• 한국의류학회지
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• 제22권2호
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• pp.250-256
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• 1998

The culture of makeup has early developed in China. Especially, beautiful eyebrows were the symbol of a beauty. This study is related to fashionable Cheong-Dae in Han Dynasty. In Han Dynasty, women painted thier eyebrows with blue color in a different color from former periods. This fact has close connection with the bordering countries on Western China. Together with Hu fashion having been in fashion during trading directive with Western China women has seemed to use Cheong-Dae for their makeup in Han Dynasty. In Hand Dynasty, Ferghana women had very often used it for their makeup. And it had produced in Ferghana, Jaguda, Kashkar. In Tang Dynasty, it has been said that Persia was the best. Let's take a look at the producing method. Soak indigo plants in water add lime and stir it up, then bubbles are formed. They are called it as Cheong-Dae. Nearly, they are produced in the course of indigo dying. So we can see inflowing course of Cheong-Dae into China through the history of Indigo dying. We can guess the use of Cheong-Dae in Egypt. Indeed, Nile Blue is used for the Protection their access from insects as well as effect of coolness visually. This guess is very reasonable because the fact is considered that some people dye with indigo color by the way of sedimentation in Peniasula of Sinai. Also, the PH of Cheong-Dae is about 7. So, it does no harm in skin and its color is dark blue. Cheong-Dae has effects of insecticide and removal of fever. Cheong-Dae that had been used in Peninsula of Egypt seems to have been carried into China through Silk Route. And by trial to make Cheong-Dae it is proved that its ingredient is plant.

• 한국응용과학기술학회지
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• 제34권3호
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• pp.602-612
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• 2017

본 연구에서는 잣나무 잎으로 70% 에탄올 추출물과 증류수 추출물을 얻은 후 항산화 효과, 항염증, 미백효과 등 다양한 효과를 검증하고자 연구를 수행하였다. 항산화 실험 결과, 폴리페놀, 플라보노이드 효과에서는 폴리페놀과 플라보노이드 함량이 농도 의존적으로 증가하였다. 폴리페놀과 플라보노이드 함량은 증류수 추출물에 비해 에탄올 추출물에서 높은 것으로 확인되었다. B16F10, RAW264.7 세포에서 농도별로 세포독성이 나타나지 않았으며, NO 생성 억제능 측정 결과, LPS로 유도된 NO 생성을 효과적으로 억제하여 항염증 활성이 있을 것으로 예측되었다. 멜라닌 생합성 억제능 측정결과, 유의한 감소효과를 확인하였으며, western blot을 수행하여 MITF, Tyrosinase 단백질 발현억제 실험결과, 농도 의존적으로 현저히 억제됨을 확인할 수 있었다. 따라서 본 연구결과로부터 잣나무 잎추출물은 화장품 소재로서의 다양한 활용 가능성이 있을 것으로 사료된다.

• Journal of Nutrition and Health
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• 제35권1호
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• pp.115-123
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• 2002

This study was carried out to investigate the utilization status of internet dietary information by gender(boys: 363, girls: 366) in adolescent(middle & high school students). The results were summarized as follows. The internet using frequency of 6-7times per week had 45.0% of subjects and the using time of internet per a time was shown mainly'<2hours(68.5%)'. The main place for internet use was home(79.0%) and favorite search engine was 'Yahoo'(45.7%) and 'Daum'(19.3%). As main purpose using internet were mentioned 'social intercourse'(45.0%) and data search'(24.8%). The organization that offer to reliable internet information was educational institution'(49.4%). The problems in using information site were 'poor information'(26.4%), 'slow connection speed'(22.6%), and 'don't arouse interest'(18.8%). The search experience about dietary information had only 27.9% of subjects and search purpose was 'for homework'(33.3%) and 'for health'(32.0). The satisfaction degree of dietary information was not high. The connection motive to dietary information was mainly 'by site navigation casualty'(55.7%). Only 7.7% of subjects had experience of nutrition counseling using internet, and the motive of nutrition counseling was also 'by site navigation causally'(55.8%). The purpose of counseling was 'for diet'(41.5%) and 'for health problem'(30.2%), and the satisfaction degree of counseling result was very low. As the ask of improvement for counseling site were pointed out 'poor in answer content'(44.8%) and 'lazy answer'(31.0%). The subjects wanted to get the dietary information about 'growth in status'(41.4%), 'diet related skin beauty'(14.6%), the update period less 1 month, and the way of 'free board'(32.3%), 'game'(21.1%) and 'animation'(19.3%) as offer tool. The results of this study showed that although the internet using percent and frequency of subjects was high, they used dietary information very seldom and they are dissatisfied with internet nutritional information. Therefore, the information donor should consider which dietary information was needed and what is the optimal tool for adolescent.

