• Investigative Magnetic Resonance Imaging
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• 제24권3호
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• pp.141-153
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• 2020

Purpose: Myocardial T1 and T2 relaxation times are affected by technical factors such as cardiovascular magnetic resonance platform/vendor. We aimed to validate T1 and T2 mapping sequences using a phantom; establish reference T1, T2, and extracellular volume (ECV) measurements using two sequences at 3T in normal Koreans; and compare the protocols and evaluate the differences from previously reported measurements. Materials and Methods: Eleven healthy subjects underwent cardiac magnetic resonance imaging (MRI) using 3T MRI equipment (Verio, Siemens, Erlangen, Germany). We did phantom validation before volunteer scanning: T1 mapping with modified look locker inversion recovery (MOLLI) with 5(3)3 and 4(1)3(1)2 sequences, and T2 mapping with gradient echo (GRE) and TrueFISP sequences. We did T1 and T2 mappings on the volunteers with the same sequences. ECV was also calculated with both sequences after gadolinium enhancement. Results: The phantom study showed no significant differences from the gold standard T1 and T2 values in either sequence. Pre-contrast T1 relaxation times of the 4(1)3(1)2 protocol was 1142.27 ± 36.64 ms and of the 5(3)3 was 1266.03 ± 32.86 ms on the volunteer study. T2 relaxation times of GRE were 40.09 ± 2.45 ms and T2 relaxation times of TrueFISP were 38.20 ± 1.64 ms in each. ECV calculation was 24.42% ± 2.41% and 26.11% ± 2.39% in the 4(1)3(1)2 and 5(3)3 protocols, respectively, and showed no differences at any segment or slice between the sequences. We also calculated ECV from the pre-enhancement T1 relaxation time of MOLLI 5(3)3 and the post-enhancement T1 relaxation time of MOLLI 4(1)3(1)2, with no significant differences between the combinations. Conclusion: Using phantom-validated sequences, we reported the normal myocardial T1, T2, and ECV reference values of healthy Koreans at 3T. There were no statistically significant differences between the sequences, although it has limited statistical value due to the small number of subjects studied. ECV showed no significant differences between calculations based on various pre- and post-mapping combinations.

• 한국자기공명학회논문지
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• 제14권1호
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• pp.9-17
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• 2010

The water proton relaxation rates increase linearly with concentrations of contrast agents, and could be expressed as a function of the concentrations. In this paper, we have investigated MR properties of two different contrast agents, $GdCl_3$ and $CoCl_2$. Relaxivity coefficients were calculated from individual contrast agent solutions, and used for predicting relaxation rates at mixtures of two contrast agents. From the experimental results, we have discussed the feasibility of constructing water solutions with the desired relaxation times using specific mixtures of contrast agents.

• Food Science and Biotechnology
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• 제17권5호
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• pp.895-898
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• 2008

The mobility of water in set yogurt during fermentation was studied using nuclear magnetic resonance (NMR) relaxometry. The spin-spin relaxation was analyzed using a 2-fraction model, resulting in 2 spin-spin relaxation time constants $T_{21}$ and $T_{22}$. Both $T_{21}$ and $T_{22}$ exhibited rapid changes between 2 and 4 hr of fermentation, coinciding with the drop in pH and the rise in lactic acid bacteria count. The spin-lattice relaxation time $T_1$ increased over the fermentation period. Both $T_1$ and $T_2$ showed an increase in the mobility of water upon gel formation during fermentation. Water redistribution within the gel matrix due to casein aggregation and structure forming may be responsible for the changes in mobility.

• 대한간호학회지
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• 제17권2호
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• pp.110-115
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• 1987

This study was done in order to help alleviate or prevent the anxiety resulting from cardiac catheterization among adult patients. This goal may be re-ached through providing relaxation techenique to the patients. Such an informativeness would make it possible to establish a basis for comprehensive nursing intervention. The results of this study are summarized as fellows: 1. The first hypothesis:“The experimental group with relaxation informativeness will have less score of state anxiety level before cardiac catheterization than the control group without relaxation informativeness”was accepted. (t=3.72, p=.001). 2. The second hypothesis: “The experimental group with relaxation technique informativeness will have less score of distress level during the procedure than the control group without relaxation technique informativeness”was accepted. (t=2.36, p=.023) 3. Additional analysis; It is seen that most cardiac patients were satisfied with precardiac catheterization procedure information provided by medical teams. (experimental group: 90%, control group: 85%) The relaxation technique informativeness contributed to the decrease of anxiety level. Patients showed interest in reusing the relaxation technique informativeness in the event of further need. In conclusion, the researcher thinks that it is necessary that nurses provide Patients with relaxation technique to reduce the anxiety level with cardiac catheterigation. This will enable them to practice effective comprehensive nursing.

