Browse > Article
http://dx.doi.org/10.14400/JDC.2016.14.11.607

Inhibitory Effects of Gosambaeksunpibokhap-bang(GBBB) Extract in an Atopic Dermatitis Animal Model  

Lee, Da-Yeong (Dept. of Beauty Health Care, Daejon University)
Seung, Yun-Chel (Dept. of Oriental Health Care, Joongbu University)
Cheong, Kyu-Jin (College of Pharmacy, Chungnam National University)
Publication Information
Journal of Digital Convergence / v.14, no.11, 2016 , pp. 607-618 More about this Journal
Abstract
In order to clarify the Gosambaeksunpibokhap-bang(GBBB)'s therapeutic possibility on atopic dermatitis (AD), influences of GBBB on the changes of various immune-related factors and histological changes in NC/Nga mice were evaluated. Experimental results are as follows. Sign of recovery from AD was observed in GBBB treated group with naked eye test. The ratio of white blood cells, neutrophil, lymphocytes, monocyte in blood were decreased to 54%, 63%, 57% and 86% respectively in the GBBB group. IL-4, IL-5, IL-13, Histamine and IgE were significantly decreased to 40%, 80%, 62%, 61% and 57% respectively in the GBBB group. H&E staining showed thickness of epidermis and dermis were decreased by GBBB and inhibited the infiltration of lymphocytes. On the basis of these results, GBBB was confirmed that the possibility as an AD treatment applied externally to the skin. In the further study, immune control mechanism of GBBB will be demonstrated through the additional molecular biological research.
Keywords
Atopic dermatitis(AD); NC/Nga mouse; IgE; Histamine; Mast cell;
Citations & Related Records
Times Cited By KSCI : 13  (Citation Analysis)
연도 인용수 순위
1 Dae-Beom Son, Eun-Sung Seo, Chae-Sung Yun, Nam-Kwen Kim, Chung-Yeon Hwang, "Effects of Chunggi-san Administration along with Samhwangseze -gamibang on NC/Nga Atopic Mice". Korean J. Oriental Physiology & Pathology, Vol. 22. No. 5, pp. 1168-1177, 2008.
2 Cetkovic-Cvrlje M and Eizirik DL., "TNF and IFN${\gamma}$ potentiate the deleterious effects of IL-1${\beta}$ on mouse pancreatic islets mainly via generation of nitric oxide". Cytokine. Vol. 6, pp. 399-406, 1994.   DOI
3 Homey B. Steinhoff M. Ruzkcka T. Leung DY., "Cytokines and chemokines orchestrate atopic skin inflammation". J Allergy Clin Immunol, Vol. 118, pp. 178-189, 2006.   DOI
4 Jae-Hong Jun, Yoon-Ho Kang, "The effects of scutellaria baicalensis georgi on allergic contact dermatitis induced by DNCB in mice". Institute of Oriental Medicine, Dongguk University, 1998.
5 Young-hui Ku, "Therapeutic Effects of Cheonggisan Extract on NC/Nga Mice with Atopic Dermatitis-like Skin Lesions". Doctoral dissertation. Dongguk University, 2007.
6 Sang-Hyun Lee, Yong-Gab Yun, "Study for Treatment of Atopic Dermatitis in Oriental Medical Prescription". The Journal of Traditional Korean Medicine, Vol. 15, No. 1, pp. 56-69, 2006.
7 Se-Hee Kim, "The Use of Oriental and Complementary Alternative Medicine in Children with Atopic Dermatitis. Master's thesis". Pochon CHA University, 2007.
8 Yong-Mean Park, "Advances In the Pathophysiology of Atopic Dermatitis". Allergy Asthma & Respiratory Disease, Vol. 16, No. 3, pp. 189-196, 2006.
9 Hae-Sung Lee, Jong-Suh Kim and Bok-Yang Pyun, "Changes of the Prevalence and the Allergens of Atopic Dermatitis in Children : In between the Year of 1992 and 2002". Allergy Asthma & Respiratory Disease, Vol. 12, No. 4, pp. 263-271, 2002.