• 대한물리치료과학회지
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• 제4권2호
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• pp.399-403
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• 1997

The purpose of this study was to determine the efficacy of electrode placement on procaine iontophoresis. Thirty-three healthy students with an age range of 19 to 34 years, were participated in this study. The subjects were randomly assigned into 3 groups. Each subjects received iontophoresis on the proximal 1/3 of volar surface of dominant forearm with soft cotton pad($3.5{\times}3.5cm$) soaked in 2 ml of 4% procaine hydrochloride (pH 5.1) at 4 mA for 10 minutes(total current 40 mA min) of anodal DC. In transversal electrode placement(TEP) group, dispersive electrode was placed on the proximal 1/3 of dorsal surface of the forearm. In longitudinal electrode placement (LEP) group and control group, dispersive electrode were placed on the distal 1/3 of volar surface of the forearm. After procaine iontophoresis, duration of anesthesia were evaluated at five minutes intervals on five random locations in the iontophoretically area using a 21-gauge sterile hypodermic needle pressed with 1 mm invagination until return the sharp pin-pricking pain sensation. The data were ana lysed with one-way ANOVA to determine signific~nt differences between groups. The results showed significantly differences in the local anesthetic duration between the 3 groups(p<0.001). The anesthetic durations of TEP group and LEP group were significantly longer when compared with control group(p<0.05). Anesthetic durations of TEP group and LEP group were not significantly difference, but anesthetic duration of LEP group tends to longer than TEP group. In view of these results, clinicians should consider the electrode placement method when performing the iontophoresis.

• Archives of Pharmacal Research
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• 제27권9호
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• pp.923-929
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• 2004

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries. Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E$_2$ (PGE$_2$), tumor necrosis factor-a (TNF-$\alpha$) and interleukin-1$\beta$(IL-1$\beta$), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner. These results suggest that stylopine suppress the NO and PGE$_2$ production in macrophages by inhibiting the iNOS and COX-2 expressions. These biological activities of stylopine may contribute to the anti-inflammatory activity of Cheli-donium majus.

• 대한화장품학회지
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• 제38권4호
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• pp.339-356
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• 2012

기능성화장품의 중요성이 부각되고 있는 현 시점에서 우리나라 여대생들의 기능성화장품에 대한 사용실태 및 구매행동에 관하여 분석하였다. 시장 세분화를 통하여 더 많은 고객의 니즈를 충족시키고 기능성화장품의 지속적인 발전방안을 제시하고자 한다. 본 연구의 대상은 서울의 4년제 여자대학교 2곳을 선정하여 340명에게 설문지를 배포하고 300명의 실증자료를 얻어 SPSS WIN 15.0프로그램을 이용하여 분석하였다. 대다수의 여대생들이 기능성화장품을 사용하고 있는 것으로 나타났으며, 피부고민 해결방안으로 주로 기능성화장품을 사용하고 있는 것으로 나타났다. 기능성화장품의 구매 장소로는 백화점이 가장 많았고, 구매 시 고려사항으로는 제품의 효능 및 효과가 가장 많았다. 기능성화장품 중에는 자외선차단제를 가장 많이 사용하는 것으로 나타났다.

