is to identify the factors determining users' acceptance of individualized virtual community. While there has been considerable research on the Technology Acceptance Model (TAM) that has predicted whether individuals will accept and voluntarily use information systems, limitations of the TAM include the omission of an important characteristics of individual construct in the context of individualized community. Based on literature relating to the theory of reasoned action (TRA), the theory of planned behavior (TPB) and the TAM, this study extends the applicability of the TAM in a individualized community context, by adding characteristics of individual-based construct ("subjective norm", "self-efficacy", "self-presentation" and "sharing information to exchange various information") to the model. Analysis was conducted on using the structural equation modeling approach. The result supports the extended TAM in predicting users' intentions to using personalized community. Several implications for IT/IS acceptance research and individualized community service management practices are discussed.

• Journal of Life Science
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• v.21 no.2
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• pp.328-333
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• 2011

Melatonin has been known as an animal hormone. However, melatonin exists in diverse organisms including higher plants. The biosynthesis and physiological roles for melatonin in plants is still largely unknown, although both dicot and monocot plants have melatonin and some medicinal plants even contain large amounts of melatonin. In this study we detected melatonin in diverse Viola plants, in which melatonin had not been examined so far, by reverse phase HPLC analysis, demonstrating the wide existence of melatonin in the genus of Viola. We then fed tryptophan (Trp) and tryptamine (TAM) to the incubation medium for Viola leaf sections to test their effects on melatonin formation. Trp is also the hypothesized starting material of melatonin in plants, and TAM is the following intermediate produced by the decarboxylation of Trp. Trp feeding did not affect the contents of melatonin. In contrast, TAM feeding clearly increased the level of melatonin in Viola leaves. Because TAM is derived from Trp, we concluded that the Trp-TAM pathway exists in Viola plants as well. Ineffectiveness of Trp feeding to the change of melatonin contents supports the hypothesis that the decarboxylation step from Trp to TAM is the rate-limiting step in plant melatonin biosynthesis.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.9
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• pp.97-106
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• 2004

A new test strategy for embedded SOC test is proposed. The SOC test is evaluated by the degree that is the amount of the total reduced test time. Since the test time for a embedded core is determined by the configuration of test wrapper, the total test time is decided by the length of the largest TAM used by the test wrapper. So the DFT(Design for Test) must be involved in the design flow. And the efficient test strategy must be settled. The all Previous test strategies are the methods that find a sub-optimal configurations of scan-chains to minimize the test time after the total TAM lines are divided into a few groups. But this is the NP-complete problem so that all attempts which examine such a TAM configuration and scan-chain division are impossible. In this thesis, a new methodology for this problem is proposed and the efficiency of the methodology is proved.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.1
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• pp.13-16
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• 2010

The effect of exogenous administration of tamoxifen (TAM) on hormonal profile and sexual maturity in Indian native Kadaknath (KN) fowl was investigated. Day-old chicks from the same hatch were randomly divided into 15 groups with 20 chicks in each group (5 treatments${\times}$3 replicates). The chicks were placed in battery brooders with wire-mesh floors and reared under uniform husbandry conditions (14 h light/d, 25-32${^{\circ}C}$) on a standard basal diet. At the age of two weeks (wk), birds from the control group ($T_{1}$) were injected with maize oil intramuscularly (I/M), whereas the other four experimental groups $T_{2}$, $T_{3}$, $T_{4}$ and $T_{5}$ were given tamoxifen (I/M) dissolved in maize oil at the rate of 0.5 mg (0.5 TAM), 1.0 mg (1.0 TAM), 2.5 mg (2.5 TAM) and 5.0 mg (5.0 TAM)/kg body weight, respectively, up to 30 wks on every alternate day. At every 6-wk interval, blood samples were collected from nine birds of each treatment group for estimation of estrogen and progesterone. The same birds were sacrificed for determination of the weight of ovary, oviduct, liver and adipose tissue. There was no significant difference in egg production traits except onset of lay and egg number. Low doses of TAM ($T_{3}$) advanced the onset of egg laying by 15 days over the control. Tamoxifen influenced the hormonal profile (estrogen and progesterone) in a dose dependent manner. However, higher doses of TAM suppressed ovary and oviductal growth. From this study, it may be concluded that lower doses of TAM enhanced sexual maturity while higher doses suppressed ovary and oviductal growth.

• Journal of Digital Convergence
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• v.11 no.1
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• pp.89-97
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• 2013

After introducing iPhone in Korea, the craze for iPhone was perceived to be extraordinaire phenomenon and the mobile businesses and researchers paid attention to it. This research purposes to explore more predictive model that explain to adopt the smartphones in Korea. This research show that all of models, TPB, TAM and the integrated model, are significant to explain intention to use the smartphones. TPB explains the higher than TAM, and the integrated model explains the slightly higher than TPB. These results suggest that researcher explore and build the more predictive model that comprise social influences and personal attributes than TAM that is employed broad to study new information communication systems and devices.

• Journal of Information Technology Applications and Management
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• v.11 no.2
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• pp.149-166
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• 2004

In the wake of Fishbein and Ajzen's the Theory of Reasoned Action (TRA), Davis (1989) proposed a Technology Acceptance Model (TAM) to account for how perceived ease of use, perceived usefulness, and attitude predict behavioral intention to use Information Systems (IS). However, TAM is incomplete in one important respect: it does not account for social influence In the acceptance and utilization of new information systems. This study investigated the relationships between organizational tasks and intention to use internet using TAM. For using internet, social network is an important factor because the natural characteristic of internet is community-based. The results showed that Organizational Culture (OC) plays an important role in explaining intention to use the internet. Using O'Reilly et al. 's measurements, we extended and empirically validated the proposed model using Structured Equation Modeling (SEM). These findings enable future researchers and practitioners to apply the OC variable in the various contextual domains.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.5
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• pp.638-641
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• 2008

In this paper, a model to classify the method using the fuzzy TAM with preprocessing of data was developed. The preprocessing method can be divide the problem using the characteristics in the case of category type factor. In case of continuous type factor, if there was exist factor's range which is not overlapping by class, the data belong to the range was fixed and eliminated in classification. After these preprocessing of data, classified operation of Fuzzy TAM is performed.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.521-526
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• 2007

This study proposed an expanded technology acceptance model (TAM) incorporating perceived fee (PFE) and perceived enjoyment into the original TAM We examined that the extended TAM provides supplementary information about behavior intentions (BI) toward mobile data services (MDS). This study also investigated some significant differences in the relative influence of the determinants of BI toward MDS depending on experience. The extended TAM was empirically evaluated by using survey data collected from 149 inexperienced users and 393 experienced users. The findings indicated that PFE is the strongest determinant of BI toward MDS, and the antecedents leading to users' BI vary over time. The results may provide further insights into MDS practitioners and marketing managers.