• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.1
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• pp.17-23
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• 2010

The corporate R&D(Research and Development) has a primary role of new product development and its potential is the most crucial factor to estimate corporate future value. However, its systemic inadequacies and inefficiencies, the shorten product life-cycle to satisfy customer needs, the global operations by outsourcing strategy, and the reduction of product cost, are starting to expose to R&D business processes. The three-phased execution strategy for R&D innovation is introduced to establish master plan for new R&D model. From information technology point of view, PLM(Product Life-cycle Management) is one of the business total solutions in product development area. It is not a system, but the strategic business approach that collaboratively manage the product from beginning stage to end of life in all business areas PLM functions and capabilities are usually used as references to re-design new R&D process. BPA(Business Process Assessment) and 5DP(Design Parameters) in PI6sigma developed by Samsung SDS Consulting division are introduced to establish R&D master plan and re-design process respectively. This research provides a case study for R&D process innovation. How process assessment and PMM(Process Maturity Model) can be applied in business processes, and also it explains process re-design by 5DP method.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.264-272
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• 2021

Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors. A recent study demonstrated that systemic treatment with gintonin enhances paracellular permeability of the blood-brain barrier (BBB) through the LPA1/3 receptor. However, little is known about whether gintonin can enhance brain delivery of donepezil (DPZ) (Aricept), which is a representative cognition-improving drug used in AD clinics. In the present study, we examined whether systemic administration of gintonin can stimulate brain delivery of DPZ. Methods: We administered gintonin and DPZ alone or coadministered gintonin with DPZ intravenously or orally to rats. Then we collected the cerebral spinal fluid (CSF) and serum and determined the DPZ concentration through liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Results: Intravenous, but not oral, coadministration of gintonin with DPZ increased the CSF concentration of DPZ in a concentration- and time-dependent manner. Gintonin-mediated enhancement of brain delivery of DPZ was blocked by Ki16425, a LPA1/3 receptor antagonist. Coadministration of vascular endothelial growth factor (VEGF) + gintonin with DPZ similarly increased CSF DPZ concentration. However, gintonin-mediated enhancement of brain delivery of DPZ was blocked by axitinip, a VEGF receptor antagonist. Mannitol, a BBB disrupting agent that increases the BBB permeability, enhanced gintonin-mediated enhancement of brain delivery of DPZ. Conclusions: We found that intravenous, but not oral, coadministration of gintonin facilitates brain delivery of DPZ from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of DPZ for treatment of patients with AD.

• Journal of Engineering Education Research
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• v.23 no.4
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• pp.3-13
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• 2020

The purpose of this study is to analyze the differences in the perception and education requirements between industry and engineering students on engineering convergence competency, and to suggest implications for fostering engineers suitable to industry demand and direction of focus improvement in the current engineering education field. To this end, 73 industrial representatives and 104 engineering students are surveyed the engineering convergence competency and educational needs. The results of this analysis are as follows: first, the difference in engineering convergence competency by background variable was significantly different in gender of engineering students. Second, it is found that there is a significant difference between the current level and the required level of engineering convergence competency from an industry perspective. In the IPA results, it shows that new knowledge generation and future-oriented vision skills are urgently needed to be improved. And it is showed that the creative thinking, knowledge utilization, communication, and cooperation capabilities skills need to be maintained continuously. Third, as a result of the analysis of the differences in recognition of the current competency levels between industry and engineering students, there is statistically significant differences in systemic thinking, communication and cooperation, understanding of other academic fields, humanities, and future-oriented perspectives. Therefore, it is necessary to specific plans and efforts to reduce this perception gap should be prepared at the university.

• Journal of the Korean Institute of Gas
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• v.6 no.1 s.17
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• pp.59-65
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• 2002

This paper presents new IT model, PIIS that integrates the safety control, construction, and operation managements in a conventional gas industry The systemic approach based on the PIIS model may reduce or increase the parameters as maximizing the safety, risk and crisis management, and increasing the cost-effective productivity The rapid synchronization and integration of the process using the PIIS model may produce more profits and satisfactions between customer and gas supplier. Thus, the PIIS model should quickly be introduced to gas industry at the beginning stage of engineering design and construction processes for maximizing production, effectiveness, and safety of the system from the exploration of a natural gas to a final consumption.

