• Communications for Statistical Applications and Methods
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• v.11 no.3
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• pp.519-527
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• 2004

Relationship between the partial likelihood ratio statistics for logisitic models and the partial goodness-of-fit statistics for corresponding log-linear models is discussed. This paper shows how definitions of suppression in logistic model can be adapted for log-linear model and how they are related to confounding in terms of collapsibility for categorical data. Several $2{times}2{times}2$ contingency tables are illustrated.

• The Journal of the Acoustical Society of Korea
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• v.20 no.7
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• pp.37-46
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• 2001

This paper proposes a new noise suppression method using the Wavelet transform analysis. The noise suppressor using the Wavelet transform shows the more effective advantages in a babble noise than one using the short-time Fourier transform. We designed a new channel structure based on spectral subtraction of Wavelet transform coefficients and used the Wavelet mask pattern with more higher time resolution in high frequency. It showed a good adaptation capability for babble noise with a non-stationary property. To evaluate the performance of proposed noise canceller, the informal subjective listening tests (Mos tests) were performed in background noise environments (car noise, street noise, babble noise) of mobile communication. The proposed noise suppression algorithm showed about MOS 0.2 performance improvements than the suppression algorithm of EVRC in informal listening tests. The noise reduction by the proposed method was shown in spectrogram of speech signal.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.373-376
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• 2000

We investigate some properties of commonly used residual plots in linear regression and provide some systematic insight into the relationships among the plots. We discuss three issues of linear regression in this stream of context. First of all, we introduce two graphical comparison methods to display the variance inflation factor. Secondly, we show that the role of a suppressor variable in linear regression can be checked graphically. Finally, we show that several other types of standardized regression coefficients, besides the ordinary one, can be obtained in residual plots and the correlation coefficients of one of these residual plots can be used in ranking the relative importance of variables.

• Communications for Statistical Applications and Methods
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• v.7 no.1
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• pp.37-46
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• 2000

We investigate some properties of commonly used residual plots in linear regression and provide some systematic insight into the relationships among the plots. We discuss three issues of linear regression in this stream of context. First of all we introduce two graphical comparison methods to display the variance inflation factor. Secondly we show that the role of a suppressor variable in linear regression can be checked graphiclly. Finally we show that several other types of standardized regression coefficients besides the ordinary one can be obtained in residual plots and the correlation coefficients of one of these residual plots can be used in ranking the relative importance of variables.

• Clinical and Experimental Pediatrics
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• v.57 no.7
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• pp.333-336
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• 2014

Reports of constitutional ring chromosome 22, r(22) are rare. Individuals with r(22) present similar features as those with the 22q13 deletion syndrome. The instability in the ring chromosome contributes to the development of variable phenotypes. Central nervous system (CNS) atypical teratoid rhabdoid tumors (ATRTs) are rare, highly malignant tumors, primarily occurring in young children below 3 years of age. The majority of ATRT cases display genetic alterations of SMARCB1 (INI1/hSNF5 ), a tumor suppressor gene located on 22q11.2. The coexistence of a CNS ATRT in a child with a r(22) is rare. We present a case of a 4-month-old boy with 46,XY,r(22)(p13q13.3), generalized hypotonia and delayed development. High-resolution microarray analysis revealed a 3.5-Mb deletion at 22q13.31q13.33. At 11 months, the patient had an ATRT ($5.6cm{\times}5.0cm{\times}7.6cm$) in the cerebellar vermis, which was detected in the brain via magnetic resonance imaging.

• Journal of Nutrition and Health
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• v.24 no.5
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• pp.431-441
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• 1991

To investigate the influence of age and dietary fat level on the immune function and the growing potential of the fibroblast cells, male rats of 2 month, 6 month and 30 month of age were fed either 6% or 30% fat diet for 16 weeks. The weight of thymus decreased linearly with increasing age. And this age-dependent degeneration of thymus was delayed in rats fed low fat diets. The blastogenesis of spleen lymphocytes to PHA, ConA, and PWM was decreased with increasing age, however, no effect of dietary fat level was observed. The age-related decline in ratios of PHA/ConA response may suggest that T suppressor cell activity increases with age. In cell culture system, lung fibroblast cells from 30M rats showed lower plating efficiency. longer doubling time. and shorter cumulative doubling potential than those from 2M or 6M animals. Also. the morphology of fibroblasts from 30M rats was tended to be rouned rather than flattened and more variable in size and being generally larger. wherease those from 2M and 6M rats were uniform in size and adhered tightly to the culture vessel in ordered arrays. Therefore fibroblast cell culture system tried in this study reflects the changes of cellular aging.

