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Biological Activity Investigation, and Phenol Compounds Isolation from Barks of Prunus Sargentii R.  

Park, Jung-Mi (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Jin-Young (Department of Cosmeceutical Science, Daegu Haany University)
Park, Tae-Soon (Department of Cosmeceutical Science, Daegu Haany University)
Park, Gun-Hye (Department of Cosmeceutical Science, Daegu Haany University)
Park, Kang-Soo (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Tae-Hoon (Department of Herbal Medicinal Phamacology, Daegu Haany University)
Cho, Young-Je (Department of Food Engineering, Kyungpook National University)
Kwon, O-Jun (Gyeongbuk Regional Innovation Agency)
Choi, Kyung-Im (Department of Beauty Coordination, Daegu Health College)
An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Korean Journal of Medicinal Crop Science / v.16, no.3, 2008 , pp. 173-182 More about this Journal
Abstract
Prunus sargentii of Rosaceae familiy, has been reported to have radical scavenging activity and anti-inflammatory effect. On these facts, this research was conducted to evaluate pharmaceutical activities of the bark extracts P. sargentii. Free radical scavenging activities of fraction (Fr) -5${\sim}$10 isolated from P. sargentii was higher than 80% respectively at 10ppm. The superoxide dismutase (SOD)-like activity of Fr-5, 9 were about 97, 84%, respectively at 1,000 ppm. Xanthine oxidase inhibitory effect of Fr-9, 10 were about 75, 78%, respectively at 1,000 ppm. The tyrosinase inhibitory effect related to skin-whitening was 72, 68% in Fr-2, 9 isolated from Prunus sargentii R. at 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 98% for Fr-8 at 500 ppm. Isolation of the methanol soluble fraction from P. sargentii yielded two major phenol compounds, (-)-epicatechin and taxifolin. The structure of the compound was certainly determined by chemical analyses, as well as NMR and Mass spectroscopy. The present study was carried out in a search for new cosmetic material from the bark from P. sargentii. and, (-)-epicatechin and taxifolin were isolated as active principles. So P. sargentii R. methanolic extracts may be used for the cosmetic material.
Keywords
Prunus sargentii R.; Biological activities; Epicatechin; Taxifolin;
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Times Cited By KSCI : 8  (Citation Analysis)
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