• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.3
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• pp.229-235
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• 2013

To investigate the effect of the flexible artery wall on the blood flow, three-dimensional numerical simulations were carried out for analyzing the time-dependent incompressible flows of Newtonian fluids constrained by a flexible wall. The Navier-Stokes equations for fluid flow were solved using the P2P1 Galerkin finite element method, and mesh movement was achieved using an arbitrary Lagrangian-Eulerian formulation. The Newmark method was employed for solving the dynamic equilibrium equations for the deformation of a linear elastic solid. To avoid complexity due to the necessity of additional mechanical constraints, we used a combined formulation that includes both the fluid and structure equations of motion to produce a single coupled variational equation. The results showed that the flexibility of the carotid wall significantly affects flow phenomena during the pulse cycle. The flow field was also found to be strongly influenced by the bifurcation angle.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.1
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• pp.71-77
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• 2015

Ultrasonic imprinting is a micropattern replication technology for a thermoplastic polymer surface that uses ultrasonic vibration energy; it has the advantages of a short cycle time and low energy consumption. Recently, ultrasonic imprinting has been further developed to extend its functionality: (i) selective ultrasonic imprinting using mask films and (ii) repetitive ultrasonic imprinting for composite pattern development. In this study, selective ultrasonic imprinting was combined with repetitive imprinting in order to replicate versatile micropatterns. For this purpose, a repetitive imprinting technology was further extended to utilize mask films, which enabled versatile micropatterns to be replicated using a single mold with micro-prism patterns. The replicated hybrid micropatterns were optically evaluated through laser light images, which showed that versatile optical diffusion characteristics can be obtained from the hybrid micropatterns.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.24 no.1
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• pp.51-58
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• 2014

A LFSR is commonly used for various stream cryptography applications to generate random numbers. A Leap-ahead LFSR was presented to generate a multi-bits random number per cycle. It only requires a single LFSR and it has an advantages in hardware complexity. However, it suffers from the significant reduction of maximum period of the generated random numbers. This paper presents the new segmented Leap-ahead LFSR to solve this problem. It consists of two segmented LFSRs. We prove the efficiency of the proposed segmented architecture using the precise mathematical analysis. We also demonstrate the proposed comparison results with other counterparts using Xinilx Vertex5 FPGA. The proposed architecture can increase 2.5 times of the maximum period of generated random numbers compared to the typical Leap-ahead architecture.

• The Journal of Society for e-Business Studies
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• v.17 no.1
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• pp.53-74
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• 2012

This study developed a method for selection of available human resources for incomingjob allocation that considers factors affecting resource performance in the business process management (BPM) environment. For many years, resource selection has been treated as a very important issue in scheduling due to its direct influence on the speed and quality of task accomplishment. Even though traditional resource selection can work well in many situations, it might not be the best choice when dealing with human resources. Humanresource performance is easily affected by several factors such as workload, queue, working hours, inter-arrival time, and others. The resource-selection rule developed in the present study considers factors that affect human resource performance. We used a Bayesian Network (BN) to incorporate those factors into a single model, which we have called the Bayesian Selection Rule (BSR). Our simulation results show that the BSR can reduce waiting time, completion time and cycle time.

• Journal of the Society of Naval Architects of Korea
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• v.49 no.1
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• pp.68-78
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• 2012

A layout of an LNG FPSO should be elaborately determined as compared with that of an onshore plant because many topside process systems are installed on the limited area; the deck of the LNG FPSO. Especially, the layout should be made as multi-deck, not single-deck and have a minimum area. In this study, a multi-floor layout for the liquefaction process, the dual mixed refrigerant(DMR) cycle, of LNG FPSO was determined by using the optimization technique. For this, an optimization problem for the multi-floor layout was mathematically formulated. The problem consists of 589 design variables representing the positions of topside process systems, 125 equality constraints and 2,315 inequality constraints representing limitations on the layout of them, and an objective function representing the total layout cost. To solve the problem, a hybrid optimization method that consists of the genetic algorithm(GA) and sequential quadratic programming(SQP) was used in this study. As a result, we can obtain a multi-floor layout for the liquefaction process of the LNG FPSO which satisfies all constraints related to limitations on the layout.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.11
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• pp.1565-1571
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• 2003