• 한국식품과학회지
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• 제30권5호
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• pp.1085-1091
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• 1998

본 실험에서는 변형력 완화시험을 통하여 고기풀을 주원료로 하는 시중 게맛살과 어묵의 물성학적 성질을 조사하였다. 또한 변형력완화시험과 T.P.A.값과의 상관관계를 조사하였다. 시료의 내부구조적 변화에 의한 영향을 가능한 한 피하기 위하여 인장율 20%에서, 또한 변형속도는 2.4 mm/sec의 조건에서 실험을 실시하였다. 어묵과 맛살의 변형력완화시험결과 초기변형력의 경우 2종류의 어묵(370.4 g)과 5종류의 맛살의 평균값(436.4 g)은 유사한 값을 나타내었으나, 변형력완화시간과 점성성분은 2종류 어묵의 평균값(17256.1 sec, $1.357{\times}10^{10}$ poise)이 5종류의 맛살의 평균값(6110 sec,$0.519^{\ast}10^{10}$ poise)보다 월등히 높은 값을 나타내었다. 변형력완화시험 결과와 T.P.A.결과를 비교시 지수항의 직선식에 대한 절편값은 T.P.A.실험에서의 경도 및 껌성, 씹힘성과 높은 상관관계(r=0.93, 0.93, 0.95, p

• 한국자기공명학회논문지
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• 제18권1호
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• pp.15-23
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• 2014

The structural properties and relaxation processes of $MCsSO_4$ (M = Na, K, or Rb) crystals were investigated by measuring the NMR spectra and spin-lattice relaxation rates $1/T_1$ of their $^{23}Na$, $^{39}K$, $^{87}Rb$, and $^{133}Cs$ nuclei. According to the NMR spectra, the $MCsSO_4$ crystals contain two crystallographically inequivalent sites each for the M and Cs ions. Further, the relaxation rates of all these nuclei do not change significantly over the investigated temperature range, indicating that no phase transitions occur in these crystals in this range. The variations in the $1/T_1$ values of the $^{23}Na$, $^{39}K$, $^{87}Rb$, and $^{133}Cs$ nuclei in these three crystals with increasing temperature are approximately proportional to $T^2$, indicating that Raman processes may be responsible for the relaxation. Therefore, for nuclear quadrupole relaxation of the $^{23}Na$, $^{39}K$, $^{87}Rb$, and $^{133}Cs$ nuclei, Raman processes with n = 2 are more effective than direct processes.

• 한국식품과학회지
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• 제35권1호
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• pp.57-61
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• 2003

냉동 및 해동과정 중의 돈육의 NMR 자기완화시간의 변화를 측정하고, $T_2\;CPMG$ 데이터의 연속 분배 분석을 통하여 근육 내 물의 상태 변화를 조사하였다. 고형 지방 함량은 온도가 낮아질수록 약간 증가하는 경향을 보였으나, 어는점인 $-4^{\circ}C$에서 급격하게 증가되어 $-25^{\circ}C$에서 85%의 고형 지방 함량을 나타내었다. 이와 반대로 자기완화시간은 온도가 낮아질수록 감소하는 경향을 보여, 온도에 따라 물의 상태가 변화하여 얼음 결정을 형성하는 것을 알 수 있었다. 특히 $T_2$ 자기완화시간은 냉동보다 해동시의 $T_2$가 더 높게 나타나 형성되었던 얼음 결정이 녹으면서 원래 상태로 복원되지 않고 육즙 유출을 형성하였음을 예상할 수 있었다. 따라서 $T_2\;CPMG$ 데이터의 연속 분배 분석을 수행하여 온도에 따른 물의 상태 변화를 조사하였다. 주성분은 $30{\sim}45\;ms$의 $T_2$로 온도가 낮아질수록 함량이 감소하였으며, $-4^{\circ}C$ 이하에서는 검출되지 않았다. $-4^{\circ}C$ 이하에서는 $T_s$만이 검출되었고, 피크의 크기는 온도가 낮아질수록 감소되어 $-25^{\circ}C$에서는 아무런 피크도 나타나지 않았다. 해동 중의 $T_2$ 성분의 변화는 $-4^{\circ}C$ 이하에서는 냉동과정과 마찬가지로 $T_s$ 1개의 피크만이 검출되었고, $-4^{\circ}C$이상으로 단계적으로 승온하는 과정에서 냉동시보다 $T_m$과 $T_l$의 면적이 더 넓게 나타나, 냉동과 해동과정을 거치면서 결합수와 자유수간의 상태 변화가 일어났음을 알 수 있었다.