• Journal of Technology Innovation
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• v.30 no.1
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• pp.57-104
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• 2022

The government has supported the innovation of private firms by intervening the market for various purposes, such as preventing market failure, alleviating information asymmetry, and allocating resources efficiently. Although the government's R&D budget increased rapidly in the 2000s, it is not clear whether the government intervention has made desirable impact on the market. To address this, the current study attempts to explore this issue by doing a systematic literature review on foreign and domestic papers in an integrated way. In total, 168 studies are analyzed using contents analysis approach and various lens, such as policy additionality, policy tools, firm size, unit of analysis, data and method, are adopted for analysis. Overlapping policy target, time lag between government intervention and policy effects, non-linearity of financial supports, interference between different polices, and out-dated R&D tax incentive system are reported as factors hampering the effect of the government intervention. Many policy prescriptions, such as program evaluation indices reflecting behavioral additionality, an introduction of policy mix and evidence-based policy using machine learning, are suggested to improve these hurdles.

• Journal of the Korean Society for Railway
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• v.9 no.5 s.36
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• pp.555-560
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• 2006

This study finds out and suggests success factors for the application of RIMS project through the case study of Seoul Metro and literature survey. The successful application of RIMS needs expert knowledge and concept of BOM, standardization of maintenance planning, check lists of heavy maintenance inspection, organization structure of rolling stock maintenance offices, material management system of warehousing and the process of parts repairing between offices, connection of material ordering system, problem solving of circular spare parts administration among inspection, maintenance, and material organizational units, systemic serial number management of parts with RFID, daily closing diary connected with work process chart, and sufficient period of RIMS's test run. RIMS contributes to real time management of rolling stock maintenance, transparency of management, reliability of train operation, customer satisfaction, and management innovation.

• International Journal of Quality Innovation
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• v.1 no.1
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• pp.64-74
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• 2000

This paper investigates the issue of performance testing on web browsing environments. Among the typical non-functional characteristics, index of link validity will be deeply explored. A framework to certify link correctness in web site is proposed. All possible navigation paths are first formulated to represent a usage model with the Markov chain property, which is then used to generate test script file statistically. With collecting any existing failure information followed by tracing these testing browsed paths, certification analysis may be performed by applying Markov chain theory. The certification result will yield some significant information such as: test coverage, reliability measure, confidence interval, etc. The proposed mechanism may provide not only completed but also systemic methodologies to find any linking errors and other web technologies errors. Besides, an actual practice of the proposed approach to a web-based system will be demonstrated quantitatively through a certification tool.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.3
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• pp.159-175
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• 2021

Business ecosystem is becoming more inclined towards platform ecosystem, which attracts multi-side participants based on digital technology. The burgeoning interest in digital ecosystem leads to the rapid rise of research. In this paper, we suggest a research agenda, focusing on the benefits of complementors in platform ecosystem. First, we outline the extant papers on benefits from platform to participants from economic perspective, strategic management perspective, technology management perspective, and economic sociological perspective to provide comprehensive understanding about platform ecosystem. Second, we suggest systemic framework to provide integrative insights on the the topic of benefit from platform to complementors- (1) open innovation view, (2) economic performance view, and (3) sociological view. Specifically, we focus on empirical studies that investigate the relationship between the benefits from platform and spillover effects on complementors based on various dataset. In addition, by reviewing the past empirical research, we suggest future research agenda and implications for policy in platform ecosystem.

• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.193-198
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• 2022

Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood-perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven-tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit-receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF microcirculation pathway.

• Asian Journal of Innovation and Policy
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• v.9 no.2
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• pp.223-239
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• 2020

It is important for urban planners and policy makers to understand complex, diverse urban demands and social structure, but this is not easy due to lack of data that represents the dynamics of residents at micro-geographical level. This paper explores how to create population data at at a micro-level by allocating population data to building. It attempted to allocate population data stored in a grid layer (100 meters by 100 meters) into a building footprint layer that represents the appearance of physical buildings. For the allocation, this paper describes a systemic approach that classifies grid cells into five prototypical patterns based on the composition of residential building types in a grid cell. This approach enhances allocation accuracy by accommodating heterogeneity of urban space rather than relying on the assumption of uniform spatial homogeneity of populations within an aerial unit. Unlike the methods that disaggregate population data to the parcel, this approach is more applicable to Asian cities where large multifamily residential parcels are common. However, it should be noted that this paper does not demonstrate the validity of the allocated population since there is a lack of the actual data available to be compared with the current estimated population. In the case of water and electricity, the data is already attached to an individual address, and hence, it can be considered to the purpose of the validation for the allocation. By doing so, it will be possible to identify innovative methods that create a population distribution dataset representing the comprehensive and dynamic nature of the population at the micro geographical level.