Physiological mechanisms, involved in unusual ovulatory sequences in domestic hen are remaining undefined. One hundred individually caged white leghorn birds were divided into two equal groups viz. control and treatment, and 2-bromo-$\alpha$-ergocryptine, was administered to birds in the treatment group to modulate prolactin (PRL) secretion from anterior pituitary gland. The effect of modulation of PRL concentrations on egg production, sequence length and intersequence pause length were studied by analysis of oviposition records of the birds from 24 to 72 weeks of age. The surviving 48 birds in the control and treatment groups averaged $34.58{\pm}1.7$ and $25.67{\pm}1.15$ sequences of oviposition, with a mean sequence length of $9.92{\pm}0.63$ and ${\pm}1.12$ days respectively. Most of the birds had a single characteristically long sequence during the entire reproductive cycle, which averaged $46.04{\pm}3.09$ days in the control birds and $59.33{\pm}4.44$ days in the treated birds. 2-bromo-$\alpha$-ergocriptine treatments had significantly decreased (p$\leq$0.01) the circulating concentrations of PRL compared to the birds of the control group. This resulted in a significant increase (p$\leq$0.01) in the number of laying days in birds of the treatment group with a concomitant decrease in the intersequence pause length. The decreased PRL levels during prime sequences in birds of the both groups, reveals the negative role of the circulating PRL levels on egg production with concomitant shorter intersequence pause length. Hence, modulation of PRL with dopamine agonist may enhance the reproductive efficiency of hens later in life.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.38 no.12
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• pp.44-55
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• 2001

MAC(Multiply and ACcumulate) is the core operation of multimedia data processing. Because MAC units implemented on traditional DSP units or embedded processors have latency of three cycles and cannot operate on multiple data simultaneously, then, performances are seriously limited. Many high end general purpose microprocessors have SIMD MAC unit as a functional unit. But these high end MAC units must support pipeline structure for various operation modes and high clock frequency, which makes control logic complex and increases chip area. In this paper, a 64bit SIMD MAC unit for embedded processors is designed. It is implemented to have a latency of one clock cycle to remove pipeline control logics and a minimal area overhead for SIMD support is added to existing Booth multipliers.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.5
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• pp.58-65
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• 2015

This paper presents the design of an implantable stimulation IC intended for neural prosthetic devices using $0.18-{\mu}m$ standard CMOS technology. The proposed single-channel biphasic current stimulator prototype is designed to deliver up to 1 mA of current to the tissue-equivalent $10-k{\Omega}$ load using 12.8-V supply voltage. To utilize only low-voltage standard CMOS transistors in the design, transistor stacking with dynamic gate biasing technique is used for reliable operation at high-voltage. In addition, active charge balancing circuit is used to maintain zero net charge at the stimulation site over the complete stimulation cycle. The area of the total stimulator IC consisting of DAC, current stimulation output driver, level-shifters, digital logic, and active charge balancer is $0.13mm^2$ and is suitable to be applied for multi-channel neural prosthetic devices.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.621-623
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• 2012

To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma ($P_{trend}$ <0.05) in six genes ($IL1RN$, $IL2$, $IL12RB1$, $JAK3$, $TNFRSF13B$, and $XRCC3$). The most significant association was seen for $IL2$ variant rs2069762 ($OR_{TG+GG}$ vs. TT=3.43 (1.29-9.11), $P_{trend}$=0.002, min$P$=0.005). These findings suggest that common genetic variants in $IL2$ might play a role in the pathogenesis of childhood lymphoma.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.347-350
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• 2012

TP53 is the mostly commonly mutated gene in many cancers and the P53 tumor suppressor protein is involved in multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control and apoptosis. A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis. The aim of this study was to understand the association of the 72 codon polymorphism with acute leukemia development and prognosis. A total of 288 acute leukemia cases comprising 147 acute lymphocytic leukemia (ALL) and 141 acute myeloid leukemia (AML), as well as 245 controls were recruited for analysis of the TP53 72 polymorphism using PCR-RFLP method. Significant association of homozygous arginine genotype with AML was observed (${\chi}^2$- 133.53; df-2, p < 0.001. When data were analyzed with respect to clinical variables, elevation in mean WBC, blast %, LDH levels and slight reduction in DFS in ALL cases with the arginine genotype was observed. In contrast, AML patients with Pro/Pro had elevated WBC, Blast%, LDH levels with slightly reduced DFS. Our study indicates that Arg/Arg genotype might confer increased risk to development of acute myeloid leukemia.