• Communications for Statistical Applications and Methods
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• 제11권3호
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• pp.519-527
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• 2004

Relationship between the partial likelihood ratio statistics for logisitic models and the partial goodness-of-fit statistics for corresponding log-linear models is discussed. This paper shows how definitions of suppression in logistic model can be adapted for log-linear model and how they are related to confounding in terms of collapsibility for categorical data. Several $2{times}2{times}2$ contingency tables are illustrated.

• 한국음향학회지
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• 제20권7호
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• pp.37-46
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• 2001

본 논문에서는 웨이블릿 변환을 이용한 주변 잡음제거기를 제안하였다. 기존의 고정된 시간-주파수 해상도를 가지는 단구간 푸리에 분석법 대신 다양한 시간-주파수 해상도를 제공하는 웨이블릿 분석법을 사용함으로써 시간 특성이 변하는 베이블 (Babble) 잡음에 좀더 효율적인 잡음제거 방법을 설계하였다. 본 논문에 제안된 웨이블릿 변환 잡음제거기는 스펙트럴 차감법에 기반하여 구성하였으며, 고주파 영역에서 높은 시간 해상도를 갖는 웨이블릿 마스크 패턴을 사용함으로써 시간 특성이 빠르게 변화하는 고주파 잡음에 더욱 효율적인 동작을 하도록 설계하였다. 성능평가를 위해 차량 잡음, 길거리 잡음, 베이블 잡음과 같은 이동통신에서 많이 사용하는 주변잡음에서 시험하였으며, 그 주관적 음질 평가 결과 베이블 잡음의 경우 기존의 EVRC(Enhanced Variable Rate Coder) 잡음 제거기보다 Mos (Mean Opinion Score) 0.2의 성능 개선을 이룰 수 있었다. 출력 음성의 스펙트로그램에서도 성능 개선을 확인할 수 있었다.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2000년도 춘계공동학술대회 논문집
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• pp.373-376
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• 2000

We investigate some properties of commonly used residual plots in linear regression and provide some systematic insight into the relationships among the plots. We discuss three issues of linear regression in this stream of context. First of all, we introduce two graphical comparison methods to display the variance inflation factor. Secondly, we show that the role of a suppressor variable in linear regression can be checked graphically. Finally, we show that several other types of standardized regression coefficients, besides the ordinary one, can be obtained in residual plots and the correlation coefficients of one of these residual plots can be used in ranking the relative importance of variables.

• Communications for Statistical Applications and Methods
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• 제7권1호
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• pp.37-46
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• 2000

We investigate some properties of commonly used residual plots in linear regression and provide some systematic insight into the relationships among the plots. We discuss three issues of linear regression in this stream of context. First of all we introduce two graphical comparison methods to display the variance inflation factor. Secondly we show that the role of a suppressor variable in linear regression can be checked graphiclly. Finally we show that several other types of standardized regression coefficients besides the ordinary one can be obtained in residual plots and the correlation coefficients of one of these residual plots can be used in ranking the relative importance of variables.

• Clinical and Experimental Pediatrics
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• 제57권7호
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• pp.333-336
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• 2014

Reports of constitutional ring chromosome 22, r(22) are rare. Individuals with r(22) present similar features as those with the 22q13 deletion syndrome. The instability in the ring chromosome contributes to the development of variable phenotypes. Central nervous system (CNS) atypical teratoid rhabdoid tumors (ATRTs) are rare, highly malignant tumors, primarily occurring in young children below 3 years of age. The majority of ATRT cases display genetic alterations of SMARCB1 (INI1/hSNF5 ), a tumor suppressor gene located on 22q11.2. The coexistence of a CNS ATRT in a child with a r(22) is rare. We present a case of a 4-month-old boy with 46,XY,r(22)(p13q13.3), generalized hypotonia and delayed development. High-resolution microarray analysis revealed a 3.5-Mb deletion at 22q13.31q13.33. At 11 months, the patient had an ATRT ($5.6cm{\times}5.0cm{\times}7.6cm$) in the cerebellar vermis, which was detected in the brain via magnetic resonance imaging.

• Journal of Nutrition and Health
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• 제24권5호
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• pp.431-441
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• 1991

To investigate the influence of age and dietary fat level on the immune function and the growing potential of the fibroblast cells, male rats of 2 month, 6 month and 30 month of age were fed either 6% or 30% fat diet for 16 weeks. The weight of thymus decreased linearly with increasing age. And this age-dependent degeneration of thymus was delayed in rats fed low fat diets. The blastogenesis of spleen lymphocytes to PHA, ConA, and PWM was decreased with increasing age, however, no effect of dietary fat level was observed. The age-related decline in ratios of PHA/ConA response may suggest that T suppressor cell activity increases with age. In cell culture system, lung fibroblast cells from 30M rats showed lower plating efficiency. longer doubling time. and shorter cumulative doubling potential than those from 2M or 6M animals. Also. the morphology of fibroblasts from 30M rats was tended to be rouned rather than flattened and more variable in size and being generally larger. wherease those from 2M and 6M rats were uniform in size and adhered tightly to the culture vessel in ordered arrays. Therefore fibroblast cell culture system tried in this study reflects the changes of cellular aging.