• Journal of the Korean Professional Engineers Association
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• v.19 no.2
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• pp.10-20
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• 1986

This paper describes a countermeasure of electric utilities and customer equipment in order to minimize an effect of sensitive electrical and electronic equipment on the voltage disturbances. After being studied, some schemes to solve were discovered. Firstly, in the electric utilities, the reduction of frequency and influence of voltage drop's time are not easy to realize because of the standpoint of effect and economy. Secondly, in the customer equipment, there are some equipment to minimize the voltage disturbances, Such as an UPSs, a noise suppressors and a power conditioners. One of them should be established on the computer control and automated systems, the electromagnetic switch of delay-release type should be adopted on the electromagnetic switch, the controlling circuit should be adopted on the variable speed motors which is being considered a countermeasure for a momentary under-voltage drops, the luminaire adhering a instantaneous restrike device should be adopted on the HID lamp. And also, the scheme of extending a setting time of relay on the undervoltage relay and the forming method of sequence which is automatic reclosing at this time of instantaneous suspension of an electric supply have been studied.

• Journal of Gastric Cancer
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• v.15 no.1
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• pp.39-45
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• 2015

Purpose: Recent studies have revealed recurrent alterations in the cell adhesion gene FAT4, a candidate tumor suppressor gene, in cancer. FAT atypical cadherin 4 (FAT4) is a transmembrane receptor involved in the Hippo signaling pathway, which is involved in the control of organ size. Here, we investigated the loss of FAT4 expression and its association with clinicopathological risk factors in gastric cancer. Materials and Methods: We assessed the expression of FAT4 by using immunohistochemistry on three tissue microarrays containing samples from 136 gastric cancer cases, radically resected in the Soonchunhyang University Cheonan Hospital between July 2006 and June 2008. Cytoplasmic immunoexpression of FAT4 was semi-quantitatively scored using the H-score system. An H-score of ${\geq}10$ was considered positive for FAT4 expression. Results: Variable cytoplasmic expressions of FAT4 were observed in gastric cancers, with 33 cases (24.3%) showing loss of expression (H-score <10). Loss of FAT4 expression was associated with an increased rate of perineural invasion (H-score <10 vs. ${\geq}10$, 36.4% vs. 16.5%, P=0.015), high pathologic T stage (P=0.015), high tumor-node-metastasis stage (P=0.017), and reduced disease-free survival time (H-score <10 vs. ${\geq}10$, mean survival $62.7{\pm}7.3$ months vs. $79.1{\pm}3.1$ months, P=0.025). However, no association was found between the loss of FAT4 expression and tumor size, gross type, histologic subtype, Lauren classification, lymphovascular invasion, or overall survival. Conclusions: Loss of FAT4 expression appears to be associated with invasiveness in gastric cancer.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.3
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• pp.191-198
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• 2007

The p53 which is well known as tumor suppressor gene is located at 17p13. p53 is a sequence-specific DNA binding transcription factor that responds to certain cytotoxic stresses, such as DNA damage, by enhancing the transcription of genes that regulate cell-cycle progression as well as programmed cell death. The p63 gene that is located at 3q27-29, is recognized members of the p53 family, and responsible for the transcription of 6 isoforms. Three isoforms ($TAp63{\alpha}$, $TAp63{\beta}$, $TAp63{\gamma}$) contain an N-terminal transactivation (TA) domain and can induce apoptosis. The other 3 isoforms (${\Delta}Np63{\alpha}$, ${\Delta}Np63{\beta}$, ${\Delta}Np63{\gamma}$) lack the TA domain and may function in a dominant-negative fashion by inhibiting the transactivation functions of p53 and TAp63 proteins, and thus act as oncoproteins. A number of studies have investigated the role of p63 in human squamous cell carcinomas from different organs. Only a few studies have examined ${\Delta}Np63$ isoform in oral squamous cell carcinoma including normal epithelium. This study aimed to evaluate expression of ${\Delta}Np63$ isoform in human oral squamous cell carcinoma tissue and normal mucosa. The 3 cases of well differenciated oral squamous cell carcinoma specimen including adjacent normal mucosa were examined, and immunohistochemical study with monoclonal antibody(4A4) and tumor cell apoptosis analysis with Transmission Electon Microscopy were studied. And, RT-PCR analysis was done for expression of ${\Delta}Np63$ isoform. The results were as followed. 1. Normal gingiva showed the restricted p63 expression in basal cell layer. 2. Well differentiated squamous cell carcinoma showed mainly p63 expression in overall area of malignancy, especially in basal cell layer to adjacent stromal tissue. 3. Tumor cells around keratinized area with no p63 expression disclosed less micro-organelle in decreased size cytoplasm and severe chromatin margination with nuclear destruction that means apoptosis. 4. Comparison of mRNA expression of ${\Delta}Np63$ isoform by RT-PCR showed variable expression of ${\Delta}Np63$ isoform, but ${\Delta}Np63{\alpha}$ was most highly expressed in all 3 tumor specimen. From theses results, it should be suggested that ${\Delta}Np63$ isoform expression in well differentiated squamous cell carcinoma was closely related to tumor oncogenesis, expecially overexpression of ${\Delta}Np63{\alpha}$ is a most important factor in tumor genesis of oral squamous cell carcinoma.