10 Hyun-A Joo, Hyeon-Jin Bae, Min-Cheol Park, Sang -Chul Baek, Seok-Hoon Hong, Hyun-Ju Yang, Hyun-Woo Cho, Soo-Young Jung, Jeong-Hee Cho, Chung-Yeon Hwang, "A Clinical Study for the effect of cosmetic cream containing Samwhangsejegamibang Extracts on Atopic dermatitis patients". The journal of Korean Medicine Ophthalmology & Otolaryngolog -y & Dermatology, Vol. 25, No. 3. pp. 129-149, 2012.   DOI
11 Hong-Yoon Go, Dong-hee Kim, "Study on Combination of External Gosamgamibang and Internal Chenggihaedok-san for the Treatment of Atopic Dermatitis". Journal of physiology & pathology in Korean Medicine, Vol. 23, No. 6, pp. 1282-1291, 2009.
12 Jeong-Hyo Hong, "A research Western medical science, The Korean traditional medicine, Local clinic and Naturopathy about Atopy". The Korean Society For Eco Early Childhood Education, Vol. 7, No. 1, pp. 65-85, 2008.
13 Yun-Shil Lee, "Therapeutic effects of Dictamni Radicis Cortex extracts on atopic dermatitis-like skin lesions of NC/Nga mouce induced by DNCB". Doctoral dissertation. Daejeon University, 2014.
14 Sang-Hee Cho, Su-Young Lee, "A Effect of the Squat Convergence Exercise Among Knee Joint Angle on Quadricpes Strength in the Patients With Patellofemoral Pain Syndrome", Journal of the Korea Convergence Society, Vol. 7 No. 2, pp. 43-52, 2016.
15 Sung-Hye Park, Kyoung-Ok Cha, "Oriental and Western Food Effects Analysis of Misutgaru for Fusion Remedy in Diabetes Mellitus", Journal of the Korea Convergence Society, Vol. 7 No. 1, pp. 137-143, 2016.   DOI
16 Sook-Hyun Bang, "The clinical effect of topical Diphenylcyclopropenone(DPCP) therapy in the treatment of atopic dermatitis in children and adolescence". Doctoral dissertation, Ewha woman University, 2004..
17 Da-Hae Song, Hyung-Ju Kim, "The Effect of Kushen Ethanol Extract Cream to NC/Nga mice Induced by Dermatophagoides farinae". The Korean Society of Cosmetology, Vol. 15, No. 4, pp. 1243-1252, 2009.
18 Seung-Il Jeong, Byung-Min Choi, Young Gab Yun, Jang Won Lee, Seon Il Jang, "A Noble Therapeutic Approach of Atopic dermatitis by Development of Th2 Chemokine Inhibitors from Natural Products: Inhibitory Effect of Sophora flavescens Extract in Atopic Dermatitis Model mice, NC/Nga". The Korean Journal of Oriental Medical Prescription, Vol. 17, No. 1, pp. 141-151, 2009.
19 Hyueng-Jun Choi, "Effect of Betula platyphylla on mast cell-mediated allergic inflammation in vivo and in vitro. Doctoral dissertation". Daegu Haany University, 2012.
20 Kum-Lan Kim, Tae-Boo Choe, "Studies of Xanthium strumarium extract suppressing Th17-cell differentiation and anti-dermatitic effect in BMAC-induced Atopy Dermatitis of NC/Nga Mice". Korean Journal of Biotechnology and Bioengineering, Vol. 24, No. 4, pp. 383-392, 2009.
21 Eun-Hoi Cheong, "Effect of Frutus Xanthii extract in atopic dermatitis induced mice model". Master's thesis. Konkuk University, 2007.
22 Jung-Sun Kim, "Effects of Kochiae Fructus on Histamine Unduced Itch, Erythema and Wheal Responses in Normal Healthy Persons". Doctoral dissertation. Kyunh Hee University, 2002.
23 Min-Chul Park, "A Literature study about comparison of Eastern-Western medicine on the Atopic dermatitis". Doctoral dissertation. Wonkwang University, 2001.
24 Young-Sook Han, Mi-Yun Yoon, Mi-Yeon Jeon, Kyeong-Seon Kim, Jin-Yi Kim, Hye-Min Kim, Hua Ci, Doo-ho Yang, "Effect of Skin Care for Acne Through Applying Sea Tangle". The Korean Society of Esthetics & Cosmeceutics, Vol. 2, No. 1, pp. 61-66, 2007.