• 기술사
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• 제19권2호
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• pp.10-20
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• 1986

전압외란(voltage disturbances)에 대하여 민감함 전기전자기기가 받는 영향을 최소화하기 위한 방안으로 전력공급자측에서의 대책과 수용가기기에서의 대응책에 대하여 조사연구하였다. 전력공급자에서의 대책으로는 전압강하 시간의 단축에 대하여 검토하였는데, 효과와 경제성으로 보아 실현가능성이 적었다. 수용가기기에서의 대응책으로는 컴퓨터제어(computer control)와 자동화시스템(automated systems) 등에는 무정전 전원장치 또는 노이즈 서프레서(noise suppressor)나 파워콘디쇼너(power conditioners)를 설치하고, 전자개폐기는 지연석방형 전자개폐기를 채용하며, 가변속제어전동기에는 순간전압부하에 대한 대책이 고려된 제어회로를 채용하고, 고압방전등에는 순간재점등장치가 붙은 등기구를 채용하며, 부족전압계전기는 계전기의 정전시감을 연장하는 방안과 순간정전시에는 자동으로 재투입하는 sequence를 구성하는 방법등이 효과적인 대책으로 검토되었다.

• Journal of Gastric Cancer
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• 제15권1호
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• pp.39-45
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• 2015

Purpose: Recent studies have revealed recurrent alterations in the cell adhesion gene FAT4, a candidate tumor suppressor gene, in cancer. FAT atypical cadherin 4 (FAT4) is a transmembrane receptor involved in the Hippo signaling pathway, which is involved in the control of organ size. Here, we investigated the loss of FAT4 expression and its association with clinicopathological risk factors in gastric cancer. Materials and Methods: We assessed the expression of FAT4 by using immunohistochemistry on three tissue microarrays containing samples from 136 gastric cancer cases, radically resected in the Soonchunhyang University Cheonan Hospital between July 2006 and June 2008. Cytoplasmic immunoexpression of FAT4 was semi-quantitatively scored using the H-score system. An H-score of ${\geq}10$ was considered positive for FAT4 expression. Results: Variable cytoplasmic expressions of FAT4 were observed in gastric cancers, with 33 cases (24.3%) showing loss of expression (H-score <10). Loss of FAT4 expression was associated with an increased rate of perineural invasion (H-score <10 vs. ${\geq}10$, 36.4% vs. 16.5%, P=0.015), high pathologic T stage (P=0.015), high tumor-node-metastasis stage (P=0.017), and reduced disease-free survival time (H-score <10 vs. ${\geq}10$, mean survival $62.7{\pm}7.3$ months vs. $79.1{\pm}3.1$ months, P=0.025). However, no association was found between the loss of FAT4 expression and tumor size, gross type, histologic subtype, Lauren classification, lymphovascular invasion, or overall survival. Conclusions: Loss of FAT4 expression appears to be associated with invasiveness in gastric cancer.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권3호
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• pp.191-198
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• 2007

The p53 which is well known as tumor suppressor gene is located at 17p13. p53 is a sequence-specific DNA binding transcription factor that responds to certain cytotoxic stresses, such as DNA damage, by enhancing the transcription of genes that regulate cell-cycle progression as well as programmed cell death. The p63 gene that is located at 3q27-29, is recognized members of the p53 family, and responsible for the transcription of 6 isoforms. Three isoforms ($TAp63{\alpha}$, $TAp63{\beta}$, $TAp63{\gamma}$) contain an N-terminal transactivation (TA) domain and can induce apoptosis. The other 3 isoforms (${\Delta}Np63{\alpha}$, ${\Delta}Np63{\beta}$, ${\Delta}Np63{\gamma}$) lack the TA domain and may function in a dominant-negative fashion by inhibiting the transactivation functions of p53 and TAp63 proteins, and thus act as oncoproteins. A number of studies have investigated the role of p63 in human squamous cell carcinomas from different organs. Only a few studies have examined ${\Delta}Np63$ isoform in oral squamous cell carcinoma including normal epithelium. This study aimed to evaluate expression of ${\Delta}Np63$ isoform in human oral squamous cell carcinoma tissue and normal mucosa. The 3 cases of well differenciated oral squamous cell carcinoma specimen including adjacent normal mucosa were examined, and immunohistochemical study with monoclonal antibody(4A4) and tumor cell apoptosis analysis with Transmission Electon Microscopy were studied. And, RT-PCR analysis was done for expression of ${\Delta}Np63$ isoform. The results were as followed. 1. Normal gingiva showed the restricted p63 expression in basal cell layer. 2. Well differentiated squamous cell carcinoma showed mainly p63 expression in overall area of malignancy, especially in basal cell layer to adjacent stromal tissue. 3. Tumor cells around keratinized area with no p63 expression disclosed less micro-organelle in decreased size cytoplasm and severe chromatin margination with nuclear destruction that means apoptosis. 4. Comparison of mRNA expression of ${\Delta}Np63$ isoform by RT-PCR showed variable expression of ${\Delta}Np63$ isoform, but ${\Delta}Np63{\alpha}$ was most highly expressed in all 3 tumor specimen. From theses results, it should be suggested that ${\Delta}Np63$ isoform expression in well differentiated squamous cell carcinoma was closely related to tumor oncogenesis, expecially overexpression of ${\Delta}Np63{\alpha}$ is a most important factor in tumor genesis of oral squamous cell carcinoma.