• 디지털융복합연구
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• 제14권11호
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• pp.607-618
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• 2016

아토피 피부염(AD)에 대한 고삼백선피복합방(GBBB)의 치료적 가능성을 증명하기 위해 동물모델에서 다양한 면역 관련 인자들과 조직학적 변화에 대한 GBBB의 영향을 평가하였다. 실험 결과는 다음과 같다. GBBB도포군은 관능평가 결과에서 AD의 개선징후를 나타냈다. GBBB 도포군은 대조군에 비해 혈액 내 백혈구, 호중구, 림프구, 단핵구 면역세포 비율이 54%, 63%, 57%, 86%로 감소되었다. 또한 GBBB도포군은 대조군에 비해 혈청 내 IL-4, IL-5, IL-13, Histamine 및 IgE 생성량이 각각 40%, 80%, 62%, 61%, 57%로 유의성 있게 감소되었다. H&E 염색에서 GBBB 도포군은 대조군에 비하여 비만세포가 피부로 침윤되는 것이 억제되었으며 피부두께 역시 상대적으로 감소되었다. 이 결과를 바탕으로 GBBB는 피부에 직접 도포하는 AD 치료제로서 가능성이 있음이 확인하였다. 후속연구에서는 분자생물학적 연구를 통해 GBBB의 면역조절 기전을 구체적으로 밝히고자 한다.

• 대한화장품학회지
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• 제44권1호
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• pp.23-29
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• 2018

본 연구에서는 생체재료인 콜라겐과 합성 단량체인 아크릴아마이드를 연속가교 하여, 하이드로젤 기반의 콜라겐 겔을 제조하였다. 아크릴아마이드의 함량 및 가교 정도에 따라, 1.5 kPa에서 3.0 kPa까지 다양한 강도(E)를 갖는 콜라겐 겔을 제조할 수 있었다. 또한, 콜라겐 겔에 다공성 기공을 도입하고 진피세포를 내부에 담지하여, 겔 강도에 따른 세포 성장 및 거동을 확인하였다. 상대적으로 강도가 높은 겔에서 세포의 성장은 느렸지만 GAG 합성 및 분비는 활성화되는 것을 확인하였다. 콜라겐 겔의 기계적 물성에 따라 세포의 성장 및 활성이 영향을 받는 것을 알 수 있었으며, 이는 향후 인공피부 제조 및 응용, 나아가 다양한 조직공학 분야의 기반 기술로 활용 가능하리라 기대된다.

• Archives of Pharmacal Research
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• 제28권2호
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• pp.203-208
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• 2005

Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but reduced the release of nitric oxide (NO) and prostaglandin $E_2\;(PGE_2)$ upon stimulation by IFN-${\gamma}$/LPS or LPS. The inhibitory effects were found to be in conjuction with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in IFN-${\gamma}$/LPS stimulated RAW 264.7 cells. Moreover, scoparone also attenuated the production of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-6 in LPS-stimulated RAW264.7 cells. These results suggest that scoparone decreases the production of the inflammatory mediators such as NO and $PGE_2$ in macrophages by inhibiting iNOS and COX-2 expression.

• 한국약용작물학회지
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• 제16권3호
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• pp.173-182
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• 2008

Prunus sargentii of Rosaceae familiy, has been reported to have radical scavenging activity and anti-inflammatory effect. On these facts, this research was conducted to evaluate pharmaceutical activities of the bark extracts P. sargentii. Free radical scavenging activities of fraction (Fr) -5${\sim}$10 isolated from P. sargentii was higher than 80% respectively at 10ppm. The superoxide dismutase (SOD)-like activity of Fr-5, 9 were about 97, 84%, respectively at 1,000 ppm. Xanthine oxidase inhibitory effect of Fr-9, 10 were about 75, 78%, respectively at 1,000 ppm. The tyrosinase inhibitory effect related to skin-whitening was 72, 68% in Fr-2, 9 isolated from Prunus sargentii R. at 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 98% for Fr-8 at 500 ppm. Isolation of the methanol soluble fraction from P. sargentii yielded two major phenol compounds, (-)-epicatechin and taxifolin. The structure of the compound was certainly determined by chemical analyses, as well as NMR and Mass spectroscopy. The present study was carried out in a search for new cosmetic material from the bark from P. sargentii. and, (-)-epicatechin and taxifolin were isolated as active principles. So P. sargentii R. methanolic extracts may be used for the cosmetic material.