25 Tae-Hoon Kim, "Partial purification of mitogcnic inducer and study of tumoricidal activity of duchesnea chrysantha". Master's thesis. Seoul Unversity, 2001.
26 Kyoung-Min Min, "Anti-Atopic Dermatitis Effect of Some Natural Products". Master's thesis. Kangwon National University, 2010.
27 Qian Qi Wu Yuansheng, " Diagnosis and treatment of dermatology combined with traditional Chinese and western medicine". Guangdong Science and Technology Press. p. 174, 2005.
28 Ju CY.Heo TS.Han DH.Jung HJ. Jung SK.Rhee HK, "A questionnaire analysis about the understanding allergic disease and the attitude toward oriental medical treatment". Korean J Orient Int Med. Vol. 21, No. 4, pp. 565-573, 2000.
29 Jee-Su Park, Yun-Hee Kim, Tak-Lim Kang, "Effect of Yeonkyo-san in Atopic Dermatitis Animal Model". Korean J. Oriental Physiology & Pathology, Vol. 20, No. 1, pp. 58-64, 2006.
30 Young-Hui Ku, Seung-Ug Hong, "Therapeutic Effects of Cheonggi-san Extract on NC/Nga Mice with Atopic Dermatitis-like Skin Lesions". J Korean Oriental Med., Vol. 29, No. 1, pp. 179-191, 2008.
31 Bong-Soo Nam, Jae-Hun Cho, Yoon-Byum Kim, Byung-Yoon Chae, "A Clinical Study on Atopic Dermatitis". J Korean Oriental Med., Vol. 21, No. 4, pp. 204-215, 2000.
32 Koh Dj, You HJ, Lee JY, Kim DG, "Clinical Assessment of Efficacy, Safety and Usefulness of Traditional Herbal Medicine(THM) on atopic Dermatitis". The Association of Pediatrics of Korean Medicine, Vol. 20, No. 2, pp. 129-137, 2006.
33 Jae-Hoon Jung, "Anti-inflammatory effects of herbal mixture (Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) on acute atopic dermatitis mice". Doctoral dissertation. Kyungwon University, 2011.
34 Jeong-Jin Kim, Sung-Wan Yang, Nak-Won Son, Kyoo-Seok Ahn, "Anti-inflammatory action by Gamisangryosamul-tang and The effect of Ziyang-Go on atopic dermatitis-like lesion and pruritus in NC/Nga mice". Korean J. Oriental Physiology & Pathology, Vol. 17, No. 2, pp. 428-435, 2003.
35 Sang-Ho Shin, Mi-Bo Kim, Seok-Mi Byun, Ho-sub Lee, Sun-Gyoo Park, Woo-Shin Ko, Hwa-jung Yoon, "A Review on External Treatment for Atopic Dermatitis in Korean Journals". The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology, Vol. 21, No. 2, pp. 80-93, 2008.
36 Jong-Man Yoon, Dae-Bok Kim, Yang-Chun Park, "Effect of Taeyeol-go on Atopic Dermatitis". Research Institute of Korean Medicine, Taejon University, Vol. 15, No. 2, pp. 187-192, 2006.
37 Tomkinson a.Duez C. Cieslewicz G. Pratt JC. Joetham A. Shanafelt MC. et al "A murine IL-4 receptor antagonist that inhibits IL-4 and IL-13 induced responses prevents antigen-induced airway eosinophilia and airway huperresponsiveness". J. Immunol. Vol. 166, pp. 5792-5800, 2001.   DOI
38 Woo-Young Kim, "Anti-inflammatory effects of herbal medicine, KH-02 extract on acute atopic dermatitis mice". Master's thesis. Kyung Hee University, 2012.
39 Boo-Yong Sim, Sung-Hwan Kim, Dong-Hee Ki-m, "Anti-inflammatory effect of Baecksunpijibujabokh -ap-bang in Atopic dermatitis model mice". The Korea Association Herbology, Vol. 29, No. 3, pp. 51-58, 2014.   DOI
40 Mi-Sook Yoon, "Effects of walnut extracts on Atopic dermatitis". Doctoral dissertation. Catholic University of Daegu, 2001.