• Investigative Magnetic Resonance Imaging
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• 제15권1호
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• pp.48-56
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• 2011

목적 : 본 연구에서는 금 나노 입자를 통한 국소 가열과 MR 온도 영상 기법을 결합한 Theragnosis 개념에 대한 가초연구로 금 나노 입자의 특성 및 제조 조건에 따른 MR 변수의 변화를 연구하였다. 대상 및 방법 : 실험실에서 제조된 구형과 막대형 금 나노 입자를 사용하였다. 구형 입자는 합성방법과 교반속도(stirring speed: rpm)를 변수로 설정하였고, 막대형 입자눈 첨가된 구형 입자의 양을 변수로 하여 조건을 다양화하였다. 금 나노 입자를 2% 아가로즈 젤에 1:1 로 혼합하여 임상용 1.5T MRI 시스템에서 신호를 획득하였고, $T_1$과 $T_2$ 이완시간의 측정을 위해 TR과 TE를 조절하였다. 획득한 영상의 화소별 신호 강도플 이용하여 제작한 소프트웨어로 $T_1$과 $T_2$ 이완곡선을 추정하였고, 통계 분석으로 유의성을 검증하였다. 결과 : 구형 입자의 평균 $T_1$ 값은 $1.86{\pm}0.04$초, 막대형은 평균 $2.08{\pm}0.04$초로 막대형이 더 걸게 측정되었고, 반면 평균 $T_2$ 값은 구형과 막대형 각각 $57{\pm}2.4$ ms와 $35.45{\pm}0.1$ ms로 구형 나노 입자에서 더 길게 측정되었다. 결론 : 금 나노 입자의 형태적 특성 및 제조 조건에 따른 MR 영상 변수 $T_1$과 $T_2$ 이완시간의 변화를 확인하였다. 금 나노 입자를 이용한 MR 영상 연구의 수행 시 금 나노 입자의 형태와 제조 조건에 따른 적절한 TR과 TE로 최적화된 영상을 얻을 수 있을 것으로 기대된다.

• 한국자기공명학회논문지
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• 제16권2호
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• pp.111-121
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• 2012

The spin-lattice relaxation times, $T_1$, and spin-spin relaxation times, $T_2$, of the $^{27}Al$ and $^{87}Rb$ nuclei in $RbAl(CrO_4)_2{\cdot}2H_2O$ crystals were investigated. The presence of only one resonance line for the $^{27}Al$ nuclei indicates that the results in a dynamical averaging of the crystal electric field that produces a cubic symmetry field. The changes in the temperature dependence of $T_1$ are related to variations in the symmetry of the octahedra of water molecules surrounding $Al^+$ and $Rb^+$. The $T_1$ values for the $^{27}Al$ and $^{87}Rb$ nuclei are different due to differences in the local environments of these ions. We also compared these $^{27}Al$ and $^{87}Rb$ NMR results with those obtained for $RbAl(CrO_4)_2{\cdot}2H_2O$ crystals. The relaxation mechanisms of $RbAl(XO_4)_2{\cdot}nH_2O$ (X=Cr and S) crystals are characterized by completely different NMR behaviors.

• Journal of Biosystems Engineering
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• 제19권2호
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• pp.138-147
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• 1994

The stress relaxation and creep characteristics of fruits have usually been fit to an exponential expression based on a generalized Maxwell model and Burger's model. It is known that two to three terms in the expansion of those models are necessary to obtain a satisfactory fit to the rheological characteristics of fruits. Since four to six constants appear in the models, it is very difficult to determine their physical meaning according to the experimental conditions and levels. Therefore in order to ease the comparison of data, this study was conducted to develop the linearized rheological model of the fruit from the previous studies of stress relaxation and creep characteristics of fruits. Stress relaxation and creep characteristics were able to normalize and presented in the linear form of $t/S(t)=K_1+k_2t$ and $t/C(t)={K_1}^{\prime}+{K_2}^{\prime}t$, respectively. It was possible to compare the effects of experimental conditions and levels much easier from the linearized models developed in this study than from the generalized Maxwell model and Burger's model.